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1. Full Text Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity
by Navina, Sarah and Acharya, Chathur and DeLany, James P and Orlichenko, Lidiya S and Baty, Catherine J and Shiva, Sruti S and Durgampudi, Chandra and Karlsson, Jenny M and Lee, Kenneth and Bae, Kyongtae T and Furlan, Alessandro and Behari, Jaideep and Liu, Shiguang and McHale, Teresa and Nichols, Larry and Papachristou, Georgios Ioannis and Yadav, Dhiraj and Singh, Vijay P
Science Translational Medicine, ISSN 1946-6234, 11/2011, Volume 3, Issue 107, pp. 107ra110 - 107ra110
Obesity increases the risk of adverse outcomes during acute critical illnesses such as burns, severe trauma, and acute pancreatitis. Although individuals with... 
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | ULTRASTRUCTURAL FINDINGS | FREE FATTY-ACIDS | SERUM INTERLEUKIN-18 | LIPASE-DEFICIENT MICE | ACUTE LUNG INJURY | ACINAR-CELLS | ALCOHOLIC PANCREATITIS | APICAL EXOCYTOSIS | COMPUTED-TOMOGRAPHY | CELL BIOLOGY | Immunohistochemistry | Multiple Organ Failure - metabolism | Acinar Cells - metabolism | Humans | Pancreas - pathology | Pancreatitis, Acute Necrotizing - physiopathology | Necrosis - metabolism | Obesity - physiopathology | Fatty Acids, Unsaturated - metabolism | Pancreas - metabolism | Obesity - metabolism | Acinar Cells - pathology | Animals | Multiple Organ Failure - etiology | Necrosis - etiology | Pancreatitis, Acute Necrotizing - metabolism | Mice, Obese | Mice | Pancreatitis - metabolism | In Vitro Techniques | Lipolysis - physiology | Fatty Acids - metabolism | Pancreatitis - physiopathology | Pancreatitis, Acute Necrotizing - pathology
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2. Full Text Mitochondrial function in sepsis: Acute phase versus multiple organ failure
by Singer, Mervyn
Critical Care Medicine, ISSN 0090-3493, 09/2007, Volume 35, Issue 9 Suppl, pp. S441 - S448
OBJECTIVE:To describe temporal changes in mitochondrial function during the septic process, including the recovery phase. DESIGN:Literature review.... 
Mitochondria | Hibernation | Multiple organ failure | Oxygen consumption | Sepsis | Biogenesis | Metabolism | multiple organ failure | oxygen consumption | mitochondria | metabolism | biogenesis | hibernation | sepsis | CRITICAL CARE MEDICINE | Multiple Organ Failure - metabolism | Acute Disease | Animals | Energy Metabolism | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Humans | Oxygen Consumption | Mitochondria - metabolism | Mitochondria - ultrastructure
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3. Full Text Harmful molecular mechanisms in sepsis
by Rittirsch, Daniel and Ward, Peter A and Flierl, Michael A
Nature Reviews Immunology, ISSN 1474-1733, 10/2008, Volume 8, Issue 10, pp. 776 - 787
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and clinicians and are a tremendous burden for health-care systems.... 
TUMOR-NECROSIS-FACTOR | ACTIVATED PROTEIN-C | MIGRATION INHIBITORY FACTOR | DISSEMINATED INTRAVASCULAR COAGULATION | SEPTIC SHOCK | MOBILITY GROUP BOX-1 | CHOLINERGIC ANTIINFLAMMATORY PATHWAY | ACUTE LUNG INJURY | IMMUNOLOGY | END-PRODUCTS RAGE | INNATE IMMUNITY | Inflammation Mediators - immunology | Multiple Organ Failure - metabolism | Blood Coagulation Factors - immunology | Sepsis - immunology | Cytokines - metabolism | Humans | Toll-Like Receptors - immunology | Neutrophils - immunology | Complement System Proteins - immunology | Inflammation - immunology | Blood Coagulation Factors - metabolism | Fibrinolysis | Complement System Proteins - metabolism | Inflammation - metabolism | Animals | Sepsis - metabolism | Autonomic Nervous System - immunology | Inflammation Mediators - metabolism | Multiple Organ Failure - immunology | Autonomic Nervous System - metabolism | Toll-Like Receptors - metabolism | Apoptosis | Cytokines - immunology | Sepsis | Immune response | Research | T cells | Health aspects | Risk factors
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4. Full Text Inflammation and organ failure severely affect midazolam clearance in critically ill children
by Vet, Nienke and Brussee, Janneke and Hoog, Matthijs and Mooij, Miriam and Verlaat, Carin and Jerchel, I.S and Schaik, Ron and Koch, Birgit and Tibboel, Dick and Knibbe, Catherijne and Wildt, Saskia and SKIC Dutch Collaborative PICU Res and SKIC (Dutch collaborative PICU research network)
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2016, Volume 194, Issue 1, pp. 58 - 66
Rationale: Various in vitro, animal, and limited human adult studies suggest a profound inhibitory effect of inflammation and disease on cytochrome P-450 3A... 
