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science & technology (26) 26
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1. Full Text Factorial versus multi‐arm multi‐stage designs for clinical trials with multiple treatments
by Jaki, Thomas and Vasileiou, Despina
Statistics in medicine, ISSN 0277-6715, 02/2017, Volume 36, Issue 4, pp. 563 - 580
factorial design | multi‐arm multi‐stage designs (MAMS) | familywise error rate | multi-arm multi-stage designs (MAMS) | Statistics & Probability | Physical Sciences | Life Sciences & Biomedicine | Medical Informatics | Public, Environmental & Occupational Health | Mathematics | Medicine, Research & Experimental | Science & Technology | Mathematical & Computational Biology | Research & Experimental Medicine | Data Interpretation, Statistical | Sample Size | Randomized Controlled Trials as Topic - methods | Humans | Osteoarthritis, Knee | Physical Therapy Modalities | Treatment Outcome | Statistics as Topic | Models, Statistical | Osteoarthritis, Hip - therapy | Exercise Therapy | Clinical trials | Simulation | Sample size | Medical treatment | Comparative studies | Medical statistics | Factorial experiments | Index Medicus | s
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2. Full Text Designing multi‐arm multi‐stage clinical trials using a risk–benefit criterion for treatment selection
by Jaki, Thomas and Hampson, Lisa V
Statistics in medicine, ISSN 0277-6715, 02/2016, Volume 35, Issue 4, pp. 522 - 533
multiple endpoints | treatment selection | familywise error rate | safety | multi‐arm multi‐stage (MAMS) | Safety | Multiple endpoints | Treatment selection | Familywise error rate | Multi-arm multi-stage (MAMS) | Statistics & Probability | Physical Sciences | Life Sciences & Biomedicine | Medical Informatics | Public, Environmental & Occupational Health | Mathematics | Medicine, Research & Experimental | Science & Technology | Mathematical & Computational Biology | Research & Experimental Medicine | Decision Making | Benzoates - therapeutic use | HIV Seropositivity | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Insulin Resistance | Models, Statistical | Telmisartan | Clinical Trials, Phase III as Topic | Sample Size | Computer Simulation | Endpoint Determination | Patient Safety | Research Design | Benzimidazoles - therapeutic use | Clinical trials | Hypothesis testing | Simulation | Efficiency | Experiments | Index Medicus | s
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3. Full Text Comparison of multi-arm multi-stage design and adaptive randomization in platform clinical trials
by Lin, Jianchang and Bunn, Veronica
Contemporary clinical trials, ISSN 1551-7144, 2016, Volume 54, pp. 48 - 59
Hematology, Oncology and Palliative Medicine | Cardiovascular | Platform trials | Bayesian adaptive design | Adaptive randomization | Multi-arm multi-stage (MAMS) | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Adaptive Clinical Trials as Topic | Sample Size | Humans | Bayes Theorem | Treatment Outcome | Random Allocation | Randomized Controlled Trials as Topic | Clinical trials | Comparative analysis | Index Medicus
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4. Full Text Adaptive platform trials using multi-arm, multi-stage protocols: getting fast answers in pandemic settings [version 1; peer review: 2 approved]
by Noor, Nurulamin M and Pett, Sarah L and Esmail, Hanif and Crook, Angela M and Vale, Claire L and Sydes, Matthew R and Parmar, Mahesh K.B
F1000 research, ISSN 2046-1402, 2020, Volume 9, p. 1109
COVID-19 | Adaptive Clinical Trials as Topic | Coronavirus Infections | SARS-CoV-2 | Pandemics | Humans | Betacoronavirus | Pneumonia, Viral | Research Design
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5. Full Text Type I error rates of multi-arm multi-stage clinical trials: Strong control and impact of intermediate outcomes
by Bratton, Daniel J and Parmar, Mahesh K.B and Phillips, Patrick P.J and Choodari-Oskooei, Babak
Trials, ISSN 1745-6215, 07/2016, Volume 17, Issue 1, pp. 309 - 309
False positive rate | MAMS | Familywise error rate | Multi-stage | Multi-arm | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Data Interpretation, Statistical | Clinical Trials as Topic - statistics & numerical data | Time Factors | Humans | Endpoint Determination | Models, Statistical | Research Design - statistics & numerical data | Clinical trials | Analysis | Medical errors | Index Medicus
