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Nature neuroscience, ISSN 1546-1726, 2012, Volume 15, Issue 5, pp. 746 - 753
Endocannabinoid mediated spike timing-dependent depression (t-LTD) is crucially involved in the development of the sensory neocortex. t-LTD at excitatory... 
Astrocytes/drug effects | Electric Stimulation | Rats, Wistar | 2-Amino-5-phosphonovalerate/pharmacology | Calcium/metabolism | Synapses/drug effects | Time Factors | Naphthalenes/pharmacology | Sodium Channel Blockers/pharmacology | Thalamus/cytology | Long-Term Synaptic Depression/drug effects | Animals, Newborn | Calcium Channel Blockers/pharmacology | Excitatory Amino Acid Antagonists/pharmacology | Dizocilpine Maleate/pharmacology | Excitatory Postsynaptic Potentials/drug effects | Probability | Rats | Benzoxazines/pharmacology | Biophysics | Signal Transduction/drug effects | Neocortex/cytology | Patch-Clamp Techniques | Animals | Glutamic Acid/metabolism | Morpholines/pharmacology | Pyrazoles/pharmacology | Piperidines/pharmacology | Tetrodotoxin/pharmacology | In Vitro Techniques | Receptor, Cannabinoid, CB1/antagonists & inhibitors | D-SERINE | NEUROTRANSMITTER RELEASE | INHIBITORY SYNAPSES | PYRAMIDAL CELLS | SYNAPTIC-TRANSMISSION | RAT SOMATOSENSORY CORTEX | LONG-TERM POTENTIATION | GLIAL-CELLS | PRESYNAPTIC NMDA | NEUROSCIENCES | PLASTICITY | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Piperidines - pharmacology | Tetrodotoxin - pharmacology | Pyrazoles - pharmacology | Astrocytes - drug effects | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Synapses - physiology | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Naphthalenes - pharmacology | Astrocytes - ultrastructure | Astrocytes - physiology | Signal Transduction - drug effects | Benzoxazines - pharmacology | Thalamus - cytology | Neocortex - cytology | Signal Transduction - physiology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dizocilpine Maleate - pharmacology | Methyl aspartate | Depression, Mental | Physiological aspects | Genetic aspects | Research | Risk factors | Synapses
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 592 - 600
When chronic alterations in neuronal activity occur, network gain is maintained by global homeostatic scaling of synaptic strength, but the stability of... 
MOUSE-BRAIN | HIPPOCAMPAL SLICE CULTURES | AXON TERMINALS | GAIN-CONTROL | SYNAPTIC-TRANSMISSION | GABA RELEASE | CB1 CANNABINOID RECEPTOR | RAT HIPPOCAMPUS | EXPRESSION | NEUROSCIENCES | PLASTICITY | Cannabinoid Receptor Modulators - metabolism | Cannabinoid Receptor Modulators - pharmacology | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Nerve Net - physiology | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Neural Inhibition - physiology | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Neurons - physiology | Benzamides - pharmacology | Homeostasis - drug effects | Tetrodotoxin - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | Synapses - drug effects | Synapses - physiology | Enzyme Inhibitors - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Morpholines - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Calcium Channel Blockers - pharmacology | Down-Regulation - drug effects | Hippocampus - cytology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Agatoxins | Conotoxins - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Polyamines - pharmacology | Animals | Homeostasis - physiology | Benzoxazines - pharmacology | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Brain | Physiological aspects | Homeostasis | Research | Synapses | Injuries
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2016, Volume 36, Issue 32, pp. 8461 - 8470
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2012, Volume 74, Issue 5, pp. 801 - 808
The steroid 17β-estradiol (E2) is well known to influence hippocampal functions such as memory, affective behaviors, and epilepsy. There is growing awareness... 