Critical Illness | Pediatrics | Inflammation | Midazolam | Pharmacokinetics | RHEUMATOID-ARTHRITIS | ADVANCED CANCER | critical illness | TRANSPORTERS | GENOTYPE | INJURY | DRUG-METABOLIZING-ENZYMES | VARIABILITY | ACUTE-PHASE RESPONSE | IN-VITRO | midazolam | inflammation | RESPIRATORY SYSTEM | pediatrics | pharmacokinetics | CRITICAL CARE MEDICINE | Multiple Organ Failure - metabolism | Prospective Studies | Humans | Child, Preschool | Infant | Male | Midazolam - pharmacokinetics | Inflammation - metabolism | Adolescent | Anesthetics, Intravenous - pharmacokinetics | Female | Child | Infant, Newborn | Index Medicus | Abridged Index Medicus
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5. Full Text The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
by Shapiro, Nathan I and Schuetz, Philipp and Yano, Kiichiro and Sorasaki, Midori and Parikh, Samir M and Jones, Alan E and Trzeciak, Stephen and Ngo, Long and Aird, William C
Critical Care, ISSN 1364-8535, 10/2010, Volume 14, Issue 5, pp. R182 - R182
Introduction: Previous reports suggest that endothelial activation is an important process in sepsis pathogenesis. We investigated the association between... 
SKIN BIOPSIES | INTERCELLULAR-ADHESION MOLECULE-1 | SUSPECTED INFECTION | SEPTIC SHOCK | SOLUBLE E-SELECTIN | EMERGENCY-DEPARTMENT PATIENTS | GROWTH-FACTOR | TIME-COURSE | PHENOTYPIC HETEROGENEITY | INTENSIVE-CARE | CRITICAL CARE MEDICINE | Biomarkers - metabolism | Multiple Organ Failure - metabolism | Severity of Illness Index | Prospective Studies | Endothelial Cells - metabolism | Humans | Middle Aged | Male | Sepsis - complications | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Hospital Mortality - trends | Sepsis - pathology | Plasminogen Activator Inhibitor 1 - metabolism | Sepsis - metabolism | Adult | Female | Signal Transduction - physiology | Aged | Multiple Organ Failure - complications | Vascular Cell Adhesion Molecule-1 - metabolism | Cohort Studies | Multiple Organ Failure - pathology | Complications and side effects | Care and treatment | Organ transplant recipients | Sepsis | Diagnosis | Research | Health aspects
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6. Full Text Survival in critical illness is associated with early activation of mitochondrial biogenesis
by Carré, Jane E and Orban, Jean-Christophe and Re, Lorenza and Felsmann, Karen and Iffert, Wiebke and Bauer, Michael and Suliman, Hagir B and Piantadosi, Claude A and Mayhew, Terry M and Breen, Patrick and Stotz, Martin and Singer, Mervyn
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2010, Volume 182, Issue 6, pp. 745 - 751
Rationale: We previously reported outcome-associated decreases in muscle energetic status and mitochondrial dysfunction in septic patients with multiorgan... 
Multiple organ failure | Sepsis | Mitochondrial dysfunction | Pathophysiology | OXIDATIVE STRESS | mitochondrial dysfunction | multiple organ failure | CYTOCHROME-C-OXIDASE | SKELETAL-MUSCLE | CARBON-MONOXIDE | RESPIRATORY SYSTEM | pathophysiology | NITRIC-OXIDE | SUBUNIT-IV | DYSFUNCTION | ILL PATIENTS | sepsis | CRITICAL CARE MEDICINE | Multiple Organ Failure - metabolism | Multiple Organ Failure - mortality | Mitochondria, Muscle - pathology | Humans | Middle Aged | Mitochondria, Muscle - metabolism | Male | Muscle, Skeletal - metabolism | Survival Rate | Case-Control Studies | Transcription Factors - metabolism | Critical Illness - mortality | Energy Metabolism | Time Factors | Mitochondrial Proteins - metabolism | Female | Aged | Muscle, Skeletal - pathology | Mitochondrial Diseases - physiopathology | B. Critical Care
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7. Full Text A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure
by Aubdool, Aisah A and Thakore, Pratish and Argunhan, Fulye and Smillie, Sarah-Jane and Schnelle, Moritz and Srivastava, Salil and Alawi, Khadija M and Wilde, Elena and Mitchell, Jennifer and Farrell-Dillon, Keith and Richards, Daniel A and Maltese, Giuseppe and Siow, Richard C and Nandi, Manasi and Clark, James E and Shah, Ajay M and Sams, Anette and Brain, Susan D
Circulation, ISSN 0009-7322, 07/2017, Volume 136, Issue 4, pp. 367 - 383
BACKGROUND:Research into the therapeutic potential of α-calcitonin gene–related peptide (α-CGRP) has been limited because of its peptide nature and short... 
