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Cancer Cell, ISSN 1535-6108, 2008, Volume 13, Issue 3, pp. 193 - 205
Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). By using a model... 
CELLCYCLE | BREAST-CANCER | ENDOTHELIAL PROGENITOR CELLS | RECTAL-CANCER | MAMMARY-TUMORS | ONCOLOGY | HEMATOPOIETIC STEM-CELLS | IN-VIVO | GROWTH-FACTOR | PRECURSOR CELLS | CANCER-THERAPY | RADIATION-THERAPY | CELL BIOLOGY | Myeloid Cells - enzymology | Bone Marrow Cells - enzymology | Neoplasms, Experimental - enzymology | Antineoplastic Agents - therapeutic use | Monocytes - immunology | Subcutaneous Tissue - surgery | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Neovascularization, Pathologic - enzymology | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | Monocytes - transplantation | Melanoma, Experimental | Stem Cells - enzymology | Time Factors | Matrix Metalloproteinase 9 - genetics | Myeloid Cells - immunology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Diphosphonates - therapeutic use | Bone Marrow Cells - drug effects | Myeloid Cells - drug effects | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Imidazoles - therapeutic use | Protease Inhibitors - therapeutic use | Signal Transduction | Mice, Inbred C57BL | Imidazoles - pharmacology | Matrix Metalloproteinase 9 - deficiency | Neoplasms, Experimental - radiotherapy | Mice, Inbred C3H | Mice, Knockout | Monocytes - drug effects | Monocytes - enzymology | Subcutaneous Tissue - radiation effects | Animals | Subcutaneous Tissue - blood supply | Matrix Metalloproteinase Inhibitors | Myeloid Cells - transplantation | Mice | CD11b Antigen - metabolism | Endothelial Cells - enzymology | Neoplasms, Experimental - drug therapy | Diphosphonates - pharmacology | Neoplasms, Experimental - blood supply | Neovascularization | Nuclear radiation | Analysis | Tumors
Journal Article
Clinical Immunology, ISSN 1521-6616, 2013, Volume 149, Issue 3, pp. 556 - 565
Abstract PTPN22 is a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems. Polymorphisms in... 
Allergy and Immunology | Autoimmunity | Genetic predisposition | T regulatory cells (Treg) | PTPN22 | Autoreactive cells | Immune tolerance | RHEUMATOID-ARTHRITIS | ALLELE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | IMMUNOLOGY | VARIANT | R620W POLYMORPHISM | INTERFERON | NK CELLS | REGULATORY T-CELLS | SUSCEPTIBILITY GENE | ASSOCIATION | T-Lymphocytes - enzymology | Dendritic Cells - immunology | Humans | Dendritic Cells - pathology | Killer Cells, Natural - pathology | Monocytes - immunology | Isoenzymes - metabolism | Lupus Erythematosus, Systemic - immunology | Monocytes - pathology | Killer Cells, Natural - immunology | Cell Differentiation | B-Lymphocytes - pathology | Diabetes Mellitus, Type 1 - immunology | T-Lymphocytes - pathology | Adaptive Immunity | Diabetes Mellitus, Type 1 - enzymology | Lupus Erythematosus, Systemic - enzymology | B-Lymphocytes - enzymology | Isoenzymes - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Diabetes Mellitus, Type 1 - pathology | Arthritis, Rheumatoid - enzymology | Immunity, Innate | Arthritis, Rheumatoid - pathology | Killer Cells, Natural - enzymology | Polymorphism, Genetic | Monocytes - enzymology | Animals | B-Lymphocytes - immunology | Dendritic Cells - enzymology | T-Lymphocytes - immunology | Arthritis, Rheumatoid - immunology | Lupus Erythematosus, Systemic - pathology | Tyrosine | Rheumatoid factor | Phosphatases | Dendritic cells | Type 1 diabetes | Phenols
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2015, Volume 35, Issue 3, pp. 547 - 557
OBJECTIVE—Atherosclerosis, an inflammatory disease of arterial vessel walls, requires migration and matrix metalloproteinase (MMP)-9–dependent invasion of... 
