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Journal of the National Cancer Institute, ISSN 0027-8874, 01/2018, Volume 110, Issue 1, pp. 109 - 120
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as... 
CELL LUNG-CANCER | PHASE-II TRIAL | OXIDATIVE STRESS | ONCOLOGY | NAB-PACLITAXEL | ACTIVATION PROTEIN | DEPENDENT INVASION | PANCREATIC-CANCER | MONOCLONAL-ANTIBODY | DIFFERENTIATION | STROMAL CELLS | Lung Neoplasms - drug therapy | Up-Regulation | Pyrazoles - therapeutic use | Reactive Oxygen Species - metabolism | Cell Count | Humans | Middle Aged | Male | Oropharyngeal Neoplasms - pathology | Head and Neck Neoplasms - chemistry | RNA Interference | Cancer-Associated Fibroblasts - chemistry | Aged, 80 and over | NADPH Oxidases - genetics | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Lung Neoplasms - chemistry | NADPH Oxidases - antagonists & inhibitors | Head and Neck Neoplasms - drug therapy | Carcinoma, Squamous Cell - chemistry | Survival Rate | Adenocarcinoma - drug therapy | Disease Progression | Phenotype | Carcinoma, Squamous Cell - drug therapy | Head and Neck Neoplasms - genetics | Mice | Neoplasm Transplantation | Carcinoma, Non-Small-Cell Lung - chemistry | Carcinoma, Squamous Cell - genetics | Colorectal Neoplasms - chemistry | Cell Transdifferentiation - genetics | Myofibroblasts - chemistry | Actins - analysis | Cell Transdifferentiation - drug effects | Adult | Female | Adenocarcinoma - genetics | Cancer-Associated Fibroblasts - physiology | Pyridines - therapeutic use | Lung Neoplasms - genetics | Myofibroblasts - pathology | Carcinoma, Non-Small-Cell Lung - genetics | NADPH Oxidases - analysis | Mouth Neoplasms - chemistry | NADPH Oxidase 4 | Cancer-Associated Fibroblasts - pathology | Animals | Esophageal Neoplasms - genetics | Mouth Neoplasms - pathology | Oropharyngeal Neoplasms - chemistry | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Colorectal Neoplasms - pathology | Esophageal Neoplasms - drug therapy | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2012, Volume 287, Issue 39, pp. 32800 - 32824
Human head and neck squamous cell carcinoma (HNSCC) is a highly malignant cancer associated with major morbidity and mortality. In this study, we determined... 
SOX2 | IN-VITRO | ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | MARKER NANOG | NF-KAPPA-B | TRANSCRIPTIONAL REGULATION | CD44 | BREAST | MICRORNA | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Drug Resistance, Neoplasm | Mouth Neoplasms - metabolism | Neoplasm Proteins - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Isoenzymes - metabolism | Hyaluronan Receptors - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Neoplasm Proteins - genetics | Mouth Neoplasms - genetics | Cell Survival - drug effects | Nanog Homeobox Protein | Isoenzymes - genetics | Hyaluronic Acid - genetics | MicroRNAs - biosynthesis | Signal Transduction - genetics | Cisplatin - pharmacology | Retinal Dehydrogenase - genetics | Hyaluronan Receptors - genetics | Homeodomain Proteins - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Epigenesis, Genetic - genetics | Hyaluronic Acid - metabolism | Octamer Transcription Factor-3 - metabolism | Mouth Neoplasms - pathology | RNA, Neoplasm - genetics | MicroRNAs - genetics | Index Medicus | Hyaluronan | Self-renewal | MicroRNA | Signal Transduction | Extracellular Matrix | Head and Neck Cancer | Differentiation | Cancer Stem Cells
Journal Article
Cancer Research, ISSN 0008-5472, 02/2014, Volume 74, Issue 3, pp. 751 - 764
Journal Article
The Journal of Pathology, ISSN 0022-3417, 08/2015, Volume 236, Issue 4, pp. 505 - 516
Although tumour budding is an adverse prognostic factor for many cancer types, the molecular mechanisms governing this phenomenon are incompletely understood.... 
