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Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 1/2017, Volume 390, Issue 1, pp. 15 - 24
3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical... 
Neurosciences | Biomedicine | Monoamine receptors | Neurochemical profile | MDMA analogues | Monoamine transporters | Pharmacology/Toxicology | 3,4-Methylenedioxy- N -methylamphetamine (MDMA) | 3,4-Methylenedioxy-N-methylamphetamine (MDMA) | POSTTRAUMATIC-STRESS-DISORDER | NICOTINIC RECEPTORS | NOREPINEPHRINE | ECSTASY | DRUGS | DOPAMINE | PHARMACOLOGY & PHARMACY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE-ASSISTED PSYCHOTHERAPY | SEROTONIN | INDUCED NEUROTOXICITY | UP-REGULATION | Tyrosine 3-Monooxygenase - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Receptors, Serotonin, 5-HT2 - chemistry | Stress Disorders, Post-Traumatic - metabolism | Humans | Neurotransmitter Uptake Inhibitors - pharmacology | Benzofurans - pharmacology | Serotonin 5-HT2 Receptor Agonists - pharmacology | Receptors, Serotonin, 5-HT2 - drug effects | Structure-Activity Relationship | Receptors, Serotonin, 5-HT2 - metabolism | Neurotransmitter Uptake Inhibitors - metabolism | Benzofurans - chemistry | Catechol O-Methyltransferase - metabolism | Monoamine Oxidase - chemistry | Indoles - metabolism | Tyrosine 3-Monooxygenase - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Stress Disorders, Post-Traumatic - drug therapy | Indoles - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Radioligand Assay | Serotonin 5-HT2 Receptor Agonists - metabolism | Binding Sites | Monoamine Oxidase Inhibitors - pharmacology | Vesicular Monoamine Transport Proteins - chemistry | Vesicular Monoamine Transport Proteins - antagonists & inhibitors | Serotonin 5-HT2 Receptor Agonists - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotransmitter Uptake Inhibitors - chemistry | Monoamine Oxidase Inhibitors - metabolism | Protein Binding | Protein Conformation | Monoamine Oxidase Inhibitors - chemistry | Catechol O-Methyltransferase - chemistry | Indoles - chemistry | Benzofurans - metabolism | Monoamine Oxidase - metabolism | Monoamine oxidase | Batteries | Methamphetamine | Ecstasy (Drug) | Resveratrol | Post-traumatic stress disorder
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 864 - 879
Currently available drugs against Alzheimer's disease (AD) are only able to ameliorate the disease symptoms resulting in a moderate improvement in memory and... 
Human acetylcholinesterase | MAO-A | Molecular modeling | Human butyrylcholinesterase | Metal chelating properties | ADME+T properties | Antioxidant properties | MAO-B | Alzheimer's disease | Molecular docking | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | SEROTONIN 5-HT1A | DRUGS | POTENTIAL TREATMENT | NITRIC-OXIDE | FORCE-FIELD | OXIDASE-INHIBITORS | ADME plus T properties | RATIONAL DESIGN | HYBRIDS | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Monoamine Oxidase - chemistry | Piperidines - pharmacology | Drug Design | Indans - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - chemistry | Chemistry Techniques, Synthetic | Piperidines - metabolism | Chelating Agents - chemistry | Indans - metabolism | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Monoamine Oxidase Inhibitors - metabolism | Indans - chemical synthesis | Protein Conformation | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Chelating Agents - chemical synthesis | Chelating Agents - metabolism | Acetylcholinesterase - metabolism | Indans - pharmacology | Monoamine Oxidase - metabolism | Antioxidants | Enzymes | Monoamine oxidase | Analysis | Models | Drug discovery | Target marketing
Journal Article
ChemMedChem, ISSN 1860-7179, 06/2016, Volume 11, Issue 12, pp. 1264 - 1269
Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a... 
