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Molecular psychiatry, ISSN 1476-5578, 10/2010, Volume 17, Issue 1, pp. 85 - 98
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown... 
schizophrenia | genes | working memory | dopamine | mice | prefrontal cortex | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Sensory Gating - drug effects | Gene Expression Regulation, Enzymologic - drug effects | Hyperkinesis - genetics | Action Potentials - genetics | Prefrontal Cortex - physiopathology | Motor Activity - drug effects | Schizophrenia - complications | Memory, Short-Term - physiology | Schizophrenia - pathology | Receptors, Dopamine D2 - metabolism | Hyperkinesis - drug therapy | Prefrontal Cortex - pathology | Prefrontal Cortex - drug effects | Dopamine Agents - pharmacology | Reaction Time - drug effects | Sensory Gating - genetics | Mice, Inbred DBA | Pyramidal Cells - drug effects | Action Potentials - drug effects | Dopamine - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Memory, Short-Term - drug effects | Amphetamine - adverse effects | Reaction Time - genetics | Maze Learning - drug effects | Hyperkinesis - etiology | Mice, Knockout | Dystrophin-Associated Proteins | Carrier Proteins - genetics | Motor Activity - genetics | Animals | Memory Disorders - drug therapy | Memory Disorders - etiology | Gene Expression Regulation, Enzymologic - genetics | Mice | Dysbindin | Stress, Psychological - physiopathology | Genetic aspects | Prefrontal cortex | Research | Binding proteins | Properties | Dopaminergic mechanisms | Genetic regulation | Index Medicus
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 06/2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Index Medicus | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences
Journal Article
Nature neuroscience, ISSN 1546-1726, 01/2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 21, pp. 7152 - 7167
... (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Chromatin - metabolism | Immobility Response, Tonic - physiology | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Fear - drug effects | Green Fluorescent Proteins - genetics | Protein Methyltransferases - metabolism | Neurons - ultrastructure | Excitatory Amino Acid Agents - pharmacology | Exploratory Behavior - drug effects | Behavior, Animal - drug effects | Excitatory Postsynaptic Potentials - genetics | Animals, Newborn | Membrane Potentials - drug effects | Adaptation, Ocular - genetics | Maze Learning - physiology | Food Preferences - drug effects | Histone-Lysine N-Methyltransferase | Affect - physiology | Behavior, Animal - physiology | Mice, Transgenic | Avoidance Learning - physiology | Avoidance Learning - drug effects | Mice | Membrane Potentials - genetics | Electroshock - adverse effects | Age Factors | Food Preferences - physiology | Protein Methyltransferases - genetics | Adaptation, Ocular - drug effects | Motor Activity - drug effects | Fear - physiology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Receptors, N-Methyl-D-Aspartate - genetics | Exploratory Behavior - physiology | Transfection - methods | Neurons - physiology | Chromatin Immunoprecipitation - methods | Immobility Response, Tonic - drug effects | Neurons - drug effects | Sucrose - administration & dosage | Affect - drug effects | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation - physiology | Hippocampus - cytology | Maze Learning - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Gene Expression Regulation - drug effects | Motor Activity - genetics | Animals | Sweetening Agents - administration & dosage | Index Medicus
Journal Article
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 11/2013, Volume 80, Issue 4, pp. 997 - 1009
... of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Motor Activity - physiology | Small-Conductance Calcium-Activated Potassium Channels - genetics | Calcium Signaling - physiology | Humans | Motor Activity - drug effects | Excitatory Postsynaptic Potentials - drug effects | Psychomotor Performance - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Attention - physiology | Reflex, Startle - drug effects | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Reflex, Startle - physiology | Action Potentials - drug effects | Dopamine - metabolism | Receptors, N-Methyl-D-Aspartate - drug effects | Hallucinogens - pharmacology | Conditioning, Classical - drug effects | N-Methylaspartate - metabolism | Mice, Transgenic | Sensory Gating - physiology | Excitatory Amino Acid Agonists - pharmacology | Dependovirus | Conditioning, Classical - physiology | Receptors, N-Methyl-D-Aspartate - physiology | Action Potentials - physiology | Animals | Calcium Signaling - drug effects | Mice | Electrophysiological Phenomena | In Vitro Techniques | Phenols | Methyl aspartate | Genetic aspects | Dopamine | Neurons | Analysis | Cell culture | Substance abuse treatment | Mental disorders | Parkinsons disease | Schizophrenia | Proteins | Rodents | Addictive behaviors | Physiology | Mutation | Behavior | Localization | Drug dosages | Index Medicus
Journal Article