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1. Clinical pharmacokinetics of therapeutic monoclonal antibodies
by Keizer, Ron J and Huitema, Alwin D.R and Schellens, Jan H.M and Beijnen, Jos H
Clinical pharmacokinetics, ISSN 0312-5963, 2010, Volume 49, Issue 8, pp. 493 - 507
pharmacokinetics | monoclonal-antibodies | drug interactions | pharmacokinetic-pharmacodynamic-relationships | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Drug Administration Routes | Humans | Immunologic Factors - administration & dosage | Antibodies, Monoclonal - pharmacokinetics | Antibodies, Monoclonal - therapeutic use | Mice, Knockout | Tissue Distribution | Immunologic Factors - pharmacokinetics | Absorption | Animals | Drug Interactions | Antibodies, Monoclonal - administration & dosage | Mice | Immunologic Factors - therapeutic use | Index Medicus
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2. Population pharmacokinetics of therapeutic monoclonal antibodies
by Dirks, Nathanael L and Meibohm, Bernd
Clinical pharmacokinetics, ISSN 0312-5963, 2010, Volume 49, Issue 10, pp. 633 - 659
Drug-interactions | Pharmacodynamics | Monoclonal-antibodies | Population-pharmacokinetics | Pharmacokinetic-modelling | Pharmacokinetics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Humans | Antibodies, Monoclonal - pharmacokinetics | Antibodies, Monoclonal - therapeutic use | Female | Male | Metabolic Clearance Rate | Clinical Trials as Topic | Structure-Activity Relationship
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3. Full Text Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts
by Abuqayyas, Lubna and Balthasar, Joseph P
The AAPS journal, ISSN 1550-7416, 9/2012, Volume 14, Issue 3, pp. 445 - 455
Biochemistry, general | Biotechnology | Biomedicine | anti-cancer antibody | Pharmacy | pharmacokinetics | mAb–mAb interaction | Pharmacology/Toxicology | anti-VEGF antibody | drug–drug interaction of biologics | drug-drug interaction of biologics | mAb-mAb interaction | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Animals | Colorectal Neoplasms - immunology | Area Under Curve | Carcinoembryonic Antigen - immunology | Antibodies, Monoclonal - pharmacokinetics | Transplantation, Heterologous | Vascular Endothelial Growth Factor A - immunology | Mice | Mice, Inbred BALB C | Viral antibodies | Antigens | Biological products | Drug interactions | Gastrointestinal diseases | Colorectal cancer | Monoclonal antibodies | Antibodies | Permeability | CEA (Oncology) | Tumors | Endothelial growth factors | Index Medicus
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4. Full Text Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N‑Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates
by van Geel, Remon and Wijdeven, Marloes A and Heesbeen, Ryan and Verkade, Jorge M. M and Wasiel, Anna A and van Berkel, Sander S and van Delft, Floris L
Bioconjugate chemistry, ISSN 1043-1802, 11/2015, Volume 26, Issue 11, pp. 2233 - 2242
Carbohydrate Sequence | Trastuzumab - chemistry | Click Chemistry | Maytansine - analogs & derivatives | Humans | Models, Molecular | Molecular Sequence Data | Glycosylation | Azides - chemistry | Immunoconjugates - chemistry | Maytansine - chemistry | Polysaccharides - chemistry | Protein Stability | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal, Humanized - chemistry | Monoclonal antibodies | Toxicity | Biochemistry | Index Medicus
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5. Full Text Multimechanistic monoclonal antibodies (MAbs) targeting Staphylococcus aureus alpha-toxin and clumping factor A: Activity and efficacy comparisons of a MAb combination and an engineered bispecific antibody approach
by Tkaczyk, C and Kasturirangan, S and Minola, A and Jones-Nelson, O and Gunter, V and Shi, Y.Y and Rosenthal, K and Aleti, V and Semenova, E and Warrener, P and Tabor, D and Stover, C.K and Corti, D and Rainey, G and Sellman, B.R
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 08/2017, Volume 61, Issue 8
