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1. Full Text DYNAMIC CHANGES OF MACROPHAGE M1/M2 POLARIZATION IN MONOCROTALINE ‐INDUCED PULMONARY ARTERIAL HYPERTENSION
Respirology, ISSN 1323-7799, 11/2017, Volume 22, Issue S3, pp. 76 - 76
Monocrotaline
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2. Full Text Ultrasensitive immunoassay for monocrotaline using monoclonal antibody produced by N, N’-carbonyldiimidazole mediated hapten-carrier protein conjugates
by Sakamoto, Seiichi and Nagamitsu, Rika and Yusakul, Gorawit and Miyamoto, Tomofumi and Tanaka, Hiroyuki and Morimoto, Satoshi
Talanta, ISSN 0039-9140, 06/2017, Volume 168, pp. 67 - 72
Monocrotaline (MCT) is a naturally occurring pyrrolizidine alkaloid mainly produced in plant genus (Fabaceae), in which various toxicities have been reported.... 
Monocrotaline (MCT) | N’-carbonyldiimidazole (CDI) | Enzyme-linked immunosorbent assay (ELISA) | Crotalaria | Monoclonal antibody (MAb) | CHEMISTRY, ANALYTICAL | PULMONARY-HYPERTENSION | LINKED-IMMUNOSORBENT-ASSAY | RATS | TOXICITY | N '-carbonyldiimidazole (CDI) | PYRROLIZIDINE ALKALOID MONOCROTALINE | METABOLISM | LIVER | Enzyme -linked immunosorbent assay (ELISA) | Haptens - chemistry | Animals | Enzyme-Linked Immunosorbent Assay | Cattle | Serum Albumin, Bovine - immunology | Imidazoles - chemistry | Immunoassay - methods | Monocrotaline - immunology | Serum Albumin, Bovine - chemistry | Haptens - immunology | Antibodies, Monoclonal - immunology | Monocrotaline - analysis | Cytokinins | Enzymes | Usage | Chemical tests and reagents | Lysine | Analysis | Monoclonal antibodies | Albumin | Enzyme-linked immunosorbent assay | Index Medicus
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3. Full Text Activity of pyrrolizidine alkaloids against biofilm formation and Trichomonas vaginalis
by da Silva Negreiros Neto, Themístocles and Gardner, Dale and Hallwass, Fernando and Leite, Ana Jéssica Matias and de Almeida, Camila Guimarães and Silva, Laura Nunes and de Araújo Roque, Alan and de Bitencourt, Fernanda Gobbi and Barbosa, Euzébio Guimarães and Tasca, Tiana and Macedo, Alexandre José and de Almeida, Mauro Vieira and Giordani, Raquel Brandt
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2016, Volume 83, pp. 323 - 329
Graphical abstract Our results point out the applicability of PAs for semi-synthesis as well as indicate these molecules as promising leads for further studies... 
Internal Medicine | Medical Education | Usaramine | Pyrrolizidine alkaloids | Monocrotaline | Biological activity | CAATINGA | MEDICINE, RESEARCH & EXPERIMENTAL | INFECTIONS | BRAZILIAN SEMIARID REGION | EFFICACY | VIRULENCE | BACTERIAL BIOFILMS | SYMPHYTI | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | OINTMENT | Biofilms - drug effects | Cell Line | Staphylococcus epidermidis - ultrastructure | Staphylococcus epidermidis - drug effects | Microbial Viability - drug effects | Monocrotaline - chemical synthesis | Humans | Monocrotaline - pharmacology | Pyrrolizidine Alkaloids - chemistry | Trichomonas vaginalis - physiology | Proton Magnetic Resonance Spectroscopy | Carbon-13 Magnetic Resonance Spectroscopy | Trichomonas vaginalis - drug effects | Female | Monocrotaline - isolation & purification | Monocrotaline - chemistry | Pyrrolizidine Alkaloids - isolation & purification | Pyrrolizidine Alkaloids - pharmacology
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4. Full Text Lysine Adduction by Reactive Metabolite(s) of Monocrotaline
by Li, Weiwei and Wang, Kai and Lin, Ge and Peng, Ying and Zheng, Jiang
Chemical Research in Toxicology, ISSN 0893-228X, 03/2016, Volume 29, Issue 3, pp. 333 - 341
Pyrrolizidine alkaloids (PAs) are known hepatotoxins. The execution of the toxicities of the alkaloids requires metabolic activation. Protein modification by... 
