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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 27, pp. 10832 - 10836
The study of membrane proteins remains a challenging task, and approaches to unravel their dynamics are scarce... 
ATP binding cassette transporters | Deuterium | Hydrolysis | Average linear density | Mass spectroscopy | Biochemistry | Dimers | Detergents | Exporters | Membrane proteins | ATPase cycle | Structural biology | Detergent | DOMAIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HYDROLYSIS | MASS-SPECTROMETRY | ATP-BINDING | BINDING CASSETTE TRANSPORTER | detergent | P-GLYCOPROTEINS | ALTERNATING ACCESS | structural biology | MOLECULAR-BASIS | HYDROGEN-EXCHANGE | Protein Structure, Tertiary | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Multidrug Resistance-Associated Proteins - chemistry | Adenosine Triphosphatases - metabolism | Trypsin - metabolism | Bacillus subtilis - genetics | Membrane Transport Proteins - chemistry | Deuterium Exchange Measurement | Trypsin - pharmacology | Peptide Mapping | Escherichia coli - genetics | Membrane Transport Proteins - genetics | Mass Spectrometry | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Protein Conformation | Mutagenesis - physiology | Catalysis | Multidrug Resistance-Associated Proteins - metabolism | Bacillus subtilis - metabolism | Physiological aspects | Molecular dynamics | Research | Binding proteins | Adenosine triphosphate | Bacillus subtilis | Escherichia coli | Biochemistry, Molecular Biology | Bacterial Proteins | Life Sciences | Trypsin | Mutagenesis | Adenosine Triphosphatases | Membrane Transport Proteins | Biomolecules | Multidrug Resistance-Associated Proteins | Biological Sciences
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2002, Volume 277, Issue 4, pp. 2908 - 2915
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 2008, Volume 75, Issue 6, pp. 1302 - 1312
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 5, p. e63404
Although multidrug-resistance-associated protein-1 (MRP1) is a major contributor to multi-drug resistance (MDR... 
OXIDATIVE STRESS | GAMMA-GLUTAMYLCYSTEINE SYNTHETASE | TRANSCRIPTION FACTOR NRF2 | MRP/GS-X PUMP | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR P-GLYCOPROTEIN | ANTICANCER DRUGS | DRUG-RESISTANCE | ADAPTIVE RESPONSE | RESPONSIVE ELEMENT | INDUCIBLE EXPRESSION | Immunohistochemistry | Antioxidants - metabolism | Drug Resistance, Multiple - drug effects | Humans | Lung Neoplasms - metabolism | Molecular Sequence Data | 5' Flanking Region - genetics | Gene Knockdown Techniques | Small Cell Lung Carcinoma - metabolism | Base Sequence | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Response Elements - genetics | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Drug Resistance, Multiple - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | Mutation - genetics | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Software | Multidrug Resistance-Associated Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Comparative analysis | Drug resistance | Lung cancer | Cancer | Drugs | Oxidative stress | Genes | Regulatory sequences | Drug development | Tissues | Cancer therapies | Proteins | Antioxidants | Toxicology | Reporter gene | Rodents | Localization | MRP1 protein | Enzymes | Small cell lung carcinoma | Multidrug resistance | Gene expression | Pathology | Correlation analysis | Regulatory mechanisms (biology)
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2888 - 2897
Multidrug resistance-associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs... 
MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | THERAPY | MULTIDRUG-RESISTANCE PROTEINS | ENDOTHELIAL DYSFUNCTION | CHRONIC HYPOXIA | PHOSPHODIESTERASE TYPE-5 | ARTERIAL-HYPERTENSION | SMOOTH-MUSCLE-CELLS | CYCLIC-NUCLEOTIDES | CAMP | Propionates - metabolism | Humans | Leukotriene Antagonists - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Hypertension, Pulmonary - prevention & control | Vasodilation | RNA Interference | Multidrug Resistance-Associated Proteins - genetics | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Cyclic AMP - metabolism | Leukotriene Antagonists - therapeutic use | Cyclic AMP-Dependent Protein Kinases - metabolism | Lung - pathology | Enzyme Inhibitors - metabolism | Cells, Cultured | Propionates - therapeutic use | Vasoconstriction | Familial Primary Pulmonary Hypertension | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Muscle, Smooth, Vascular - cytology | Enzyme Inhibitors - therapeutic use | Mice, Knockout | Pulmonary Artery - cytology | Quinolines - metabolism | Animals | Cyclic GMP - metabolism | Hypoxia - pathology | Hypoxia - physiopathology | Mice | Quinolines - therapeutic use | Hypertension, Pulmonary - pathology | Multidrug Resistance-Associated Proteins - metabolism | Prevention | Physiological aspects | Cellular proteins | Research | Drug resistance | Pulmonary hypertension | Life Sciences | Human health and pathology | Pulmonology and respiratory tract
Journal Article
Translational Research, ISSN 1931-5244, 2013, Volume 162, Issue 6, pp. 398 - 409
Journal Article
Leukemia, ISSN 1476-5551, 2007, Volume 21, Issue 3, pp. 427 - 438
.... An important mechanism underlying drug resistance is represented by overexpression of membrane drug transporters such as multidrug resistance-associated protein 1 (MRP1... 
AML | PERIPHERAL-BLOOD | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | PI3K/Akt | p53 | P-GLYCOPROTEIN | HEMATOPOIETIC-CELLS | PI3K/AKT PATHWAY | SOUTHWEST-ONCOLOGY-GROUP | ONCOLOGY | PROSTATE-CANCER CELLS | MDM2 | GENE-EXPRESSION | drug resistance | CYCLE PROGRESSION | HEMATOLOGY | Leukocytes, Mononuclear - metabolism | Phosphorylation | Proto-Oncogene Proteins c-mdm2 - genetics | Leukemia, Promyelocytic, Acute - pathology | Tumor Suppressor Protein p53 - biosynthesis | Jurkat Cells - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid - genetics | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Fluorescent Dyes - metabolism | Male | Cell Line, Tumor - drug effects | Multidrug Resistance-Associated Proteins - biosynthesis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Bone Neoplasms - pathology | Gene Expression Regulation, Leukemic - genetics | Leukemia, Myeloid - pathology | Genes, p53 | Neoplastic Stem Cells - metabolism | Aged, 80 and over | Adult | Female | Multidrug Resistance-Associated Proteins - genetics | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Acute Disease | Leukocytes, Mononuclear - drug effects | Neoplasm Proteins - biosynthesis | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins c-akt - physiology | Leukemia-Lymphoma, Adult T-Cell - pathology | Gene Expression Regulation, Leukemic - physiology | Rhodamine 123 - metabolism | Drug Resistance, Neoplasm - genetics | Androstadienes - pharmacology | Leukemia, Myeloid - metabolism | Phosphatidylinositol 3-Kinases - physiology | Aged | Protein Processing, Post-Translational | Osteosarcoma - pathology | Jurkat Cells - drug effects | Complications and side effects | Chemotherapy | Research | Drug resistance | Health aspects | Risk factors | Cancer
Journal Article