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Nature (London), ISSN 1476-4687, 2011, Volume 471, Issue 7339, pp. 467 - 472
Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38... 
PATHOGENESIS | B-CELL LYMPHOMA | BLIMP-1 | GENE | MULTIDISCIPLINARY SCIENCES | STRESS-RESPONSE | EXOSOME | CLASSIFICATION | DIFFERENTIATION | HUMAN CANCER | SOMATIC MUTATIONS | Ribonucleases - genetics | Ribonucleases - chemistry | Genomics | Humans | Molecular Sequence Data | NF-kappa B - metabolism | DNA Repair - genetics | Multiple Myeloma - drug therapy | DNA Mutational Analysis | Protein Biosynthesis - genetics | Multiple Myeloma - enzymology | Proto-Oncogene Proteins B-raf - metabolism | Amino Acid Sequence | Oncogenes - genetics | Models, Molecular | Exons - genetics | Signal Transduction - genetics | Multiple Myeloma - metabolism | Mutation - genetics | Open Reading Frames - genetics | Genome, Human - genetics | Homeodomain Proteins - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | RNA Processing, Post-Transcriptional - genetics | Proto-Oncogene Proteins B-raf - genetics | CpG Islands - genetics | Blood Coagulation - genetics | Protein Conformation | Histones - metabolism | Transcription, Genetic - genetics | Exosome Multienzyme Ribonuclease Complex | Methylation | Homeostasis - genetics | Multiple Myeloma - genetics | Usage | Multiple myeloma | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Methods | Cancer | Proteins | Pathogenesis | Homeostasis | Genetics | Genomes | Mutation | Kinases | Mass spectrometry
Journal Article
Journal Article
PLoS pathogens, ISSN 1553-7374, 2018, Volume 14, Issue 3, p. e1006950
Expression from the HIV-1 LTR can be repressed in a small population of cells, which contributes to the latent reservoir. The factors mediating this repression... 
CELLS | VIROLOGY | ELONGATION | TAT | PURIFICATION | PATHS | EXOSOME TARGETING COMPLEX | MICROBIOLOGY | LATENCY | TERMINATION | PARASITOLOGY | RNA Helicases - metabolism | Exoribonucleases - genetics | HIV-1 - pathogenicity | Virus Latency | Humans | Transcriptional Activation | RNA, Nuclear - metabolism | Exosome Multienzyme Ribonuclease Complex - metabolism | RNA Helicases - genetics | Transcription, Genetic | Exosome Multienzyme Ribonuclease Complex - genetics | Nuclear Proteins - genetics | Virus Activation | Repressor Proteins - metabolism | HIV Infections - genetics | HIV Infections - virology | HIV Long Terminal Repeat - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | HIV-1 - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Gene Expression Regulation, Viral | HeLa Cells | RNA, Nuclear - genetics | Exoribonucleases - metabolism | HIV Infections - metabolism | HIV infection | Research | Genetic transcription | Transcription factors | Laboratories | Latent infection | Infections | Activation | RNA polymerase | Gene expression | Ribonucleic acid--RNA | Recruitment | Surveillance | Repressors | Lymphocytes | Human immunodeficiency virus--HIV | Transcription activation | Life Sciences | Genetics | RNA | Ribonucleic acid | HIV | Human immunodeficiency virus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2017, Volume 114, Issue 9, pp. 2349 - 2354
.... The understanding of the molecular mechanisms underlying RV replication and pathogenesis has been hampered by the lack of an entirely plasmid-based reverse genetics system... 
SEE COMMENTARY | Vaccine | Reporter virus | Rotavirus | Reverse genetics | reverse genetics | NSP1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | reporter virus | INNATE IMMUNE-RESPONSE | VACCINIA VIRUS | BLUETONGUE VIRUS | CLONED CDNA | vaccine | MESSENGER-RNA | rotavirus | RNA-CAPPING ENZYME | SYNTHETIC RNA | EXPRESSION | Luciferases - metabolism | Cricetulus | Humans | Methyltransferases - metabolism | Reverse Genetics - methods | DNA, Complementary - genetics | Methyltransferases - genetics | Multienzyme Complexes - metabolism | Green Fluorescent Proteins - genetics | Orthoreovirus - metabolism | Vaccinia virus - genetics | Viral Proteins - metabolism | Luciferases - genetics | Base Sequence | Nucleotidyltransferases - metabolism | Genes, Reporter | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Transduction, Genetic | Vaccinia virus - metabolism | Orthoreovirus - genetics | Orthoreovirus, Mammalian - genetics | Gene Expression Regulation | Viral Nonstructural Proteins - genetics | Viral Proteins - genetics | DNA-Directed RNA Polymerases - genetics | Multienzyme Complexes - genetics | Plasmids - metabolism | Animals | Epithelial Cells - virology | Plasmids - chemistry | Cell Line, Tumor | Nucleotidyltransferases - genetics | Viral Nonstructural Proteins - metabolism | DNA-Directed RNA Polymerases - metabolism | Phosphoric Monoester Hydrolases - metabolism | DNA, Complementary - metabolism | Orthoreovirus, Mammalian - metabolism | Genetic aspects | Gene expression | Health aspects | Rotaviruses | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 6, pp. E1166 - E1173
Journal Article
PLoS genetics, ISSN 1553-7404, 2011, Volume 7, Issue 6, p. e1002107
.... We studied bacterial diversification in the mammalian gut, one of the most complex bacterial environments, where usually hundreds of species and thousands of bacterial strains stably coexist... 