Monoclonal antibodies | Clumping factor A | Alpha toxin | Staphylococcus aureus | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Hemolysin Proteins - immunology | Staphylococcal Infections - drug therapy | Coagulase - immunology | Staphylococcal Infections - immunology | Bacterial Toxins - immunology | Methicillin-Resistant Staphylococcus aureus - drug effects | Mice, Inbred C57BL | Bacteremia - drug therapy | Antibodies, Monoclonal - therapeutic use | Methicillin-Resistant Staphylococcus aureus - immunology | Virulence Factors | Bacteremia - microbiology | Methicillin-Resistant Staphylococcus aureus - pathogenicity | Antibodies, Neutralizing - immunology | Animals | Antibodies, Neutralizing - therapeutic use | Antibodies, Bacterial - immunology | Female | Mice | Mice, Inbred BALB C | Antibodies, Bacterial - therapeutic use | Antibodies, Monoclonal - immunology | Index Medicus
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6. Full Text MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
by Kolbeck, Roland, PhD and Kozhich, Alexander, PhD and Koike, Masamichi, PhD and Peng, Li, PhD and Andersson, Cecilia K., PhD and Damschroder, Melissa M., BA and Reed, Jennifer L., PhD and Woods, Robert, MS and Dall'Acqua, William W., PhD and Stephens, Geoffrey L., PhD and Erjefalt, Jonas S., PhD and Bjermer, Leif, MD and Humbles, Alison A., PhD and Gossage, David, MD and Wu, Herren, PhD and Kiener, Peter A., PhD and Spitalny, George L., PhD and Mackay, Charles R., PhD and Molfino, Nestor A., MD and Coyle, Anthony J., PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2010, Volume 125, Issue 6, pp. 1344 - 1353.e2
Allergy and Immunology | antibody-dependent cell-mediated cytotoxicity | IL-5 | FcγRIIIα | basophil | eosinophil | monoclonal antibody | Asthma | IL-5 receptor | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Biological and medical sciences | Medical sciences | Chronic obstructive pulmonary disease, asthma | Pneumology | Recombinant Fusion Proteins - immunology | Surface Plasmon Resonance | Epitope Mapping | Eosinophils - metabolism | Epitopes - metabolism | Eosinophils - drug effects | Interleukin-5 Receptor alpha Subunit - immunology | Cell Count | Humans | Antibodies, Monoclonal - adverse effects | Macaca fascicularis | Interleukin-5 Receptor alpha Subunit - metabolism | Male | Recombinant Fusion Proteins - metabolism | Receptors, IgG - metabolism | Protein Engineering | Female | Eosinophils - pathology | Mutagenesis, Site-Directed | Antibody-Dependent Cell Cytotoxicity | Interleukin-5 Receptor alpha Subunit - genetics | Antibody Affinity | Animals | Antibodies, Monoclonal - administration & dosage | Recombinant Fusion Proteins - genetics | Index Medicus | Abridged Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Clinical Medicine | gamma RIII alpha | Lungmedicin och allergi | Respiratory Medicine and Allergy
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7. Full Text Intravenous anti–IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis
by Rothenberg, Marc E., MD, PhD and Wen, Ting, PhD and Greenberg, Allison, BA and Alpan, Oral, MD and Enav, Benjamin, MD and Hirano, Ikuo, MD and Nadeau, Kari, MD, PhD and Kaiser, Sergio, PhD and Peters, Thomas, Dr rer nat and Perez, Antonio, MD, PhD and Jones, Ieuan, BA and Arm, Jonathan P., MD and Strieter, Robert M., MD, FCCP, MACP and Sabo, Ronald, BA and Gunawardena, Kulasiri A., MD, MRCP
Journal of allergy and clinical immunology, ISSN 0091-6749, 2014, Volume 135, Issue 2, pp. 500 - 507
Allergy and Immunology | cytokine | TH2 cells | targeted therapy | transcriptome | eosinophilic esophagitis | mast cell | QAX576 | randomized clinical trial | IL-13 | barrier function | mAb | 2 cells | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Interleukin-13 - antagonists & inhibitors | Humans | Middle Aged | Risk Factors | Antibodies, Monoclonal - adverse effects | Transcriptome | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Gene Expression Profiling | Gene Regulatory Networks | Proton Pump Inhibitors - therapeutic use | Young Adult | Eosinophilic Esophagitis - immunology | Antibodies, Monoclonal - administration & dosage | Adolescent | Biomarkers | Adult | Eosinophilic Esophagitis - drug therapy | Female | Drug Resistance | Eosinophilic Esophagitis - genetics | Cluster Analysis | Esophagitis | Medical colleges | Care and treatment | Biomedical research | Disease | Biopsy | Laboratories | Statistical methods | Dysphagia | Gene expression | Index Medicus | Abridged Index Medicus
