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Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7332, pp. 105 - 110
Studies in embryonic development have guided successful efforts to direct the differentiation of human embryonic and induced pluripotent stem cells (PSCs) into... 
VIVO | NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | ENDODERM | DEFINED CONDITIONS | GENERATION | SPECIFICATION | FATE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | Index Medicus | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 1208 - 1208
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, pp. e23899 - e23899
The Wnt/beta-catenin signalling pathway shares a key component, beta-catenin, with the cadherin-based adhesion system. The signalling function of beta-catenin... 
TYROSINE PHOSPHORYLATION | WNT PATHWAY | DEPENDENT TRANSCRIPTION | FACTOR SCATTER FACTOR | BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | ADHERENS JUNCTIONS | BETA-CATENIN | CELL-CELL ADHESION | NUCLEAR TRANSLOCATION | N-CADHERIN | Embryo, Mammalian - drug effects | Transcription, Genetic - drug effects | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transcriptional Activation - drug effects | Mesoderm - drug effects | Cytoplasm - metabolism | Epithelial-Mesenchymal Transition - drug effects | Protein Transport - drug effects | Mesoderm - cytology | Epithelial-Mesenchymal Transition - genetics | Hepatocyte Growth Factor - pharmacology | Embryo, Mammalian - metabolism | Protein Binding - drug effects | HEK293 Cells | Cell Membrane - metabolism | Epithelial Cells - cytology | Cell Membrane - drug effects | Endocytosis - drug effects | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Dogs | Mesoderm - metabolism | Mice | Cytoplasm - drug effects | Regulators | Phosphorylation | Wnt protein | Transcription | Mesenchyme | Colorectal cancer | Activation | Biology | Cell adhesion & migration | Signal transduction | β-catenin | Embryogenesis | Endocytosis | Cell growth | Tumorigenesis | Trends | Growth factors | Chromosomes | Medical research | Gastrulation | Hepatocyte growth factor | Gene expression | Cadherin | Adhesion | Embryonic growth stage | Signaling | Insects | Morphology | Stem cells | Ligands | Mutation | Endoplasmic reticulum | Cytoplasm | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7194, pp. 519 - 523
In the three decades since pluripotent mouse embryonic stem (ES) cells were first described they have been derived and maintained by using various empirical... 
MAINTENANCE | ACTIVATION | COMMITMENT | MECHANISM | TERATOCARCINOMA | MULTIDISCIPLINARY SCIENCES | PLURIPOTENCY | MOUSE ES CELLS | DIFFERENTIATION | EXPRESSION | PROTEIN-KINASE INHIBITORS | Embryonic Stem Cells - metabolism | Diphenylamine - pharmacology | Embryonic Stem Cells - cytology | Diphenylamine - analogs & derivatives | STAT3 Transcription Factor - deficiency | Benzamides - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Survival - drug effects | Pluripotent Stem Cells - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Pyrimidines - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Regeneration - physiology | Pluripotent Stem Cells - metabolism | Regeneration - drug effects | Animals | MAP Kinase Signaling System - drug effects | Embryonic Stem Cells - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Differentiation - drug effects | Pluripotent Stem Cells - drug effects | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Morphogenesis | Cytokines | Influence | Regeneration (Biology) | Research | Genetic transcription | Embryonic stem cells | Properties | Protein kinases | Proteins | Signal transduction | Cyclin-dependent kinases | Stem cells | Cell cycle | Kinases | Apoptosis | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 50, Issue 1, pp. 75 - 86
Abstract Successful bone tissue engineering generally requires an osteoconductive scaffold that consists of extracellular matrix (ECM) to mimic the natural... 
