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monophenol monooxygenase - antagonists & inhibitors (1449) 1449
index medicus (905) 905
monophenol monooxygenase - metabolism (863) 863
animals (789) 789
tyrosinase (674) 674
enzyme inhibitors - pharmacology (658) 658
humans (549) 549
biochemistry & molecular biology (505) 505
mice (504) 504
melanins - biosynthesis (411) 411
enzyme inhibitors - chemistry (406) 406
chemistry, medicinal (394) 394
melanogenesis (363) 363
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kinetics (316) 316
pharmacology & pharmacy (303) 303
mushroom tyrosinase (293) 293
cell line, tumor (276) 276
mechanism (249) 249
plant extracts - pharmacology (243) 243
molecular structure (238) 238
melanin (223) 223
structure-activity relationship (222) 222
chemistry, applied (220) 220
pigmentation (209) 209
melanocytes - drug effects (206) 206
dose-response relationship, drug (204) 204
antioxidants - pharmacology (203) 203
dermatology (202) 202
skin (202) 202
food science & technology (199) 199
melanins - antagonists & inhibitors (194) 194
monophenol monooxygenase - chemistry (194) 194
plant extracts - chemistry (194) 194
acid (186) 186
melanins - metabolism (177) 177
cell survival - drug effects (174) 174
melanoma (174) 174
analysis (171) 171
melanocytes - metabolism (166) 166
inhibition (160) 160
chemistry, organic (156) 156
enzymes (155) 155
cells (150) 150
monophenol monooxygenase - genetics (150) 150
enzyme inhibitors - isolation & purification (148) 148
in-vitro (144) 144
enzyme inhibitors - chemical synthesis (141) 141
antioxidant (140) 140
flavonoids (139) 139
cell biology (132) 132
melanocytes (131) 131
chemistry, multidisciplinary (127) 127
antioxidants (122) 122
derivatives (121) 121
inhibitory concentration 50 (119) 119
tyrosinase inhibitor (119) 119
kojic acid (118) 118
melanoma, experimental - metabolism (116) 116
cell line (115) 115
oxidation-reduction (115) 115
antioxidants - chemistry (114) 114
biotechnology & applied microbiology (113) 113
cells, cultured (109) 109
molecular docking simulation (106) 106
tyrosinase inhibitors (104) 104
skin pigmentation - drug effects (101) 101
inhibitors (100) 100
plant sciences (99) 99
tumor cells, cultured (95) 95
expression (91) 91
constituents (87) 87
antioxidant activity (86) 86
human melanocytes (86) 86
pyrones - pharmacology (83) 83
biosynthesis (82) 82
flavonoids - pharmacology (82) 82
melanocytes - enzymology (82) 82
skin - drug effects (82) 82
melanoma, experimental - pathology (80) 80
chemistry (78) 78
microphthalmia-associated transcription factor - metabolism (77) 77
models, molecular (76) 76
enzyme activation - drug effects (75) 75
phenols - pharmacology (75) 75
fungal proteins - antagonists & inhibitors (74) 74
melanoma - metabolism (74) 74
chromatography, high pressure liquid (73) 73
plant extracts - isolation & purification (73) 73
female (71) 71
proteins (70) 70
activation (69) 69
free radical scavengers - pharmacology (69) 69
agriculture, multidisciplinary (68) 68
catechol oxidase - antagonists & inhibitors (68) 68
free radicals (68) 68
plant leaves - chemistry (68) 68
protein binding (68) 68
enzyme inhibitors - metabolism (67) 67
melanocytes - cytology (67) 67
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1. Full Text Inhibitory effect of morin on tyrosinase: Insights from spectroscopic and molecular docking studies
by Wang, Yajie and Zhang, Guowen and Yan, Jiakai and Gong, Deming
Food Chemistry, ISSN 0308-8146, 11/2014, Volume 163, pp. 226 - 233
Tyrosinase is a key enzyme in the production of melanin in the human body, excessive accumulation of melanin can lead to skin disorders. Morin is an important... 
