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1. Current neurochemical and pharmacological aspects of biogenic amines
: their function, oxidative deamination and inhibition
by Yu, Peter M and Tipton, Keith F and Boulton, A. A
1995, Progress in brain research, ISBN 044481938X, Volume 106., xiv, 358
Monoamine oxidase | Inhibitors | Metabolism | Biogenic amines | Physiological effect
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2. Full Text Neurochemical binding profiles of novel indole and benzofuran MDMA analogues
by Shimshoni, Jakob A and Winkler, Ilan and Golan, Ezekiel and Nutt, David
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 1/2017, Volume 390, Issue 1, pp. 15 - 24
3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical... 
Neurosciences | Biomedicine | Monoamine receptors | Neurochemical profile | MDMA analogues | Monoamine transporters | Pharmacology/Toxicology | 3,4-Methylenedioxy- N -methylamphetamine (MDMA) | 3,4-Methylenedioxy-N-methylamphetamine (MDMA) | POSTTRAUMATIC-STRESS-DISORDER | NICOTINIC RECEPTORS | NOREPINEPHRINE | ECSTASY | DRUGS | DOPAMINE | PHARMACOLOGY & PHARMACY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE-ASSISTED PSYCHOTHERAPY | SEROTONIN | INDUCED NEUROTOXICITY | UP-REGULATION | Tyrosine 3-Monooxygenase - metabolism | Vesicular Monoamine Transport Proteins - metabolism | Receptors, Serotonin, 5-HT2 - chemistry | Stress Disorders, Post-Traumatic - metabolism | Humans | Neurotransmitter Uptake Inhibitors - pharmacology | Benzofurans - pharmacology | Serotonin 5-HT2 Receptor Agonists - pharmacology | Receptors, Serotonin, 5-HT2 - drug effects | Structure-Activity Relationship | Receptors, Serotonin, 5-HT2 - metabolism | Neurotransmitter Uptake Inhibitors - metabolism | Benzofurans - chemistry | Catechol O-Methyltransferase - metabolism | Monoamine Oxidase - chemistry | Indoles - metabolism | Tyrosine 3-Monooxygenase - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Stress Disorders, Post-Traumatic - drug therapy | Indoles - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Radioligand Assay | Serotonin 5-HT2 Receptor Agonists - metabolism | Binding Sites | Monoamine Oxidase Inhibitors - pharmacology | Vesicular Monoamine Transport Proteins - chemistry | Vesicular Monoamine Transport Proteins - antagonists & inhibitors | Serotonin 5-HT2 Receptor Agonists - chemistry | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotransmitter Uptake Inhibitors - chemistry | Monoamine Oxidase Inhibitors - metabolism | Protein Binding | Protein Conformation | Monoamine Oxidase Inhibitors - chemistry | Catechol O-Methyltransferase - chemistry | Indoles - chemistry | Benzofurans - metabolism | Monoamine Oxidase - metabolism | Monoamine oxidase | Batteries | Methamphetamine | Ecstasy (Drug) | Resveratrol | Post-traumatic stress disorder | Index Medicus
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3. Full Text New Frontiers in Selective Human MAO-B Inhibitors
by Carradori, Simone and Silvestri, Romano
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 17, pp. 6717 - 6732
Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme and neuropsychiatric/degenerative disorder, personality traits, type II... 
IN-VITRO | CHEMISTRY, MEDICINAL | HUMAN BRAIN | ANALOGS | ALZHEIMERS-DISEASE | MONOAMINE-OXIDASE-B | BIOLOGICAL EVALUATION | BINDING-SITE | DERIVATIVES | ALCOHOL DEPENDENCE | PARKINSONS-DISEASE | Monoamine Oxidase Inhibitors - pharmacology | Isoenzymes - genetics | Humans | Isoenzymes - chemistry | Structure-Activity Relationship | Monoamine Oxidase - genetics | Polymorphism, Genetic | Monoamine Oxidase - chemistry | Isoenzymes - metabolism | Protein Conformation | Monoamine Oxidase Inhibitors - chemistry | Isoenzymes - antagonists & inhibitors | Monoamine Oxidase - metabolism
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4. Full Text The therapeutic potential of monoamine oxidase inhibitors
by Tipton, Keith F and Edmondson, Dale and Youdim, Moussa B. H
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2006, Volume 7, Issue 4, pp. 295 - 309
Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such. It now seems that many of these agents... 