inhibitors | multitarget-directed ligands | cholinesterases | Alzheimer's disease | cytotoxicity | monoamine oxidase | MONOAMINE-OXIDASE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | MULTIPOTENT | DONEPEZIL | CHOLINERGIC HYPOTHESIS | POTENTIAL TREATMENT | PHARMACOLOGY & PHARMACY | CHOLINESTERASE/MONOAMINE OXIDASE-INHIBITORS | PHARMACOLOGICAL EVALUATION | AGGREGATION | HYBRIDS | Cholinesterase Inhibitors - toxicity | Humans | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Tacrine - therapeutic use | Monoamine Oxidase - chemistry | Indoles - metabolism | Cholinesterase Inhibitors - metabolism | Drug Design | Inhibitory Concentration 50 | Quinolines - toxicity | Tacrine - chemistry | Monoamine Oxidase Inhibitors - therapeutic use | Cell Survival - drug effects | Tacrine - metabolism | Quinolines - chemistry | Alzheimer Disease - drug therapy | Indoles - toxicity | Acetylcholinesterase - chemistry | Blood-Brain Barrier - metabolism | Hep G2 Cells | Quinolines - chemical synthesis | Quinolines - metabolism | Monoamine Oxidase Inhibitors - toxicity | Monoamine Oxidase Inhibitors - metabolism | Indoles - therapeutic use | Ligands | Quinolines - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Indoles - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Tacrine - toxicity | Antioxidants | Monoamine oxidase | Permeability | Drug therapy | Analysis | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 05/2016, Volume 24, Issue 10, pp. 2342 - 2351
A series of 4-hydroxyl aurone derivatives were designed synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's disease.... 
Aurone derivatives | Multifunctional agents | β-Amyloid aggregation | Monoamine oxidase | Alzheimer's disease | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | ALLOSTERIC INHIBITORS | DISCOVERY | beta-Amyloid aggregation | BETA-AMYLOID PLAQUES | MONOAMINE-OXIDASE-B | BIOLOGICAL EVALUATION | METAL CHELATION | AGGREGATION | COUMARIN DERIVATIVES | Antioxidants - chemistry | Humans | Benzofurans - pharmacology | Monoamine Oxidase Inhibitors - chemical synthesis | Benzofurans - chemistry | Benzofurans - pharmacokinetics | Monoamine Oxidase Inhibitors - pharmacokinetics | Chelating Agents - pharmacokinetics | Swine | Amyloid beta-Peptides - metabolism | Copper - metabolism | Protein Aggregates - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Peptide Fragments - metabolism | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Benzofurans - chemical synthesis | Models, Molecular | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Blood-Brain Barrier - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Monoamine Oxidase Inhibitors - chemistry | Antioxidants - pharmacokinetics | Chelating Agents - chemical synthesis | Monoamine Oxidase - metabolism | Hydroxides | Drug therapy | Analysis | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 886 - 896
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLUTAMATE RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAO-B | CELL BIOLOGY | PUTRESCINE | CHANNEL | MONOAMINE-OXIDASE-B | SELEGILINE | CULTURED ASTROCYTES | L-DEPRENYL | MICE | DENTATE GYRUS | Memory - drug effects | RNA, Small Interfering - genetics | Alzheimer Disease - complications | Amyloid beta-Peptides - pharmacology | Humans | Ion Channels - genetics | Memory Disorders - metabolism | Male | Peptide Fragments - pharmacology | Monoamine Oxidase - genetics | GABA Antagonists - therapeutic use | Bestrophins | Eye Proteins - genetics | Putrescine - pharmacology | Disease Models, Animal | Astrocytes - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Dentate Gyrus - metabolism | Cerebellum - metabolism | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Mice, Transgenic | Hippocampus - cytology | Mice, Inbred ICR | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Maze Learning | Memory Disorders - drug therapy | Memory Disorders - etiology | Eye Proteins - metabolism | Ion Channels - metabolism | gamma-Aminobutyric Acid - biosynthesis | Alzheimer Disease - metabolism | Receptors, GABA - metabolism | Plaque, Amyloid - metabolism | Mice | Astrocytes - metabolism | Monoamine Oxidase - metabolism | Care and treatment | Monoamine oxidase | Analysis | Physiological aspects | GABA | Diagnosis | Alzheimer's disease | Risk factors | Models | Alzheimers disease | Memory | Rodents
Journal Article