Inhibitory mechanism | Morin | Multi-spectroscopic technique | Tyrosinase | Molecular docking | ACID | FOOD SCIENCE & TECHNOLOGY | VIEWPOINT | FLAVONOIDS | NUTRITION & DIETETICS | MUSHROOM TYROSINASE | KINETICS | CHEMISTRY, APPLIED | BOVINE SERUM-ALBUMIN | Catalytic Domain | Enzyme Inhibitors - chemistry | Humans | Molecular Docking Simulation | Monophenol Monooxygenase - antagonists & inhibitors | Kinetics | Spectrum Analysis | Binding Sites | Circular Dichroism | Flavonoids - chemistry | Monophenol Monooxygenase - chemistry | Hydrogen
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2. Full Text Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
by Kim, Y.-J and Uyama, H
Cellular and Molecular Life Sciences, ISSN 1420-682X, 8/2005, Volume 62, Issue 15, pp. 1707 - 1723
Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders,... 
Life Sciences | Biochemistry, general | hyperpigmentation | Life Sciences, general | inhibitor | melanogenesis | food browning | Biomedicine general | Tyrosinase | Cell Biology | Food browning | Inhibitor | Melanogenesis | Hyperpigmentation | Enzyme Inhibitors - pharmacology | Monophenol Monooxygenase - classification | Monophenol Monooxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Fungi - metabolism | Forecasting | Melanins - biosynthesis | Food Industry | Plants - metabolism | Animals | Enzyme Inhibitors - chemistry | Maillard Reaction | Polyphenols | Cosmetics | Agriculture | Flavonoids - pharmacology | Monophenol Monooxygenase - chemistry | Phenols - pharmacology | SLOW-BINDING INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 4-SUBSTITUTED RESORCINOLS | KOJIC ACID | tyrosinase | CELL BIOLOGY | MELANIN BIOSYNTHESIS PATHWAY | AGARICUS-BISPORUS TYROSINASE | MUSHROOM TYROSINASE | POLYPHENOL OXIDASE | COPPER ACTIVE-SITE | DOPAMINE BETA-MONOOXYGENASE | NEUROSPORA-CRASSA | Pigments | Enzymes | Skin diseases | Biosynthesis
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3. Full Text Condensed Tannins from Ficus virens as Tyrosinase Inhibitors: Structure, Inhibitory Activity and Molecular Mechanism
by Chen, XX and Shi, Y and Chai, WM and Feng, HL and Zhuang, JX and Chen, QX
PLOS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91809
Condensed tannins from Ficus virens leaves, fruit, and stem bark were isolated and their structures characterized by C-13 nuclear magnetic resonance... 
SKIN PIGMENTATION | IN-VITRO | TOF MS ANALYSIS | MUSHROOM TYROSINASE | KINETICS | MULTIDISCIPLINARY SCIENCES | LEAVES | DOPAMINE | IONS | HPLC | RADICAL SCAVENGING ACTIVITY | Oxidoreductases - antagonists & inhibitors | Plant Extracts - chemistry | Plant Extracts - pharmacology | Molecular Conformation | Chelating Agents - chemistry | Models, Molecular | Substrate Specificity | Monophenol Monooxygenase - antagonists & inhibitors | Chelating Agents - pharmacology | Proanthocyanidins - chemistry | Copper - chemistry | Proanthocyanidins - pharmacology | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Catalysis | Ficus - chemistry | Monophenol Monooxygenase - chemistry | Polymerization | Biological products | Ionization | Mass spectrometry | Quinone | High performance liquid chromatography | Tannic acid | Procyanidins | Nuclear magnetic resonance--NMR | Enzyme activity | Molecular structure | Ecosystems | Bark | Fluorescence | Molecular docking | Fruits | Wetlands | Leaves | Quinones | Tannins | Enzymatic activity | Lasers | Education | Life sciences | Inhibition | Copper | Hydroxyl groups | Food | Spectroscopy | Enzymes | Free radicals | Ions | Mass spectroscopy | Desorption | Liquid chromatography | High-performance liquid chromatography | Quenching | Flavonoids | Phytochemicals | Molecular modelling | Inhibitors | Scientific imaging | Chelates | Tyrosinase | Nuclear magnetic resonance | NMR
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4. Full Text Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors
by Pillaiyar, Thanigaimalai and Manickam, Manoj and Namasivayam, Vigneshwaran
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2017, Volume 32, Issue 1, pp. 403 - 425
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic... 