DNA CROSS-LINKING | CHEMISTRY, MEDICINAL | PULMONARY-HYPERTENSION | PYRROLE | PYRROLIZIDINE ALKALOIDS | N-OXIDES | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | IN-VITRO | HEPATIC VENOOCCLUSIVE DISEASE | TOXIC METABOLITES | LIVER | TOXICOLOGY | Peptides - chemistry | Injections, Intraperitoneal | Male | Monocrotaline - toxicity | Serum Albumin, Bovine - metabolism | Mice, Inbred Strains | Animals | Peptides - metabolism | Cattle | Serum Albumin, Bovine - chemistry | Lysine - metabolism | Mice | Lysine - chemistry | Monocrotaline - metabolism | Monocrotaline - administration & dosage | Monocrotaline - chemistry | Index Medicus
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5. Full Text Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells
by Silva-Neto, J.P and Barreto, R.A and Pitanga, B.P.S and Souza, C.S and Silva, A.R and Silva, V.D and Velozo, E.S and Cunha, S.D and Batatinha, M.J.M and Tardy, M and Ribeiro, C.S.O and Costa, S.L and Costa, M.F.D and El-Bachá, R.S
Toxicon, ISSN 0041-0101, 2010, Volume 55, Issue 1, pp. 105 - 117
Plants of genus (Leguminosae) present large amounts of the pyrrolizidine alkaloid monocrotaline (MCT) and cause intoxication to animals and humans. Therefore,... 
Vimentin | MAPs | Glia | Pyrrolizidine alkaloids | Monocrotaline | Genotoxicity | DNA CROSS-LINKING | ARTERY ENDOTHELIAL-CELLS | MICROTUBULE-ASSOCIATED PROTEIN-2 | METABOLIC-ACTIVATION | ASTROCYTE PRIMARY CULTURES | N-OXIDE | IN-VITRO | FIBRILLARY ACIDIC PROTEIN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCED PULMONARY-HYPERTENSION | Immunohistochemistry | Mutagens - metabolism | Mutagens - toxicity | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Neuroglia - pathology | Vimentin - metabolism | Humans | Neuroglia - drug effects | Dose-Response Relationship, Drug | Time Factors | Seeds - chemistry | Cell Survival - drug effects | Monocrotaline - chemical synthesis | Cell Size - drug effects | Crotalaria - chemistry | Monocrotaline - analogs & derivatives | Monocrotaline - toxicity | Comet Assay | Cell Shape - drug effects | Seeds - toxicity | Crotalaria - toxicity | Cell Line, Tumor | Monocrotaline - isolation & purification | Mutagens - isolation & purification | DNA Damage | Oxidative Stress - drug effects | Monocrotaline - metabolism
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6. Full Text Involvement of astrocytic CYP1A1 isoform in the metabolism and toxicity of the alkaloid pyrrolizidine monocrotaline
by Nascimento, Ravena P and Oliveira, Joana L and Carvalho, José Leilton C and Santos, William A and Pires, Thyago Rubens C and Batatinha, Maria José M and El-Bachá, Ramon S and Silva, Victor Diógenes A and Costa, Silvia L
Toxicon, ISSN 0041-0101, 08/2017, Volume 134, pp. 41 - 49
Monocrotaline (MCT) and its pyrrole derivative, dehydromonocrotaline (DHMC), interact with molecular targets in cells of the central nervous system. DHMC... 
CYP1A1 P450 | Neurotoxicity | Astrocytes | GSH | Monocrotaline | HUMAN BRAIN | RAT | HYPEROXIC LUNG INJURY | CROTALARIA-RETUSA | GLIAL-CELLS | PRIMARY CULTURES | IN-VITRO | CYTOPLASMIC VACUOLATION | CYTOCHROME-P450 ENZYMES | C6 CELL-LINE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Cell Line | Cell Survival | Crotalaria - chemistry | Rats | Monocrotaline - analogs & derivatives | Monocrotaline - toxicity | Cytochrome P-450 CYP1A1 - metabolism | Animals | Cytochrome P-450 CYP1A1 - drug effects | Glutathione - drug effects | Protein Isoforms - chemistry | Omeprazole - pharmacology | Monocrotaline - metabolism | Astrocytes - metabolism | Omeprazole | Alkaloids | Metabolites | Analysis | Cytochrome P-450 | Cimetidine | Physiological aspects | Index Medicus
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7. Full Text LEFT VENTRICLE FREE WALL MASS LOSS IN A MONOCROTALINE INDUCED PULMONARY HYPERTENSION RAT MODEL
by Holda, Mateusz and Holda, Jakub and Tyrak, Kamil and Kopec, Grzegorz and Podolec, Piotr
Journal of the American College of Cardiology, ISSN 0735-1097, 03/2018, Volume 71, Issue 11, pp. A1950 - A1950
Rats from study group and paired controls were sacrificed in 3 study points: I - if right ventricular free wall (RVFW) thickness >0.7 mm in echocardiography... 
