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1. Full Text Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
by Pardee, Keith and Green, Alexander A and Takahashi, Melissa K and Braff, Dana and Lambert, Guillaume and Lee, Jeong Wook and Ferrante, Tom and Ma, Duo and Donghia, Nina and Fan, Melina and Daringer, Nichole M and Bosch, Irene and Dudley, Dawn M and O’Connor, David H and Gehrke, Lee and Collins, James J
Cell, ISSN 0092-8674, 05/2016, Volume 165, Issue 5, pp. 1255 - 1266
The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here,... 
DENGUE | EPIDEMIC | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIAGNOSTICS | CELL BIOLOGY | Zika Virus - classification | Molecular Diagnostic Techniques - methods | Zika Virus - genetics | Macaca mulatta | Dengue - virology | Molecular Diagnostic Techniques - economics | Zika Virus - isolation & purification | Genetic Techniques | Zika Virus Infection - virology | Animals | Zika Virus Infection - diagnosis | Blood - virology | Computer Simulation | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Viral - isolation & purification | Dengue - diagnosis | Usage | Sensors | RNA | Dengue viruses | Genomics | Biomedical engineering | Index Medicus
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2. Full Text Prospective Evaluation of a Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System in a Hospital Clinical Microbiology Laboratory for Identification of Bacteria and Yeasts: a Bench-by-Bench Study for Assessing the Impact on Time to Identification and Cost-Effectiveness
by K. E. Tan and B. C. Ellis and R. Lee and P. D. Stamper and S. X. Zhang and K. C. Carroll
Journal of Clinical Microbiology, ISSN 0095-1137, 10/2012, Volume 50, Issue 10, pp. 3301 - 3308
Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ANAEROBIC-BACTERIA | MICROBIOLOGY | ROUTINE IDENTIFICATION | Microbiological Techniques - methods | Molecular Diagnostic Techniques - methods | Bacteria - chemistry | Fungi - classification | Humans | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - economics | Fungi - isolation & purification | Mycoses - microbiology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Fungi - chemistry | Molecular Diagnostic Techniques - economics | Bacteria - isolation & purification | Time Factors | Cost-Benefit Analysis | Bacteria - classification | Mycoses - diagnosis | Bacterial Infections - diagnosis | Microbiological Techniques - economics | Bacterial Infections - microbiology | Index Medicus | Bacteriology
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3. Full Text Target product profile for a diagnostic assay to differentiate between bacterial and non-bacterial infections and reduce antimicrobial overuse in resource-limited settings: An expert consensus
by Dittrich, Sabine and Tadesse, Birkneh Tilahun and Moussy, Francis and Chua, Arlene and Zorzet, Anna and Tängdén, Thomas and Dolinger, David L and Page, Anne-Laure and Crump, John A and D'Acremont, Valerie and Bassat, Quique and Lubell, Yoel and Newton, Paul N and Heinrich, Norbert and Rodwell, Timothy J and González, Iveth J and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0161721 - e0161721
Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is... 
C-REACTIVE PROTEIN | TESTS | MULTIDISCIPLINARY SCIENCES | PROCALCITONIN | INFANTS | MALARIA | ANTIBIOTIC-TREATMENT | PNEUMONIA | CULTURE | FEVER | CHILDREN | Diagnosis, Differential | Molecular Diagnostic Techniques - methods | Reagent Kits, Diagnostic - economics | Humans | Reagent Kits, Diagnostic - standards | Fever - diagnosis | Molecular Diagnostic Techniques - economics | Consensus | Sensitivity and Specificity | Molecular Diagnostic Techniques - standards | Developing Countries | Bacterial Infections - diagnosis | Practice Guidelines as Topic | Usage | Bacterial infections | Research | Diagnosis | Drug therapy | Antibacterial agents | Drugs | Working groups | Microbiology | Laboratories | Diagnostic tests | Infections | Shelf life | Assaying | Antiinfectives and antibacterials | Epidemiology | Tropical diseases | Illnesses | Humidity | Bacteria | Children | Public health | Vector-borne diseases | Malaria | Publications | Health | Patients | Fever | International organizations | Medicine | Studies | Hospitals | Infectious diseases | Antibiotics | Storage conditions | Product development | Diagnostic systems | Ambulatory care | Index Medicus | Infectious Medicine | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Infektionsmedicin
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4. Full Text A low cost point-of-care viscous sample preparation device for molecular diagnosis in the developing world; an example of microfluidic origami
by Govindarajan, A V and Ramachandran, S and Vigil, G D and Yager, P and Böhringer, K F
Lab on a chip, ISSN 1473-0197, 01/2012, Volume 12, Issue 1, pp. 174 - 181
The lab-on-a-chip concept has led to several point-of-care (POC) diagnostic microfluidic platforms. However, few of these can process raw samples for molecular... 