inhibitors | Parkinson's disease | human tyrosinase | structure-activity relationships | skin whitening agents | Skin whitening agents | Inhibitors | Structure-activity relationships | Human tyrosinase | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPLIT-FACE TRIAL | 4-N-BUTYLRESORCINOL 0.1-PERCENT CREAM | BENZALDEHYDE THIOSEMICARBAZONES | B16 MELANOMA-CELLS | IN-VITRO | MUSHROOM TYROSINASE | BIOLOGICAL EVALUATION | POLYPHENOL OXIDASE-INHIBITORS | PARKINSONS-DISEASE | RATIONAL DESIGN | Animals | Melanins - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Monophenol Monooxygenase - antagonists & inhibitors | Catalysis | Skin Lightening Preparations | Melanins - biosynthesis | structure–activity relationships | Parkinson’s disease
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5. Full Text Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase
by Mann, Tobias and Gerwat, Wolfram and Batzer, Jan and Eggers, Kerstin and Scherner, Cathrin and Wenck, Horst and Stäb, Franz and Hearing, Vincent J and Röhm, Klaus-Heinrich and Kolbe, Ludger
Journal of Investigative Dermatology, ISSN 0022-202X, 07/2018, Volume 138, Issue 7, pp. 1601 - 1608
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target for inhibiting hyperpigmentation. Numerous... 
OXIDATION | MECHANISM | ACTIVE-SITE | 4-SUBSTITUTED RESORCINOLS | DEPIGMENTATION | 4-N-BUTYLRESORCINOL | RHODODENDROL | HYDROQUINONE | MAMMALIAN TYROSINASE | CYTOTOXICITY | DERMATOLOGY | Fungal Proteins - chemistry | Species Specificity | Monophenol Monooxygenase - isolation & purification | Skin - metabolism | Humans | Middle Aged | Skin Lightening Preparations - administration & dosage | Substrate Specificity | Male | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Melanins - metabolism | Monophenol Monooxygenase - metabolism | Enzyme Inhibitors - administration & dosage | Recombinant Proteins - isolation & purification | Enzyme Inhibitors - chemistry | HEK293 Cells | Inhibitory Concentration 50 | Female | Molecular Structure | Skin Aging - physiology | Monophenol Monooxygenase - chemistry | High-Throughput Screening Assays - methods | Recombinant Proteins - metabolism | Drug Evaluation, Preclinical - methods | Tissue Culture Techniques | Skin Aging - drug effects | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Skin Lightening Preparations - chemistry | Hyperpigmentation - drug therapy | Treatment Outcome | Skin Lightening Preparations - pharmacology | Animals | Aged | Molecular Docking Simulation | Skin - drug effects | Agaricales - chemistry | Fungal Proteins - metabolism
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6. Full Text Functionalized Carbon Quantum Dots with Dopamine for Tyrosinase Activity Monitoring and Inhibitor Screening: In Vitro and Intracellular Investigation
by Chai, Lujing and Zhou, Jin and Feng, Hui and Tang, Cong and Huang, Yuanyuan and Qian, Zhaosheng
ACS Applied Materials & Interfaces, ISSN 1944-8244, 10/2015, Volume 7, Issue 42, pp. 23564 - 23574
Sensitive assay of tyrosinase (TYR) activity is in urgent demand for both fundamental research and practical application, but the exploration of functional... 
