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Journal of Neurochemistry, ISSN 0022-3042, 10/2009, Volume 111, Issue 2, pp. 614 - 623
Journal Article
Experimental Dermatology, ISSN 0906-6705, 11/2017, Volume 26, Issue 11, pp. 1105 - 1111
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of... 
screening | animal model | drugs | scratching | locomotion | DRUG | DESLORATADINE | DERMATOLOGY | SCRATCHING BEHAVIOR | ASIMADOLINE | ITCH | THERAPY | NEURONS | MICE | TOFACITINIB | BRAIN | Chloroquine - metabolism | Skin - metabolism | Motor Activity - drug effects | Male | Antipruritics - pharmacology | Dose-Response Relationship, Drug | Pruritus - physiopathology | Cyproheptadine - pharmacology | Neurokinin-1 Receptor Antagonists - pharmacology | Injections, Subcutaneous | Signal Processing, Computer-Assisted | Behavior, Animal - drug effects | Pruritus - psychology | Morphinans - pharmacology | Pruritus - chemically induced | Disease Models, Animal | Aprepitant | Drug Administration Routes | Vibration | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Animals | Antidepressive Agents, Tricyclic - pharmacology | Narcotic Antagonists - pharmacology | Video Recording | Chloroquine - administration & dosage | Mice | Amitriptyline - pharmacology | Pattern Recognition, Automated - methods | Spiro Compounds - pharmacology | Usage | Analysis | Pruritus | Automation | Animal models | Amitriptyline | Antiinflammatory agents | Toxicity | Chloroquine | Inflammation | Drug development | Cyproheptadine | Skin | Drug dosages | Locomotor activity | Index Medicus
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 1/2011, Volume 67, Issue 1, pp. 63 - 71
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 9/2017, Volume 234, Issue 17, pp. 2597 - 2605
Journal Article
Pharmaceutical Biology, ISSN 1388-0209, 8/2012, Volume 50, Issue 8, pp. 1053 - 1061
Context: Sinomenium acutum (Thumb.) Rehd. et Wils. (Menispermaceae, SA) has been used as a traditional Chinese medicine in the treatment of various diseases... 
Sinomenine | immune system | cardiovascular system | nervous system | adaptogen | Cardiovascular system | Nervous system | Adaptogen | Immune system | ABILITY IN-VITRO | MORPHINANE ALKALOIDS | ACTIVATION | SPINAL-CORD | PAEONIFLORIN | RAT MODEL | PLANT SCIENCES | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | MEDICAL LABORATORY TECHNOLOGY | NF-KAPPA-B | CELL | EXPRESSION | Humans | Drugs, Chinese Herbal - pharmacology | Anti-Inflammatory Agents - adverse effects | Neurotransmitter Agents - pharmacology | Alkaloids - analysis | Anti-Inflammatory Agents - therapeutic use | Antirheumatic Agents - adverse effects | Antirheumatic Agents - pharmacology | Drugs, Chinese Herbal - therapeutic use | Morphinans - adverse effects | Morphinans - pharmacology | Drugs, Chinese Herbal - adverse effects | Antirheumatic Agents - therapeutic use | Morphinans - therapeutic use | Sinomenium - chemistry | Anti-Inflammatory Agents - pharmacology | Morphinans - analysis | Cardiovascular Agents - pharmacology | Cardiovascular Agents - therapeutic use | Ethnopharmacology | Neurotransmitter Agents - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Neurotransmitter Agents - therapeutic use | Drugs, Chinese Herbal - chemistry | Neurotransmitter Agents - adverse effects | Antirheumatic Agents - chemistry | Cardiovascular Agents - adverse effects | Cardiovascular Agents - chemistry
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2004, Volume 32, Issue 4, pp. 447 - 454
Oxycodone undergoes N -demethylation to noroxycodone and O -demethylation to oxymorphone. The cytochrome P450 (P450) isoforms capable of mediating the... 
NEUROPATHIC PAIN | 3A CYP3A | PHARMACOKINETICS | POOR METABOLIZERS | PHARMACOLOGY & PHARMACY | CONTROLLED-RELEASE OXYCODONE | CANCER PAIN | N-DEMETHYLATION | CODEINE | RECEPTOR-BINDING | POSTOPERATIVE PAIN | Intestines - drug effects | Microsomes - metabolism | Intestinal Mucosa - metabolism | Morphinans - antagonists & inhibitors | Oxidoreductases, N-Demethylating - genetics | Quinidine - antagonists & inhibitors | Cytochrome P-450 CYP3A | Humans | Microsomes, Liver - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | DNA, Complementary - genetics | Cytochrome P-450 Enzyme System - metabolism | Ketoconazole - metabolism | Metabolic Clearance Rate | Ketoconazole - pharmacology | Microsomes - drug effects | Morphinans - metabolism | Oxymorphone - metabolism | Microsomes, Liver - drug effects | Quinidine - adverse effects | Biotransformation | Protein Binding - drug effects | Molecular Structure | Oxidoreductases, N-Demethylating - metabolism | Oxycodone - metabolism | Cytochrome P-450 CYP2D6 - genetics | Cytochrome P-450 CYP2D6 - pharmacology | Morphinans - chemistry | Aryl Hydrocarbon Hydroxylases - pharmacology | Oxycodone - pharmacology | Oxymorphone - chemistry | Quinidine - pharmacology | Microsomes, Liver - chemistry | Aryl Hydrocarbon Hydroxylases - metabolism | Intestines - ultrastructure | Oxidoreductases, N-Demethylating - pharmacology | Methylation - drug effects | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Kinetics
Journal Article