Microfluidic Analytical Techniques - methods | Sputum - microbiology | Viscosity | Molecular Diagnostic Techniques - methods | DNA, Bacterial - isolation & purification | Molecular Diagnostic Techniques - instrumentation | Microfluidic Analytical Techniques - instrumentation | Mucins - chemistry | Molecular Diagnostic Techniques - economics | Sputum - chemistry | Animals | Point-of-Care Systems | Escherichia coli - genetics | Models, Biological | Swine | Molecular Typing - economics | Molecular Typing - methods | Paper | Developing Countries | Microfluidic Analytical Techniques - economics | Molecular Typing - instrumentation | Capillary Action
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5. Full Text A simple, inexpensive device for nucleic acid amplification without electricity-toward instrument-free molecular diagnostics in low-resource settings
by LaBarre, Paul and Hawkins, Kenneth R and Gerlach, Jay and Wilmoth, Jared and Beddoe, Andrew and Singleton, Jered and Boyle, David and Weigl, Bernhard
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e19738 - e19738
Background: Molecular assays targeted to nucleic acid (NA) markers are becoming increasingly important to medical diagnostics. However, these are typically... 
HIV-1 | REVERSE-TRANSCRIPTION | ASSAY | TECHNOLOGIES | VIRUS | MEDIATED ISOTHERMAL AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | DNA AMPLIFICATION | LAMP | RAPID DETECTION | Reference Standards | Electricity | Molecular Diagnostic Techniques - instrumentation | Plasmodium falciparum - genetics | Nucleic Acid Amplification Techniques - economics | Molecular Diagnostic Techniques - standards | Developing Countries | Hot Temperature | Molecular Diagnostic Techniques - economics | Nucleic Acid Amplification Techniques - instrumentation | Nucleic Acid Amplification Techniques - standards | Nucleic acids | Diagnostic equipment (Medical) | Chemical tests and reagents | Analysis | Communicable diseases | Developed countries | Malaria | Diagnostic tests | Innovations | Nuclear electric power generation | Chemical reactions | Instrumentation | Cold storage | Temperature profiles | Assaying | Polymerase chain reaction | Phase change materials | Amplification | Infectious diseases | Sample preparation | Acids | Exothermic reactions | Diagnostic systems | Deoxyribonucleic acid--DNA | Methods | Index Medicus | Deoxyribonucleic acid | DNA
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6. Full Text Cost-Effectiveness of a Novel Molecular Test for Cytologically Indeterminate Thyroid Nodules
by Li, Henry and Robinson, Karen A and Anton, Blair and Saldanha, Ian J and Ladenson, Paul W
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2011, Volume 96, Issue 11, pp. E1719 - E1726
Context: Determining which patients with thyroid nodules require surgery is limited by cytologically indeterminate findings. A new approach for preoperative... 
DECISION-ANALYSIS | MALIGNANCY | MANAGEMENT | FINE-NEEDLE-ASPIRATION | ULTRASOUND | DIAGNOSTIC-TOOL | ENDOCRINOLOGY & METABOLISM | QUALITY-OF-LIFE | PAPILLARY | CANCER | CARCINOMA | Cost-Benefit Analysis - economics | Quality-Adjusted Life Years | Thyroid Nodule - pathology | Biopsy, Fine-Needle - economics | Humans | Thyroid Nodule - economics | Cytological Techniques | Decision Support Techniques | Thyroid Nodule - diagnosis | Adult | Molecular Diagnostic Techniques - economics | Index Medicus | Abridged Index Medicus
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7. Full Text Exosome cancer diagnostic reaches market
by Sheridan, Cormac
Nature biotechnology, ISSN 1087-0156, 04/2016, Volume 34, Issue 4, pp. 359 - 360
  The first blood-based cancer diagnostic to exploit free-floating exosomes became commercially available in the US on January 21. The launch of this liquid... 
