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1. Full Text Lysine Adduction by Reactive Metabolite(s) of Monocrotaline
by Li, Weiwei and Wang, Kai and Lin, Ge and Peng, Ying and Zheng, Jiang
Chemical research in toxicology, ISSN 0893-228X, 03/2016, Volume 29, Issue 3, pp. 333 - 341
Peptides - chemistry | Injections, Intraperitoneal | Male | Monocrotaline - toxicity | Serum Albumin, Bovine - metabolism | Mice, Inbred Strains | Animals | Peptides - metabolism | Cattle | Serum Albumin, Bovine - chemistry | Lysine - metabolism | Mice | Lysine - chemistry | Monocrotaline - metabolism | Monocrotaline - administration & dosage | Monocrotaline - chemistry | Index Medicus
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2. Full Text Activity of pyrrolizidine alkaloids against biofilm formation and Trichomonas vaginalis
by da Silva Negreiros Neto, Themístocles and Gardner, Dale and Hallwass, Fernando and Leite, Ana Jéssica Matias and de Almeida, Camila Guimarães and Silva, Laura Nunes and de Araújo Roque, Alan and de Bitencourt, Fernanda Gobbi and Barbosa, Euzébio Guimarães and Tasca, Tiana and Macedo, Alexandre José and de Almeida, Mauro Vieira and Giordani, Raquel Brandt
Biomedicine & pharmacotherapy, ISSN 0753-3322, 2016, Volume 83, pp. 323 - 329
Internal Medicine | Medical Education | Usaramine | Pyrrolizidine alkaloids | Monocrotaline | Biological activity | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Biofilms - drug effects | Cell Line | Staphylococcus epidermidis - ultrastructure | Staphylococcus epidermidis - drug effects | Microbial Viability - drug effects | Monocrotaline - chemical synthesis | Humans | Monocrotaline - pharmacology | Pyrrolizidine Alkaloids - chemistry | Trichomonas vaginalis - physiology | Proton Magnetic Resonance Spectroscopy | Carbon-13 Magnetic Resonance Spectroscopy | Trichomonas vaginalis - drug effects | Female | Monocrotaline - isolation & purification | Monocrotaline - chemistry | Pyrrolizidine Alkaloids - isolation & purification | Pyrrolizidine Alkaloids - pharmacology | Index Medicus
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3. Full Text Involvement of astrocytic CYP1A1 isoform in the metabolism and toxicity of the alkaloid pyrrolizidine monocrotaline
by Nascimento, Ravena P and Oliveira, Joana L and Carvalho, José Leilton C and Santos, William A and Pires, Thyago Rubens C and Batatinha, Maria José M and El-Bachá, Ramon S and Silva, Victor Diógenes A and Costa, Silvia L
Toxicon (Oxford), ISSN 0041-0101, 08/2017, Volume 134, pp. 41 - 49
CYP1A1 P450 | Neurotoxicity | Astrocytes | GSH | Monocrotaline | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Cell Line | Cell Survival | Crotalaria - chemistry | Rats | Monocrotaline - analogs & derivatives | Monocrotaline - toxicity | Cytochrome P-450 CYP1A1 - metabolism | Animals | Cytochrome P-450 CYP1A1 - drug effects | Glutathione - drug effects | Protein Isoforms - chemistry | Omeprazole - pharmacology | Monocrotaline - metabolism | Astrocytes - metabolism | Omeprazole | Alkaloids | Metabolites | Analysis | Cytochrome P-450 | Cimetidine | Physiological aspects | Index Medicus
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4. Improving Topical Skin Delivery of Monocrotaline Via Liposome Gel-based Nanosystems
by Yu, Jiandong and Chen, Zhi and Yin, Yan-Zhi and Tang, Chaoyuan and Hu, Enying and Zheng, Shuang and Liu, Qi and Xiong, Yang
Current drug delivery, ISSN 1567-2018, 01/2019, Volume 16, Issue 10, pp. 940 - 950
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Viscosity | Gels - chemical synthesis | Liposomes - chemical synthesis | Rats | Male | Skin Absorption | Rats, Sprague-Dawley | Drug Delivery Systems | Liposomes - chemistry | Animals | Drug Liberation | Gels - chemistry | Monocrotaline - metabolism | Administration, Topical | Monocrotaline - administration & dosage | Monocrotaline - chemistry | Nanotechnology | Encapsulation | Drug delivery systems | Soybeans | Gels | Toxicity | Monocrotaline | Glycerol | pH effects | Retention | Cholesterol | Citric acid | Buffer solutions | Vitamin E | Choline | Phosphatidylcholine | Triethanolamine | Skin | Liposomes | Deionization