SYSTEM | BACTERIA | ADAPTIVE RADIATION | EXPERIMENTAL EVOLUTION | MICROBIAL DIVERSITY | FLAGELLAR | REGULON | GENETICS & HEREDITY | MUTATIONS | MODEL | MOTILITY | Selection, Genetic | Gastrointestinal Tract - microbiology | Nutritional Physiological Phenomena | Bile Acids and Salts - metabolism | Multienzyme Complexes - genetics | Transcription Factors - genetics | Biodiversity | DNA-Binding Proteins - genetics | Immunity, Innate | Mutation - genetics | Gastrointestinal Tract - immunology | Phenotype | Animals | Genetic Fitness | Escherichia coli - genetics | Escherichia coli - metabolism | Trans-Activators - genetics | Escherichia coli Proteins - genetics | Mice | Escherichia coli - growth & development | Flagella - genetics | Gene Expression Regulation, Bacterial | Bacterial Outer Membrane Proteins - genetics | Genetic aspects | Research | Escherichia coli | Biological diversity | Bacterial Outer Membrane Proteins | Multienzyme Complexes | Gastrointestinal Tract | Trans-Activators | Bile Acids and Salts | Life Sciences | Microbiology and Parasitology | Escherichia coli Proteins | Genetics | Transcription Factors | Mutation | Flagella | DNA-Binding Proteins | Competition | Immunization | Microbiology | Permeability | Diversification | Experiments | Signal transduction | Antibiotics | Evolutionary biology | E coli | Population | Bacteria | Evolution
Journal Article
PLoS genetics, ISSN 1553-7404, 2010, Volume 6, Issue 9, p. e1001130
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 2013, Volume 20, Issue 7, pp. 851 - 858
...). Exosome-mediated degradation is assisted by Trf4/Trf5-Air1/Air2-Mtr4 polyadenylation (TRAMP), a surveillance complex containing the noncanonical poly(A) polymerase... 
CRYPTIC UNSTABLE TRANSCRIPTS | PERVASIVE TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERGENIC TRANSCRIPTION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | BIOPHYSICS | BINDING PROTEINS NRD1 | GENE-EXPRESSION | POLY(A) POLYMERASE | POLYMERASE-II TRANSCRIPTS | BIDIRECTIONAL PROMOTERS | RNA DEGRADATION | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Saccharomyces cerevisiae Proteins - biosynthesis | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | RNA, Messenger - biosynthesis | RNA Helicases - physiology | Transcription, Genetic | RNA, Fungal - genetics | Gene Expression Regulation, Fungal | RNA-Binding Proteins - physiology | In Situ Hybridization, Fluorescence | Exosome Multienzyme Ribonuclease Complex - physiology | Saccharomyces cerevisiae Proteins - genetics | RNA, Fungal - metabolism | Polynucleotide Adenylyltransferase - physiology | Proton-Phosphate Symporters - genetics | RNA, Antisense - metabolism | Polyadenylation | Metalloendopeptidases - physiology | Models, Genetic | Nuclear Proteins - physiology | Saccharomyces cerevisiae Proteins - physiology | Histone Deacetylases - physiology | Proton-Phosphate Symporters - biosynthesis | Histone-Lysine N-Methyltransferase - physiology | DNA Helicases - physiology | RNA, Antisense - genetics | Cytogenetics | Research | Genetic transcription | DNA methylation | Gene expression | Molecular biology | Ribonucleic acid--RNA | Rrp6 | Nrd1-Nab3-Sen1 | transcription termination | PHO84 regulation | antisense RNA | yeast | single molecule FISH | antisense 3′ end processing
Journal Article
Journal Article