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Current Medicinal Chemistry, ISSN 0929-8673, 01/2015, Volume 22, Issue 3, pp. 373 - 404
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2017, Volume 141, pp. 211 - 220
Several Pt(IV) prodrugs containing SAA, a histone deacetylases inhibitor, were designed and prepared for multiply targeting genomic DNA, histone deacetylases... 
HDAC inhibitor | Multi-target | PARP-1 inhibitor | Overcoming drug-resistance | Pt(IV) prodrug | HDAC INHIBITORS | POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITOR | CHEMISTRY, MEDICINAL | COMPLEXES | RIBOSE POLYMERASE | ANTITUMOR-ACTIVITY | CELL-DEATH | BREAST-CANCER | POTENT INHIBITOR | CISPLATIN | ANTICANCER DRUGS | Poly(ADP-ribose) Polymerase Inhibitors - chemistry | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Prodrugs - chemistry | Structure-Activity Relationship | Organoplatinum Compounds - pharmacology | Dose-Response Relationship, Drug | Poly(ADP-ribose) Polymerase Inhibitors - chemical synthesis | Histone Deacetylase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | Organoplatinum Compounds - chemistry | Histone Deacetylases - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Antineoplastic Agents - chemistry | Histone Deacetylase Inhibitors - chemistry | DNA, Neoplasm - drug effects | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Organoplatinum Compounds - chemical synthesis | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Prodrugs - chemical synthesis | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects | DNA, Neoplasm - genetics | Prodrugs - pharmacology | Drug Screening Assays, Antitumor | Medicine, Experimental | Enzymes | Medical research | Drug resistance | Analysis | DNA | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Balanced modulation of several targets is one of the current strategies for the treatment of multi-factorial diseases. Based on the knowledge of inflammation... 
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | MECHANISM | CRYSTAL-STRUCTURE | DRUG DISCOVERY | CANDIDATE | DUAL INHIBITORS | DERIVATIVES | ANTIMICROBIAL ACTIVITY | LIGAND DESIGN | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 48 - 59
Journal Article
Molecules, ISSN 1420-3049, 06/2017, Volume 22, Issue 6, p. 913
Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our... 
PDGFRβ inhibitor angiogenesis | VEGFR-2 inhibitor | (2-oxoindolin-3-ylidene)methylpyrrole | Multi-target kinase inhibitor | GASTROINTESTINAL STROMAL TUMOR | ANGIOGENESIS | FLK-1/KDR | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | multi-target kinase inhibitor | GROWTH | SUNITINIB | PDGFR beta inhibitor angiogenesis | PUMA | NF-KAPPA-B | CARCINOMA | Cell Proliferation | Humans | Indoles - chemical synthesis | Receptor, Platelet-Derived Growth Factor beta - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Dose-Response Relationship, Drug | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Pyrrolidinones - pharmacology | Indoles - pharmacology | Neovascularization, Pathologic - prevention & control | Angiogenesis Inhibitors - chemical synthesis | Receptor, Platelet-Derived Growth Factor beta - metabolism | Cell Survival - drug effects | Protein Kinase Inhibitors - chemical synthesis | Gene Expression | Protein Structure, Secondary | HCT116 Cells | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Pyrrolidinones - chemical synthesis | Pyrroles - pharmacology | Cell Line, Tumor | Pyrroles - chemistry | Neovascularization, Pathologic - genetics | Molecular Docking Simulation | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Indoles - chemistry | Tyrosine | Binding | Cell proliferation | Derivatives | Vascular endothelial growth factor receptors | Metastases | Substitutes | Angiogenesis | Inhibitors | Molecular modelling | Condensates | Protein-tyrosine kinase receptors | Solid tumors | Chemical synthesis | Protein-tyrosine kinase | Tumors | Cancer
Journal Article
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 2019, Volume 19, Issue 4, pp. 264 - 275
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2017, Volume 141, pp. 373 - 385
VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors... 
Multi-target | RTK inhibitors | Hinge-binding group | Anti-angiogenesis agents | 1H-indazol-3-amine | DESIGN | CHEMISTRY, MEDICINAL | ACID | 3D-QSAR | UREAS | TYROSINE KINASE INHIBITORS | HINGE-BINDING FRAGMENTS | EXPLORATION | GROWTH | BIOLOGICAL EVALUATION | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Thiourea - pharmacology | Neovascularization, Pathologic - pathology | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Thiourea - chemical synthesis | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Angiogenesis Inhibitors - chemical synthesis | Cell Survival - drug effects | Protein Kinase Inhibitors - chemical synthesis | Human Umbilical Vein Endothelial Cells - drug effects | Indazoles - chemistry | Angiogenesis Inhibitors - pharmacology | Thiourea - chemistry | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Indazoles - pharmacology | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Antimitotic agents | Amines | Pharmacy | Drugstores | Nuclear nonproliferation | Antineoplastic agents | Vascular endothelial growth factor
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 810 - 822
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2015, Volume 105, pp. 274 - 288
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 738 - 749
Journal Article