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8. Full Text Authorized manufacturing changes for therapeutic monoclonal antibodies (mAbs) in European Public Assessment Report (EPAR) documents
by Vezér, Balázs and Buzás, Zsuzsanna and Sebeszta, Miklós and Zrubka, Zsombor
Current medical research and opinion, ISSN 0300-7995, 05/2016, Volume 32, Issue 5, pp. 829 - 834
Biosimilars | Comparability | European Public Assessment Report | Biosimilarity | Monoclonal antibodies | Manufacturing | Biologicals | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Antibodies, Monoclonal - therapeutic use | Biosimilar Pharmaceuticals - therapeutic use | Biosimilar Pharmaceuticals - administration & dosage | Antibodies, Monoclonal - administration & dosage | Humans | Index Medicus
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9. Full Text Anti-Glycan IgG mAbs
Science (American Association for the Advancement of Science), ISSN 0036-8075, 01/2019, Volume 363, Issue 6423, p. 193
Immunoglobulin G | Monoclonal antibodies
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10. Full Text Benralizumab - a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity - a novel approach for the treatment of asthma
by Ghazi, Aasia and Trikha, Anita and Calhoun, William J
Expert opinion on biological therapy, ISSN 1471-2598, 01/2012, Volume 12, Issue 1, pp. 113 - 118
IL-5 | MEDI-563 | asthma | IL-5Rα | benralizumab | Benralizumab | Asthma | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Interleukin-5 - chemistry | Immunotherapy - methods | Antibodies, Monoclonal, Humanized - therapeutic use | Eosinophils - drug effects | Interleukin-5 Receptor alpha Subunit - immunology | Humans | Antibodies, Monoclonal - therapeutic use | Treatment Outcome | Clinical Trials as Topic | Inflammation | Interleukin-5 Receptor alpha Subunit - chemistry | Phenotype | Time Factors | Models, Biological | Antibodies, Neutralizing - chemistry | Asthma - immunology | Asthma - therapy | Models, Genetic | Antibodies, Monoclonal - immunology | Pharmacodynamics | Interleukin 5 | Reviews | Leukocytes (eosinophilic) | Monoclonal antibodies | Cytotoxicity | Data processing | Pharmacokinetics | Antibody-dependent cell-mediated cytotoxicity | Index Medicus
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11. Full Text A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
by Noy-Porat, Tal and Makdasi, Efi and Alcalay, Ron and Mechaly, Adva and Levy, Yinon and Bercovich-Kinori, Adi and Zauberman, Ayelet and Tamir, Hadas and Yahalom-Ronen, Yfat and Israeli, Ma’ayan and Epstein, Eyal and Achdout, Hagit and Melamed, Sharon and Chitlaru, Theodor and Weiss, Shay and Peretz, Eldar and Rosen, Osnat and Paran, Nir and Yitzhaki, Shmuel and Shapira, Shmuel C and Israely, Tomer and Mazor, Ohad and Rosenfeld, Ronit
Nature communications, ISSN 2041-1723, 12/2020, Volume 11, Issue 1, pp. 4303 - 4303
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epitope Mapping | Antibodies, Viral - metabolism | Chlorocebus aethiops | Spike Glycoprotein, Coronavirus - metabolism | Humans | Antibodies, Neutralizing - metabolism | Epitopes | Peptide Library | Betacoronavirus - metabolism | Betacoronavirus - immunology | Angiotensin-Converting Enzyme 2 | Antibodies, Neutralizing - immunology | SARS-CoV-2 | Animals | Peptidyl-Dipeptidase A - metabolism | Protein Binding | Antibodies, Viral - immunology | Spike Glycoprotein, Coronavirus - immunology | Protein Interaction Domains and Motifs | Antibodies, Monoclonal - metabolism | Spike Glycoprotein, Coronavirus - chemistry | Vero Cells | Antibodies, Monoclonal - immunology | Binding | Pandemics | Phages | Severe acute respiratory syndrome | Viral diseases | Antibodies | Viruses | Coronaviruses | Severe acute respiratory syndrome coronavirus 2 | COVID-19 | Domains | Spikes | Receptors | Phage display | Lymphocytes | Neutralizing | Monoclonal antibodies | Libraries | Index Medicus
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