fluorometric assay | tyrosinase | intracellular imaging | inhibitor screening | carbon quantum dots | EMERGENT NANOLIGHTS | ALPHA-ARBUTIN | ALKALINE-PHOSPHATASE | MATERIALS SCIENCE, MULTIDISCIPLINARY | OXIDASE ACTIVITY | NANOSCIENCE & NANOTECHNOLOGY | CYTOCHROME-C | NANOPARTICLES | SPECTROPHOTOMETRIC ASSAY | BIOLOGICAL APPLICATIONS | FLUORESCENT-PROBE | PROBING BIOCATALYTIC TRANSFORMATIONS | Dopamine - chemistry | Electron Transport | Quantum Dots - chemistry | Oxidation-Reduction | Monophenol Monooxygenase - isolation & purification | Biosensing Techniques | Fluorescence | Monophenol Monooxygenase - antagonists & inhibitors | Carbon - chemistry
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7. Full Text In Situ Fluorogenic and Chromogenic Reactions for the Sensitive Dual-Readout Assay of Tyrosinase Activity
by Zhao, Jiahui and Bao, Xingfu and Wang, Shuang and Lu, Shasha and Sun, Jian and Yang, Xiurong
Analytical Chemistry, ISSN 0003-2700, 10/2017, Volume 89, Issue 19, pp. 10529 - 10536
As a well-known copper-containing oxidase, tyrosinase has been anticipated to serve as the biomarker of skin diseases. We describe here an exquisite label-free... 
NANOPARTICLES | CHEMISTRY, ANALYTICAL | MOIETY | VITILIGO | RESORCINOL | GROWTH | DOPAMINE | MELANOMA-CELLS | EMISSION | FLUORESCENT-PROBE | QUANTUM DOTS | Dopamine - chemistry | Fluorescent Dyes - chemical synthesis | Temperature | Catecholamines - metabolism | Humans | Catecholamines - chemistry | Fluorescent Dyes - metabolism | Colorimetry | Monophenol Monooxygenase - antagonists & inhibitors | Monophenol Monooxygenase - metabolism | Tyramine - chemistry | Pyrones - chemistry | Cattle | Enzyme Inhibitors - chemistry | Tyramine - metabolism | Dopamine - metabolism | Resorcinols - metabolism | Fluorescent Dyes - chemistry | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Spectrometry, Fluorescence | Monophenol Monooxygenase - blood | Pressure | Animals | Resorcinols - chemistry | Pyrones - metabolism | Tyrosine | Chemical reactions | Usage | Amines | Chemical properties
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8. Full Text Investigating the Selectivity of Metalloenzyme Inhibitors
by Day, Joshua A and Cohen, Seth M
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2013, Volume 56, Issue 20, pp. 7997 - 8007
The inhibitory activity of a broad group of known metalloenzyme inhibitors against a panel of metalloenzymes was evaluated. Clinically approved inhibitors were... 
IRON TRANSPORT | POTENT | CHEMISTRY, MEDICINAL | PHARMACOKINETICS | TRANSFERRIN | CARBONIC-ANHYDRASE-II | CRYSTAL-STRUCTURE | TYROSINASE INHIBITORS | HISTONE DEACETYLASE INHIBITORS | CANCER | INTEGRASE INHIBITORS | Metalloproteins - antagonists & inhibitors | Histone Deacetylase 2 - antagonists & inhibitors | Matrix Metalloproteinase 2 - metabolism | Humans | Enzyme Inhibitors - pharmacology | Carbonic Anhydrase II - metabolism | Hydroxamic Acids - chemistry | Enzyme Assays | Monophenol Monooxygenase - antagonists & inhibitors | Matrix Metalloproteinase 12 - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Monophenol Monooxygenase - metabolism | Metalloproteins - metabolism | Biocatalysis - drug effects | Enzyme Inhibitors - chemistry | Peptidyl-Dipeptidase A - metabolism | Molecular Structure | Histone Deacetylase 2 - metabolism | Kinetics | Hydroxamic Acids - pharmacology | Enzymes - metabolism
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9. Full Text Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine
by Ji, Shuai and Li, Ziwei and Song, Wei and Wang, Yongrui and Liang, Wenfei and Li, Kai and Tang, Shunan and Wang, Qi and Qiao, Xue and Zhou, Demin and Yu, Siwang and Ye, Min
Journal of Natural Products, ISSN 0163-3864, 02/2016, Volume 79, Issue 2, pp. 281 - 292
Traditional herbal medicines have been reported to possess significant bioactivities. In this investigation, a combined strategy using both phytochemical and... 