Biotechnology - methods | Molecular Diagnostic Techniques - methods | Neoplasms - genetics | Humans | Biotechnology - economics | Neoplasms - diagnosis | Molecular Diagnostic Techniques - economics | Exosomes | Medical examination | Diagnosis | Product introduction | Biotechnology industry | Blood | Cancer | Medical diagnosis | Biopsy
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8. Full Text Towards Clinical Molecular Diagnosis of Inherited Cardiac Conditions: A Comparison of Bench-Top Genome DNA Sequencers
by Li, Xinzhong and Buckton, Andrew J and Wilkinson, Samuel L and John, Shibu and Walsh, Roddy and Novotny, Tomas and Valaskova, Iveta and Gupta, Manu and Game, Laurence and Barton, Paul J. R and Cook, Stuart A and Ware, James S
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e67744 - e67744
Background: Molecular genetic testing is recommended for diagnosis of inherited cardiac disease, to guide prognosis and treatment, but access is often limited... 
MUTATIONS | PREVALENCE | FIDELITY | ION TORRENT | HIGH-THROUGHPUT | MULTIDISCIPLINARY SCIENCES | High-Throughput Nucleotide Sequencing - economics | Molecular Diagnostic Techniques - methods | Exons | Humans | Molecular Diagnostic Techniques - instrumentation | Heredity | Molecular Diagnostic Techniques - economics | Genetic Testing - methods | Sequence Analysis, DNA | Genetic Testing - instrumentation | Arrhythmias, Cardiac - diagnosis | Genetic Testing - economics | High-Throughput Nucleotide Sequencing - instrumentation | Genome, Human | High-Throughput Nucleotide Sequencing - methods | Arrhythmias, Cardiac - genetics | Usage | Care and treatment | Prognosis | Analysis | Nucleotide sequencing | Heart diseases | Genetic screening | DNA sequencing | Multiplexing | Heart | Cardiac arrhythmia | Biomedical research | Arrhythmia | Cardiomyopathy | Genomics | Genes | Cardiovascular disease | Genomes | Gene sequencing | Long QT syndrome | Diagnosis | Cardiology | Bioinformatics | Deoxyribonucleic acid--DNA | Platforms | Internal medicine | Nucleotide sequence | Medical treatment | Workflow | Capital | Disease control | Coronary artery disease | Polymerase chain reaction | Medicine | Diagnostic systems | Mutation | Genetic testing | Index Medicus | Deoxyribonucleic acid | Coronary heart disease | DNA
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9. Full Text MRSA screening by the Xpert MRSA PCR assay: pooling samples of the nose, throat, and groin increases the sensitivity of detection without increasing the laboratory costs
by Blanc, D S and Nahimana, I and Zanetti, G and Greub, G
European Journal of Clinical Microbiology & Infectious Diseases, ISSN 0934-9723, 4/2013, Volume 32, Issue 4, pp. 565 - 568
The performance of the Xpert MRSA polymerase chain reaction (PCR) assay on pooled nose, groin, and throat swabs (three nylon flocked eSwabs into one tube) was... 
Medical Microbiology | Internal Medicine | Biomedicine | SYSTEM | INFECTIOUS DISEASES | ANATOMICAL SITES | CARRIAGE | SPECIMENS | ADMISSION | SWABS | SURVEILLANCE | MICROBIOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | CULTURE | Molecular Diagnostic Techniques - methods | Costs and Cost Analysis | Specimen Handling - economics | Bacteriological Techniques - methods | Mass Screening - economics | Humans | Specimen Handling - methods | Carrier State - microbiology | Molecular Diagnostic Techniques - economics | Mass Screening - methods | Polymerase Chain Reaction - economics | Polymerase Chain Reaction - methods | Staphylococcal Infections - diagnosis | Sensitivity and Specificity | Carrier State - diagnosis | Staphylococcal Infections - microbiology | Groin - microbiology | Methicillin-Resistant Staphylococcus aureus - isolation & purification | Nose - microbiology | Bacteriological Techniques - economics | Pharynx - microbiology | Medicine, Preventive | Analysis | Staphylococcus aureus | Staphylococcus aureus infections | Preventive health services | Index Medicus
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10. Full Text Multiplex molecular testing for management of infectious gastroenteritis in a hospital setting: a comparative diagnostic and clinical utility study
by Halligan, E and Edgeworth, J and Bisnauthsing, K and Bible, J and Cliff, P and Aarons, E and Klein, J and Patel, A and Goldenberg, S
Clinical Microbiology and Infection, ISSN 1198-743X, 08/2014, Volume 20, Issue 8, pp. O460 - O467
Laboratory diagnosis and clinical management of inpatients with diarrhoea is complex and time consuming. Tests are often requested sequentially and undertaken... 