CA1 | EXCITABILITY | STEROIDS | SYNAPSES | ESTROGEN-RECEPTOR-ALPHA | SYNAPTIC-TRANSMISSION | NEURONS | RELEASE | BINDING | NEUROSCIENCES | Cannabinoid Receptor Modulators - metabolism | CA1 Region, Hippocampal - cytology | Electric Stimulation | Estrogens - pharmacology | Male | Receptors, Metabotropic Glutamate - metabolism | Pyridazines - pharmacology | Lactones - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Castration | Piperidines - pharmacology | Excitatory Amino Acid Agents - pharmacology | Neurons - physiology | Female | Neurons - drug effects | Endocannabinoids | Estradiol - pharmacology | Pyrazoles - pharmacology | Enzyme Inhibitors - pharmacology | NAD - pharmacology | Cannabinoid Receptor Modulators - agonists | Morpholines - pharmacology | Rats | Biophysics | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Naphthalenes - pharmacology | Patch-Clamp Techniques | Animals | Benzoxazines - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Phenols | In Vitro Techniques | Neural Inhibition - drug effects | Benzodioxoles - pharmacology | Inhibitory Postsynaptic Potentials - drug effects | Brain | Epilepsy | Estrogen | GABA | Hormones, Sex | Estradiol | Studies | Rodents | Gender differences | Behavior | Males | Females | Presynapse | Emotional behavior | gamma -Aminobutyric acid | Neurosteroids | Memory | Sex | Estrogen receptors | Cannabinoid CB1 receptors | Anandamide | Synaptic transmission | Hippocampus | Steroid hormones | Synapses
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2010, Volume 30, Issue 2, pp. 545 - 555
Marijuana is a widely used drug that impairs memory through interaction between its psychoactive constituent, Delta-9-tetrahydrocannabinol (Delta(9)-THC), and... 
CA1 Region, Hippocampal - cytology | Receptor, Adenosine A1 - physiology | Neurons - cytology | Xanthines - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Receptor, Cannabinoid, CB1 - physiology | Excitatory Postsynaptic Potentials - physiology | Quinoxalines - pharmacology | Neural Inhibition - physiology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Caffeine - pharmacology | Dronabinol - pharmacology | Electric Stimulation - methods | Pyrazoles - pharmacology | Presynaptic Terminals - drug effects | Mice, Inbred C57BL | Morpholines - pharmacology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Calcium Channel Blockers - pharmacology | GABA Antagonists - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Analysis of Variance | Phosphinic Acids - pharmacology | Benzoxazines - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Adenosine - metabolism | Picrotoxin - pharmacology | Presynaptic Terminals - metabolism | Glutamic Acid - metabolism | Mice | Receptor, Cannabinoid, CB1 - deficiency | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Propanolamines - pharmacology | Neural Inhibition - drug effects
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 12/2012, Volume 224, Issue 3, pp. 363 - 376
Pupillometry can be used to characterize autonomic drug effects.This study was conducted to determine the autonomic effects of... 
Pupil | Neurosciences | Biomedicine | Serotonin | Pupillometry | Pupillary reflex | Norepinephrine | Pharmacology/Toxicology | Psychiatry | MDMA | YOHIMBINE | PSYCHIATRY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE ECSTASY | PHARMACODYNAMICS | CLINICAL PHARMACOKINETICS | NEUROSCIENCES | ALPHA-ADRENOCEPTOR | FLUCTUATIONS | AGONIST CLONIDINE | PAROXETINE | PHARMACOLOGY & PHARMACY | MYDRIASIS | Doxazosin - pharmacology | Autonomic Agents - pharmacokinetics | Humans | Mydriasis - physiopathology | Mydriatics - blood | Miosis - physiopathology | Adrenergic Agonists - pharmacology | Autonomic Agents - pharmacology | Male | N-Methyl-3,4-methylenedioxyamphetamine - blood | Adrenergic alpha-2 Receptor Agonists - pharmacology | Recovery of Function | Mydriatics - pharmacology | Young Adult | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Time Factors | Light | Reaction Time - drug effects | Adult | Body Temperature Regulation - drug effects | Clonidine - pharmacology | Female | Mydriatics - pharmacokinetics | Autonomic Agents - blood | Affect - drug effects | Reflex, Pupillary - drug effects | Dopamine Uptake Inhibitors - pharmacology | Miosis - prevention & control | Morpholines - pharmacology | Thiophenes - pharmacology | Randomized Controlled Trials as Topic | Cross-Over Studies | Mydriasis - chemically induced | Duloxetine Hydrochloride | Adrenergic Uptake Inhibitors - pharmacology | Hemodynamics - drug effects | Carbazoles - pharmacology | Propanolamines - pharmacology | Serotonin Uptake Inhibitors - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - pharmacokinetics | Side effects | Pharmacology | Eyes & eyesight | Index Medicus | Drug abuse | Sympathomimetics | Drug tolerance | clonidine | Duloxetine | Light effects | Parasympathetic nervous system | Reflexes | reboxetine
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2011, Volume 31, Issue 41, pp. 14600 - 14610
Orexin A and B are hypothalamic peptides known to modulate arousal, feeding, and reward via OX1 and OX2 receptors. Orexins are also antinociceptive in the... 
