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1. Full Text Chemical probes of endocannabinoid metabolism
by Blankman, Jacqueline L and Cravatt, Benjamin F
Pharmacological Reviews, ISSN 0031-6997, 2013, Volume 65, Issue 2, pp. 849 - 871
The endocannabinoid signaling system regulates diverse physiologic processes and has attracted considerable attention as a potential pharmaceutical target for... 
ALPHA-KETOHETEROCYCLE INHIBITORS | ACID AMIDE HYDROLASE | RAT CEREBELLAR MEMBRANES | LONG-TERM DEPRESSION | ACTIVITY IN-VIVO | PHARMACOLOGY & PHARMACY | COPPER(I)-CATALYZED AZIDE-ALKYNE | BONE CANCER PAIN | CANNABINOID RECEPTOR AGONIST | PROBLEM DRUG-USE | N-ACYL ETHANOLAMINE | Endocannabinoids - metabolism | Substance-Related Disorders - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Humans | Amidohydrolases - antagonists & inhibitors | Glycerides - metabolism | Pain - metabolism | Polyunsaturated Alkamides - metabolism | Enzyme Inhibitors - therapeutic use | Depression - drug therapy | Arachidonic Acids - metabolism | Depression - metabolism | Animals | Signal Transduction - drug effects | Pain - drug therapy | Enzyme Inhibitors - chemistry | Endocannabinoids - biosynthesis | Ligands | Molecular Structure | Substance-Related Disorders - drug therapy | Disease Models, Animal | Review
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2. Full Text Ruthenium(ii) polypyridyl complexes and DNA - From structural probes to cellular imaging and therapeutics
by Gill, Martin R and Thomas, Jim A
Chemical Society Reviews, ISSN 0306-0012, 04/2012, Volume 41, Issue 8, pp. 3179 - 3192
In the last few decades, coordination complexes based on d(6) metal centres and polypyridyl ligand architectures been developed as structure- and site-specific... 
LIGHT-SWITCH | CANCER-CELLS | STRANDED-DNA | BASE MISMATCHES | BINDING MODE | TRANSITION-METAL-COMPLEXES | ANTICANCER DRUG CISPLATIN | CRYSTAL-STRUCTURE | MAJOR ADDUCT | G-QUADRUPLEX DNA | CHEMISTRY, MULTIDISCIPLINARY | Molecular Probes - toxicity | Organometallic Compounds - toxicity | Pyridines - chemistry | Humans | Molecular Imaging - methods | DNA - metabolism | Ruthenium - chemistry | DNA - chemistry | Molecular Probes - chemistry | Molecular Probes - metabolism | Organometallic Compounds - metabolism | Cell Line, Tumor | Organometallic Compounds - therapeutic use | Organometallic Compounds - chemistry | Molecular Probes - therapeutic use
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3. Full Text Glycopolymer probes of signal transduction
by Kiessling, Laura L and Grim, Joseph C and Grim, Joseph C
Chemical Society Reviews, ISSN 0306-0012, 05/2013, Volume 42, Issue 10, pp. 4476 - 4491
Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the... 
CONCANAVALIN-A | OPENING METATHESIS POLYMERIZATION | L-SELECTIN | C-TYPE LECTIN | DENDRITIC CELLS | CHONDROITIN SULFATE PROTEOGLYCANS | DC-SIGN | SURFACE-PLASMON RESONANCE | CHEMISTRY, MULTIDISCIPLINARY | STRONGLY INHIBIT AGGLUTINATION | SYNTHETIC MULTIVALENT LIGANDS | Signal Transduction | Humans | Receptors, Cell Surface - metabolism | Mucins - chemistry | Polysaccharides - metabolism | Biomimetic Materials - metabolism | Molecular Probes - chemistry | Molecular Probes - metabolism | Mucins - metabolism | Polysaccharides - chemistry | Polymers - chemistry | Receptors, Cell Surface - chemistry | Biomimetic Materials - chemistry | Carbohydrates | Reproduction | Cellular communication | Glycopolymers | Derivatives | Polymers | Glycan | Bearing
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4. Full Text Mitochondria-Targeted Small Molecule Therapeutics and Probes
by Smith, Robin A.J and Hartley, Richard C and Murphy, Michael P
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2011, Volume 15, Issue 12, pp. 321 - 3038
Significance: Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing... 
Forum Review Articles | ANTIOXIDANT MITOQ | PEPTIDE ANTIOXIDANTS | OXIDATIVE-PHOSPHORYLATION | SPIN TRAP | PHOSPHONIUM | REACTIVE OXYGEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | SUPEROXIDE-DISMUTASE | CU-64-LABELED TRIPHENYLPHOSPHONIUM | CELL-DEATH | Animals | Molecular Probes - metabolism | Antioxidants - metabolism | Humans | Organophosphorus Compounds - pharmacology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Molecular Targeted Therapy | Organophosphorus Compounds - metabolism | Antioxidants | Physiological aspects | Mitochondria | Research | Peptides
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5. Full Text Target validation using chemical probes
by Bunnage, Mark E and Chekler, Eugene L. Piatnitski and Jones, Lyn H
Nature Chemical Biology, ISSN 1552-4450, 04/2013, Volume 9, Issue 4, pp. 195 - 199
  Fully proled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target... 