DEFENSE | METABOLITES | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | FLAVONOIDS | POTENT TYROSINASE INHIBITORS | KAPPA-B | IDENTIFICATION | PLANT SCIENCES | CHALCONES | ROOTS | PHARMACOLOGY & PHARMACY | EXTRACT | Carbon Tetrachloride - pharmacology | Humans | Drugs, Chinese Herbal - pharmacology | GA-Binding Protein Transcription Factor - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Structure-Activity Relationship | Acetylcholinesterase | Liver - drug effects | MCF-7 Cells | Rhizome - chemistry | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | GPI-Linked Proteins - antagonists & inhibitors | Drugs, Chinese Herbal - isolation & purification | Pyrrolizidine Alkaloids - isolation & purification | Pyrrolizidine Alkaloids - pharmacology | Nitric Oxide - biosynthesis | Glycyrrhiza uralensis - chemistry | NF-kappa B - antagonists & inhibitors | Plants, Medicinal - chemistry | Liver - metabolism | Glycyrrhiza - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Pyrrolizidine Alkaloids - chemistry | Influenza A Virus, H1N1 Subtype - drug effects | Hep G2 Cells | Animals | Drugs, Chinese Herbal - chemistry | Plant Roots - chemistry | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Medicine, Traditional
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10. Full Text Downregulation of melanogenesis: drug discovery and therapeutic options
by Pillaiyar, Thanigaimalai and Manickam, Manoj and Jung, Sang-Hun
Drug Discovery Today, ISSN 1359-6446, 02/2017, Volume 22, Issue 2, pp. 282 - 298
Melanin, primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a process called melanogenesis. However, the... 
ALPHA-MSH | SIGNALING PATHWAYS | IN-VITRO | TYROSINASE ACTIVITY | SUPPRESSES MELANIN SYNTHESIS | DEPENDENT PROTEIN-KINASE | C-KIT | PHARMACOLOGY & PHARMACY | STEM-CELL FACTOR | INHIBITS MELANOGENESIS | HUMAN MELANOCYTES | Melanins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Nitric Oxide - antagonists & inhibitors | Down-Regulation | Humans | Copper-transporting ATPases - metabolism | Monophenol Monooxygenase - antagonists & inhibitors | Autophagy | Drug Discovery | Melanins - metabolism | Monophenol Monooxygenase - metabolism | Animals | Wnt Signaling Pathway | Mitogen-Activated Protein Kinases - metabolism | Health aspects | Drug discovery | Skin diseases | Care and treatment | Skin
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11. Full Text Inhibitory Effects of Propyl Gallate on Tyrosinase and Its Application in Controlling Pericarp Browning of Harvested Longan Fruits
by Lin, Yi-Fen and Hu, Yong-Hua and Lin, He-Tong and Liu, Xuan and Chen, Yi-Hui and Zhang, Shen and Chen, Qing-Xi
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 03/2013, Volume 61, Issue 11, pp. 2889 - 2895
Tyrosinase (EC 1.14.18.1), also known as polyphenol oxidase (PPO), is a key enzyme in pigment biosynthesis of organisms. The inhibitory effects of propyl... 
