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monastrol (71) 71
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Tetrahedron, ISSN 0040-4020, 01/2015, Volume 71, Issue 1, pp. 139 - 146
Journal Article
Phosphorus, Sulfur, and Silicon and the Related Elements, ISSN 1042-6507, 11/2019, Volume 194, Issue 11, pp. 1020 - 1027
A new series of mononuclear ruthenium(II) complexes of the type [Ru(PPh 3 ) 2 (N,S-L 1-3 ) 2 ] 2H 3 O + .(Cl − ) 2. XH 2 O, [RuCl(dmso) 3 (N,S-L 1-3 )], and... 
Anti-HIV activity | anti-Dyrk1A activity | ruthenium(II) complexes | monastrol and analogs | cytotoxicity
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2010, Volume 20, Issue 14, pp. 4073 - 4076
A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via... 
Biginelli reaction | Hantzsch reaction | Oxygen-bridged nitrogen heterocycles | Monastrol analogs | EG5 | POTENT | CHEMISTRY, MEDICINAL | HETEROCYCLES | CHEMISTRY, ORGANIC | INHIBITORS | IDENTIFICATION | Thiones - chemistry | Pyrimidines - chemistry | Oxygen - chemistry
Journal Article
Heterocycles, ISSN 0385-5414, 2017, Volume 94, Issue 10, pp. 1856 - 1869
The synthesis of triazolyl monastrol analogues through a Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition (CuAAC) reactions and their biological evaluation... 
Cu-Catalysis | Triazole | AZIDES | Click Chemistry | BIGINELLI REACTION | CHEMISTRY, ORGANIC | Monastrol Analogue | Anticancer Activity | MITOTIC KINESIN EG5 | TERMINAL ALKYNES | DISCOVERY | SOLVENT-FREE | CYCLOADDITIONS | INHIBITORS | DIHYDROPYRIMIDINE | IN-SITU
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2007, Volume 59, Issue 2, pp. 157 - 164
The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs... 
Biomedicine | Chemosensitivity | Oncology | Cancer Research | Confocal microscopy | Human glioblastoma cells | Pharmacology/Toxicology | Kinesin inhibitors | Monastrol analogues | monastrol analogues | PROTEIN | P-GLYCOPROTEIN | PACLITAXEL | kinesin inhibitors | POTENT | ONCOLOGY | confocal microscopy | IN-VIVO | BIOLOGICAL EVALUATION | human glioblastoma cells | PHARMACOLOGY & PHARMACY | chemosensitivity | MULTIDRUG-RESISTANCE | BRAIN | Fluoresceins - pharmacology | Cysteine - analogs & derivatives | Flow Cytometry - methods | Paclitaxel - pharmacology | Tubulin Modulators - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Tubulin - metabolism | Spindle Apparatus - metabolism | Time Factors | Cysteine - pharmacology | Rotenone - pharmacology | Glioblastoma - metabolism | Molecular Structure | Kinesin - antagonists & inhibitors | Quinazolines - chemistry | Insecticides - pharmacology | Cell Survival - drug effects | Tetrahydroisoquinolines - pharmacology | Thiones - chemistry | Pyrimidines - pharmacology | Kinesin - metabolism | Acridines - pharmacology | Glioblastoma - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Spindle Apparatus - drug effects | Vinblastine - pharmacology | Thiones - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Quinazolines - pharmacology | Brain tumors
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 138, pp. 300 - 312
The α βδ subtype of the γ-aminobutyric acid (GABA) type A receptors (GABA Rs) has been shown to be implicated in high-affinity binding of the neuromodulator... 
Biginelli cyclocondensation | GHB high-affinity binding sites | Allosteric modulators | GABAA receptor | Monastrol analogues | GABA | receptor | Index Medicus
Journal Article
ANTICANCER RESEARCH, ISSN 0250-7005, 04/2014, Volume 34, Issue 4, pp. 1837 - 1842
Background/Aim: Glioblastoma multiforme is the most malignant type of glioma. Ecto-5'-nucleotidase (ecto-5'NT), a glioma-overexpressed enzyme can induce a... 
ANTIPROLIFERATIVE ACTIVITY | ANALOGS | ecto-5 ' nucleotidase | ADENOSINE | PROLIFERATION | CANCER | SMALL-MOLECULE INHIBITOR | MALIGNANT GLIOMA | EG5 | MITOTIC KINESIN | Glioma | ONCOLOGY | LaSOM 63 | CHECKPOINT | monastrol
Journal Article
Letters in Organic Chemistry, ISSN 1570-1786, 07/2007, Volume 4, Issue 5, pp. 357 - 361
A highly efficient and environmentally benign reaction of dimedone with various aldehydes and N-arylthioureas to afford monastrol analogues is revealed. The... 
Multicomponent reactions | Microwaves | Electronic and steric effects | Monastrol | microwaves | BLOCKERS | multicomponent reactions | BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS | CHEMISTRY, ORGANIC | electronic and steric effects | monastrol
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 09/2017, Volume 138, pp. 300 - 312
The (alpha(4)beta delta subtype of the gamma-aminobutyric acid (GABA) type A receptors (GABA(A)Rs) has been shown to be implicated in high-affinity binding of... 
ACTIVATION | CHEMISTRY, MEDICINAL | GHB high-affinity binding sites | GAMMA-HYDROXYBUTYRIC ACID | BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS | PROTOCOL | MITOTIC KINESIN EG5 | Biginelli cyclocondensation | CATALYST | Monastrol analogues | INHIBITOR MONASTROL | THIONES | Allosteric modulators | GABA(A) receptor | TARGETS | AGONIST
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2013, Volume 2013, Issue 21, pp. 4594 - 4606
Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive... 
Fused‐ring systems | Medicinal chemistry | Nitrogen heterocycles | Cyclization | Alk­aloids | Alkaloids | Fused-ring systems | DESIGN | RNA | MONASTROL | ANALOGS | BIGINELLI REACTION | ADENOSINE | CHEMISTRY, ORGANIC | MECHANISMS | THEOPHYLLINE | MITOTIC KINESIN | INHIBITOR | Theophylline
Journal Article
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2015, Volume 6, Issue 5, pp. 906 - 915
Journal Article
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