ENERGY HOMEOSTASIS | SYNAPTIC-TRANSMISSION | FEEDING-BEHAVIOR | PHOSPHOLIPASE-C | NEURONS | SPINAL-CORD | DIACYLGLYCEROL LIPASE | STRESS-INDUCED ANALGESIA | NEUROSCIENCES | HIPPOCAMPAL SYNAPSES | HYPOCRETIN OREXIN | Cannabinoid Receptor Modulators - pharmacology | Benzoxazoles - pharmacology | Electric Stimulation | Neural Pathways - drug effects | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | gamma-Aminobutyric Acid - metabolism | Periaqueductal Gray - drug effects | Male | Receptors, Neuropeptide - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Pain - metabolism | Neural Pathways - physiology | Lactones - pharmacology | Neural Inhibition - physiology | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Pain - drug therapy | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Urea - analogs & derivatives | Endocannabinoids | Disease Models, Animal | Pyrazoles - pharmacology | Animals, Newborn | Orexins | Enzyme Inhibitors - pharmacology | Receptors, Neuropeptide - antagonists & inhibitors | Morpholines - pharmacology | Rats | Neuropeptides - metabolism | Pain Measurement - drug effects | Orexin Receptors | Pain - pathology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Calcium Channel Blockers | Glycerides - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Benzoxazines - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Periaqueductal Gray - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Urea - pharmacology
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 1740-634X, 2011, Volume 37, Issue 5, pp. 1164 - 1176
The rostromedial tegmental nucleus (RMTg), a structure located just posterior to the ventral tegmental area (VTA), is an important site involved in aversion... 
cannabinoids | patch clamp | electrophysiology | rat | morphine | GABAERGIC TAIL | NEGATIVE REWARD SIGNALS | AVERSIVE STIMULI | PSYCHIATRY | SYNAPTIC-TRANSMISSION | LATERAL HABENULA | SUBSTANTIA-NIGRA | CANNABINOID CB1 | NEUROSCIENCES | IN-VITRO | AREA | PHARMACOLOGY & PHARMACY | OPIOID RECEPTORS | Electric Stimulation | Cannabinoids - antagonists & inhibitors | Male | Ventral Tegmental Area - cytology | Neural Pathways - physiology | Nicotine - pharmacology | Neural Inhibition - physiology | Piperidines - pharmacology | Time Factors | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Action Potentials - drug effects | Nicotinic Agonists - pharmacology | Pyrazoles - pharmacology | Physical Stimulation | Morphine - pharmacology | Tegmentum Mesencephali - cytology | Morpholines - pharmacology | Rats | Rats, Sprague-Dawley | Naphthalenes - pharmacology | Action Potentials - physiology | Cocaine - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Benzoxazines - pharmacology | Cannabinoids - agonists | Narcotics - pharmacology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | cannabinoid | neuropharmacology | addiction & substance abuse | neurophysiology | Original | dopamine
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2011, Volume 31, Issue 24, pp. 8905 - 8919
Astrocytes show a complex structural and physiological interplay with neurons and respond to neuronal activation in vitro and in vivo with intracellular... 
