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1. Full Text Therapy-induced tumour secretomes promote resistance and tumour progression
by Obenauf, Anna C and Zou, Yilong and Ji, Andrew L and Vanharanta, Sakari and Shu, Weiping and Shi, Hubing and Kong, Xiangju and Bosenberg, Marcus C and Wiesner, Thomas and Rosen, Neal and Lo, Roger S and Massagué, Joan
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Lung Neoplasms - secretion | Melanoma - secretion | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - secretion | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
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2. Full Text Less Is More: Antipsychotic Drug Effects Are Greater with Transient Rather Than Continuous Delivery
by Samaha, Anne-Noël and Reckless, Greg E and Seeman, Philip and Diwan, Mustansir and Nobrega, José N and Kapur, Shitij
Biological Psychiatry, ISSN 0006-3223, 2008, Volume 64, Issue 2, pp. 145 - 152
Background Most studies on the effects of antipsychotics focus on achieving threshold levels of the drug. The speed and frequency with which drug... 
Psychiatry | Antipsychotics | D2 receptors | supersensitivity | conditioned avoidance | kinetics | dopamine | C-FOS | PSYCHIATRY | FOS MESSENGER-RNA | BEHAVIORAL SENSITIZATION | NEUROSCIENCES | PREFRONTAL CORTEX | EXTRACELLULAR GLUTAMATE | DOPAMINE-D-2 RECEPTOR OCCUPANCY | NUCLEUS-ACCUMBENS | VACUOUS CHEWING MOVEMENTS | IN-VIVO | antipsychotics | CHRONIC HALOPERIDOL | Gene Expression - drug effects | Haloperidol - administration & dosage | Motor Activity - drug effects | Biological Availability | Male | Receptors, Dopamine D2 - metabolism | Corpus Striatum - metabolism | Injections, Subcutaneous | Receptors, Dopamine D2 - drug effects | Dextroamphetamine - pharmacology | Conditioning, Classical - drug effects | Drug Administration Schedule | Infusion Pumps | RNA, Messenger - genetics | Haloperidol - pharmacokinetics | Rats | Treatment Outcome | Antipsychotic Agents - pharmacokinetics | Rats, Sprague-Dawley | Metabolic Clearance Rate - physiology | Antipsychotic Agents - administration & dosage | Animals | Corpus Striatum - drug effects | Proto-Oncogene Proteins c-fos - genetics | Avoidance Learning - drug effects | Kinetics
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3. Full Text Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
by Au Yeung, Chi Lam and Co, Ngai-Na and Tsuruga, Tetsushi and Yeung, Tsz-Lun and Kwan, Suet-Ying and Leung, Cecilia S and Li, Yong and Lu, Edward S and Kwan, Kenny and Wong, Kwong-Kwok and Schmandt, Rosemarie and Lu, Karen H and Mok, Samuel C
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, p. 11150
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that... 
APOPTOSOME | MESSENGER-RNAS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | CHEMORESISTANCE | DIAGNOSTIC BIOMARKERS | MICRORNAS | TUMOR-GROWTH | EXPRESSION | PROGRESSION | Exosomes - drug effects | Exosomes - metabolism | Paclitaxel - pharmacology | Apoptosis - drug effects | Humans | Ovarian Neoplasms - pathology | MicroRNAs - metabolism | Adipocytes - drug effects | Ovarian Neoplasms - genetics | Stromal Cells - drug effects | Female | Ovarian Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Ovarian Neoplasms - drug therapy | Fibroblasts - metabolism | Neoplasm Invasiveness | Stromal Cells - metabolism | Fibroblasts - pathology | Adipocytes - pathology | Paclitaxel - therapeutic use | Apoptotic Protease-Activating Factor 1 - metabolism | Cell Movement - drug effects | Drug Resistance, Neoplasm - genetics | Adipocytes - metabolism | Fibroblasts - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Drug Resistance, Neoplasm - drug effects
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4. Full Text Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling
by Brink, Willem J and Berg, Dirk‐Jan and Bonsel, Floor E M and Hartman, Robin and Wong, Yin‐Cheong and Graaf, Piet H and Lange, Elizabeth C M
British Journal of Pharmacology, ISSN 0007-1188, 10/2018, Volume 175, Issue 19, pp. 3832 - 3843
Background and Purpose Because biological systems behave as networks, multi‐biomarker approaches increasingly replace single biomarker approaches in drug... 
