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Journal of Neurochemistry, ISSN 0022-3042, 09/2007, Volume 102, Issue 6, pp. 1749 - 1757
Imatinib, a protein tyrosine kinase inhibitor, may prevent the growth of glioblastoma cells. Unfortunately, its brain distribution is restricted by... 
CGP74588 | mouse | p‐glycoprotein | imatinib | blood–brain barrier | breast cancer resistance protein | Imatinib | Blood-brain barrier | Mouse | Breast cancer resistance protein | p-glycoproteinz | blood-brain barrier | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | p-glycoprotein | C-KIT | DRUG-RESISTANCE | DEFICIENT MICE | GF120918 | NEUROSCIENCES | REVERSAL | IN-VITRO | PHARMACOKINETICS | TYROSINE KINASE INHIBITOR | MULTIDRUG-RESISTANCE | Male | Piperazines - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | ATP Binding Cassette Transporter, Subfamily B, Member 1 | ATP-Binding Cassette Transporters - genetics | Biological Transport, Active - physiology | ATP-Binding Cassette Transporters - metabolism | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Subfamily B - genetics | Piperazines - pharmacokinetics | Immunosuppressive Agents - pharmacology | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Tetrahydroisoquinolines - pharmacology | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Blood-Brain Barrier - drug effects | Imatinib Mesylate | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Mice | Benzamides | ATP-Binding Cassette Transporters - antagonists & inhibitors | Physiological aspects | Breast cancer | Proteins | Neurosciences | Inhibitor drugs | Rodents | Biochemistry | Glycoproteins | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2006, Volume 44, Issue 4, pp. 768 - 775
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 05/2013, Volume 305, Issue 4, pp. G286 - G294
The bile salt export pump (BSEP), encoded by the abcb11 gene, is the major canalicular transporter of bile acids from the hepatocyte. BSEP malfunction in... 
Progressive familial intrahepatic cholestasis | ABC transporter | Bile acid | Bile salt export pump | PHYSIOLOGY | bile acid | SALT EXPORT PUMP | KNOCKOUT MICE | LIVER-DISEASE | P-GLYCOPROTEIN | DEOXYCHOLIC-ACID | PRIMARY BILIARY-CIRRHOSIS | progressive familial intrahepatic cholestasis | bile salt export pump | MULTIDRUG-RESISTANCE | GASTROENTEROLOGY & HEPATOLOGY | BILE-ACIDS | FAMILIAL INTRAHEPATIC CHOLESTASIS | PRIMARY SCLEROSING CHOLANGITIS | Cholestasis - genetics | Ursodeoxycholic Acid - administration & dosage | Liver - pathology | Cholestasis - metabolism | RNA, Messenger - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP-Binding Cassette Transporters - genetics | Biological Transport | Liver - drug effects | Taurochenodeoxycholic Acid - toxicity | Time Factors | Bile Canaliculi - pathology | Multidrug Resistance-Associated Proteins - genetics | Disease Models, Animal | Taurochenodeoxycholic Acid - metabolism | Liver - metabolism | Gene Expression Regulation | Mice, Knockout | Cholestasis - pathology | Animals | Diet | ATP Binding Cassette Subfamily B Member 11 | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ursodeoxycholic Acid - toxicity | Bile Canaliculi - drug effects | Bile Canaliculi - metabolism | Mice | Infusions, Intravenous | Ursodeoxycholic Acid - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Taurochenodeoxycholic Acid - administration & dosage | Index Medicus
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2008, Volume 107, Issue 5, pp. 1358 - 1368
The human brain endothelial capillary cell line hCMEC/D3 has been developed recently as a model for the human blood‐brain barrier. In this study a further... 
transendothelial transport | p‐glycoprotein | blood‐brain barrier | ABCB1 | permeability | ABCG2 | p-glycoprotein | Transendothelial transport | Permeability | Blood-brain barrier | blood-brain barrier | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | MICROVESSEL ENDOTHELIUM | TRANSFERRIN RECEPTOR | IN-VITRO MODEL | SITES | MULTIDRUG-RESISTANCE | ASTROCYTIC FACTORS | EXPRESSION | CULTURE MODEL | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Flow Cytometry - methods | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Brain - blood supply | ATP-Binding Cassette Transporters - genetics | Biological Transport | Sucrose - metabolism | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Receptors, Transferrin - genetics | Neoplasm Proteins - genetics | Cell Line | Brain - cytology | Endothelial Cells - metabolism | RNA, Messenger - genetics | Receptors, Transferrin - metabolism | Blood-Brain Barrier - metabolism | Analysis of Variance | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Endothelial Cells - cytology | Midazolam - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | Proteins | Propranolol hydrochloride | Medical colleges | Brain | Transferrin | Messenger RNA | Analysis | Morphine | Oligosaccharides | Endothelium | Dyes and dyeing | Neurology | Cell culture | Biochemistry | Pharmacology | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 07/2003, Volume 63, Issue 14, pp. 4048 - 4054
ABCG2 is a plasma membrane efflux pump that is able to confer resistance to several anticancer agents, including mitoxantrone, camptothecins, anthracyclines,... 
ORGANIC ANION TRANSPORTER | LEUKOTRIENE C-4 | ONCOLOGY | MEMBRANE-VESICLES | ANTICANCER AGENTS | MITOXANTRONE-RESISTANT | DRUG-RESISTANCE | MULTIDRUG-RESISTANCE | CELL-LINES | PLASMA-MEMBRANE | CANCER RESISTANCE PROTEIN
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. E10083 - E10091
EmrE is a small multidrug resistance transporter found in Escherichia coli that confers resistance to toxic polyaromatic cations due to its proton-coupled... 