Advanced Basic Science | Dentistry | Extracellular matrix (ECM) | Bone morphogenic protein (BMP)-2 | Bone tissue engineering | Cell-derived matrix | Microenvironment | Polymer mesh scaffold | MIGRATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | CONSTRUCTS | STRENGTH | MESENCHYMAL STEM-CELLS | CARTILAGE | MULTI-LINEAGE DIFFERENTIATION | MORPHOGENESIS | VASCULARIZATION | EXTRACELLULAR-MATRIX | Bone Morphogenetic Protein 2 - pharmacology | Bone and Bones - pathology | Calcium - metabolism | Humans | Extracellular Matrix - metabolism | Fibroblasts - ultrastructure | Bone and Bones - drug effects | Tissue Scaffolds - chemistry | Mesenchymal Stromal Cells - cytology | Placenta - cytology | Skull - pathology | Female | Skull - drug effects | Wound Healing - drug effects | Disease Models, Animal | Osseointegration - drug effects | Bone Regeneration - drug effects | Mesenchymal Stromal Cells - drug effects | Extracellular Matrix - drug effects | Osteogenesis - drug effects | Biocompatible Materials - pharmacology | Rats, Sprague-Dawley | Pregnancy | Extracellular Matrix - ultrastructure | Animals | Cell Differentiation - drug effects | Mice, Nude | Fibroblasts - drug effects | Immobilized Proteins - pharmacology | Polymers - pharmacology | Polymers - chemistry | Fibroblasts - cytology | Fibronectins | Biological products | Glycosaminoglycans | Tissue engineering | Analysis | Stem cells | Anticoagulants (Medicine) | Polymer industry | Polymers | Index Medicus | Finite element method | Biomedical materials | Biocompatibility | Bones | Coating | Scaffolds | Heparins | Defects
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2012, Volume 369, Issue 1, pp. 101 - 114
Embryonic development is controlled by a small set of signal transduction pathways, with vastly different phenotypic outcomes depending on the time and place... 
Development | Calvarial mesenchyme | Mouse model | Ror2 | Hair follicles | Wnt5a | PLANAR CELL POLARITY | CONVERGENT EXTENSION | DEVELOPMENTAL BIOLOGY | BETA-CATENIN | XENOPUS EMBRYOS | GENE-EXPRESSION | HAIR FOLLICLE MORPHOGENESIS | BONE-MASS | TUMOR-SUPPRESSOR | AXIS FORMATION | RECEPTOR TYROSINE KINASE | Embryo, Mammalian - drug effects | Meninges - embryology | Skin - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Embryo, Mammalian - metabolism | Bone and Bones - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | Female | Models, Animal | Hair Follicle - embryology | Repressor Proteins - metabolism | Skin - embryology | Calcification, Physiologic - genetics | Calcification, Physiologic - drug effects | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Osteogenesis - drug effects | Tetracycline - pharmacology | Embryonic Development - genetics | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Meninges - drug effects | beta Catenin - metabolism | Hair Follicle - drug effects | Pregnancy | Hair Follicle - cytology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Mice | Bone and Bones - abnormalities | Bone and Bones - embryology | Embryonic Development - drug effects | Skin - drug effects | Index Medicus | development | hair follicles | calvarial mesenchyme | mouse model
Journal Article
Molecular Plant, ISSN 1674-2052, 05/2012, Volume 5, Issue 3, pp. 750 - 762
Ubiquitin-26S proteasome system (UPS) has been shown to play central roles in light and hormone-regulated plant growth and development. Previously, we have... 
photomorphogenesis | Arabidopsis | strigolactone | protein degradation | F-box protein | SCF complex | ARABIDOPSIS-THALIANA | SEED-GERMINATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PIL5 | HELIX TRANSCRIPTION FACTOR | NEGATIVE REGULATOR | PLANT SCIENCES | AUXIN TRANSPORT | PHYTOCHROME-INTERACTING FACTORS | DEGRADATION | LIGHT SIGNAL-TRANSDUCTION | Organ Specificity - drug effects | Seeds - radiation effects | Arabidopsis - growth & development | Epistasis, Genetic - drug effects | Lactones - pharmacology | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Biosynthetic Pathways - radiation effects | Seeds - growth & development | Biological Transport - radiation effects | Light | Biological Transport - drug effects | Germination - radiation effects | Germination - drug effects | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Indoleacetic Acids - metabolism | Morphogenesis - radiation effects | Seeds - drug effects | Ubiquitin-Protein Ligases - metabolism | Seedlings - drug effects | Mutation - genetics | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Organ Specificity - radiation effects | Phenotype | Biosynthetic Pathways - drug effects | Carrier Proteins - metabolism | Epistasis, Genetic - radiation effects | Genes, Plant - genetics | Gibberellins - pharmacology | Morphogenesis - drug effects | Plant Growth Regulators - metabolism | Seedlings - radiation effects | Seeds | Hormones | Plant growth | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 06/2012, Volume 125, Issue 11, pp. 2638 - 2654
Normal mammary morphogenesis involves transitions between simple and multilayered epithelial organizations. We used electron microscopy and molecular markers... 
