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BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 07/2012, Volume 1821, Issue 7, pp. 1012 - 1021
Monoacylglycerol lipases (MGLs) catalyse the hydrolysis of monoacylglycerol into free fatty acid and glycerol. MGLs have been identified throughout all genera... 
X-ray crystallography | Monoacylglycerol lipase | Molecular dynamics simulation | Open conformation | Evolutionary conservation | Small-angle X-ray scattering | SYSTEM | MACROMOLECULAR STRUCTURES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA/BETA HYDROLASE FOLD | MOUSE MONOGLYCERIDE LIPASE | CELL BIOLOGY | PSEUDOMONAS SP LP7315 | BIOPHYSICS | PURIFICATION | FORCE-FIELD | PROTEINS | SCATTERING | Phenylmethylsulfonyl Fluoride - chemistry | Escherichia coli | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Monoacylglycerol Lipases - chemistry | Monoacylglycerol Lipases - genetics | Monoacylglycerol Lipases - metabolism | Cloning, Molecular | Conserved Sequence | Monoglycerides - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Protein Structure, Secondary | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Bacillus - genetics | Recombinant Proteins - genetics | Monoglycerides - metabolism | Molecular Dynamics Simulation | Sequence Alignment | Bacillus - enzymology | Hydrophobic and Hydrophilic Interactions | Bacterial Proteins - metabolism | Structural Homology, Protein | Glycerin | Enzymes | Analysis | Crystals | Physiological aspects | Glycerol | Lipase | Structure | Fatty acids | Monoglycerides | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 17467 - 17477
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2016, Volume 31, Issue 1, pp. 137 - 146
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 9/2014, Volume 43, Issue 19, pp. 6859 - 6869
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17558 - 17563
Proinflammatory macrophages are key mediators in several pathologies; thus, controlling their activation is necessary. The endocannabinoid system is implicated... 
Enzymes | Receptors | Antiinflammatories | Messenger RNA | Cell lines | Macrophage activation | Inflammation | Macrophages | Endocannabinoids | Cannabinoid receptors | FAAH | Glyceryl prostaglandin | COX-2 | Anandamide | Prostaglandin synthase | prostaglandin synthase | CELLS | MONOACYLGLYCEROL LIPASE | 2-ARACHIDONYL GLYCEROL | MULTIDISCIPLINARY SCIENCES | ARACHIDONIC-ACID | INTERNATIONAL-UNION | CANNABINOID RECEPTORS | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | ACID AMIDE HYDROLASE | glyceryl prostaglandin | INHIBITORS | BLOCKADE | anandamide | Endocannabinoids - metabolism | Inflammation - chemically induced | Endocannabinoids - pharmacology | Gene Expression - drug effects | Monoacylglycerol Lipases - antagonists & inhibitors | Male | Interleukin-1beta - genetics | Monoacylglycerol Lipases - genetics | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Cyclooxygenase 2 - genetics | Esters - chemistry | Interleukin-1beta - metabolism | Lipocalins - genetics | Prostaglandin D2 - metabolism | Female | Glycerol - chemistry | Intramolecular Oxidoreductases - metabolism | Carbamates - pharmacology | Lipocalins - metabolism | Cell Line | Lipopolysaccharides - toxicity | Enzyme-Linked Immunosorbent Assay | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Glycerides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Arachidonic Acids - pharmacology | Prostaglandin D2 - chemistry | Glycerides - pharmacology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Intramolecular Oxidoreductases - genetics | Cyclooxygenase 2 - metabolism | Macrophages - drug effects | Inflammation - prevention & control | Mice | Prostaglandin D2 - pharmacology | Macrophage Activation - drug effects | Prostaglandins | Physiological aspects | Lipid metabolism | Research | Health aspects | Biological Sciences
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2010, Volume 13, Issue 9, pp. 1113 - 1119
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system.... 
PRECIPITATED WITHDRAWAL | NEUROPATHIC PAIN | ACID AMIDE HYDROLASE | IN-VIVO | ANANDAMIDE | DELTA-TETRAHYDROCANNABINOL | CANNABINOID RECEPTOR ADAPTATION | MICE | RAT-BRAIN | NEUROSCIENCES | KNOCKOUT MOUSE | Cannabinoid Receptor Modulators - metabolism | Analgesics - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | Neuronal Plasticity - drug effects | Male | Benzodioxoles - administration & dosage | Pain - metabolism | Brain - physiology | Monoacylglycerol Lipases - genetics | Enzyme Inhibitors - administration & dosage | Monoacylglycerol Lipases - metabolism | Neuronal Plasticity - physiology | Piperidines - pharmacology | Pain - drug therapy | Female | Models, Animal | Endocannabinoids | Amidohydrolases - metabolism | Synapses - drug effects | Piperidines - administration & dosage | Synapses - physiology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Analgesics - administration & dosage | Amidohydrolases - antagonists & inhibitors | Mice, Transgenic | Mice, Knockout | Brain - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Animals | Cannabinoid Receptor Modulators - antagonists & inhibitors | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Complications and side effects | Cannabinoids | Drug tolerance | Physiological aspects | Neuropharmacology | Research | Properties | Drug receptors | Index Medicus
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 09/2014, Volume 43, Issue 19, pp. 6859 - 6869
The endocannabinoid system, most popularly known as the target of the psychoactive component of marijuana, Delta super(9)-tetrahydrocannabinol (THC), is a... 
Networks | Enzymes | Inhibitors | Eyes | Derivatives | Lipase | Metabolism | Diseases
Journal Article