PROTEIN-KINASE-C | OXIDATIVE STRESS | MESSENGER-RNA | ANTI-PARKINSON DRUG | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | MAO-B INHIBITOR | L-DEPRENYL | RAT-BRAIN | SUBSTANTIA-NIGRA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | Monoamine Oxidase Inhibitors - therapeutic use | Monoamine Oxidase Inhibitors - pharmacology | Humans | Structure-Activity Relationship | Neurodegenerative Diseases - drug therapy | Monoamine Oxidase - chemistry | Animals | Signal Transduction - drug effects | Models, Biological | Monoamine Oxidase Inhibitors - metabolism | Signal Transduction - physiology | Monoamine Oxidase Inhibitors - chemistry | Cerebral Cortex - drug effects | Monoamine Oxidase - metabolism | Neurodegenerative Diseases - classification
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5. Full Text Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation
by Wu, Ming-Yu and Esteban, Gerard and Brogi, Simone and Shionoya, Masahi and Wang, Li and Campiani, Giuseppe and Unzeta, Mercedes and Inokuchi, Tsutomu and Butini, Stefania and Marco-Contelles, Jose
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 864 - 879
Currently available drugs against Alzheimer's disease (AD) are only able to ameliorate the disease symptoms resulting in a moderate improvement in memory and... 
Human acetylcholinesterase | MAO-A | Molecular modeling | Human butyrylcholinesterase | Metal chelating properties | ADME+T properties | Antioxidant properties | MAO-B | Alzheimer's disease | Molecular docking | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | SEROTONIN 5-HT1A | DRUGS | POTENTIAL TREATMENT | NITRIC-OXIDE | FORCE-FIELD | OXIDASE-INHIBITORS | ADME plus T properties | RATIONAL DESIGN | HYBRIDS | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Monoamine Oxidase - chemistry | Piperidines - pharmacology | Drug Design | Indans - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - chemistry | Chemistry Techniques, Synthetic | Piperidines - metabolism | Chelating Agents - chemistry | Indans - metabolism | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Monoamine Oxidase Inhibitors - metabolism | Indans - chemical synthesis | Protein Conformation | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Chelating Agents - chemical synthesis | Chelating Agents - metabolism | Acetylcholinesterase - metabolism | Indans - pharmacology | Monoamine Oxidase - metabolism | Antioxidants | Enzymes | Monoamine oxidase | Analysis | Models | Drug discovery | Target marketing
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6. Full Text Novel reversible monoamine oxidase A inhibitors: Highly potent and selective 3-(1 H-pyrrol-3-yl)-2-oxazolidinones
by Valente, Sergio and Tomassi, Stefano and Tempera, Giampiero and Saccoccio, Stefania and Agostinelli, Enzo and Mai, Antonello
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 23, pp. 8228 - 8232
Monoamine oxidases (MAOs) are involved in various psychiatric and neurodegenerative disorders; hence, MAO inhibitors are useful agents in the therapy of... 
CRYSTAL-STRUCTURES | CHEMISTRY, MEDICINAL | MAO-B | DIFFERENTIATION | BIOCHEMISTRY | Oxazolidinones - chemical synthesis | Monoamine Oxidase Inhibitors - pharmacology | Stereoisomerism | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Oxazolidinones - chemistry | Pyrroles - pharmacology | Animals | Pyrroles - chemical synthesis | Cattle | Isoenzymes - metabolism | Oxazolidinones - pharmacology | Pyrroles - chemistry | Monoamine Oxidase Inhibitors - chemistry | In Vitro Techniques | Isoenzymes - antagonists & inhibitors | Monoamine Oxidase - metabolism | Life Sciences | Isoenzymes | Oxazolidinones | Biochemistry, Molecular Biology | Pyrroles | Monoamine Oxidase Inhibitors | Monoamine Oxidase
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7. Full Text Potent inhibitions of monoamine oxidase A and B by acacetin and its 7-O-(6-O-malonylglucoside) derivative from Agastache rugosa
by Lee, Hyun Woo and Ryu, Hyung Won and Baek, Seung Cheol and Kang, Myung-Gyun and Park, Daeui and Han, Hyoung-Yun and An, Ju Hyeon and Oh, Sei-Ryang and Kim, Hoon
International Journal of Biological Macromolecules, ISSN 0141-8130, 11/2017, Volume 104, Issue Pt A, pp. 547 - 553
Five compounds were isolated from the leaves of and tested for monoamine oxidase (MAO) inhibitory activity. Acacetin, a flavonoid, potently inhibited... 