heart failure | inflammation | hypertension | oxidative stress | receptors, calcitonin gene-related peptide | INDUCED RENAL DAMAGE | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | ANGIOTENSIN-II | BLOOD-PRESSURE | II-INDUCED HYPERTENSION | MESSENGER-RNA | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | NEUROGENIC VASODILATATION | Multiple Organ Failure - metabolism | Calcitonin Gene-Related Peptide - analogs & derivatives | Oxidative Stress - physiology | Cardiomegaly - pathology | Hypertension - drug therapy | Male | Cardiotonic Agents - therapeutic use | Multiple Organ Failure - pathology | Calcitonin Gene-Related Peptide - pharmacology | Mice, Inbred C57BL | Cardiomegaly - drug therapy | Heart Failure - metabolism | Cardiotonic Agents - pharmacology | Heart Failure - pathology | Hypertension - pathology | Heart Failure - drug therapy | Hypertension - metabolism | Animals | Multiple Organ Failure - prevention & control | Calcitonin Gene-Related Peptide - therapeutic use | Mice | Oxidative Stress - drug effects | Blood Flow Velocity - physiology | Blood Flow Velocity - drug effects | Cardiomegaly - metabolism | Heart failure | Hypertension | Complications and side effects | Control | Blood pressure | Cardiovascular diseases | Risk factors | 10095 | 10094 | 10101 | 10012 | 10111 | Original s
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8. Full Text Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure
by Kojima, M and Gimenes, JA and Langness, S and Morishita, K and Lavoie-Gagne, O and Eliceiri, B and Costantini, TW and Coimbra, R
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, ISSN 2163-0755, 01/2017, Volume 82, Issue 1, pp. 42 - 49
BACKGROUND: Previous studies have shown that mesenteric lymph (ML) has a crucial role in driving the systemic inflammatory response after trauma/hemorrhagic... 
SURGERY | extracellular vesicles | PERMEABILITY | MECHANISM | DUCT LIGATION | hemorrhagic shock | ACUTE LUNG INJURY | microvesicles | Exosomes | HEMORRHAGIC-SHOCK | CELL COMMUNICATION | PATHWAY | mesenteric lymph | TRAUMA | CRITICAL CARE MEDICINE | Mesentery - metabolism | Multiple Organ Failure - metabolism | Tumor Necrosis Factor-alpha - metabolism | Microscopy, Electron, Transmission | Shock, Hemorrhagic - metabolism | Lymph - cytology | Cells, Cultured | Rats | Immunoblotting | Male | NF-kappa B - metabolism | Wounds and Injuries - physiopathology | Rats, Sprague-Dawley | Wounds and Injuries - metabolism | Animals | Flow Cytometry | Exosomes - physiology | Shock, Hemorrhagic - physiopathology | Multiple Organ Failure - physiopathology | Disease Models, Animal
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9. Full Text Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges
by Hattori, Kohshi and Hattori, Yuichi and Suzuki, Tokiko and Matsuda, Naoyuki
Pharmacology and Therapeutics, ISSN 0163-7258, 09/2017, Volume 177, pp. 56 - 66
Sepsis is one of the most common reasons for critically ill patients to be admitted to an intensive care unit and, despite advances in overall medical care, it... 
Sepsis | Inflammation | Organ dysfunction | Endothelial cells | Apoptosis | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | ACUTE LUNG INJURY | RANDOMIZED CONTROLLED-TRIAL | ENDOTHELIAL-CELL APOPTOSIS | PUNCTURE-INDUCED SEPSIS | ADENOSINE A RECEPTORS | GLUCOCORTICOID-RECEPTOR EXPRESSION | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | MURINE SEPTIC PERITONITIS | NF-KAPPA-B | Multiple Organ Failure - metabolism | Sepsis - immunology | Endothelial Cells - metabolism | Humans | NF-kappa B - metabolism | Sepsis - complications | Sepsis - drug therapy | Animals | Sepsis - metabolism | Multiple Organ Failure - etiology | Multiple Organ Failure - immunology | Multiple Organ Failure - drug therapy | Cytokines - immunology | Acute respiratory distress syndrome | Medical colleges | Lung diseases, Obstructive | Chromosomal proteins | Endothelial growth factors | Septic shock | Cyclic adenylic acid | Cyclic guanylic acid | Endothelium | Nitric oxide | Sphingosine | Health aspects | Mitogens | Protein binding
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