Membrane protein | NMR | Coupled transport | Protein dynamics | Multidrug transport | MULTIDRUG TRANSPORTER | MULTIDISCIPLINARY SCIENCES | protein dynamics | ESCHERICHIA-COLI | ACTIVE-TRANSPORT | coupled transport | P-GLYCOPROTEIN | STATE ANALYSIS | CONFORMATIONAL-CHANGES | SUBSTRATE-BINDING | PROTON RELEASE | multidrug transport | DYNAMICS | membrane protein | RESIDUE | Protons | Antiporters - chemistry | Escherichia coli - drug effects | Proteolipids - metabolism | Substrate Specificity | Onium Compounds - metabolism | Phosphatidylcholines - metabolism | Organophosphorus Compounds - metabolism | Xenobiotics - chemistry | Xenobiotics - pharmacology | Thermodynamics | Biological Transport | Antiporters - genetics | Dicyclohexylcarbodiimide - toxicity | Escherichia coli - metabolism | Organophosphorus Compounds - pharmacology | Protein Interaction Domains and Motifs | Xenobiotics - metabolism | Binding Sites | Onium Compounds - chemistry | Phosphatidylglycerols - metabolism | Recombinant Proteins - metabolism | Gene Expression | Protein Structure, Secondary | Recombinant Proteins - chemistry | Antiporters - metabolism | Escherichia coli Proteins - metabolism | Organophosphorus Compounds - chemistry | Recombinant Proteins - genetics | Onium Compounds - pharmacology | Phosphatidylcholines - chemistry | Molecular Dynamics Simulation | Phosphatidylglycerols - chemistry | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Binding | Kinetics | Drug Resistance, Multiple, Bacterial - genetics | Escherichia coli Proteins - chemistry | Hydrogen-Ion Concentration | Proteolipids - chemistry | Physiological aspects | Carrier proteins | Observations | Protein-protein interactions | Exchanging | Efflux | Drug delivery systems | Nuclear magnetic resonance--NMR | Escherichia coli | Multidrug resistance | Antiport | Substrates | Multidrug resistant organisms | E coli | Cations | Transport | Transporter | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2014, Volume 88, Issue 1, pp. 106 - 118
Important reactions of drug metabolism, including UGT mediated glucuronidation and steroidsulfatase mediated hydrolysis of sulfates, take place in the... 
Estradiol-17β-glucuronide | Transport | Endoplasmic reticulum | Estrone-3-sulfate | Liver | Biotransformation | RAT-LIVER | COTRANSPORTING POLYPEPTIDE | UDP-GLUCURONIC ACID | NUCLEOTIDE-SUGAR TRANSPORTER | Estradiol-17 beta-glucuronide | HEPATOCELLULAR TRANSPORT | LIVER MICROSOMAL VESICLES | ARYLSULFATASE-C | CANALICULAR ISOFORM | HUMAN PLACENTAL STERYLSULFATASE | PHARMACOLOGY & PHARMACY | BILE-ACIDS | Endoplasmic Reticulum, Rough - metabolism | Estradiol - metabolism | Estradiol - analogs & derivatives | Rats, Wistar | Taurocholic Acid - metabolism | Liver - metabolism | Endoplasmic Reticulum - metabolism | Rats | Permeability | Membrane Potentials - physiology | Rats, Sprague-Dawley | Animals | Glucuronides - metabolism | Biological Transport | Endoplasmic Reticulum, Smooth - metabolism | Kinetics | In Vitro Techniques | Intracellular Membranes - metabolism | Glucuronides - genetics | Index Medicus | E3S, estrone-3-sulfate | RER, rough endoplasmic reticulum | TC, taurocholate | ABC, ATP binding cassette | E17βG, estradiol-17β-glucuronide | UDPGA, Uridine diphosphate glucuronic acid | DHEAS, dehydroepiandrosteronesulfate | Ntcp, Na-taurocholate co-transporting polypeptide | UGTs, Uridine diphosphate glucuronosyltransferases | HPTLC, high performance thin layer chromatography | Oatp, organic anion transporting polypeptide | G6P, glucose-6-phosphate | SER, smooth endoplasmic reticulum | NE, nuclear envelope | STS, steroidsulfatase | ER, endoplasmic reticulum | CYPs, cytochrome P450s | MRP2, multidrug resistance associated protein 2
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0139370 - e0139370
Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs) that mediate the uptake of a diverse group of drugs and endogenous... 
CELLS | IN-VITRO | PHARMACOKINETICS | MECHANISM | DETERMINANTS | MULTIDISCIPLINARY SCIENCES | JUICE | CATECHINS | MULTIDRUG-RESISTANCE | DRUG-DRUG INTERACTIONS | Caco-2 Cells | Atorvastatin Calcium - pharmacokinetics | Metformin - pharmacokinetics | Organic Cation Transport Proteins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cells, Cultured | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Cation Transporter 2 | Organic Anion Transporters - metabolism | Digoxin - pharmacokinetics | Tissue Distribution | Hepatocytes - cytology | Biological Transport | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Catechin - analogs & derivatives | Catechin - pharmacology | Solute Carrier Organic Anion Transporter Family Member 1b1 | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Tea - chemistry | Catechin | Research | Digoxin | Green tea | Health aspects | Drugs | Cell culture | Liver | Oct-2 protein | Proteins | Catechins | Toxicology | Rodents | Inhibition | P-Glycoprotein | Statins | Pharmaceutical sciences | Polypeptides | Glycoprotein | Epigallocatechin-3-gallate | Glycoproteins | Pharmacology | Substrates | Tea | Organic anion transporting polypeptide | Enterocytes | Epigallocatechin gallate | Hepatocytes | Atorvastatin | Extrusion | Metformin | Transport | Index Medicus
Journal Article