Acacetin 7-O-(6-O-malonylglucoside) | Acacetin | Monoamine oxidase inhibition | SELECTIVE-INHIBITION | APOPTOSIS | CELLS | POLYMER SCIENCE | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESSENTIAL OIL | IN-VITRO | CHEMISTRY, APPLIED | EXPRESSION | Monoamine Oxidase Inhibitors - pharmacology | Agastache - chemistry | Flavones - metabolism | Humans | Structure-Activity Relationship | Flavones - chemistry | Monoamine Oxidase - chemistry | Monoamine Oxidase Inhibitors - metabolism | Glucosides - chemistry | Inhibitory Concentration 50 | Protein Conformation | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Flavones - pharmacology | Monoamine Oxidase - metabolism | Monoamine oxidase | Research institutes | Index Medicus
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8. Full Text Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease
by Benek, Ondrej and Soukup, Ondrej and Pasdiorova, Marketa and Hroch, Lukas and Sepsova, Vendula and Jost, Petr and Hrabinova, Martina and Jun, Daniel and Kuca, Kamil and Zala, Dominykas and Ramsay, Rona R and Marco‐Contelles, José and Musilek, Kamil
ChemMedChem, ISSN 1860-7179, 06/2016, Volume 11, Issue 12, pp. 1264 - 1269
Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a... 
inhibitors | multitarget-directed ligands | cholinesterases | Alzheimer's disease | cytotoxicity | monoamine oxidase | MONOAMINE-OXIDASE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | MULTIPOTENT | DONEPEZIL | CHOLINERGIC HYPOTHESIS | POTENTIAL TREATMENT | PHARMACOLOGY & PHARMACY | CHOLINESTERASE/MONOAMINE OXIDASE-INHIBITORS | PHARMACOLOGICAL EVALUATION | AGGREGATION | HYBRIDS | Cholinesterase Inhibitors - toxicity | Humans | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Tacrine - therapeutic use | Monoamine Oxidase - chemistry | Indoles - metabolism | Cholinesterase Inhibitors - metabolism | Drug Design | Inhibitory Concentration 50 | Quinolines - toxicity | Tacrine - chemistry | Monoamine Oxidase Inhibitors - therapeutic use | Cell Survival - drug effects | Tacrine - metabolism | Quinolines - chemistry | Alzheimer Disease - drug therapy | Indoles - toxicity | Acetylcholinesterase - chemistry | Blood-Brain Barrier - metabolism | Hep G2 Cells | Quinolines - chemical synthesis | Quinolines - metabolism | Monoamine Oxidase Inhibitors - toxicity | Monoamine Oxidase Inhibitors - metabolism | Indoles - therapeutic use | Ligands | Quinolines - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Indoles - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Tacrine - toxicity | Antioxidants | Monoamine oxidase | Permeability | Drug therapy | Analysis | Index Medicus
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9. Full Text Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies
by Khattab, Sherine N and Hassan, Seham Y and Bekhit, Adnan A and El Massry, Abdel Moneim and Langer, Vratislav and Amer, Adel
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 10, pp. 4479 - 4489
A series of 2-benzyl-3-(2-arylidenehydrazinyl)quinoxalines , 4-benzyl-1-aryl-[1,2,4]triazolo[4,3-a]quinoxalines and... 
Quinoxalines | Monoamine oxidase inhibitors | Oxidation | Oxidative cyclization | [1,2,4]Triazolo[4,3-a]quinoxalines | MONOAMINE-OXIDASE | CHEMISTRY, MEDICINAL | AMINO-ACIDS | DERIVATIVES | [1,2,4]Tnazolo[4,3-a]quinoxalines | Mitochondria - enzymology | Monoamine Oxidase Inhibitors - pharmacology | Quinoxalines - adverse effects | Monoamine Oxidase Inhibitors - adverse effects | Humans | Models, Molecular | Quinoxalines - chemistry | Rats | Crystallography, X-Ray | Male | Monoamine Oxidase Inhibitors - chemical synthesis | Quinoxalines - pharmacology | Monoamine Oxidase - chemistry | Animals | Cattle | Protein Binding | Mice | Monoamine Oxidase Inhibitors - chemistry | Quinoxalines - chemical synthesis | Monoamine Oxidase - metabolism | Enzymes | Monoamine oxidase | Universities and colleges | Heterocyclic compounds | Medicinal Chemistry | 3-a]quinoxalines | 4]Triazolo | Organisk kemi | Läkemedelskemi | Organic Chemistry
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10. Full Text GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
by Jo, Seonmi and Yarishkin, Oleg and Hwang, Yu Jin and Chun, Ye Eun and Park, Mijeong and Woo, Dong Ho and Bae, Jin Young and Kim, Taekeun and Lee, Jaekwang and Chun, Heejung and Park, Hyun Jung and Lee, Da Yong and Hong, Jinpyo and Kim, Hye Yun and Oh, Soo-Jin and Park, Seung Ju and Lee, Hyo and Yoon, Bo-Eun and Kim, Youngsoo and Jeong, Yong and Shim, Insop and Bae, Yong Chul and Cho, Jeiwon and Kowall, Neil W and Ryu, Hoon and Hwang, Eunmi and Kim, Daesoo and Lee, C. Justin