propyl gallate | pericarp browning | longan (Dimocarpus longan Lour.) | diphenolase activity | tyrosinase | phenolic metabolism | inhibition kinetics | QUALITY | ACID | DECAY | FOOD SCIENCE & TECHNOLOGY | OXIDASE | THIOSEMICARBAZONES | KINETICS | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | WATER | Catechol Oxidase - antagonists & inhibitors | Fruit - chemistry | Food Preservation - methods | Fruit - drug effects | Sapindaceae - enzymology | Enzyme Inhibitors - pharmacology | Sapindaceae - drug effects | Propyl Gallate - pharmacology | Fruit - enzymology | Monophenol Monooxygenase - antagonists & inhibitors | Catechol Oxidase - chemistry | Sapindaceae - chemistry | Plant Proteins - chemistry | Plant Proteins - antagonists & inhibitors | Kinetics | Monophenol Monooxygenase - chemistry
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12. Full Text Mushroom Tyrosinase:  Recent Prospects
by Seo, Sung-Yum and Sharma, Vinay K and Sharma, Niti
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 05/2003, Volume 51, Issue 10, pp. 2837 - 2853
Tyrosinase, also known as polyphenol oxidase, is a copper-containing enzyme, which is widely distributed in microorganisms, animals, and plants. Nowadays... 
Immobilization | Activators | Mushroom tyrosinase | Inhibitors | Biochemical character | Clinical studies | inhibitors | immobilization | mushroom tyrosinase | FOOD SCIENCE & TECHNOLOGY | EDIBLE MUSHROOM | ASCORBIC-ACID DERIVATIVES | PRODRUG THERAPY MDEPT | biochemical character | CARBON-PASTE ELECTRODE | activators | AGARICUS-BISPORUS TYROSINASE | SODIUM DODECYL-SULFATE | POLYPHENOL OXIDASE | L-DOPA | AGRICULTURE, MULTIDISCIPLINARY | clinical studies | COPPER ACTIVE-SITE | SLOW-BINDING INHIBITOR | CHEMISTRY, APPLIED | Enzyme Inhibitors | Vitiligo - enzymology | Neoplasms - enzymology | Substrate Specificity | Enzymes, Immobilized | Monophenol Monooxygenase - antagonists & inhibitors | Monophenol Monooxygenase - metabolism | Antioxidants | Food Industry | Cosmetics | Plants - chemistry | Agaricales - enzymology | Monophenol Monooxygenase - chemistry
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13. Full Text Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach
by Jacobsen, Jennifer A and Fullagar, Jessica L and Miller, Melissa T and Cohen, Seth M
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2011, Volume 54, Issue 2, pp. 591 - 602
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment... 
ANTHRAX LETHAL FACTOR | MATRIX METALLOPROTEINASES | CHEMISTRY, MEDICINAL | ENHANCED PFE(3+) VALUES | IRON CHELATORS | BIOLOGICAL EVALUATION | DRUG DESIGN | ZINC-BINDING GROUPS | TYROSINASE INHIBITORS | HISTONE DEACETYLASE INHIBITORS | MODEL COMPLEXES | Hydroxyquinolines - chemistry | Humans | Nitric Oxide Synthase Type II - chemistry | Iron | Monophenol Monooxygenase - antagonists & inhibitors | Structure-Activity Relationship | Bacterial Toxins - antagonists & inhibitors | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Nitric Oxide Synthase Type II - antagonists & inhibitors | Drug Design | Copper | Monophenol Monooxygenase - chemistry | Recombinant Proteins - antagonists & inhibitors | Antigens, Bacterial - chemistry | Sulfonamides - chemistry | Chelating Agents - chemistry | Recombinant Proteins - chemistry | Hydroxyquinolines - chemical synthesis | Bacterial Toxins - chemistry | Zinc | Sulfonamides - chemical synthesis | Small Molecule Libraries | Matrix Metalloproteinases - chemistry | Matrix Metalloproteinase Inhibitors | Ligands | Chelating Agents - chemical synthesis
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14. Full Text Synthesis and biological evaluation of novel hydroxybenzaldehyde-based kojic acid analogues as inhibitors of mushroom tyrosinase
by Xie, Wenlin and Zhang, Huilin and Zhang, Jingai and He, Jingjing and Yu, Qiuyan and Luo, Chunxiang and Li, Shangru
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2017, Volume 27, Issue 3, pp. 530 - 532
Two series of novel kojic acid analogues ( – ) and ( – ) were designed and synthesized, and their mushroom tyrosinase inhibitory activities was evaluated. The... 
