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Nature Neuroscience, ISSN 1097-6256, 09/2010, Volume 13, Issue 9, pp. 1113 - 1119
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system.... 
PRECIPITATED WITHDRAWAL | NEUROPATHIC PAIN | ACID AMIDE HYDROLASE | IN-VIVO | ANANDAMIDE | DELTA-TETRAHYDROCANNABINOL | CANNABINOID RECEPTOR ADAPTATION | MICE | RAT-BRAIN | NEUROSCIENCES | KNOCKOUT MOUSE | Cannabinoid Receptor Modulators - metabolism | Analgesics - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | Neuronal Plasticity - drug effects | Male | Benzodioxoles - administration & dosage | Pain - metabolism | Brain - physiology | Monoacylglycerol Lipases - genetics | Enzyme Inhibitors - administration & dosage | Monoacylglycerol Lipases - metabolism | Neuronal Plasticity - physiology | Piperidines - pharmacology | Pain - drug therapy | Female | Models, Animal | Endocannabinoids | Amidohydrolases - metabolism | Synapses - drug effects | Piperidines - administration & dosage | Synapses - physiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Analgesics - administration & dosage | Amidohydrolases - antagonists & inhibitors | Mice, Transgenic | Mice, Knockout | Brain - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Animals | Cannabinoid Receptor Modulators - antagonists & inhibitors | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Complications and side effects | Cannabinoids | Drug tolerance | Physiological aspects | Neuropharmacology | Research | Properties | Drug receptors | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 808 - 819
Background and purpose JZL184 is a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme that preferentially catabolizes the endocannabinoid... 
monoacylglycerol lipase | endocannabinoid | | frontal cortex | NF‐κB | cytokines | brain | plasma | JZL | 184 | TNF | 10 | IL-1β | IL-10 | IL-6 | JZL184 | NF-κB | TNF-α | 2-AG | CELLS | IL-1 | 2-ARACHIDONYL GLYCEROL | NF-B | RECEPTOR | NECROSIS-FACTOR-ALPHA | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | COX-2 EXPRESSION | IN-VIVO | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | CANNABINOIDS | Benzodioxoles - antagonists & inhibitors | Spleen - immunology | Frontal Lobe - metabolism | Male | Spleen - drug effects | Prostaglandins - blood | Lipopolysaccharides | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Glycerides - blood | Arachidonic Acids - blood | Enzyme Inhibitors - chemistry | Anti-Anxiety Agents - therapeutic use | Benzodioxoles - therapeutic use | Peritonitis - metabolism | Rats | Encephalitis - immunology | Random Allocation | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Cannabinoid Receptor Antagonists - therapeutic use | Monoacylglycerol Lipases - blood | Peritonitis - drug therapy | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Endocannabinoids - metabolism | Nerve Tissue Proteins - blood | Monoacylglycerol Lipases - antagonists & inhibitors | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Encephalitis - drug therapy | Encephalitis - metabolism | Cytokines - blood | Nerve Tissue Proteins - antagonists & inhibitors | Cytokines - metabolism | Peritonitis - immunology | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Spleen - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Piperidines - therapeutic use | Frontal Lobe - drug effects | Cannabinoid Receptor Antagonists - chemistry | Frontal Lobe - immunology | Cytokines - antagonists & inhibitors | Endocannabinoids - blood | Prostaglandins - metabolism | Glycerin | Brain | Unsaturated fatty acids | Cytokines | Glycerol | Lipase | Mitogens | Plasma | Rodents | Index Medicus | Cannabinoids 2012, Part Two | Themed Section
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 03/2013, Volume 92, Issue 8-9, pp. 498 - 505
The present study tested whether the selective monoacylglycerol lipase (MAGL) inhibitor JZL184 would reduce allodynia and paw edema in the carrageenan test.... 
Allodynia | CB2 receptor | 2-arachidonylglycerol (2-AG) | Pain | Monoacylglycerol lipase (MAGL) | Endogenous cannabinoid | CB1 receptor | Fatty acid amide hydrolase | Inflammation | Carrageenan | Anandamide | receptor | MEDICINE, RESEARCH & EXPERIMENTAL | PERIAQUEDUCTAL GRAY | FOS PROTEIN EXPRESSION | ENDOCANNABINOID SYSTEM | 2-ARACHIDONOYL GLYCEROL | STRESS-INDUCED ANALGESIA | NEUROPATHIC PAIN | CB2 RECEPTORS | ACID AMIDE HYDROLASE | FAAH INHIBITOR | PHARMACOLOGY & PHARMACY | CANNABINOID-INDUCED ANTINOCICEPTION | Hyperalgesia - chemically induced | Inflammation - chemically induced | Inflammation - pathology | Monoacylglycerol Lipases - antagonists & inhibitors | Pain - chemically induced | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - genetics | Piperidines - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Physical Stimulation | Diclofenac - therapeutic use | Mice, Inbred C57BL | Amidohydrolases - antagonists & inhibitors | Pain Measurement - drug effects | Edema - drug therapy | Pain - pathology | Mice, Knockout | Animals | Receptor, Cannabinoid, CB1 - genetics | Hyperalgesia - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Mice | Pyridines - pharmacology | Edema - chemically induced | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Lipase | Fatty acids | Carrageenin | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases | Animal models | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2011, Volume 163, Issue 7, pp. 1464 - 1478
Journal Article
Journal Article
Journal Article