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 886 - 896
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLUTAMATE RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAO-B | CELL BIOLOGY | PUTRESCINE | CHANNEL | MONOAMINE-OXIDASE-B | SELEGILINE | CULTURED ASTROCYTES | L-DEPRENYL | MICE | DENTATE GYRUS | Memory - drug effects | RNA, Small Interfering - genetics | Alzheimer Disease - complications | Amyloid beta-Peptides - pharmacology | Humans | Ion Channels - genetics | Memory Disorders - metabolism | Male | Peptide Fragments - pharmacology | Monoamine Oxidase - genetics | GABA Antagonists - therapeutic use | Bestrophins | Eye Proteins - genetics | Putrescine - pharmacology | Disease Models, Animal | Astrocytes - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Dentate Gyrus - metabolism | Cerebellum - metabolism | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Mice, Transgenic | Hippocampus - cytology | Mice, Inbred ICR | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Maze Learning | Memory Disorders - drug therapy | Memory Disorders - etiology | Eye Proteins - metabolism | Ion Channels - metabolism | gamma-Aminobutyric Acid - biosynthesis | Alzheimer Disease - metabolism | Receptors, GABA - metabolism | Plaque, Amyloid - metabolism | Mice | Astrocytes - metabolism | Monoamine Oxidase - metabolism | Care and treatment | Monoamine oxidase | Analysis | Physiological aspects | GABA | Diagnosis | Alzheimer's disease | Risk factors | Models | Alzheimers disease | Memory | Rodents
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11. Inhibitor design for monoamine oxidases
by Ramsay, Rona R
Current Pharmaceutical Design, ISSN 1381-6128, 2013, Volume 19, Issue 14, pp. 2529 - 2539
Flavin-containing monoamine oxidases (MAO A and MAO B) located on the outer membrane of mitochondria oxidise amines and generate hydrogen peroxide. Inhibitors... 
Steady-state kinetic analysis | Redox state | Monoamine oxidase | Structure-based drug design | Neurotransmitter levels | Covalently-bound FAD | Anti-depressant | structure-based drug design | METHYLENE-BLUE | covalently-bound FAD | LIGAND-BINDING | BENZYLAMINE ANALOGS | ACTIVE-SITE | ALZHEIMERS-DISEASE | redox state | neurotransmitter levels | SEROTONIN TOXICITY | IMIDAZOLINE LIGANDS | steady-state kinetic analysis | MAO-A | SPECIES-DIFFERENCES | PHARMACOLOGY & PHARMACY | monoamine oxidase | B-CATALYZED OXIDATION | Monoamine Oxidase Inhibitors - therapeutic use | Monoamine Oxidase Inhibitors - pharmacology | Humans | Models, Molecular | Substrate Specificity | Monoamine Oxidase - genetics | Monoamine Oxidase - chemistry | Drug Design | Molecular Structure | Monoamine Oxidase Inhibitors - chemistry | Kinetics | Binding Sites | Monoamine Oxidase - metabolism
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12. Full Text Synthesis, biological evaluation, and molecular simulation of chalcones and aurones as selective MAO-B inhibitors
by Morales-Camilo, Nicole and Salas, Cristian O and Sanhueza, Claudia and Espinosa-Bustos, Christian and Sepu´lveda-Boza, Silvia and Reyes-Parada, Miguel and Gonzalez-Nilo, Fernando and Caroli-Rezende, Marcos and Fierro, Ange´lica
Chemical Biology and Drug Design, ISSN 1747-0277, 2014, Volume 85, Issue 6, pp. 685 - 695
A series of chalcones and aurones were synthesized and evaluated in vitro as monoamine oxidase inhibitors (MAOi). Our results show that aurones, which had not... 
Chalcones | Monoamine oxidase inhibitors | QSAR | Aurones | Molecular modeling | chalcones | aurones | molecular modeling | monoamine oxidase inhibitors | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRUCTURAL REVISION | XANTHOHUMOL | SULFURETIN | BREAST-CANCER CELLS | MONOAMINE-OXIDASE-B | DYNAMICS | HIV-1 PROTEASE | NF-KAPPA-B | EXPRESSION | DERIVATIVES | Chalcones - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Humans | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Monoamine Oxidase Inhibitors - chemical synthesis | Benzofurans - chemistry | Monoamine Oxidase - chemistry | Chalcones - chemical synthesis | Chalcones - pharmacology | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Quantitative Structure-Activity Relationship | Monoamine Oxidase - metabolism | Oxidases | Analysis
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