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5. Full Text Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells
by Silva-Neto, J.P and Barreto, R.A and Pitanga, B.P.S and Souza, C.S and Silva, V.D and Silva, A.R and Velozo, E.S and Cunha, S.D and Batatinha, M.J.M and Tardy, M and Ribeiro, C.S.O and Costa, M.F.D and El-Bachá, R.S and Costa, S.L
Toxicon (Oxford), ISSN 0041-0101, 2010, Volume 55, Issue 1, pp. 105 - 117
Vimentin | MAPs | Glia | Pyrrolizidine alkaloids | Monocrotaline | Genotoxicity | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Plant poisons toxicology | Pharmacognosy. Homeopathy. Health food | General pharmacology | Animal poisons toxicology. Antivenoms | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Immunohistochemistry | Mutagens - metabolism | Mutagens - toxicity | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Neuroglia - pathology | Vimentin - metabolism | Humans | Neuroglia - drug effects | Dose-Response Relationship, Drug | Time Factors | Seeds - chemistry | Cell Survival - drug effects | Monocrotaline - chemical synthesis | Cell Size - drug effects | Crotalaria - chemistry | Monocrotaline - analogs & derivatives | Monocrotaline - toxicity | Comet Assay | Cell Shape - drug effects | Seeds - toxicity | Crotalaria - toxicity | Cell Line, Tumor | Monocrotaline - isolation & purification | Mutagens - isolation & purification | DNA Damage | Oxidative Stress - drug effects | Monocrotaline - metabolism | Index Medicus
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6. Full Text Ultrasensitive immunoassay for monocrotaline using monoclonal antibody produced by N, N’-carbonyldiimidazole mediated hapten-carrier protein conjugates
by Sakamoto, Seiichi and Nagamitsu, Rika and Yusakul, Gorawit and Miyamoto, Tomofumi and Tanaka, Hiroyuki and Morimoto, Satoshi
Talanta (Oxford), ISSN 0039-9140, 06/2017, Volume 168, pp. 67 - 72
Monocrotaline (MCT) | N’-carbonyldiimidazole (CDI) | Enzyme-linked immunosorbent assay (ELISA) | Crotalaria | Monoclonal antibody (MAb) | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Haptens - chemistry | Animals | Enzyme-Linked Immunosorbent Assay | Cattle | Serum Albumin, Bovine - immunology | Imidazoles - chemistry | Immunoassay - methods | Monocrotaline - immunology | Serum Albumin, Bovine - chemistry | Haptens - immunology | Antibodies, Monoclonal - immunology | Monocrotaline - analysis | Cytokinins | Enzymes | Usage | Chemical tests and reagents | Lysine | Analysis | Monoclonal antibodies | Albumin | Enzyme-linked immunosorbent assay | Index Medicus
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7. Full Text Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells
by Sun, Na and Chen, Yiqiang and Yu, Fangli and Zhixin, Fan and Lin, Jianhui and Sun, Binfeng and Yu, Bo and Cheng, Xiaohan and Zheng, Xiaodong and Wu, Bingxiang
European journal of pharmacology, ISSN 0014-2999, 11/2019, Volume 863, pp. 172679 - 172679
Monocrotaline pyrrole | Pulmonary arterial hypertension | Proliferation | Activin A receptor type 2A | Bone morphogenetic protein 7 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Activin Receptors, Type II - metabolism | Humans | Activin Receptors, Type II - deficiency | Monocrotaline - pharmacology | Rats | Monocrotaline - analogs & derivatives | Gene Knockdown Techniques | Pulmonary Artery - cytology | Animals | Signal Transduction - drug effects | Activin Receptors, Type II - genetics | Bone Morphogenetic Protein 7 - metabolism | Cell Proliferation - drug effects | Cell Cycle - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Index Medicus
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8. Full Text Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis In Vitro and Prevents LPS-Induced Bone Loss In Vivo
by Wei, Cheng-Ming and Su, Yi-Ji and Qin, Xiong and Ding, Jia-Xin and Liu, Qian and Song, Fang-Ming and Zong, Shao-Hui and Xu, Jiake and Zhou, Bo and Zhao, Jin-Min
Cellular physiology and biochemistry, ISSN 1015-8987, 08/2018, Volume 48, Issue 2, pp. 644 - 656
