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Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 8, pp. 536 - 541
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 8, pp. 2080 - 2085
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
DESIGN | PLACEBO | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | OPTIMIZATION | GENERATION | INHIBITORS | COORDINATE | CYSTEINES | PREDICTION | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 05/2017, Volume 13, Issue 5, pp. 529 - 536
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2015, Volume 11, Issue 12, pp. 973 - 980
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 05/2017, Volume 12, Issue 5, pp. 453 - 459
Journal Article