1,2,4-Triazole | Tyrosinase inhibitors | Kojic acid | Benzaldehyde | CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | Triazoles - chemistry | Enzyme Inhibitors - pharmacology | Monophenol Monooxygenase - antagonists & inhibitors | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Pyrones - pharmacology | Monophenol Monooxygenase - metabolism | Dose-Response Relationship, Drug | Triazoles - pharmacology | Pyrones - chemistry | Enzyme Inhibitors - chemistry | Molecular Structure | Pyrones - chemical synthesis | Agaricales - enzymology
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15. Full Text A novel fluorimetric sensing platform for highly sensitive detection of organophosphorus pesticides by using egg white-encapsulated gold nanoclusters
by Yan, Xu and Li, Hongxia and Hu, Tianyu and Su, Xingguang
Biosensors and Bioelectronics, ISSN 0956-5663, 05/2017, Volume 91, pp. 232 - 237
Assays for organophosphorus pesticides (OPs) with high sensitivity as well as on-site screening have been urgently required to protect ecosystem and prevent... 
Fluorescence | Organophosphorus pesticides | Gold nanoclusters | Test strips | METHYL PARATHION | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | CARBAMATE PESTICIDES | NANOSCIENCE & NANOTECHNOLOGY | ULTRASENSITIVE DETECTION | FLUORESCENCE SWITCH | QUANTUM DOTS/BI-ENZYME | IN-VITRO | BIOPHYSICS | TYROSINASE ACTIVITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | COLORIMETRIC SENSOR | DOPAMINE | BIOSENSOR | Gold - chemistry | Limit of Detection | Metal Nanoparticles - chemistry | Models, Molecular | Monophenol Monooxygenase - antagonists & inhibitors | Pesticides - analysis | Equipment Design | Paraoxon - analysis | Monophenol Monooxygenase - metabolism | Fluorometry - instrumentation | Animals | Paraoxon - metabolism | Chickens | Egg White - chemistry | Biosensing Techniques - instrumentation | Paper | Pesticides - metabolism | Reagent Strips - analysis | Metal Nanoparticles - ultrastructure | Enzymes | Pesticides | Detectors | Index Medicus
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16. Full Text Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells
by Wang, Shang-Ta and Chang, Wei-Chia and Hsu, Chen and Su, Nan-Wei
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 08/2017, Volume 65, Issue 32, pp. 6870 - 6876
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic... 
urolithin | ellagic acid | B16 melanoma cells | tyrosinase | melanin | HUMAN PLASMA | FOOD SCIENCE & TECHNOLOGY | MELANOGENESIS | ELLAGITANNINS | BIOAVAILABILITY | INHIBITION | TYROSINASE ACTIVITY | ANTIOXIDANT | AGRICULTURE, MULTIDISCIPLINARY | HEALTHY-VOLUNTEERS | CHEMISTRY, APPLIED | CONSUMPTION | EXTRACT | Cell Survival - drug effects | Ellagic Acid - metabolism | Colon - drug effects | Enzyme Inhibitors - pharmacology | Coumarins - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Colon - metabolism | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Coumarins - pharmacology | Animals | Melanoma, Experimental | Enzyme Inhibitors - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Monophenol Monooxygenase - genetics | Kinetics | Monophenol Monooxygenase - chemistry
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