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1. Full Text Novel opioid cyclic tetrapeptides: Trp isomers of CJ‐15,208 exhibit distinct opioid receptor agonism and short‐acting κ opioid receptor antagonism
by Ross, Nicolette C and Reilley, Kate J and Murray, Thomas F and Aldrich, Jane V and McLaughlin, Jay P
British journal of pharmacology, ISSN 0007-1188, 02/2012, Volume 165, Issue 4b, pp. 1097 - 1108
cyclic tetrapeptide | CJ‐15,208 | antinociception | analgesic | conditioned place preference | cocaine | κ‐opioid | agonist | antagonist | κ-opioid | CJ-15,208 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cricetulus | Analgesics, Opioid - pharmacology | Extinction, Psychological - drug effects | Tryptophan - chemistry | Male | Peptides, Cyclic - pharmacology | Cocaine-Related Disorders - physiopathology | Receptors, Opioid, mu - agonists | Isomerism | Narcotic Antagonists - chemistry | Peptides, Cyclic - chemistry | Pain - drug therapy | Analgesics, Opioid - chemistry | Behavior, Animal - drug effects | CHO Cells | Cricetinae | Receptors, Opioid, kappa - antagonists & inhibitors | Conditioning (Psychology) - drug effects | Mice, Inbred C57BL | Receptors, Opioid, kappa - agonists | Analgesics, Opioid - therapeutic use | Drug-Seeking Behavior - drug effects | Receptors, Opioid, kappa - physiology | Animals | Narcotic Antagonists - therapeutic use | Pain - physiopathology | Narcotic Antagonists - pharmacology | Peptides, Cyclic - therapeutic use | Cocaine-Related Disorders - drug therapy | Mice | Tryptophan - pharmacology | Tryptophan - therapeutic use | Receptors, Opioid, mu - physiology | Index Medicus | Research Papers
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2. Full Text An opioid agonist that does not induce mu-opioid receptor - Arrestin interactions or receptor internalization
by Groer, C. E and Tidgewell, K and Moyer, R. A and Harding, W. W and Rothman, R. B and Prisinzano, T. E and Bohn, L. M
Molecular pharmacology, ISSN 0026-895X, 02/2007, Volume 71, Issue 2, pp. 549 - 557
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Diterpenes - pharmacology | Cell Line | Arrestin - drug effects | Morphine - pharmacology | Receptors, Opioid, mu - metabolism | Humans | Drug Tolerance | Analgesics, Opioid - pharmacology | Diterpenes, Clerodane | Protein Transport - drug effects | Receptors, Opioid, mu - agonists | Endocytosis | Animals | Transfection | Mice | Receptors, Opioid, mu - genetics | Arrestin - metabolism | Index Medicus
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3. Full Text Structural insights into μ-opioid receptor activation
by Huang, Weijiao and Manglik, Aashish and Venkatakrishnan, A.J and Laeremans, Toon and Feinberg, Evan N and Sanborn, Adrian L and Kato, Hideaki E and Livingston, Kathryn E and Thorsen, Thor S and Kling, Ralf C and Granier, Sébastien and Gmeiner, Peter and Husbands, Stephen M and Traynor, John R and Weis, William I and Steyaert, Jan and Dror, Ron O and Kobilka, Brian K
Nature (London), ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 315 - 321
Allosteric Regulation | Crystallography, X-Ray | Heterotrimeric GTP-Binding Proteins - metabolism | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Receptor, Muscarinic M2 - chemistry | Receptors, Adrenergic, beta-2 - chemistry | Morphinans - metabolism | Binding Sites | Morphinans - pharmacology | Protein Structure, Tertiary | Morphinans - chemistry | Pyrroles - metabolism | Receptors, Opioid, mu - chemistry | Single-Chain Antibodies - pharmacology | Receptors, Opioid, mu - metabolism | Models, Molecular | Molecular Dynamics Simulation | Pyrroles - pharmacology | Animals | Protein Stability - drug effects | Heterotrimeric GTP-Binding Proteins - chemistry | Pyrroles - chemistry | Mice | Single-Chain Antibodies - chemistry | Index Medicus | Life Sciences
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4. Full Text Synthesis and Structure–Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects
by Vekariya, Rakesh H and Lei, Wei and Ray, Abhisek and Saini, Surendra K and Zhang, Sixue and Molnar, Gabriella and Barlow, Deborah and Karlage, Kelly L and Bilsky, Edward J and Houseknecht, Karen L and Largent-Milnes, Tally M and Streicher, John M and Ananthan, Subramaniam
Journal of medicinal chemistry, ISSN 0022-2623, 07/2020, Volume 63, Issue 14, pp. 7663 - 7694