tumour budding | TGFβ | epithelial–mesenchymal transition | oral squamous cell carcinoma | lymph node metastasis | epithelial-mesenchymal transition | Immunohistochemistry | Predictive Value of Tests | Mouth Neoplasms - drug therapy | Oligonucleotide Array Sequence Analysis | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Epithelial-Mesenchymal Transition - drug effects | Male | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Time Factors | Biomarkers, Tumor - metabolism | Mouth Neoplasms - genetics | Genetic Predisposition to Disease | Head and Neck Neoplasms - drug therapy | Lymphatic Metastasis | Signal Transduction - genetics | Head and Neck Neoplasms - pathology | Phenotype | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Head and Neck Neoplasms - mortality | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Gene Expression Regulation, Neoplastic | Laser Capture Microdissection | Mouth Neoplasms - metabolism | Epithelial-Mesenchymal Transition - genetics | Molecular Targeted Therapy | Head and Neck Neoplasms - metabolism | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | In Situ Hybridization | Drug Design | Polymerase Chain Reaction | Female | Retrospective Studies | Reproducibility of Results | Kaplan-Meier Estimate | Gene Expression Profiling - methods | Mouth Neoplasms - mortality | Disease-Free Survival | Transforming Growth Factor beta - genetics | Mouth Neoplasms - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Medicine (United States), ISSN 0025-7974, 2016, Volume 95, Issue 35, pp. e4592 - e4592
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 78, Issue 1, pp. 127 - 135
Purpose To examine the risk of subsequent primary malignancies (SPMs) in women diagnosed with endometrial cancer. Methods and Materials The National Cancer... 
Radiology | Hematology, Oncology and Palliative Medicine | Radiation-induced malignancies | HNPCC | Endometrial cancer | Second primary malignancies | LYNCH-SYNDROME | NONPOLYPOSIS COLORECTAL-CANCER | 2ND PRIMARY CANCERS | RISK | CERVICAL-CANCER | RADIATION-THERAPY | TRIAL | ONCOLOGY | RECOMMENDATIONS | OVARIAN | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | United States - epidemiology | Colonic Neoplasms - genetics | Follow-Up Studies | Humans | Middle Aged | Bone Neoplasms - epidemiology | Pharyngeal Neoplasms - etiology | Esophageal Neoplasms - epidemiology | Incidence | Vaginal Neoplasms - genetics | Young Adult | Neoplasms, Radiation-Induced - genetics | Endometrial Neoplasms - genetics | Lung Neoplasms - etiology | Aged, 80 and over | Intestine, Small - radiation effects | Bone Neoplasms - genetics | Neoplasms, Second Primary - genetics | Mouth Neoplasms - genetics | SEER Program | Risk Assessment | Vaginal Neoplasms - etiology | Mouth Neoplasms - etiology | Neoplasms, Second Primary - epidemiology | Mouth Neoplasms - epidemiology | Pharyngeal Neoplasms - genetics | Vaginal Neoplasms - epidemiology | Adolescent | Pharyngeal Neoplasms - epidemiology | Endometrial Neoplasms - radiotherapy | Esophageal Neoplasms - etiology | Age Factors | Neoplasms, Radiation-Induced - etiology | Urinary Bladder Neoplasms - genetics | Adult | Female | Intestinal Neoplasms - genetics | Urinary Bladder Neoplasms - epidemiology | Colonic Neoplasms - etiology | Lung Neoplasms - genetics | Urinary Bladder Neoplasms - etiology | Colonic Neoplasms - epidemiology | Intestinal Neoplasms - etiology | Intestinal Neoplasms - epidemiology | Bone Neoplasms - etiology | Neoplasms, Second Primary - etiology | Lung Neoplasms - epidemiology | Esophageal Neoplasms - genetics | Aged | Neoplasms, Radiation-Induced - epidemiology | Genetic aspects | Research | Oncology, Experimental | Cancer | Index Medicus | LARGE INTESTINE | GASTROINTESTINAL TRACT | ORAL CAVITY | ESOPHAGUS | DIGESTIVE SYSTEM | LUNGS | MEDICINE | PHARYNX | THERAPY | RADIOLOGY AND NUCLEAR MEDICINE | BLADDER | RADIOTHERAPY | RADIOLOGY | SMALL INTESTINE | NEOPLASMS | UTERUS | INTESTINES | NUCLEAR MEDICINE | FEMALE GENITALS | ORGANS | URINARY TRACT | DISEASES | RESPIRATORY SYSTEM | BRACHYTHERAPY | BODY
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0118588 - e0118588
Purpose The aim of this study was to define somatostatin (SST) and somatostatin receptor type 1 (SSTR1) methylation profiles for head and neck squamous cell... 