Cellular signal transduction | Models | Pituitary hormones | Analysis | Central nervous system agents | Plasma | Brain | Fingerprints | Central nervous system | Neuropeptides | Activation | Hormones | Drug development | Neuroendocrine system | Hormone release | Prolactin | Modelling | Bioindicators | Dopamine D2 receptors | Movement disorders | Thyroid | Pharmacology | Quinpirole | Thyroid-stimulating hormone | Adrenocorticotropic hormone | Pituitary | Biomarkers | Receptor mechanisms | Growth hormone | Pharmacokinetics
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5. Full Text Disease and drug effects on internally-generated and externally-elicited responses in first episode schizophrenia and psychotic bipolar disorder
by Keedy, Sarah K and Bishop, Jeffrey R and Weiden, Peter J and Sweeney, John A and Rosen, Cherise and Marvin, Robert and Reilly, James L
Schizophrenia Research, ISSN 0920-9964, 2014, Volume 159, Issue 1, pp. 101 - 106
Abstract Neurocognitive deficits are associated with most psychotic disorders, but may differ across diagnosis and by treatment status. This ambiguity is... 
Psychiatry | Psychosis | Dorsolateral prefrontal cortex | Saccades | Striatum | Risperidone | SACCADIC EYE-MOVEMENTS | NEUROPSYCHOLOGICAL DYSFUNCTION | PSYCHIATRY | RISPERIDONE MONOTHERAPY | VISUALLY GUIDED SACCADES | 1ST-EPISODE SCHIZOPHRENIA | SMOOTH-PURSUIT | ANTIPSYCHOTIC-DRUGS | PLACEBO-CONTROLLED TRIAL | WORKING-MEMORY | PARKINSONS-DISEASE | Psychotic Disorders - complications | Learning - drug effects | Humans | Psychotic Disorders - psychology | Bipolar Disorder - complications | Male | Treatment Outcome | Psychomotor Performance - drug effects | Schizophrenic Psychology | Bipolar Disorder - drug therapy | Bipolar Disorder - psychology | Neuropsychological Tests | Young Adult | Psychiatric Status Rating Scales | Antipsychotic Agents - therapeutic use | Space Perception - drug effects | Adult | Female | Psychotic Disorders - drug therapy | Schizophrenia - drug therapy | Saccades - drug effects | Executive Function - drug effects | Schizophrenia | Bipolar disorder | Antipsychotic drugs | saccades | striatum | dorsolateral prefrontal cortex | psychosis | risperidone
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6. Full Text The drug-drug effects of rhein on the pharmacokinetics and pharmacodynamics of clozapine in rat brain extracellular fluid by in vivo microdialysis
by Hou, Mei-Ling and Lin, Chi-Hung and Lin, Lie-Chwen and Tsai, Tung-Hu
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2015, Volume 355, Issue 1, pp. 125 - 134
Clozapine, an atypical antipsychotic agent, is highly effective in treatment-resistant schizophrenia; however, its major side effect is constipation. Instead... 
CONSTIPATION | METABOLITES | ANTIPSYCHOTICS | INHIBITION | N-DESMETHYLCLOZAPINE | DOPAMINE | CHROMATOGRAPHIC METHODS | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | NORCLOZAPINE | BLOOD | Movement - drug effects | Brain - cytology | Administration, Oral | Clozapine - administration & dosage | Neurotransmitter Agents - metabolism | Rats | Male | Clozapine - analogs & derivatives | Rats, Sprague-Dawley | Extracellular Fluid - drug effects | Clozapine - pharmacology | Extracellular Fluid - metabolism | Animals | Drug Interactions | Microdialysis | Prefrontal Cortex - drug effects | Prefrontal Cortex - metabolism | Anthraquinones - pharmacology | Clozapine - blood | Clozapine - pharmacokinetics
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7. Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells
by Manshu Peng and Yan Wang and Qiang Fu and Feifei Sun and Na Na and Jin Ouyang
Analytical Chemistry, ISSN 0003-2700, 05/2018, Volume 90, Issue 10, p. 6206
Tyrosinase (TYR) plays a vital role in melanin biosynthesis and is widely regarded as a relatively specific marker for melanocytic lesions which involve... 
Enzymes | Reactive oxygen species | Medical imaging | Parkinson's disease | Neurodegenerative diseases | Kojic acid | Melanoma | Reactive nitrogen species | Fluorescence | I.R. radiation | Biosynthesis | Fluorescent indicators | Cells | Morpholine | Vitiligo | Psoralen | Biomarkers | Infrared radiation | Intracellular | Lesions | Human behavior | Tyrosinase | Movement disorders | Melanin
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8. Full Text Pharmacodynamic potentiation of antiepileptic drugs’ effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice
by Russo, Emilio and Donato di Paola, Eugenio and Gareri, Pietro and Siniscalchi, Antonio and Labate, Angelo and Gallelli, Luca and Citraro, Rita and De Sarro, Giovambattista
Pharmacological Research, ISSN 1043-6618, 04/2013, Volume 70, Issue 1, pp. 1 - 12
It is known that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both the primary and the secondary... 