Receptors, Opioid, delta - metabolism | Analgesics, Opioid - chemical synthesis | Cricetulus | Humans | Microsomes, Liver - metabolism | Narcotic Antagonists - chemical synthesis | Male | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Morphinans - metabolism | Narcotic Antagonists - metabolism | Drug Design | Receptors, Opioid, delta - antagonists & inhibitors | Molecular Structure | CHO Cells | Morphinans - therapeutic use | Pyridines - therapeutic use | Receptors, Opioid, mu - metabolism | Pyridines - chemical synthesis | Analgesics, Opioid - therapeutic use | Morphinans - chemical synthesis | Animals | Pyridines - metabolism | Narcotic Antagonists - therapeutic use | Protein Binding | Mice | Molecular Docking Simulation | Analgesics, Opioid - metabolism | Index Medicus
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5. Full Text Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors
by Banghart, Matthew Ryan and Neufeld, Shay Quentin and Wong, Nicole Christine and Sabatini, Bernardo Luis
Neuron (Cambridge, Mass.), ISSN 0896-6273, 12/2015, Volume 88, Issue 6, pp. 1227 - 1239
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Mice, Inbred C57BL | Inhibitory Postsynaptic Potentials - physiology | Male | Mice, Transgenic | Animals | Corpus Striatum - drug effects | Corpus Striatum - physiology | Female | Enkephalins - pharmacology | Mice | Inhibitory Postsynaptic Potentials - drug effects | Receptors, Opioid, delta - physiology | Receptors, Opioid, mu - physiology | Neuropeptides | Neurophysiology | Information management | Neurons | Studies | Rodents | Ligands | Behavior | Artificial chromosomes | Experiments | Index Medicus
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6. Full Text Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum
by Atwood, Brady K and Kupferschmidt, David A and Lovinger, David M
Nature neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 4, pp. 540 - 548
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Endocannabinoids - metabolism | Receptors, Opioid, delta - metabolism | Neuronal Plasticity - drug effects | Male | Long-Term Synaptic Depression - drug effects | Corpus Striatum - metabolism | Receptors, Opioid - physiology | Female | Receptors, Opioid - metabolism | Long-Term Synaptic Depression - physiology | Oxycodone - administration & dosage | Receptors, Opioid, mu - drug effects | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Receptors, Opioid, kappa - metabolism | Rats | Receptors, Opioid, delta - drug effects | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Receptors, Opioid, kappa - physiology | Receptors, Opioid, kappa - drug effects | Animals | Analgesics, Opioid - administration & dosage | Corpus Striatum - drug effects | Mice | Receptors, Opioid - drug effects | Receptors, Opioid, delta - physiology | Receptors, Opioid, mu - physiology | Drug abuse | Depression, Mental | Opioids | Physiological aspects | Corpus striatum | Health aspects | Risk factors | Index Medicus
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7. Full Text Opioid receptors: Drivers to addiction?
by Darcq, Emmanuel and Kieffer, Brigitte Lina
Nature reviews. Neuroscience, ISSN 1471-003X, 08/2018, Volume 19, Issue 8, pp. 499 - 514
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Drug addiction | Drug abuse | Pain | Narcotics | Opioid receptors (type kappa) | Opioid receptors (type mu) | Nervous system | Opiates | Addictions | Public health | Drug use
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8. Full Text Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia
by Xu, Ji-Tian and Zhao, Jian-Yuan and Zhao, Xiuli and Ligons, Davinna and Tiwari, Vinod and Atianjoh, Fidelis E and Lee, Chun-Yi and Liang, Lingli and Zang, Weidong and Njoku, Dolores and Raja, Srinivasa N and Yaster, Myron and Tao, Yuan-Xiang
The Journal of clinical investigation, ISSN 0021-9738, 02/2014, Volume 124, Issue 2, pp. 592 - 603
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Injections, Spinal | Cell Proliferation | Spinal Cord - drug effects | Hyperalgesia - metabolism | Morphine - pharmacology | TOR Serine-Threonine Kinases - metabolism | Receptors, Opioid, mu - metabolism | Pain Management | Morphine - metabolism | Drug Tolerance - physiology | Rats | Male | Phosphatidylinositol 3-Kinases - metabolism | Spleen - cytology | Rats, Sprague-Dawley | Sirolimus - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Dose-Response Relationship, Drug | Multiprotein Complexes - metabolism | Spinal Cord - embryology | Animals | Time Factors | Pain - drug therapy | Neurons - drug effects | Complications and side effects | Receptors | Drug tolerance | Opioids | Physiological aspects | Development and progression | Research | Proteins | Spinal cord | Phosphorylation | Neurons | Rodents | Pain management | Kinases | Laboratory animals | Drug dosages | Index Medicus | Abridged Index Medicus
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