SLICE CULTURES | TRANSMITTER RELEASE | D-SERINE | SYNAPTIC-TRANSMISSION | SEMLIKI-FOREST-VIRUS | METABOTROPIC GLUTAMATE RECEPTORS | RAT HIPPOCAMPUS | LONG-TERM POTENTIATION | NEUROSCIENCES | IN-SITU | CA1 PYRAMIDAL NEURONS | Glycine - analogs & derivatives | Calcium - metabolism | Channelrhodopsins | Male | Peptide Fragments - pharmacology | Phosphopyruvate Hydratase - metabolism | Green Fluorescent Proteins - genetics | Glial Fibrillary Acidic Protein - metabolism | Piperidines - pharmacology | Neurons - physiology | Statistics, Nonparametric | Female | Tetrodotoxin - pharmacology | Electric Stimulation - methods | Transduction, Genetic - methods | Pyrazoles - pharmacology | Animals, Newborn | Mice, Inbred C57BL | Bacterial Proteins - genetics | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Tetanus Toxin - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Naphthalenes - pharmacology | Action Potentials - physiology | Carbenoxolone - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Glycine - pharmacology | Photic Stimulation - methods | Models, Biological | Benzoxazines - pharmacology | Benzoates - pharmacology | Luminescent Proteins - genetics | Mice | Pyridines - pharmacology | Aspartic Acid - analogs & derivatives | In Vitro Techniques | Aspartic Acid - pharmacology | Astrocytes - metabolism
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2005, Volume 25, Issue 45, pp. 10537 - 10545
Endocannabinoids are important mediators of short- and long-term synaptic plasticity, but the mechanisms of endocannabinoid release have not been studied... 
Medium spiny neuron | Striatum | Dopamine | Endocannabinoid | L-type calcium channel | mGluR | PURKINJE-CELLS | endocannabinoid | ENDOGENOUS CANNABINOIDS | DEPOLARIZED POSTSYNAPTIC NEURONS | GLUTAMATE UPTAKE | SYNAPTIC PLASTICITY | NEUROSCIENCES | NUCLEUS-ACCUMBENS | HIPPOCAMPAL SYNAPSES | PRESYNAPTIC TERMINALS | striatum | medium spiny neuron | DORSAL STRIATUM | RETROGRADE INHIBITION | dopamine | Cannabinoid Receptor Modulators - metabolism | Sulpiride - pharmacology | Excitatory Postsynaptic Potentials - radiation effects | Cerebellum - drug effects | Benzoxazines | Long-Term Synaptic Depression - drug effects | Corpus Striatum - cytology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Excitatory Postsynaptic Potentials - physiology | Piperidines - pharmacology | Time Factors | Dopamine - physiology | Neurons - drug effects | Electric Stimulation - methods | Endocannabinoids | Pyrazoles - pharmacology | Membrane Potentials - drug effects | Dopamine Agonists - pharmacology | Long-Term Synaptic Depression - physiology | Dopamine - pharmacology | Morpholines - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Nitrendipine - pharmacology | Calcium Channel Blockers - pharmacology | Membrane Potentials - physiology | Rats, Sprague-Dawley | Naphthalenes - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Dopamine Antagonists - pharmacology | Epistasis, Genetic | Corpus Striatum - physiology | Quinpirole - pharmacology | In Vitro Techniques | Dose-Response Relationship, Radiation | Aspartic Acid - pharmacology | Cellular | Molecular
Journal Article
British journal of pharmacology, ISSN 0007-1188, 2009, Volume 150, Issue 5, pp. 613 - 623
Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol has been demonstrated to have low affinity for both cannabinoid CB1... 
cannabidiol | CB2 receptor | CP55940 | O‐2654 | GTPγS assay | CB1 receptor | mouse brain | inverse agonism | neutral antagonism | O-2654 | GTP gamma S assay | INHIBITION | LIGANDS | SELECTIVE INVERSE AGONIST | MOUSE VAS-DEFERENS | PERIPHERAL CANNABINOID RECEPTOR | PHARMACOLOGY & PHARMACY | BINDING | BRAIN | Cricetulus | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cyclohexanes - pharmacology | Humans | Bornanes - pharmacology | Anti-Inflammatory Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Transfection | Piperidines - pharmacology | Morpholines - antagonists & inhibitors | Phenols - antagonists & inhibitors | Cyclohexanes - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Cell Membrane - metabolism | Cell Membrane - drug effects | Receptors, Cannabinoid - genetics | CHO Cells | Phenols - pharmacology | Pyrazoles - pharmacology | Cricetinae | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Cannabidiol - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Brain - drug effects | Cannabinoid Receptor Agonists | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Benzoxazines - pharmacology | Protein Binding | Mice | Cannabidiol - metabolism | In Vitro Techniques | Naphthalenes - antagonists & inhibitors | Research Papers
Journal Article