PATHOGENESIS | POTENTIAL BIOMARKER | HYPERMETHYLATION | PROMOTER METHYLATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GALANIN | TUMOR-SUPPRESSOR ACTIVITY | TACHYKININ-1 | EXPRESSION | ASSOCIATION | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Oropharyngeal Neoplasms - mortality | Male | Oropharyngeal Neoplasms - pathology | Galanin - metabolism | Carcinoma, Squamous Cell - diagnosis | Receptors, Somatostatin - genetics | DNA Methylation | Mouth Neoplasms - diagnosis | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Tachykinins - genetics | Aged, 80 and over | Biomarkers, Tumor - metabolism | Receptor, Galanin, Type 2 - genetics | Adult | Female | Transcription, Genetic | Receptors, Somatostatin - metabolism | Retrospective Studies | Odds Ratio | Mouth Neoplasms - genetics | Somatostatin - metabolism | Oropharyngeal Neoplasms - diagnosis | Promoter Regions, Genetic | Oropharyngeal Neoplasms - genetics | Somatostatin - genetics | Tachykinins - metabolism | Risk Factors | Mouth Neoplasms - mortality | Head and Neck Neoplasms - pathology | Survival Analysis | CpG Islands | Mouth Neoplasms - pathology | Head and Neck Neoplasms - diagnosis | Head and Neck Neoplasms - genetics | Receptor, Galanin, Type 2 - metabolism | Aged | Biomarkers, Tumor - genetics | Head and Neck Neoplasms - mortality | Galanin - genetics | Neoplasm Staging | Neuropeptides | Squamous cell carcinoma | Methylation | Analysis | Tachykinin receptors | Correlation | Galanin | Mucosa | Otolaryngology | Inactivation | Tissues | Epidermal growth factor | DNA methylation | Measurement methods | Tumorigenesis | Bioindicators | Neck | Somatostatin | CpG islands | Head | Deactivation | Oropharynx | Regression analysis | Gene expression | Survival | Promoters | Polymerase chain reaction | Oral cavity | Epigenetics | Biomarkers | Head and neck cancer | Aberration | Tachykinin | Tumors | Cancer | Index Medicus
Journal Article
APMIS, ISSN 0903-4641, 06/2016, Volume 124, Issue 6, pp. 475 - 486
Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the... 
malignant melanoma | pathology | genetics | Mucosal melanoma | oncology | HEAD | TERT PROMOTER MUTATIONS | RARE CANCER | MICROBIOLOGY | IMMUNOLOGY | COPY NUMBER CHANGES | BRAF MUTATIONS | CONJUNCTIVAL MELANOMA | NECK | OF-THE-LITERATURE | DYSPLASTIC NEVUS SYNDROME | KIT EXPRESSION | Melanoma - epidemiology | Nose Neoplasms - epidemiology | Humans | Middle Aged | Male | Rectal Diseases - pathology | Telomerase - genetics | Melanoma - genetics | Female | Proto-Oncogene Proteins c-kit - genetics | Surveys and Questionnaires | Rectal Diseases - genetics | Mouth Neoplasms - genetics | Promoter Regions, Genetic | Nose Neoplasms - pathology | Membrane Proteins - genetics | Surgical Procedures, Operative | Melanoma - pathology | Conjunctival Neoplasms - pathology | Mouth Neoplasms - mortality | Nose Neoplasms - genetics | Mouth Neoplasms - epidemiology | Mucous Membrane - pathology | Conjunctival Neoplasms - epidemiology | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Conjunctival Neoplasms - genetics | Sex Factors | Survival Analysis | Conjunctival Neoplasms - mortality | Mouth Neoplasms - pathology | Rectal Diseases - epidemiology | Aged | Mutation | Rectal Diseases - mortality | Melanoma - mortality | Nose Neoplasms - mortality | Surveys | Melanoma | Medical prognosis | Skin cancer | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 353 - 14
Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from... 
POINT MUTATIONS | CANCER PATIENTS | BREAST-CANCER | MUTATIONAL PROCESSES | ARRAY-CGH | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | TUMOR | OVARIAN-CANCER | MOUSE MODELS | REVEALS | Proto-Oncogene Proteins c-mdm2 - genetics | Cadherins - metabolism | Humans | Carcinogenesis - metabolism | DNA Copy Number Variations | Germ-Line Mutation | Cadherins - genetics | Neoplasm Proteins - genetics | Mouth Neoplasms - genetics | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Carcinogenesis - genetics | Cell Cycle Proteins - metabolism | Melanoma - pathology | Mucous Membrane - pathology | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Microtubule-Associated Proteins - genetics | Species Specificity | Microtubule-Associated Proteins - metabolism | Gene Expression Regulation, Neoplastic | Mouth Neoplasms - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Melanoma - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Neoplasm Recurrence, Local | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | PTEN Phosphohydrolase - metabolism | Mucous Membrane - metabolism | Skin Neoplasms - metabolism | Carcinogenesis - pathology | BRCA1 Protein - genetics | Animals | BRCA2 Protein - metabolism | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism | Skin Neoplasms - genetics | Dogs | Horses | Mouth Neoplasms - pathology | BRCA2 Protein - genetics | BRCA2 protein | MDM2 protein | BRCA1 protein | Copy number | p53 Protein | Mucosa | Melanoma | Data processing | Breast cancer | Metastases | Heterogeneity | Human performance | Tumorigenesis | Mutation | Species | PTEN protein | Tumors | Index Medicus
Journal Article