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Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy
Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7635, pp. 41 - 45
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | METABOLISM | MULTIDISCIPLINARY SCIENCES | STEM-CELL | CHEMORESISTANCE | BRAIN-METASTASIS | STROMAL CELLS | TUMOR-GROWTH | CARCINOMA | PROGRESSION | Palmitic Acid - metabolism | Palmitic Acid - pharmacology | CD36 Antigens - genetics | Cell Proliferation | Mouth Neoplasms - drug therapy | Prognosis | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Diet, High-Fat - adverse effects | Male | Mouth Neoplasms - metabolism | Antibodies, Neutralizing - immunology | Mouth Neoplasms - diagnosis | CD36 Antigens - metabolism | Neoplasm Metastasis - drug therapy | Neoplastic Stem Cells - metabolism | Neoplasm Metastasis - prevention & control | Antibodies, Neutralizing - therapeutic use | Lymphatic Metastasis - pathology | Hyaluronan Receptors - metabolism | Neoplastic Stem Cells - pathology | Female | Lipid Metabolism - genetics | Disease Models, Animal | Palmitic Acid - administration & dosage | CD36 Antigens - immunology | Antibodies, Neutralizing - pharmacology | Penetrance | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | Neoplasm Metastasis - pathology | CD36 Antigens - antagonists & inhibitors | Lymphatic Metastasis - genetics | Mouth Neoplasms - pathology | Mice | Cancer cells | Genetic aspects | Metastasis | Lipid metabolism | Gene expression | Health aspects | Fatty acids | Oral cancer | Lipids | Metabolism | Cells | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 16, pp. 12975 - 12984
The mitotic checkpoint gene CHFR (checkpoint with fork-head-associated (FHA) and RING finger domains) is silenced by promoter hypermethylation or mutated in... 
MICROTUBULE INHIBITORS | INSTABILITY | GENE | EPIGENETIC INACTIVATION | COLORECTAL-CANCER | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(ADP-RIBOSE) POLYMERASE-1 | CELL-CYCLE | BETA-CATENIN | EXPRESSION | Neoplasms - metabolism | Lung Neoplasms - drug therapy | Mouth Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Stomach Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Breast Neoplasms | Poly-ADP-Ribose Binding Proteins | Microtubules - drug effects | Genes, Tumor Suppressor - physiology | Neoplasms, Squamous Cell - drug therapy | Tumor Suppressor Proteins - genetics | Drug Design | HEK293 Cells | Female | Ubiquitination - physiology | Neoplasms, Squamous Cell - pathology | Carcinoma, Non-Small-Cell Lung - pathology | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Carcinoma, Non-Small-Cell Lung - metabolism | Microtubules - physiology | Ubiquitin-Protein Ligases - metabolism | Cell Cycle Checkpoints - physiology | Stomach Neoplasms - drug therapy | Mice, Knockout | Neoplasms - drug therapy | Poly(ADP-ribose) Polymerases - metabolism | Animals | Mouth Neoplasms - pathology | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | HeLa Cells | Poly (ADP-Ribose) Polymerase-1 | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | M Phase Cell Cycle Checkpoints - physiology | Neoplasms, Squamous Cell - metabolism | Molecular Bases of Disease | Cancer Therapy | E3 Ubiquitin Ligase | Checkpoint Control | Cell Cycle | PARP Inhibitor | Tumor Suppressor Gene | PARP-1 | CHFR
Journal Article
ACS Nano, ISSN 1936-0851, 01/2015, Volume 9, Issue 1, pp. 191 - 205
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132901
Background The prognostic role of circulating tumor cells (CTCs) after induction chemotherapy using docetaxel, cisplatin and fluorouracil (TPF) prior to... 