Original Paper | Osteoclast | Osteolysis | Monocrotaline | MAPK signaling pathways | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Monocrotaline - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Osteolysis - etiology | Protective Agents - chemistry | Protective Agents - therapeutic use | Osteoclasts - cytology | Proton-Translocating ATPases - metabolism | RANK Ligand - pharmacology | Proton-Translocating ATPases - genetics | Protective Agents - pharmacology | Skull - pathology | p38 Mitogen-Activated Protein Kinases - metabolism | Osteolysis - prevention & control | Monocrotaline - chemistry | Disease Models, Animal | Lipopolysaccharides - toxicity | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Osteogenesis - drug effects | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Macrophages - cytology | Osteoclasts - metabolism | Monocrotaline - therapeutic use | Macrophages - metabolism | Animals | Cell Differentiation - drug effects | Skull - diagnostic imaging | Proto-Oncogene Proteins c-fos - genetics | Mice | Cell culture | Acids | Homeostasis | Bone marrow | Tumor necrosis factor-TNF | Arthritis | Hydroxyapatite | Phosphatase | Kinases | Index Medicus
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9. Full Text LEFT VENTRICLE FREE WALL MASS LOSS IN A MONOCROTALINE INDUCED PULMONARY HYPERTENSION RAT MODEL
by Holda, Mateusz and Holda, Jakub and Tyrak, Kamil and Kopec, Grzegorz and Podolec, Piotr
Journal of the American College of Cardiology, ISSN 0735-1097, 03/2018, Volume 71, Issue 11, pp. A1950 - A1950
Hypertension | Ventricle | Rodents | Monocrotaline | Pulmonary hypertension
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10. Full Text DYNAMIC CHANGES OF MACROPHAGE M1/M2 POLARIZATION IN MONOCROTALINE ‐INDUCED PULMONARY ARTERIAL HYPERTENSION
Respirology (Carlton, Vic.), ISSN 1323-7799, 11/2017, Volume 22, Issue S3, pp. 76 - 76
Monocrotaline | Pulmonary hypertension
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11. Full Text Preincubation format for a sensitive immunochromatographic assay for monocrotaline, a toxic pyrrolizidine alkaloid
by Yusakul, Gorawit and Sakamoto, Seiichi and Chanpokapaiboon, Kaskamol and Tanaka, Hiroyuki and Morimoto, Satoshi
Phytochemical analysis, ISSN 0958-0344, 11/2019, Volume 30, Issue 6, pp. 653 - 660
anti‐monocrotaline monoclonal antibody | Crotalaria | monocrotaline | preincubation format for immunochromatographic assay | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Plant Sciences | Science & Technology | Immunoassay - methods | Pyrrolizidine Alkaloids - chemistry | Limit of Detection | Crotalaria - chemistry | Monocrotaline - analysis | Hypertension | Analytical methods | Cereals | Incubation | Gastroenteritis | Monocrotaline | Mass spectroscopy | Liquid chromatography | Contamination | Hepatitis | Senecionine | Vasculitis | Format | Monoclonal antibodies | Retrorsine | Mass spectrometry | Index Medicus
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12. Full Text Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats
by Luo, Jinyuan and Yang, Xiaojing and Qiu, Shuaikai and Li, Xia and Xiang, E and Fang, Yan and Wang, Yanqing and Zhang, Li and Wang, Hui and Zheng, Jiang and Guo, Yu
Toxicology (Amsterdam), ISSN 0300-483X, 04/2019, Volume 418, pp. 32 - 40
Metabolic activation | Developmental toxicity | Pyrrolizidine alkaloids | Hepatotoxicity | Sex difference | Monocrotaline | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Chemical and Drug Induced Liver Injury - embryology | Activation, Metabolic | Cytochrome P-450 CYP3A - biosynthesis | Rats, Wistar | Risk Assessment | Apoptosis - drug effects | Liver - metabolism | Enzyme Induction | Male | Monocrotaline - toxicity | Gestational Age | Liver - embryology | Pregnancy | Animals | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sex Factors | Female | Monocrotaline - metabolism | Chemical and Drug Induced Liver Injury - etiology | Alkaloids | Transmission electron microscopes | Growth | Cytochrome P-450 | Physiological aspects | Fetus | Obstetrics | Index Medicus
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