Hypertension | Ventricle | Rodents | Monocrotaline | Pulmonary hypertension
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8. Full Text Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis In Vitro and Prevents LPS-Induced Bone Loss In Vivo
by Wei, Cheng-Ming and Su, Yi-Ji and Qin, Xiong and Ding, Jia-Xin and Liu, Qian and Song, Fang-Ming and Zong, Shao-Hui and Xu, Jiake and Zhou, Bo and Zhao, Jin-Min
Cellular Physiology and Biochemistry, ISSN 1015-8987, 08/2018, Volume 48, Issue 2, pp. 644 - 656
Background/Aims: Extensive osteoclast formation plays a critical role in bone diseases, including rheumatoid arthritis, periodontitis and the aseptic loosening... 
Original Paper | Osteoclast | Osteolysis | Monocrotaline | MAPK signaling pathways | CELLS | ACTIVATION | HOMEOSTASIS | PHYSIOLOGY | ALPHA | INDUCTION | NUCLEAR FACTOR | DIFFERENTIATION | PRECURSORS | Monocrotaline - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Osteolysis - etiology | Protective Agents - chemistry | Protective Agents - therapeutic use | Osteoclasts - cytology | Proton-Translocating ATPases - metabolism | RANK Ligand - pharmacology | Proton-Translocating ATPases - genetics | Protective Agents - pharmacology | Skull - pathology | p38 Mitogen-Activated Protein Kinases - metabolism | Osteolysis - prevention & control | Monocrotaline - chemistry | Disease Models, Animal | Lipopolysaccharides - toxicity | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Osteogenesis - drug effects | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Macrophages - cytology | Osteoclasts - metabolism | Monocrotaline - therapeutic use | Macrophages - metabolism | Animals | Cell Differentiation - drug effects | Skull - diagnostic imaging | Proto-Oncogene Proteins c-fos - genetics | Mice | Cell culture | Acids | Homeostasis | Bone marrow | Tumor necrosis factor-TNF | Arthritis | Hydroxyapatite | Phosphatase | Kinases
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9. Full Text Endothelial Fate Mapping in Mice With Pulmonary Hypertension
by Qiao, Lina and Nishimura, Toshihiko and Shi, Lingfang and Sessions, Dane and Thrasher, Ama and Trudell, James R and Berry, Gerald J and Pearl, Ronald G and Kao, Peter N
Circulation, ISSN 0009-7322, 02/2014, Volume 129, Issue 6, pp. 692 - 703
BACKGROUND—Pulmonary endothelial injury triggers a reparative program, which in susceptible individuals is characterized by neointima formation, vascular... 
Monocrotaline pyrrole | Cell lineage | Vascular diseases | Pneumonectomy | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | PYRROLIZIDINE ALKALOIDS | MOUSE | RATS | monocrotaline pyrrole | pneumonectomy | LINEAGE ANALYSIS | MODEL | cell lineage | vascular diseases | ARTERIAL-HYPERTENSION | DISEASE | PERIPHERAL VASCULAR DISEASE | NEOINTIMAL FORMATION | Endothelium, Vascular - cytology | Cadherins - metabolism | Alkylating Agents - pharmacology | Humans | Actins - metabolism | Monocrotaline - pharmacology | Male | Hemodynamics - physiology | Antigens, CD - genetics | Hypertension, Pulmonary - chemically induced | Antigens, CD - metabolism | Neointima - genetics | Pulmonary Artery - metabolism | Cadherins - genetics | Disease Models, Animal | von Willebrand Factor - metabolism | Neointima - chemically induced | Mice, Inbred C57BL | Hypertension, Pulmonary - genetics | Mice, Transgenic | Monocrotaline - analogs & derivatives | Cell Lineage - physiology | Animals | Endothelium, Vascular - metabolism | Neointima - pathology | Mice | Hypertension, Pulmonary - pathology | Integrases - genetics | Pulmonary Artery - pathology | Animal experimentation | Research | Pulmonary hypertension | Endothelium
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10. Full Text Inhibition of the Ca 2+ -sensing receptor rescues pulmonary hypertension in rats and mice
by Guo, Qiang and Huang, Jian-An and Yamamura, Aya and Yamamura, Hisao and Zimnicka, Adriana M and Fernandez, Ruby and Yuan, Jason X-J
Hypertension Research, ISSN 0916-9636, 02/2014, Volume 37, Issue 2, pp. 116 - 124
hypoxia | mouse | rat | monocrotaline | NPS2143
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11. Lack of protective action of cysteine against the fetotoxic effect of monocrotaline
by Soto-Blanco, B and Medeiros, RMT and Guerra, JL and Gorniak, SL
Food and Chemical Toxicology, ISSN 0278-6915, 07/2001, Volume 39, Issue 7, pp. 635 - 639
Monocrotaline (MCT), a pyrrolizidine alkaloid present in Crotalaria species, has hepatotoxic, nephrotoxic, pneumotoxic and fetotoxic effects. However, the... 