Inflammation | Migration and invasion protein | Atherosclerosis | Serum-glucocorticoid regulated kinase | atherosclerosis | migration and invasion protein | APOE-NULL MICE | ATHEROSCLEROTIC PLAQUES | INCREASED EXPRESSION | PATHOGENIC T(H)17 CELLS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | NEOINTIMA FORMATION | MATRIX METALLOPROTEINASE-3 | inflammation | MUSCLE-CELL MIGRATION | PERIPHERAL VASCULAR DISEASE | serum-glucocorticoid regulated kinase | HEMATOLOGY | NF-KAPPA-B | E-DEFICIENT MICE | Inflammation - pathology | Protein-Serine-Threonine Kinases - deficiency | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Male | Immediate-Early Proteins - metabolism | Matrix Metalloproteinase 9 - metabolism | Carotid Artery Diseases - pathology | Matrix Metalloproteinase 9 - genetics | Peritonitis - genetics | Carotid Arteries - enzymology | Immediate-Early Proteins - deficiency | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Atherosclerosis - pathology | Macrophages - pathology | NF-kappa B p50 Subunit - metabolism | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Plaque, Atherosclerotic | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Peritonitis - enzymology | Immediate-Early Proteins - genetics | Carotid Artery Diseases - enzymology | Carotid Artery Diseases - genetics | Mutation | Inflammation - enzymology | Vascular Remodeling | I-kappa B Proteins - metabolism | Atherosclerosis - enzymology | Transfection | I-kappa B Kinase - metabolism | Thioglycolates | Aortic Diseases - enzymology | Active Transport, Cell Nucleus | Aorta - enzymology | Aortic Diseases - pathology | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Peritonitis - chemically induced | Chemotaxis | Gene Expression Regulation, Enzymologic | Animals | Apolipoproteins E - genetics | Inflammation - genetics | Carotid Arteries - pathology
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2007, Volume 178, Issue 11, pp. 7405 - 7411
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2012, Volume 32, Issue 6, pp. 1505 - 1512
OBJECTIVES—To determine whether the level of lysophosphatidylcholine (lysoPC) generated by lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with... 
Carotid plaque | Lipoprotein-associated phospholipase A2 | Inflammation | Lysophosphatidylcholine | Atherosclerosis | atherosclerosis | lysophosphatidylcholine | LOW-DENSITY-LIPOPROTEIN | OXIDIZED LDL | PHOSPHOLIPASE A | carotid plaque | lipoprotein-associated phospholipase A2 | HUMAN ENDOTHELIAL-CELLS | inflammation | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | DEPENDENT MECHANISM | EXPRESSION | CORONARY-ARTERY-DISEASE | T-LYMPHOCYTES | HUMAN-MONOCYTES | Immunohistochemistry | Inflammation - pathology | Phospholipases A2 - analysis | T-Lymphocytes - enzymology | Cytokines - analysis | Humans | Middle Aged | Muscle, Smooth, Vascular - immunology | Male | Inflammation - blood | Carotid Stenosis - immunology | Lysophospholipids - analysis | 1-Alkyl-2-acetylglycerophosphocholine Esterase - analysis | Inflammation Mediators - analysis | Plaque, Atherosclerotic - enzymology | Mass Spectrometry | Female | Lysophosphatidylcholines - blood | Plaque, Atherosclerotic - blood | Plaque, Atherosclerotic - pathology | Macrophages - immunology | Cytokines - blood | Lysophosphatidylcholines - analysis | Severity of Illness Index | Enzyme-Linked Immunosorbent Assay | Biomarkers - analysis | Inflammation Mediators - blood | Inflammation - immunology | Carotid Stenosis - pathology | Plaque, Atherosclerotic - immunology | Macrophages - enzymology | Biopsy | T-Lymphocytes - immunology | Aged | Carotid Stenosis - enzymology | Carotid Stenosis - blood | Inflammation - enzymology | Muscle, Smooth, Vascular - enzymology | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Circulation Research, ISSN 0009-7330, 06/2012, Volume 111, Issue 1, pp. 37 - 49
RATIONALE:Hyperhomocysteinemia (HHcy) accelerates atherosclerosis and increases inflammatory monocytes (MC) in peripheral tissues. However, its causative role... 
