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2012, ISBN 1439839735, xviii, 373 p., [16] p. of plates
.... This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively... 
Molecular Probe Techniques | methods | Ligands | drug effects | metabolism | Drug Discovery | Binding Sites | Nucleic Acids
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Journal of medicinal chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4350 - 4364
The design, synthesis, docking, and biological evaluation of novel potent HDAC3 and HDAC8 isoxazole- and pyrazole-based diazide probes suitable for binding ensemble profiling with photoaffinity labeling (BEProFL... 
Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Cell Membrane Permeability | Hydroxamic Acids - chemistry | Structure-Activity Relationship | Azides - chemistry | Isoxazoles - chemical synthesis | Histone Deacetylase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Neuroprotective Agents - pharmacology | Drug Design | Antineoplastic Agents - pharmacology | Azides - pharmacology | Azides - chemical synthesis | Hydroxamic Acids - pharmacology | Repressor Proteins - metabolism | Pyrazoles - pharmacology | Repressor Proteins - chemistry | Neuroprotective Agents - chemistry | Histone Deacetylases - chemistry | Models, Molecular | Histone Deacetylases - metabolism | Isoxazoles - chemistry | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | Photoaffinity Labels - chemical synthesis | Isoxazoles - pharmacology | Neuroprotective Agents - chemical synthesis | Photoaffinity Labels - pharmacology | Matrix Metalloproteinases - chemistry | Cell Line, Tumor | Matrix Metalloproteinase Inhibitors | Protein Binding | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - chemical synthesis | Drug Screening Assays, Antitumor | Photoaffinity Labels - chemistry | BEProFL | neuroprotection | diazide probes | histone deacetylases | Binding Ensemble Profiling with Photoaffinity Labeling | pyrazoles | isoxazoles | antiproliferative activity | HDAC
Journal Article
Journal Article