monocrotaline
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12. Full Text 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids
by He, Xiaobo and Xia, Qingsu and Ma, Liang and Fu, Peter P
Journal of Environmental Science and Health, Part C, ISSN 1059-0501, 01/2016, Volume 34, Issue 1, pp. 57 - 76
Pyrrolizidine alkaloids (PAs) require metabolic activation to exert cytotoxicity, genotoxicity, and tumorigenicity. We previously reported that... 
Pyrrolizidine alkaloid | 7-cysteine-DHP adducts | metabolic activation | DNA adduct formation | ACTIVATION | FORMATION IN-VIVO | DIETARY-SUPPLEMENTS | MONOCROTALINE | ALCOHOL GLUTATHIONE CONJUGATE | N-OXIDES | TUMORIGENICITY | ENVIRONMENTAL SCIENCES | ADDUCT FORMATION | ONCOLOGY | MICROSOMAL FORMATION | LIVER | TOXICOLOGY | Pyrrolizidine Alkaloids - metabolism | Glutathione - metabolism | Pyrrolizidine Alkaloids - pharmacokinetics | Humans | Microsomes, Liver - metabolism | Rats, Inbred F344 | DNA Adducts - chemistry | Male | Monocrotaline - analogs & derivatives | Cysteine - chemistry | DNA - metabolism | DNA Adducts - metabolism | Tandem Mass Spectrometry | Animals | Glutathione - analysis | Microsomes, Liver - drug effects | Monocrotaline - pharmacokinetics | Cysteine - metabolism | Monocrotaline - metabolism | Index Medicus
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13. Full Text Thromboxane A2 receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury
by Otaka, Fumisato and Ito, Yoshiya and Inoue, Tomoyoshi and Ohkubo, Hirotoki and Nishizawa, Nobuyuki and Kojo, Ken and Betto, Tomohiro and Yamane, Sakiko and Narumiya, Shuh and Koizumi, Wasaburo and Majima, Masataka
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2019, Volume 381, p. 114733
Sinusoidal obstruction syndrome (SOS) is a major complication of chemotherapy and hematopoietic stem cell transplantation. The early stage of SOS is... 
Liver Injury | Endothelial Cells | Thromboxane | Platelets | Monocrotaline | SOS
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14. Full Text Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension
by Türck, Patrick and Fraga, Schauana and Salvador, Isadora and Campos-Carraro, Cristina and Lacerda, Denise and Bahr, Alan and Ortiz, Vanessa and Hickmann, Alexandre and Koetz, Mariana and Belló-Klein, Adriane and Henriques, Amélia and Agostini, Fabiana and da Rosa Araujo, Alex Sander
Nutrition, ISSN 0899-9007, 02/2020, Volume 70, p. 110579
Pulmonary arterial hypertension (PAH) is a condition characterized by an increased resistance of pulmonary vasculature, culminating in an increase in pulmonary... 
Oxidative stress | Natural products | Blueberry | Monocrotaline | Pulmonary hypertension
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15. Full Text The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
by Amin, Kamal A and Hassan, Mohamed S and Awad, El-Said T and Hashem, Khalid S
International Journal of Nanomedicine, ISSN 1176-9114, 2011, Volume 6, Issue 1, pp. 143 - 149
Objective: The objective of the present study was to determine the ability of cerium oxide (CeO2) nanoparticles to protect against monocrotaline (MCT)-induced... 
