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Journal Article
Cell Reports, ISSN 2211-1247, 06/2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors... 
HUMAN ES | IN-VITRO | VENTRAL MESENCEPHALON | FLOOR PLATE | MIDBRAIN DOPAMINE NEURONS | SUBSTANTIA-NIGRA | RAT MODEL | LINES | PARKINSONS-DISEASE | IPS CELLS | CELL BIOLOGY | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences | Cell Biology
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
LAMINA-I NEURONS | NEUROTROPHIC FACTOR | P2X RECEPTORS | DOWN-REGULATION | OPIOID-RECEPTOR GENE | SPINAL-CORD-INJURY | UNDERLYING NEUROPATHIC PAIN | ALTERED CHLORIDE HOMEOSTASIS | NERVE INJURY | NEUROSCIENCES | INDUCED ABNORMAL PAIN | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 03/2013, Volume 38, Issue 4, pp. 552 - 562
The abuse of psychoactive 'bath salts' containing cathinones such as 3,4-methylenedioxypyrovalerone (MDPV) is a growing public health concern, yet little is... 
cathinone | monoamine transporter | uptake blocker | dopamine | designer drug | NOREPINEPHRINE | PSYCHIATRY | DOPAMINE OVERFLOW | LOCOMOTOR-ACTIVITY | MEPHEDRONE | MONOAMINE TRANSPORTERS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | LEGAL HIGHS | DRUGS | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | UPTAKE INHIBITORS | Motor Activity - physiology | Humans | Motor Activity - drug effects | Male | Corpus Striatum - metabolism | Pyrrolidines - pharmacology | Salts - chemistry | Salts - pharmacology | Psychotropic Drugs - pharmacology | HEK293 Cells | Benzodioxoles - chemistry | Dopamine - metabolism | Organ Culture Techniques | Cocaine - chemistry | Designer Drugs - pharmacology | Mice, Inbred C57BL | Rats | Psychotropic Drugs - chemistry | Random Allocation | Pyrrolidines - chemistry | Rats, Sprague-Dawley | Cocaine - pharmacology | Designer Drugs - chemistry | Animals | Corpus Striatum - drug effects | Mice | Benzodioxoles - pharmacology | Neurochemistry | Brain | Drug abuse | Salts | Dopamine | Intravenous administration | Brain slice preparation | Catecholamines | Data processing | Pharmacology | Nucleus accumbens | Side effects | Tachycardia | Monoamine transporter | Neostriatum | Cocaine | Locomotor activity | Neurotransmission | Public health | addiction & Substance Abuse | blocker | catecholamines | releaser | designer drugs | neuropharmacology | transporter | Original | Psychostimulants
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1609 - 1616
We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,... 
AMPA receptor | depression | lipopolysaccharide | NMDA receptor | inflammation | ketamine | BACILLUS-CALMETTE-GUERIN | PSYCHIATRY | MACROPHAGES | INDOLEAMINE 2,3-DIOXYGENASE | INDUCTION | NEUROSCIENCES | HIPPOCAMPUS | QUINOLINIC ACID | SICKNESS | IMMUNE ACTIVATION | PHARMACOLOGY & PHARMACY | BRAIN | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Body Weight - drug effects | Motor Activity - drug effects | Male | Ketamine - antagonists & inhibitors | Lipopolysaccharides - antagonists & inhibitors | Brain - metabolism | Quinoxalines - pharmacology | Depression - drug therapy | Drug Interactions | Liver - drug effects | Depression - chemically induced | Immobility Response, Tonic - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - biosynthesis | Ketamine - therapeutic use | Cytokines - metabolism | Drug Administration Schedule | Food Preferences - drug effects | Liver - metabolism | Mice, Inbred C57BL | Excitatory Amino Acid Antagonists - pharmacology | Antidepressive Agents - therapeutic use | Brain - drug effects | Eating - drug effects | Animals | Signal Transduction - drug effects | Mice | Ketamine - pharmacology | Receptors, AMPA - antagonists & inhibitors | Antidepressants | biological psychiatry | animal models | behavioral science | bipolar | unipolar | Original
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 01/2012, Volume 17, Issue 1, pp. 85 - 98
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect... 
schizophrenia | genes | working memory | dopamine | mice | prefrontal cortex | PREPULSE INHIBITION | 6P22.3 GENE | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL CONNECTIVITY | HIPPOCAMPAL-FORMATION | NEUROSCIENCES | GENETIC-VARIATION | PYRAMIDAL NEURONS | D2 RECEPTOR | MESSENGER-RNA | SUSCEPTIBILITY GENE | WORKING-MEMORY | Sensory Gating - drug effects | Gene Expression Regulation, Enzymologic - drug effects | Hyperkinesis - genetics | Action Potentials - genetics | Prefrontal Cortex - physiopathology | Motor Activity - drug effects | Schizophrenia - complications | Memory, Short-Term - physiology | Schizophrenia - pathology | Receptors, Dopamine D2 - metabolism | Hyperkinesis - drug therapy | Prefrontal Cortex - pathology | Prefrontal Cortex - drug effects | Dopamine Agents - pharmacology | Reaction Time - drug effects | Sensory Gating - genetics | Mice, Inbred DBA | Pyramidal Cells - drug effects | Action Potentials - drug effects | Dopamine - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Memory, Short-Term - drug effects | Amphetamine - adverse effects | Reaction Time - genetics | Maze Learning - drug effects | Hyperkinesis - etiology | Mice, Knockout | Dystrophin-Associated Proteins | Carrier Proteins - genetics | Motor Activity - genetics | Animals | Memory Disorders - drug therapy | Memory Disorders - etiology | Gene Expression Regulation, Enzymologic - genetics | Mice | Dysbindin | Stress, Psychological - physiopathology | Genetic aspects | Prefrontal cortex | Research | Binding proteins | Properties | Dopaminergic mechanisms | Genetic regulation
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Journal Article