ZEBRAFISH EMBRYOS | BROMODOMAINS | POTENT | SMALL-MOLECULE INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE INHIBITORS | IDENTIFICATION | DISCOVERY | PROTEOMICS | Molecular Probes - chemistry | Molecular Probes - metabolism | Validation Studies as Topic | Humans | Cell Membrane Permeability | Structure-Activity Relationship | Drug Evaluation, Preclinical | Molecular Targeted Therapy | Biomarkers, Pharmacological - chemistry | Biomarkers, Pharmacological - metabolism | Drug Discovery | Biology | Chemicals
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6. Full Text An Autophagic Flux Probe that Releases an Internal Control
by Kaizuka, Takeshi and Morishita, Hideaki and Hama, Yutaro and Tsukamoto, Satoshi and Matsui, Takahide and Toyota, Yuichiro and Kodama, Akihiko and Ishihara, Tomoaki and Mizushima, Noboru and Mizushima, Tohru
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 835 - 849
Macroautophagy is an intracellular degradation system that utilizes the autophagosome to deliver cytoplasmic components to the lysosome. Measuring autophagic... 
ACTIVATED PROTEIN-KINASE | INHIBITION | AMINO-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | STARVATION | ENDOPLASMIC-RETICULUM STRESS | FLOW-CYTOMETRY | MAMMALIAN-CELLS | LC3 | ORGANELLE DEGRADATION | CELL BIOLOGY | Small Molecule Libraries - pharmacology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Green Fluorescent Proteins - genetics | Autophagy - drug effects | DNA-Binding Proteins - metabolism | Cysteine Endopeptidases - metabolism | Lysosomes - metabolism | Molecular Probes - metabolism | Autophagy - genetics | Nuclear Proteins - genetics | Genes, Reporter | Phagosomes - drug effects | Lysosomes - drug effects | Green Fluorescent Proteins - metabolism | Phagosomes - metabolism | Gene Expression Regulation | Spectrometry, Fluorescence | Nuclear Proteins - metabolism | Zebrafish | DNA-Binding Proteins - genetics | Animals | High-Throughput Screening Assays | Cysteine Endopeptidases - genetics | Embryo, Nonmammalian | Mice | HeLa Cells | Molecular Probes - genetics | Internal control (Accounting) | Medical colleges | Proteases | Pharmacy | Genomics | Drug approval | Investigations
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7. Full Text Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes
by Morgan, Bruce and Van Laer, Koen and Owusu, Theresa N. E and Ezeriņa, Daria and Pastor-Flores, Daniel and Amponsah, Prince Saforo and Tursch, Anja and Dick, Tobias P
Nature Chemical Biology, ISSN 1552-4450, 06/2016, Volume 12, Issue 6, pp. 437 - 443
Genetically encoded probes based on the H2O2-sensing proteins OxyR and Orp1 have greatly increased the ability to detect elevated H2O2 levels in stimulated or... 
YEAST | MAINTENANCE | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | GENES | INTRACELLULAR HYDROGEN-PEROXIDE | SACCHAROMYCES-CEREVISIAE | EXPRESSION | Peroxiredoxins - metabolism | Homeostasis | Mitochondria - metabolism | Oxygen - metabolism | Hydrogen Peroxide - metabolism | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Molecular Probes - metabolism | Time Factors | Hydrogen Peroxide - analysis | Partial Pressure | Cytosol - metabolism | Saccharomyces cerevisiae - growth & development | Proteins | Cell growth | Biochemistry | Hydrogen peroxide
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8. Full Text Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes
by Lo, Kenneth Kam-Wing and Choi, Alex Wing-Tat and Law, Wendell Ho-Tin
Dalton Transactions, ISSN 1477-9226, 5/2012, Volume 41, Issue 2, pp. 621 - 647
The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and... 
ELECTROCHEMICAL PROPERTIES | BIOLOGICAL PROBES | IRIDIUM(III) POLYPYRIDINE COMPLEXES | NITRIC-OXIDE SYNTHASE | LABELING REAGENTS | PSEUDOMONAS-AERUGINOSA AZURINS | PROTEIN-BINDING PROPERTIES | CYCLOMETALATED PLATINUM(II) COMPLEXES | MOLECULAR LIGHT SWITCH | AMIDODIPYRIDOQUINOXALINE BIOTIN COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR | Transition Elements - chemistry | Cell Line | Luminescent Agents - chemistry | Molecular Probes - toxicity | Luminescent Agents - toxicity | Organometallic Compounds - toxicity | Humans | Molecular Probes - chemistry | Animals | Molecular Probes - metabolism | Proteins - metabolism | Organometallic Compounds - metabolism | Cells - metabolism | Organometallic Compounds - chemistry | Luminescent Agents - metabolism | Uptakes | Cellular | Covalence | Transition metals | Emission analysis | Metalorganic compounds | Biological | Localization
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