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6. Full Text The R package MAMS for designing multi-arm multi-stage clinical trials
by Jaki, Thomas and Pallmann, Philip and Magirr, Dominic
Journal of statistical software, ISSN 1548-7660, 2019, Volume 88, Issue 1, pp. 1 - 25
Conditional error | Adaptive designs | Multi-arm | Step-down procedure | Statistics & Probability | Physical Sciences | Computer Science, Interdisciplinary Applications | Technology | Computer Science | Mathematics | Science & Technology | conditional error | adaptive designs | step-down procedure | multi-arm
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7. Full Text A modest proposal for dropping poor arms in clinical trials
by Proschan, Michael A and Dodd, Lori E
Statistics in medicine, ISSN 0277-6715, 08/2014, Volume 33, Issue 19, pp. 3241 - 3252
comparisons with control | family‐wise error (FWE) rate | multi‐arm multi‐stage (MAMS) design | multiple comparisons | estimation bias | sequentially rejective methods | Estimation bias | Family-wise error (FWE) rate | Multi-arm multi-stage (MAMS) design | Sequentially rejective methods | Multiple comparisons | Comparisons with control | Statistics & Probability | Physical Sciences | Life Sciences & Biomedicine | Medical Informatics | Public, Environmental & Occupational Health | Mathematics | Medicine, Research & Experimental | Science & Technology | Mathematical & Computational Biology | Research & Experimental Medicine | Blood Pressure | Biostatistics | Controlled Clinical Trials as Topic - methods | Bias | Humans | Controlled Clinical Trials as Topic - statistics & numerical data | Models, Statistical | Hypertension - physiopathology | Clinical Trials, Phase III as Topic - methods | Hypertension - blood | Clinical Trials, Phase III as Topic - statistics & numerical data | Triglycerides - blood | Clinical Trials, Phase II as Topic - statistics & numerical data | Clinical Trials, Phase II as Topic - methods | Hypertension - diet therapy | Clinical trials | Performance evaluation | Demand | Control | Comparative analysis | Index Medicus | Multi-arm, multi-stage (MAMS) design | Family-wise error rate (FWE)
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8. Full Text Optimal design of multi‐arm multi‐stage trials
by Wason, James M. S and Jaki, Thomas
Statistics in medicine, ISSN 0277-6715, 12/2012, Volume 31, Issue 30, pp. 4269 - 4279
optimal allocation, optimal design | multi‐arm multi‐stage trials | simulated annealing | Multi-arm multi-stage trials | Optimal allocation, optimal design | Simulated annealing | Anti-Retroviral Agents - therapeutic use | Bias | Humans | Insulin Resistance | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Benzoates - administration & dosage | Sample Size | Benzimidazoles - administration & dosage | Anti-Retroviral Agents - administration & dosage | Computer Simulation | Endpoint Determination | Benzoates - pharmacology | Benzimidazoles - pharmacology | HIV Infections - drug therapy | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Clinical Trials as Topic - methods | Clinical Trials as Topic - standards | Drug Therapy, Combination | Research Design | Clinical trials | Public health | Drugs | Sample size | Medical statistics | Drug therapy | Research & development--R&D | Index Medicus
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9. Full Text A comparison of Bayesian adaptive randomization and multi‐stage designs for multi‐arm clinical trials
by Wason, James M. S and Trippa, Lorenzo
Statistics in medicine, ISSN 0277-6715, 06/2014, Volume 33, Issue 13, pp. 2206 - 2221
multi‐arm trials | group‐sequential designs | adaptive randomization | multiple testing | Multiple testing | Group-sequential designs | Multi-arm trials | Adaptive randomization | Statistics & Probability | Physical Sciences | Life Sciences & Biomedicine | Medical Informatics | Public, Environmental & Occupational Health | Mathematics | Medicine, Research & Experimental | Science & Technology | Mathematical & Computational Biology | Research & Experimental Medicine | Outcome Assessment (Health Care) - statistics & numerical data | Randomized Controlled Trials as Topic - methods | Bias | Computer Simulation | Humans | Bayes Theorem | Clinical Trials, Phase II as Topic - statistics & numerical data | Female | Receptor, ErbB-2 | Clinical Trials, Phase II as Topic - methods | Breast Neoplasms - drug therapy | Research Design | Clinical trials | Comparative analysis | Ethics | Medical statistics | Bayesian analysis | Medical treatment | Index Medicus