Oxidative stress | Hepatotoxicity | Monocrotaline | Ceruim oxide nanoparticle | ceruim oxide nanoparticle | PYRROLE | monocrotaline | PERFUSED-RAT-LIVER | CYSTEINE | NANOSCIENCE & NANOTECHNOLOGY | METABOLIC-ACTIVATION | TOXICITY | PYRROLIZIDINE ALKALOID MONOCROTALINE | RETRORSINE | GLUTATHIONE | hepatotoxicity | ENZYMES | PHARMACOLOGY & PHARMACY | oxidative stress | Nanoparticles - chemistry | Liver | Rats | Cerium - pharmacology | Male | Monocrotaline - adverse effects | Microscopy, Electron | Rats, Sprague-Dawley | Animals | Analysis of Variance | Catalase | Protective Agents - pharmacology | Histocytochemistry | Oxidative Stress - drug effects | Chemical and Drug Induced Liver Injury - etiology | Disease Models, Animal | Superoxide Dismutase | Original Research
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16. Full Text Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid
by Wang, Yu-Ping and Yan, Jian and Fu, Peter P and Chou, Ming W
Toxicology Letters, ISSN 0378-4274, 2005, Volume 155, Issue 3, pp. 411 - 420
Retronecine-based pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline, are toxic to domestic livestock and carcinogenic to laboratory... 
Retrorsine N-oxide | Riddelliine | 32P-postlabeling | Monocrotaline | Pyrrolizidine alkaloid | Monocrotaline N-oxide | Retrorsine | DNA adducts | Dehydroretronecine | Riddelliine N-oxide | Human liver microsomal metabolism | P-postlabeling | pyrrolizidine alkaloid | VIVO | CONVERSION | monocrotaline | monocrotaline N-oxide | retrorsine | RATS | METABOLIC-ACTIVATION | DNA ADDUCT FORMATION | riddelliine | INDICINE | riddelliine N-oxide | IN-VITRO | human liver microsomal metabolism | dehydroretronecine | MICE | TOXICOLOGY | retrorsine N-oxide | P-32-postlabeling | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Oxidation-Reduction | Pyrrolizidine Alkaloids - metabolism | Cytochrome P-450 CYP3A | Humans | Microsomes, Liver - metabolism | Rats, Inbred F344 | DNA Adducts - chemistry | Rats | Monocrotaline - analogs & derivatives | Chromatography, High Pressure Liquid | Animals | DNA Adducts - analysis | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Pyrrolizidine Alkaloids - analysis | Biotransformation | Female | Microsomes, Liver - enzymology | Monocrotaline - metabolism | DNA Adducts - biosynthesis | Monocrotaline - chemistry | Pyrrolizidine Alkaloids - pharmacology
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17. Full Text Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation
by Ikutomi, Masayasu and Sahara, Makoto and Nakajima, Toshiaki and Minami, Yoshiyasu and Morita, Toshihiro and Hirata, Yasunobu and Komuro, Issei and Nakamura, Fumitaka and Sata, Masataka
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 86, pp. 121 - 135
Abstract Aims It is still controversial whether bone marrow (BM)-derived endothelial progenitor cells (EPCs) can contribute to vascular repair and prevent the... 
Cardiovascular | Vascular disease | Pulmonary arterial hypertension | Endothelial progenitor cell | Monocrotaline | Post-angioplasty restenosis | CARDIAC & CARDIOVASCULAR SYSTEMS | SUBPOPULATIONS | MONOCROTALINE PYRROLE | INJURY | RATS | ANGIOGENIC PROPERTIES | TRANSPLANTATION | CELL BIOLOGY | TRANSFUSION | GENE-THERAPY | GROWTH-FACTOR | INSIGHTS | Femoral Artery - pathology | Cell Proliferation | Vascular Diseases - pathology | Vascular Diseases - therapy | Endothelial Progenitor Cells - drug effects | Humans | Bone Marrow Cells - pathology | Rats | Endothelium, Vascular - growth & development | Femoral Artery - drug effects | Hypertension, Pulmonary - therapy | Cell Differentiation - genetics | Femoral Artery - injuries | Neointima - therapy | Animals | Arterioles - growth & development | Bone Marrow Transplantation | Neointima - pathology | Endothelial Progenitor Cells - transplantation | Endothelium, Vascular - pathology | Arterioles - transplantation | Hypertension, Pulmonary - pathology | Monocrotaline - administration & dosage | Endothelial Progenitor Cells - metabolism | Development and progression | Pulmonary hypertension | Endothelium
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