Epilepsy | Pharmacodynamic | Anticonvulsant potency | Drug–drug Interaction | AEDs | Cholesterol | Statins | Drug-drug Interaction | ACID-INDUCED SEIZURES | TEMPORAL-LOBE EPILEPSY | NITRIC-OXIDE SYNTHASE | ATORVASTATIN TREATMENT | HYPERKINETIC MOVEMENT-DISORDERS | HIPPOCAMPAL CELL-DEATH | CORTICAL-NEURONS | INDUCED EXCITOTOXICITY | DEEP PREPIRIFORM CORTEX | PHARMACOLOGY & PHARMACY | NEUROLOGICAL DEFICIT | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Anticonvulsants - blood | Acoustic Stimulation | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Seizures - drug therapy | Anticonvulsants - therapeutic use | Motor Activity - drug effects | Anticonvulsants - administration & dosage | Male | Treatment Outcome | Dose-Response Relationship, Drug | Drug Synergism | Seizures - physiopathology | Rotarod Performance Test | Animals | Anticonvulsants - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Female | Mice, Inbred DBA | Mice | Drug Therapy, Combination | Disease Models, Animal | Medical colleges | Anticonvulsants | Neurosciences | Seizures (Medicine)
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9. Full Text Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling
by Soenen, Stefaan J.H and Himmelreich, Uwe and Nuytten, Nele and De Cuyper, Marcel
Biomaterials, ISSN 0142-9612, 2010, Volume 32, Issue 1, pp. 195 - 205
Abstract The in vitro labelling of cultured cells with iron oxide nanoparticles (NPs) is a frequent practice in biomedical research. To date, the potential... 
Advanced Basic Science | Dentistry | Cytotoxicity | Biomedical materials | (Iron oxide) nanoparticle | Magnetoliposome | Cell labelling | MATERIALS SCIENCE, BIOMATERIALS | CYTOSKELETON | ENGINEERING, BIOMEDICAL | MODEL | MAGNETIC NANOPARTICLES | CATIONIC MAGNETOLIPOSOMES | MESENCHYMAL STEM-CELLS | Staining and Labeling - methods | Reactive Oxygen Species - metabolism | Humans | PC12 Cells | Contrast Media - pharmacology | Cell Death - drug effects | Homeostasis - drug effects | Cell Survival - drug effects | Ferric Compounds - toxicity | Intracellular Space - drug effects | Endocytosis - drug effects | Rats | Iron - metabolism | Nanoparticles - toxicity | Cell Movement - drug effects | Focal Adhesions - drug effects | Magnetic Resonance Imaging | Animals | Focal Adhesions - metabolism | Intracellular Space - metabolism | Cytoskeleton - metabolism | Cell Proliferation - drug effects | Cell Cycle - drug effects | Chemical Phenomena - drug effects | Cytoskeleton - drug effects | Index Medicus
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10. Full Text Lymphoblast oxidative stress genes as potential biomarkers of disease severity and drug effect in Friedreich's ataxia
by Hayashi, Genki and Cortopassi, Gino
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153574
There is no current approved therapy for the ultimately lethal neuro- and cardio-degenerative disease Friedreich's ataxia (FA). Finding minimally-invasive... 
SULFUR TRANSFER | NRF2 | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | TRANSCRIPTION | GROWTH | FRATAXIN DEFICIENCY LEADS | NEURONS | PATHOLOGY | EXPRESSION | CONTRIBUTES | Lymphocytes - metabolism | Cell Line | Friedreich Ataxia - metabolism | Friedreich Ataxia - drug therapy | Friedreich Ataxia - pathology | Humans | RNA, Messenger - genetics | NF-E2-Related Factor 2 - agonists | Genetic Markers | Friedreich Ataxia - genetics | Gene Expression Regulation - drug effects | Lymphocytes - pathology | Dimethyl Fumarate - pharmacology | Lymphocytes - drug effects | Histone Deacetylase Inhibitors - pharmacology | Iron-Binding Proteins - genetics | Oxidative Stress - drug effects | Oxidative stress | Friedreich's ataxia | Usage | Physiological aspects | Influence | Research | Biological markers | Histone deacetylase | Pathogenesis | Genes | Genomics | Clinical trials | Antioxidants | Proteins | Frataxin | Transgenic animals | Rodents | Ataxia | Bioindicators | Stress response | Sulfur | Drug therapy | Drug dosages | Deoxyribonucleic acid--DNA | Medical research | Lymphoblasts | Gene expression | Patients | Signaling | Biomarkers | Apoptosis | Deoxyribonucleic acid | DNA
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