atherosclerosis | hyperhomocysteinemia | HOMOCYSTEINE | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | STROKE PREVENTION | inflammatory monocyte | CYSTATHIONINE BETA-SYNTHASE | RANDOMIZED CONTROLLED-TRIAL | ACCELERATES ATHEROSCLEROSIS | FOLIC-ACID | VASCULAR-DISEASE | DENSITY-LIPOPROTEIN | PERIPHERAL VASCULAR DISEASE | CHEMOATTRACTANT PROTEIN-1 | HEMATOLOGY | Oxidative Stress | Atherosclerosis - genetics | Tumor Necrosis Factor-alpha - blood | Male | Green Fluorescent Proteins - genetics | Inflammation - blood | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Cell Differentiation | Disease Models, Animal | Hyperlipidemias - immunology | Hyperhomocysteinemia - enzymology | Atherosclerosis - pathology | Aorta - immunology | Mice, Transgenic | Chemokine CCL2 - blood | Inflammation - etiology | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Atherosclerosis - blood | Green Fluorescent Proteins - biosynthesis | Mice | Hyperhomocysteinemia - complications | Inflammation - enzymology | Lyases - deficiency | Bone Marrow Cells - enzymology | Hyperlipidemias - enzymology | Atherosclerosis - etiology | Atherosclerosis - enzymology | Hyperhomocysteinemia - immunology | Interleukin-6 - blood | Lipids - blood | Receptors, LDL - deficiency | Superoxides - metabolism | Bone Marrow Cells - drug effects | Lyases - genetics | Aorta - enzymology | Hyperlipidemias - complications | Macrophages - immunology | Severity of Illness Index | Receptors, LDL - genetics | Hyperhomocysteinemia - blood | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Inflammation Mediators - blood | Inflammation - immunology | Antioxidants - pharmacology | Vitamin B Complex - pharmacology | Animals | Hyperhomocysteinemia - genetics | Macrophages - drug effects
Journal Article
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2007, Volume 170, Issue 2, pp. 693 - 708
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2012, Volume 189, Issue 1, pp. 365 - 372
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 11/2015, Volume 98, Issue 5, pp. 837 - 850
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 804 - 816
Objective-The role of receptors for endogenous metabolic danger signals-associated molecular patterns has been characterized recently as bridging innate immune... 
atherosclerosis | inflammation | caspase-1 | RECRUITMENT | RELEASE | PLAQUES | SIRT1 | DEFICIENT | VASCULAR INFLAMMATION | PERIPHERAL VASCULAR DISEASE | MICE | INFLAMMASOMES | HEMATOLOGY | DECREASES ATHEROSCLEROSIS | EXPRESSION | Sirtuin 1 - metabolism | Caspase Inhibitors - pharmacology | Hyperlipidemias - genetics | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Caspase 1 - metabolism | Male | Monocytes - immunology | Hyperlipidemias - enzymology | Transcription Factor AP-1 - metabolism | Atherosclerosis - enzymology | Time Factors | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Aortic Diseases - prevention & control | Aortic Diseases - enzymology | Lipoproteins, LDL - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Hyperlipidemias - immunology | Atherosclerosis - pathology | Atherosclerosis - immunology | Cytokines - metabolism | Signal Transduction | Aortic Diseases - immunology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Cell Adhesion Molecules - metabolism | Mice, Knockout | Endothelial Cells - immunology | Monocytes - enzymology | Aortic Diseases - genetics | Animals | Caspase 1 - genetics | Apolipoproteins E - genetics | Caspase 1 - deficiency | Enzyme Activation | Endothelial Cells - enzymology | Atherosclerosis - prevention & control | Endothelial Cells - drug effects | monocyte recruitment | endothelial cell activation
Journal Article