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10. Full Text Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: A case study
by Jaki, Thomas and Jaki, Thomas and Wason, James M.S and Wason, James M S
BMC cardiovascular disorders, ISSN 1471-2261, 11/2018, Volume 18, Issue 1, pp. 215 - 215
Adaptive design | Multi-arm trials | Clinical trial design | Multi-arm multi-stage trials | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Data Interpretation, Statistical | Randomized Controlled Trials as Topic - statistics & numerical data | Randomized Controlled Trials as Topic - methods | Brain Ischemia - therapy | Endovascular Procedures - adverse effects | Humans | Stroke - diagnosis | Treatment Outcome | Brain Ischemia - physiopathology | Stroke - physiopathology | Patient Selection | Sample Size | Adaptive Clinical Trials as Topic - methods | Brain Ischemia - diagnosis | Adaptive Clinical Trials as Topic - statistics & numerical data | Research Design - statistics & numerical data | Stroke - therapy | Endovascular Procedures - statistics & numerical data | Stroke (Disease) | Care and treatment | Endovascular stents | Cardiovascular system | Stroke | Ischemia | Efficiency | Clinical trials | Statistics | Recruitment | Index Medicus
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11. Full Text Changing platforms without stopping the train: experiences of data management and data management systems when adapting platform protocols by adding and closing comparisons
by Hague, Dominic and Townsend, Stephen and Masters, Lindsey and Rauchenberger, Mary and Van Looy, Nadine and Diaz-Montana, Carlos and Gannon, Melissa and James, Nicholas and Maughan, Tim and Parmar, Mahesh K. B and Brown, Louise and Sydes, Matthew R and FOCUS4 Investigator and STAMPEDE Investigator and STAMPEDE and FOCUS4 investigators and for the STAMPEDE and FOCUS4 investigators
Trials, ISSN 1745-6215, 05/2019, Volume 20, Issue 1, pp. 294 - 294
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Colorectal Neoplasms - therapy | Humans | Data Management | Male | Clinical Trials as Topic | Random Allocation | Research Design | Prostatic Neoplasms - therapy | Medicine, Experimental | Medical research | Database design | Prostate cancer | Colorectal cancer | Index Medicus | Database | Data management | Trial conduct | Adaptive trials | Platform protocol | Multi-arm multi-stage (MAMS)
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12. Full Text Adding new experimental arms to randomised clinical trials: Impact on error rates
by Choodari-Oskooei, Babak and Bratton, Daniel J and Gannon, Melissa R and Meade, Angela M and Sydes, Matthew R and Parmar, Mahesh KB
Clinical trials (London, England), ISSN 1740-7745, 6/2020, Volume 17, Issue 3, pp. 273 - 284
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Clinical Trials, Phase III as Topic | Data Interpretation, Statistical | Sample Size | Scientific Experimental Error | Randomized Controlled Trials as Topic - methods | Humans | Female | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Research Design | Prostatic Neoplasms - drug therapy | Randomization | Developmental stages | Mathematical analysis | Correlation analysis | Clinical trials | Error correction | Statistical tests | Statistics | Index Medicus | multi-arm multi-stage | Platform trials | pairwise error rate | survival time | adaptive trial designs | STAMPEDE trial | MAMS | familywise type I error rate
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13. Full Text A multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosis
by Bratton, Daniel J and Phillips, Patrick P.J and Parmar, Mahesh K.B
BMC medical research methodology, ISSN 1471-2288, 2013, Volume 13, Issue 1, pp. 139 - 139
Adaptive design | Tuberculosis | Binary outcome | Treatment selection | Multi-stage | Multi-arm | Life Sciences & Biomedicine | Health Care Sciences & Services | Science & Technology | Clinical Trials, Phase III as Topic | Sample Size | Bias | Computer Simulation | Humans | Treatment Outcome | Tuberculosis, Pulmonary - therapy | Clinical Trials, Phase II as Topic | Randomized Controlled Trials as Topic | Clinical trials | Medicine, Experimental | Medical research | Comparative analysis | Experimental design | Product development | Sample size | Index Medicus
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