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Annual Review of Biochemistry, ISSN 0066-4154, 6/2018, Volume 87, Issue 1, pp. 263 - 294
Genomic instability in disease and its fidelity in health depend on the DNA damage response (DDR), regulated in part from the complex of meiotic recombination... 
coiled-coil domain | nuclease | ATPase | BRCT domains | BRCA1 C-terminal domains | CtIP tetramerization | FHA domain | forkhead-associated domain | CtBP-interacting protein tetramerization | STRAND BREAK REPAIR | RAD50 ZINC-HOOK | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-SCATTERING | LATE GENE-EXPRESSION | PATHWAY CHOICE | PROTEIN-A RPA | END RESECTION | MRN COMPLEX | IONIZING-RADIATION | MRE11 NUCLEASE | Signal Transduction | Humans | DNA Repair Enzymes - genetics | Models, Molecular | DNA Replication | MRE11 Homologue Protein - chemistry | DNA-Binding Proteins - genetics | Immunity, Innate | DNA-Binding Proteins - chemistry | DNA-Binding Proteins - metabolism | Models, Biological | DNA Repair | DNA Repair Enzymes - metabolism | Telomere - metabolism | DNA Damage | MRE11 Homologue Protein - metabolism | DNA Repair Enzymes - chemistry | MRE11 Homologue Protein - genetics | Biological research | DNA replication | RecA proteins | Physiological aspects | Biochemical genetics | Genetic aspects | Research | DNA repair | Biology, Experimental | Recombination | DNA damage | Nijmegen breakage syndrome | Homology | Kinases | Replication forks | Genomic instability | Proteins | MRE11 protein | Damage | Deoxyribonucleic acid--DNA | Stability | Conductors | Ribonucleases | Replication protein A | Meiosis | Protein A | DNA biosynthesis | Telomeres | Scaffolding | Breakage | Replication | Genetic recombination | Adenosine triphosphatase | Cancer | Nijmegen breakage syndrome protein 1
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 01/2018, Volume 37, Issue 4, pp. 427 - 438
Deregulated AKT kinase activity due to PTEN deficiency in cancer cells contributes to oncogenesis by incompletely understood mechanisms. Here, we show that... 
ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PTEN | ONCOGENE-INDUCED SENESCENCE | CANCER | CELL BIOLOGY | HEMATOPOIETIC-CELLS | DAMAGE RESPONSE | ONCOLOGY | CELL-CYCLE CHECKPOINT | PATHWAY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | TUMORIGENESIS | Phosphorylation | Humans | MRE11 Homologue Protein - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 - genetics | Neoplasms - genetics | Fibroblasts | Neoplasms - radiotherapy | Pyrimidinones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Genomic Instability - genetics | MRE11 Homologue Protein - genetics | Genomic Instability - radiation effects | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Recombinational DNA Repair - genetics | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Down-Regulation | HCT116 Cells | Radiation Tolerance - genetics | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Signal Transduction - genetics | X-Rays - adverse effects | Mechanistic Target of Rapamycin Complex 1 - metabolism | Recombinational DNA Repair - radiation effects | Gene Expression Regulation, Neoplastic - radiation effects | Thiones - pharmacology | MRE11 Homologue Protein - metabolism | DNA Damage - radiation effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA, Small Interfering - metabolism | Gene expression | DNA repair | Health aspects | Senescence | CHK1 protein | DNA damage | Homologous recombination | Radiation | AKT protein | Genomes | Kinases | 1-Phosphatidylinositol 3-kinase | Ribosomal protein S6 kinase | Radiosensitization | Clonal deletion | MRE11 protein | Tumorigenesis | Colon | PTEN protein | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Original
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2019, Volume 38, Issue 7, pp. e101005 - n/a
Journal Article
Cell, ISSN 0092-8674, 12/1999, Volume 99, Issue 6, pp. 577 - 587
Journal Article