Breast cancer | Apico-basal polarity | Epithelial morphogenesis | Mammary gland | GLAND BRANCHING MORPHOGENESIS | STEM-CELLS | FINE-STRUCTURE | 3-DIMENSIONAL CULTURE | E-CADHERIN | HUMAN BREAST-CANCER | MESENCHYMAL TRANSITION | ELECTRON TOMOGRAPHY | CELL BIOLOGY | DUCTAL MORPHOGENESIS | DESMOSOMAL ADHESION | Desmosomes - drug effects | Desmosomes - ultrastructure | Epithelial Cells - drug effects | Extracellular Matrix - metabolism | rac GTP-Binding Proteins - metabolism | Epithelium - ultrastructure | rho-Associated Kinases - antagonists & inhibitors | Mammary Glands, Animal - growth & development | Laminin | rho-Associated Kinases - metabolism | Organoids - ultrastructure | Female | Cell Membrane - metabolism | Cell Polarity - drug effects | Epithelial Cells - cytology | Cell Membrane - drug effects | Amides - pharmacology | Tight Junctions - metabolism | Desmosomes - metabolism | Epithelium - drug effects | Cell Surface Extensions - ultrastructure | Proteoglycans | Epithelium - metabolism | Cell Surface Extensions - metabolism | Myosin-Light-Chain Kinase - metabolism | Tissue Culture Techniques | Extracellular Matrix - drug effects | Organoids - cytology | Epithelial Cells - ultrastructure | Cell Membrane - ultrastructure | Mammary Glands, Animal - cytology | Cell Shape - drug effects | Tight Junctions - ultrastructure | Cell Movement - drug effects | Mammary Glands, Animal - ultrastructure | Animals | Models, Biological | Collagen | Cell Communication - drug effects | Epithelial Cells - enzymology | Organoids - drug effects | Morphogenesis - drug effects | Mice | Pyridines - pharmacology | Drug Combinations | Index Medicus
Journal Article
The Plant Cell, ISSN 1040-4651, 9/2014, Volume 26, Issue 9, pp. 3630 - 3645
Arabidopsis thatiana seedlings undergo photomorphogenic development even in darkness when the function of DEETIOLATED1 (DET1), a repressor of... 
Phenotypes | Transcription factors | Hypocotyls | Cocktails | RESEARCH ARTICLES | Genes | Gene expression regulation | Physiological regulation | Plants | Seedlings | Plant cells | PHOTOACTIVATED PHYTOCHROMES | SEEDLING DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT DEVELOPMENT | NEGATIVE REGULATOR | PLANT SCIENCES | CELL BIOLOGY | LIGHT-SIGNAL-TRANSDUCTION | LOOP-HELIX PROTEIN | COP9 SIGNALOSOME | CHLOROPLAST DEVELOPMENT | TRANSCRIPTION FACTOR | E3 UBIQUITIN LIGASE | Darkness | Cell Wall - radiation effects | Arabidopsis - growth & development | Genes, Plant | Etiolation - drug effects | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Cell Wall - drug effects | Light | Protein Binding - drug effects | Protein Binding - radiation effects | Photosynthesis - radiation effects | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Morphogenesis - radiation effects | Proteasome Inhibitors - pharmacology | Etiolation - radiation effects | Nuclear Proteins - metabolism | Transcriptome - genetics | Seedlings - drug effects | Mutation - genetics | Arabidopsis - metabolism | Gene Expression Regulation, Plant - drug effects | Phenotype | Indoleacetic Acids - pharmacology | Models, Biological | Photosynthesis - drug effects | Morphogenesis - drug effects | Seedlings - radiation effects | Seedlings - metabolism | Arabidopsis thaliana | Botanical research | Physiological aspects | Photoreceptors | Research | Photomorphogenesis | Index Medicus
Journal Article