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Current Medicinal Chemistry, ISSN 0929-8673, 01/2015, Volume 22, Issue 3, pp. 373 - 404
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 11/2017, Volume 17, Issue 28, pp. 3131 - 3145
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 04/2017, Volume 17, Issue 9, pp. 1080 - 1095
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2042 - 2050
Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost a century after Gerhard Domagk’s pioneering work leading to the... 
Complex diseases | Sulfa-drugs | Multi-target approach | Sulfonamide | Polypharmacology | VITRO | TARGET-DIRECTED LIGANDS | DESIGN | CHEMISTRY, MEDICINAL | CARBONIC-ANHYDRASE I | CRYSTAL-STRUCTURE | INHIBITORY-ACTIVITY | CHEMISTRY, ORGANIC | BIOLOGICAL EVALUATION | POTENTIAL TREATMENT | ISOZYME-II | DUAL INHIBITORS | Antiviral agents | Drug discovery | Sulfonamides | Antidepressants
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2019, Volume 174, pp. 216 - 225
Journal Article
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 10/2019, Volume 29, Issue 10, pp. 805 - 815
Introduction: Glaucoma is a neurodegenerative disease of the eye characterized by selective retinal ganglion cell loss that provokes progressive defects in the... 
Glaucoma | ocular hypertension | α-adrenoceptor | modulator | β-adrenoceptor | drug delivery system | multi-target | combination
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 06/2016, Volume 22, Issue 21, pp. 3164 - 3170
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 11/2017, Volume 27, Issue 22, pp. 5046 - 5052
A series of 2-acetyl-5-O-(amino-alkyl)phenol derivatives was designed, synthesized and evaluated as multi-function inhibitors for the treatment of Alzheimer's... 
Blood-brain barrier | 2-Acetyl-5-O-(amino-alkyl)phenol derivatives | Alzheimer's disease | Synthesized | Designed | Multi-target inhibitor | TARGET-DIRECTED LIGANDS | CHEMISTRY, MEDICINAL | AGGREGATION INHIBITORS | CHEMISTRY, ORGANIC | DONEPEZIL | ACETYLCHOLINESTERASE | 2-Acetyl-5-O-(amino-alkyl) phenol derivatives | MANNICH BASE DERIVATIVES | METAL-CHELATING AGENTS | CHOLINESTERASE/MONOAMINE OXIDASE-INHIBITORS | HYBRIDS | Neuroprotective Agents - therapeutic use | Benzophenones - chemical synthesis | Humans | Benzophenones - pharmacology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | PC12 Cells | Monoamine Oxidase - chemistry | Neuroprotective Agents - pharmacology | Drug Design | Inhibitory Concentration 50 | Binding Sites | Phenols - pharmacology | Hydrogen Peroxide - toxicity | Protein Structure, Tertiary | Benzophenones - therapeutic use | Cell Survival - drug effects | Permeability - drug effects | Alzheimer Disease - drug therapy | Rats | Piperazines - therapeutic use | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Blood-Brain Barrier - drug effects | Piperazines - pharmacology | Blood-Brain Barrier - metabolism | Antioxidants - therapeutic use | Neuroprotective Agents - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Phenols - therapeutic use | Phenols - chemistry | Piperazines - chemical synthesis | Molecular Docking Simulation | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Drug therapy | Analysis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 48 - 59
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2019, Volume 180, pp. 283 - 290
Multi-target molecular entities, offer a path to progress both in understanding causes of disease and in defining effective small molecule treatments. Coumarin... 
Multi-target agents | Cystic fibrosis (CF) | CFTR modulators | Furocoumarins | PSORALEN DERIVATIVES | DESIGN | CHEMISTRY, MEDICINAL | PROTEIN | TRANSCRIPTION | IDENTIFICATION | IN-VITRO | COUMARIN | INHIBITORS | NF-KAPPA-B | CFTR
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 440 - 447
Aberrant angiogenesis is a hallmark of various diseases including cancers. VEGFR-2 inhibitors have been utilized as anti-angiogenic agents for several years.... 
Multi-target | RTK inhibitors | 1,2,3-Triazole | Anti-angiogenic agents | Compensatory activation | DESIGN | CHEMISTRY, MEDICINAL | VEGFR-2 | EXPLORATION | BIOLOGICAL EVALUATION | MOLECULAR DOCKING | DERIVATIVES | Antimitotic agents | Tyrosine | Medical colleges | Triazoles | Pharmacy | Drugstores | Antineoplastic agents | Vascular endothelial growth factor
Journal Article