SURVIVAL | CISPLATIN | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | PHASE-III | FLUOROURACIL | ADVANCED HEAD | CARCINOMA | NECK-CANCER | PROGRESSION | BLOOD | Oropharyngeal Neoplasms - therapy | Multivariate Analysis | Mouth Neoplasms - drug therapy | Prognosis | Neoplastic Cells, Circulating - pathology | Cell Count | Humans | Middle Aged | Carcinoma, Squamous Cell - surgery | Induction Chemotherapy | Male | Carcinoma, Squamous Cell - radiotherapy | Neoplasm Recurrence, Local - pathology | Postoperative Care | Female | Mouth Neoplasms - radiotherapy | Oropharyngeal Neoplasms - drug therapy | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Carcinoma, Squamous Cell - therapy | Oropharyngeal Neoplasms - radiotherapy | Mouth Neoplasms - therapy | Disease-Free Survival | Oropharyngeal Neoplasms - surgery | Carcinoma, Squamous Cell - drug therapy | Mouth Neoplasms - surgery | Neoplasm Staging | Chemotherapy | Metastasis | Radiotherapy | Analysis | Surgery | Cancer | Disease | Epithelial cells | Radiation | Otolaryngology | Clinical trials | Oncology | Multivariate analysis | Cancer therapies | Risk factors | Cell adhesion molecules | Cell adhesion | Peripheral blood | Drug dosages | Lymphatic system | Hematology | Tumor cells | Radiation therapy | Risk analysis | Patients | Cisplatin | Oral cavity | Cytometry | Medical prognosis | Head & neck cancer | Tumors
Journal Article
The Journal of Pathology, ISSN 0022-3417, 08/2015, Volume 236, Issue 4, pp. 505 - 516
Although tumour budding is an adverse prognostic factor for many cancer types, the molecular mechanisms governing this phenomenon are incompletely understood.... 
tumour budding | TGFβ | epithelial–mesenchymal transition | oral squamous cell carcinoma | lymph node metastasis | epithelial-mesenchymal transition | Immunohistochemistry | Predictive Value of Tests | Mouth Neoplasms - drug therapy | Oligonucleotide Array Sequence Analysis | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Epithelial-Mesenchymal Transition - drug effects | Male | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Time Factors | Biomarkers, Tumor - metabolism | Mouth Neoplasms - genetics | Genetic Predisposition to Disease | Head and Neck Neoplasms - drug therapy | Lymphatic Metastasis | Signal Transduction - genetics | Head and Neck Neoplasms - pathology | Phenotype | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Head and Neck Neoplasms - mortality | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Gene Expression Regulation, Neoplastic | Laser Capture Microdissection | Mouth Neoplasms - metabolism | Epithelial-Mesenchymal Transition - genetics | Molecular Targeted Therapy | Head and Neck Neoplasms - metabolism | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | In Situ Hybridization | Drug Design | Polymerase Chain Reaction | Female | Retrospective Studies | Reproducibility of Results | Kaplan-Meier Estimate | Gene Expression Profiling - methods | Mouth Neoplasms - mortality | Disease-Free Survival | Transforming Growth Factor beta - genetics | Mouth Neoplasms - pathology | Transforming Growth Factor beta - metabolism
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 78, Issue 5, pp. 1373 - 1380
Purpose To review outcome and toxicity of Stage IVa and IVb head-and-neck squamous cell carcinoma patients treated with concomitant chemotherapy and... 
Radiology | Hematology, Oncology and Palliative Medicine | Head-and-neck cancer | Altered fractionation | Chemotherapy | IMRT | Head-and neck cancer | ACCELERATED RADIOTHERAPY | TOXICITY | OROPHARYNGEAL CARCINOMA | CANCER | RADIATION-THERAPY | DELINEATION | ONCOLOGY | CONCURRENT CHEMOTHERAPY | CONFORMAL RADIOTHERAPY | LOCALLY ADVANCED HEAD | EXPERIENCE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Laryngeal Neoplasms - radiotherapy | Mouth Neoplasms - drug therapy | Radiotherapy Planning, Computer-Assisted - methods | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Oropharyngeal Neoplasms - mortality | Male | Antineoplastic Agents - therapeutic use | Oropharyngeal Neoplasms - pathology | Hypopharyngeal Neoplasms - mortality | Carcinoma, Squamous Cell - radiotherapy | Radiotherapy, Intensity-Modulated - adverse effects | Laryngeal Neoplasms - pathology | Carcinoma, Squamous Cell - mortality | Laryngeal Neoplasms - drug therapy | Adult | Dose Fractionation | Female | Mouth Neoplasms - radiotherapy | Retrospective Studies | Oropharyngeal Neoplasms - drug therapy | Radiotherapy, Intensity-Modulated - methods | Head and Neck Neoplasms - drug therapy | Oropharyngeal Neoplasms - radiotherapy | Treatment Outcome | Combined Modality Therapy - adverse effects | Mouth Neoplasms - mortality | Head and Neck Neoplasms - pathology | Radiography | Xerostomia - prevention & control | Head and Neck Neoplasms - radiotherapy | Hypopharyngeal Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Cisplatin - therapeutic use | Laryngeal Neoplasms - mortality | Hypopharyngeal Neoplasms - pathology | Organs at Risk - diagnostic imaging | Survival Analysis | Mouth Neoplasms - pathology | Aged | Combined Modality Therapy - methods | Head and Neck Neoplasms - mortality | Hypopharyngeal Neoplasms - drug therapy | Neoplasm Staging | Index Medicus | HEAD | NEOPLASMS | MEDICINE | IRRADIATION | FRACTIONATED IRRADIATION | DISEASES | THERAPY | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | NECK | BODY | COMBINED THERAPY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2558 - 2568
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2017, Volume 23, Issue 10, pp. 1167 - 1175
Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs), although there are no established biomarkers for predicting response.... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEAD | GEFITINIB | SOLUBLE EGFR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHASE-II | NECK-CANCER | CHEMOTHERAPY | CELL BIOLOGY | LUNG-CANCER | RECURRENT | EXPRESSION | ERLOTINIB | Cell Proliferation | Mouth Neoplasms - drug therapy | RNA Isoforms | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Male | Molecular Targeted Therapy | Gene Knockdown Techniques | RNA Splicing | Squamous Cell Carcinoma of Head and Neck | Aged, 80 and over | Adult | Female | Gefitinib | Mouth Neoplasms - genetics | Esophageal Squamous Cell Carcinoma | Head and Neck Neoplasms - drug therapy | RNA, Long Noncoding - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Carcinoma, Squamous Cell - drug therapy | Esophageal Neoplasms - genetics | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Head and Neck Neoplasms - genetics | Aged | In Vitro Techniques | Esophageal Neoplasms - drug therapy | Development and progression | Squamous cell carcinoma | Care and treatment | Genetic aspects | Gene expression | Health aspects | Clinical trials | Epidermal growth factor | Xenografts | Head and neck | Bioindicators | Mathematical models | Neck | Protein-tyrosine kinase | Genotypes | Tyrosine | Medical research | Head | Splicing | Epidermal growth factor receptors | Neurons | Cultures | Shrinkage | Ribonucleic acid--RNA | Patients | Cells | Sensitivity | Addiction | Biomarkers | Mutation | Cancer
Journal Article
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN 1469-493X, 2011, Issue 4, p. CD006386
Background Oral cavity and oropharyngeal cancers are frequently described as part of a group of oral cancers or head and neck cancer. Treatment of oral cavity... 
ADVANCED RESECTABLE HEAD | TRIAL COMPARING RADIOTHERAPY | Humans | Oropharyngeal Neoplasms [drug therapy; mortality; radiotherapy; surgery] | COMBINED POSTOPERATIVE RADIOTHERAPY | STAGE-IV HEAD | Remission Induction | ACCELERATED HYPERFRACTIONATED RADIOTHERAPY | Randomized Controlled Trials as Topic | MEDICINE, GENERAL & INTERNAL | Antineoplastic Combined Chemotherapy Protocols [adverse effects; therapeutic use] | RANDOMIZED PHASE-II | UNRESECTABLE PHARYNGEAL CARCINOMA | Combined Modality Therapy [methods; mortality] | Carcinoma, Squamous Cell [drug therapy; mortality; radiotherapy; surgery] | Survival Analysis | SQUAMOUS-CELL CARCINOMA | LOCALLY ADVANCED HEAD | Mouth Neoplasms [drug therapy; mortality; radiotherapy; surgery] | CISPLATIN PLUS 5-FLUOROURACIL | Oropharyngeal Neoplasms - drug therapy | Mouth Neoplasms - drug therapy | Oropharyngeal Neoplasms - mortality | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Carcinoma, Squamous Cell - surgery | Oropharyngeal Neoplasms - radiotherapy | Combined Modality Therapy - mortality | Carcinoma, Squamous Cell - radiotherapy | Mouth Neoplasms - mortality | Oropharyngeal Neoplasms - surgery | Carcinoma, Squamous Cell - drug therapy | Carcinoma, Squamous Cell - mortality | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mouth Neoplasms - surgery | Mouth Neoplasms - radiotherapy | Combined Modality Therapy - methods
Journal Article