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Neuropharmacology, ISSN 0028-3908, 09/2017, Volume 123, pp. 88 - 99
Here, we report the characterization of a novel hybrid D /D agonist and iron (II) specific chelator, as a multi-target-directed ligand against Parkinson's... 
Neuroprotection | Parkinson's disease | Multifunctional dopamine agonist | Drosophila | 6-OHDA | MPTP | α-synuclein | HYPOXIA-INDUCIBLE FACTOR | DROSOPHILA MODEL | INTRACELLULAR IRON | SYNUCLEIN | alpha-synuclein | SUBSTANTIA-NIGRA | NEUROSCIENCES | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE | PHARMACOLOGY & PHARMACY | KYNURENIC ACID | PC12 CELLS | PROLYL 4-HYDROXYLASE | PARKINSONS-DISEASE | Dopaminergic Neurons - pathology | Prolyl Hydroxylases - metabolism | Prolyl-Hydroxylase Inhibitors - pharmacology | 2,2'-Dipyridyl - analogs & derivatives | Male | Membrane Potential, Mitochondrial - drug effects | Corpus Striatum - metabolism | PC12 Cells | Pars Compacta - pathology | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | MPTP Poisoning - pathology | Membrane Potential, Mitochondrial - physiology | alpha-Synuclein - genetics | Corpus Striatum - pathology | Cell Survival - physiology | Dopamine - metabolism | 2,2'-Dipyridyl - pharmacology | Cell Survival - drug effects | alpha-Synuclein - toxicity | Mice, Inbred C57BL | Rats | Mitochondria - metabolism | Pars Compacta - metabolism | Mitochondria - drug effects | MPTP Poisoning - drug therapy | Piperazines - pharmacology | Pars Compacta - drug effects | Oxidopamine - toxicity | Animals | MPTP Poisoning - metabolism | Corpus Striatum - drug effects | Drosophila melanogaster | alpha-Synuclein - metabolism | Index Medicus | neuroprotection
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 04/2017, Volume 8, Issue 4, pp. 723 - 730
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 01/2019, Volume 10, Issue 1, pp. 396 - 411
We have developed a series of carbazole-derived compounds based on our hybrid D-2/D-3 agonist template to design multifunctional compounds for the symptomatic... 
agonist | Parkinson's disease | carbazole | multifunctional drug | alpha synuclein | neuroprotection | CHEMISTRY, MEDICINAL | EFFICACY | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-SYNUCLEIN | NEUROSCIENCES | D-2/D-3 agonist | IN-VITRO | D2/D3 AGONIST | MOUSE MODEL | ANIMAL-MODEL | HIGHLY POTENT | D-2/D-3 RECEPTORS | AGGREGATION | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 21, pp. 5088 - 5102
Our ongoing drug development endeavor to design compounds for symptomatic and neuroprotective treatment of Parkinson's disease (PD) led us to carry out a... 
Multifunctional drug | Neuroprotection | Alpha synuclein | Parkinson's disease | Structure activity relationship study | Dopamine agonist
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 21, pp. 5088 - 5102
Our ongoing drug development endeavor to design compounds for symptomatic and neuroprotective treatment of Parkinson’s disease (PD) led us to carry out a... 
Multifunctional drug | Neuroprotection | Alpha synuclein | Structure activity relationship study | Parkinson’s disease | Dopamine agonist | Index Medicus
Journal Article
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 10/2013, Volume 4, Issue 10, pp. 1382 - 1392
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2014, Volume 131, Issue 1, pp. 74 - 85
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 10/2014, Volume 131, Issue 1, pp. 74 - 85
In this study, in vitro and in vivo experiments were carried out with the high-affinity multifunctional D2/D3 agonist D-512 in order to explore its potential... 
substantia nigra | 6-hydroxydopamine | neuroprotection | MPTP | dopamine agonist | multifunctional drug | Parkinson’s disease | oxidative stress
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 06/2016, Volume 103, pp. 62 - 70
Parkinson’s disease (PD) is one of the major debilitating neurodegenerative disorders affecting millions of people worldwide. Progressive loss of dopamine... 
Prodrug | D-264 | Modified cysteine | Multifunctional dopamine agonist | Parkinson’s disease | Blood–brain barrier
Journal Article
Journal Article
Journal Article
NEUROPHARMACOLOGY, ISSN 0028-3908, 02/2014, Volume 77, pp. 475 - 480
Many neuropsychiatric drugs interact with more than one molecular target, and therapeutic indices might be improved by prospectively designing compounds with... 
CLOZAPINE | DIBENZO-EPINES | N-DESMETHYLCLOZAPINE | DRUGS | DOPAMINE | PHARMACOLOGY & PHARMACY | Dibenzo-epine | Multifunctional compound | Pharmacophore | NEUROSCIENCES | AGONIST
Journal Article
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