molecular diagnostics | infection control | gastroenteritis | Diagnostic accuracy | Molecular diagnostics | Gastroenteritis | Infection control | UNITED-STATES | ETIOLOGY | INFECTIOUS DISEASES | INTESTINAL DISEASE | ENTERIC PATHOGENS | FECAL SAMPLES | GENERAL-PRACTICE | MICROBIOLOGY | CRITICALLY-ILL | CLOSTRIDIUM-DIFFICILE | NOSOCOMIAL DIARRHEA | PCR | Patient Isolation - economics | Molecular Diagnostic Techniques - methods | Cross Infection - prevention & control | Humans | Middle Aged | Child, Preschool | Diarrhea - prevention & control | Gastroenteritis - diagnosis | Infant | Male | Molecular Diagnostic Techniques - economics | Gastroenteritis - prevention & control | Young Adult | Diarrhea - diagnosis | Hospitals | Time Factors | Adolescent | Aged, 80 and over | Cross Infection - diagnosis | Adult | Female | Aged | Child | Cross infection | Diagnosis | Nosocomial infections | Comparative analysis | Health aspects | Index Medicus
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11. Full Text Economic Analysis of Rapid and Sensitive Polymerase Chain Reaction Testing in the Emergency Department for Influenza Infections in Children
by Nelson, Richard E and Stockmann, Chris and Hersh, Adam L and Pavia, Andrew T and Korgenksi, Kent and Daly, Judy A and Couturier, Marc R and Ampofo, Krow and Thorell, Emily A and Doby, Elizabeth H and Robison, Jeff A and Blaschke, Anne J
The Pediatric Infectious Disease Journal, ISSN 0891-3668, 06/2015, Volume 34, Issue 6, pp. 577 - 582
BACKGROUND:Rapid multiplex polymerase chain reaction (PCR) assays simultaneously detect several respiratory viral pathogens with high sensitivity. Maximizing... 
effectiveness analysis | cost | viral diagnostic tests | Influenza | pediatrics | INFECTIOUS DISEASES | COST-EFFECTIVENESS | MANAGEMENT | CRITICALLY-ILL CHILDREN | IMMUNOLOGY | cost-effectiveness analysis | ACCURACY | IMPACT | DIAGNOSTIC ASSAYS | HOSPITALIZATIONS | COMPLICATIONS | OSELTAMIVIR TREATMENT | PCR | Emergency Service, Hospital | Molecular Diagnostic Techniques - methods | Multiplex Polymerase Chain Reaction - methods | Immunoassay - economics | Humans | Child, Preschool | Multiplex Polymerase Chain Reaction - economics | Infant | Male | Molecular Diagnostic Techniques - economics | Time Factors | Cost-Benefit Analysis | Emergency Medicine - economics | Adolescent | Immunoassay - methods | Female | Influenza, Human - diagnosis | Child | Emergency Medicine - methods | Index Medicus
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12. Full Text Optimized Use of the MALDI BioTyper System and the FilmArray BCID Panel for Direct Identification of Microbial Pathogens from Positive Blood Cultures
by Fiori, B and D'Inzeo, T and Giaquinto, A and Menchinelli, G and Liotti, F.M and De Maio, F and De Angelis, G and Quaranta, G and Nagel, D and Tumbarello, M and Posteraro, B and Sanguinetti, M and Spanu, T
Journal of Clinical Microbiology, ISSN 0095-1137, 03/2016, Volume 54, Issue 3, pp. 576 - 584
Despite the current reliance on blood cultures (BCs), the diagnosis of bloodstream infections (BSIs) can be sped up using new technologies performed directly... 
YEAST | MICROORGANISMS | BACTERIA | FLIGHT MASS-SPECTROMETRY | DESORPTION IONIZATION-TIME | PERFORMANCE | MICROBIOLOGY | STREAM INFECTIONS | TOF MS | SEPSITYPER | RAPID IDENTIFICATION | Microbiological Techniques - methods | Molecular Diagnostic Techniques - methods | Prospective Studies | Humans | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - economics | Sepsis - diagnosis | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Blood - microbiology | Molecular Diagnostic Techniques - economics | Polymerase Chain Reaction - methods | Algorithms | Time Factors | Sensitivity and Specificity | Microbiological Techniques - economics | Index Medicus | Bacteriology
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