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Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2013, Volume 711, Issue 1-3, pp. 63 - 72
Journal Article
PAIN, ISSN 0304-3959, 09/2014, Volume 155, Issue 9, pp. 1829 - 1835
Opioids provide powerful analgesia but also efficacy-limiting adverse effects, including severe nausea, vomiting, and respiratory depression, by activating... 
Postoperative pain | RESPIRATORY DEPRESSION | Morphine | NEUROSCIENCES | DISCOVERY | CLINICAL NEUROLOGY | INHIBITION | LIGANDS | mu-Opioid receptor | BETA-ARRESTINS | PAIN MODELS | Clinical trial | ANESTHESIOLOGY | VENTILATORY RESPONSE | Biased ligand
Journal Article
Pain, ISSN 0304-3959, 2014, Volume 155, Issue 9, pp. 1829 - 1835
Opioids provide powerful analgesia but also efficacy-limiting adverse effects, including severe nausea, vomiting, and respiratory depression, by activating... 
Mu-Opioid receptor | Clinical trial | Morphine | Postoperative pain | Biased ligand
Journal Article
Journal Article
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 05/2014, Volume 85, Issue 5, pp. 658 - 670
Opiates were the first drugs shown to negatively impact neurogenesis in the adult mammalian hippocampus. Literature data also suggest that norepinephrine is a... 
RAT DENTATE GYRUS | PATTERN SEPARATION | NMDA RECEPTOR | MEMORIES | CHRONIC PAIN | CHRONIC MORPHINE | PROLIFERATING CELLS | NEURONS | PHARMACOLOGY & PHARMACY | HIPPOCAMPAL NEUROGENESIS | REUPTAKE INHIBITOR
Journal Article
Journal of Neurotrauma, ISSN 0897-7151, 03/2017, Volume 34, Issue 6, pp. 1164 - 1174
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2019, Volume 29, Issue 1, pp. 73 - 77
Structure-activity relationship studies of several morphinan derivatives were conducted to obtain dual antagonists for μ- and δ-opioid receptors. We discovered... 
Opioid-induced constipation | Opioid-induced emesis/vomiting | Peripherally selective | Morphinan | μ- and δ-opioid receptor antagonist | CHEMISTRY, MEDICINAL | mu- and delta-opioid receptor antagonist | CHEMISTRY, ORGANIC | Medicine, Experimental | Complications and side effects | Medical research | Morphine | Esters | Drug discovery | Index Medicus
Journal Article