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American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2012, Volume 47, Issue 2, pp. 178 - 185
Mucins are gel-forming proteins that are responsible for the characteristic viscoelastic properties of mucus. Mucin overproduction is a hallmark of asthma, but... 
Protein disulfide isomerase | Mucus | Airway epithelium | Asthma | Endoplasmic reticulum stress | AIRWAY MUCUS HYPERSECRETION | PROTEIN-DISULFIDE-ISOMERASE | protein disulfide isomerase | BIOCHEMISTRY & MOLECULAR BIOLOGY | airway epithelium | IL-4 RECEPTOR | asthma | ENDOPLASMIC-RETICULUM STRESS | endoplasmic reticulum stress | mucus | FAMILY | CELL BIOLOGY | MUC5AC MUCIN | EPITHELIAL-CELLS | RESPIRATORY SYSTEM | COLOCALIZATION | DISEASE | GENE-EXPRESSION | Asthma - metabolism | Mucoproteins - immunology | Bronchial Hyperreactivity - immunology | Mucin-5B - genetics | Humans | Endoplasmic Reticulum - metabolism | Th2 Cells - immunology | Bronchial Hyperreactivity - genetics | Allergens - administration & dosage | Inflammation - metabolism | Allergens - immunology | Mucin 5AC - immunology | Mucoproteins - biosynthesis | Respiratory Mucosa - immunology | Asthma - immunology | Hypersensitivity, Immediate - immunology | Bronchial Hyperreactivity - metabolism | Mucoproteins - genetics | Gene Expression | Mucin-5B - immunology | Hypersensitivity, Immediate - genetics | Mice, Transgenic | Inflammation - immunology | Th2 Cells - metabolism | Asthma - genetics | Proteins - immunology | Proteins - genetics | Mucin-5B - metabolism | Animals | Proteins - metabolism | Hypersensitivity, Immediate - metabolism | Endoplasmic Reticulum - immunology | Mucin 5AC - genetics | Cell Line, Tumor | Inflammation - genetics | Mucin 5AC - metabolism | Mice | Respiratory Mucosa - metabolism | Mucin 5AC - biosynthesis | Mucin-5B - biosynthesis | Mucoproteins - metabolism | Index Medicus
Journal Article
Modern Pathology, ISSN 0893-3952, 12/2013, Volume 26, Issue 12, pp. 1642 - 1656
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2012, Volume 47, Issue 2, pp. 149 - 157
Journal Article
Journal Article
Thorax, ISSN 0040-6376, 07/2015, Volume 70, Issue 7, pp. 668 - 676
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 04/2019, Volume 849, pp. 22 - 29
Cyclic adenosine monophosphate (cAMP) is a key intracellular second messenger, which is degraded by phosphodiesterase 4 (PDE4). PDE4 suppresses cAMP levels,... 
Airway inflammatory disease | Goblet cell hyperplasia | Chronic obstructive pulmonary disease | TAS-203 | PDE4 inhibitor | MUC5AC | SPUTUM | HYPERRESPONSIVENESS | EPIDERMAL-GROWTH-FACTOR | ASTHMA | PHARMACOLOGY & PHARMACY | EXPRESSION | ROFLUMILAST | MUCUS | Respiratory System - pathology | Inflammation - pathology | Goblet Cells - drug effects | Male | Pulmonary Disease, Chronic Obstructive - pathology | Inflammation - metabolism | Inflammation - drug therapy | Hyperplasia - drug therapy | Pulmonary Disease, Chronic Obstructive - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Benzimidazoles - therapeutic use | Disease Models, Animal | Triazoles - therapeutic use | Cigarette Smoking - adverse effects | Guinea Pigs | Phosphodiesterase 4 Inhibitors - therapeutic use | Rats | Phosphodiesterase 4 Inhibitors - pharmacology | Gene Expression Regulation - drug effects | Triazoles - pharmacology | Animals | Respiratory System - metabolism | Respiratory System - drug effects | Mucin 5AC - metabolism | Benzimidazoles - pharmacology | Goblet Cells - pathology | Mucin 5AC - biosynthesis | Pulmonary Disease, Chronic Obstructive - drug therapy | Medical research | Gastrointestinal agents | Anti-inflammatory drugs | Cyclic adenylic acid | Nausea | Inflammation | Roflumilast | Cells | Asthma | Dextran | Epidermal growth factor | Interleukins | Mucins | Medicine, Experimental | Adenylic acid | Health aspects | Smoking | Index Medicus
Journal Article