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1. Full Text Multiple Sclerosis, Blood Flow, and CSF Circulation
by Wuerfel, Jens
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 9/2013, Volume 33, Issue 9, pp. 1313 - 1313
HEMATOLOGY | MRI | NEUROSCIENCES | ENDOCRINOLOGY & METABOLISM | Multiple Sclerosis - physiopathology | Female | Male | Cerebrovascular Circulation | Humans
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2. Full Text Multiple sclerosis: Blood-based biomarkers provide insight into progressive MS
by Malkki, Hemi
Nature reviews. Neurology, ISSN 1759-4758, 11/2014, Volume 10, Issue 11, p. 612
Leukocytes, Mononuclear - metabolism | Multiple Sclerosis, Chronic Progressive - diagnosis | Humans | Multiple Sclerosis, Chronic Progressive - pathology | Female | Male | Multiple Sclerosis, Chronic Progressive - blood | Multiple Sclerosis, Relapsing-Remitting - diagnosis | Biomarkers - blood | Myelin Basic Protein - blood | Cytokines - blood
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3. Full Text CD8+ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL‐18 serum levels in multiple sclerosis
by Willing, Anne and Leach, Oliver A and Ufer, Friederike and Attfield, Kathrine E and Steinbach, Karin and Kursawe, Nina and Piedavent, Melanie and Friese, Manuel A
European Journal of Immunology, ISSN 0014-2980, 10/2014, Volume 44, Issue 10, pp. 3119 - 3128
Recent findings indicate a pathogenic involvement of IL‐17‐producing CD8+ T cells in multiple sclerosis (MS). IL‐17 production has been attributed to a subset... 
Multiple sclerosis | IL‐18 | CD161 | IL‐17 | MAIT cells | IL-18 | IL-17 | INVARIANT T-CELLS | IFN-GAMMA | INTERLEUKIN-12 | INTERFERON-GAMMA PRODUCTION | IMMUNOLOGY | LESIONS | INFLAMMATION | CENTRAL-NERVOUS-SYSTEM | CHOROID-PLEXUS | BACTERIAL-INFECTION | EXPRESSION | Chemotaxis, Leukocyte | Immunohistochemistry | T-Lymphocyte Subsets - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Interleukin-18 - blood | Multiple Sclerosis - blood | Humans | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | CD8-Positive T-Lymphocytes - immunology | Analysis
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4. Full Text Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis
by Kebir, Hania and Ifergan, Igal and Alvarez, Jorge Ivan and Bernard, Monique and Poirier, Josée and Arbour, Nathalie and Duquette, Pierre and Prat, Alexandre
Annals of Neurology, ISSN 0364-5134, 09/2009, Volume 66, Issue 3, pp. 390 - 402
Objective There is substantial evidence supporting the role of interferon (IFN)‐γ–producing T helper (TH) 1 and interleukin (IL)‐17–expressing TH17 lymphocytes... 
Multiple Sclerosis - blood | Humans | Middle Aged | Interleukin-17 - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Th2 Cells - immunology | Th1 Cells - immunology | Central Nervous System - immunology | Adult | Female | Blood-Brain Barrier - immunology | Multiple Sclerosis, Relapsing-Remitting - immunology | Multiple Sclerosis, Relapsing-Remitting - blood | Mice, Inbred C57BL | Cell Migration Inhibition - immunology | Encephalomyelitis, Autoimmune, Experimental - blood | Interleukin-23 - immunology | Animals | Interferon-gamma - immunology | Multiple Sclerosis - immunology | T-Lymphocytes - immunology | Mice | In Vitro Techniques | Brain - immunology | Cell Migration Assays | Interferon-gamma - blood
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5. Full Text Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis
by Disanto, Giulio and Barro, Christian and Benkert, Pascal and Naegelin, Yvonne and Schädelin, Sabine and Giardiello, Antonella and Zecca, Chiara and Blennow, Kaj and Zetterberg, Henrik and Leppert, David and Kappos, Ludwig and Gobbi, Claudio and Kuhle, Jens and Kuhle, Jens and Lorscheider, Johannes and Yaldizli, Özgür and Derfuss, Tobias and Kappos, Ludwig and Disanto, Giulio and Zecca, Chiara and Gobbi, Claudio and Benkert, Pascal and Achtnichts, Lutz and Nedeltchev, Krassen and Kamm, Christian P and Salmen, Anke and Chan, Andrew and Lalive, Patrice H and Pot, Caroline and Schluep, Myriam and Granziera, Cristina and Du Pasquier, Renaud and Müller, Stefanie and Vehoff, Jochen and Swiss Multiple Sclerosis Cohort and Swiss Multiple Sclerosis Cohort Study Group
Annals of Neurology, ISSN 0364-5134, 06/2017, Volume 81, Issue 6, pp. 857 - 870
Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in... 
EFFICACY | MARKER | CEREBROSPINAL-FLUID BIOMARKERS | FIBRILLARY ACIDIC PROTEIN | N-ACETYLASPARTATE | CHAIN PROTEIN | IMMUNOASSAY | CSF NEUROFILAMENT | FINGOLIMOD | NEUROSCIENCES | PROGRESSION | CLINICAL NEUROLOGY | Recurrence | Brain - diagnostic imaging | Cross-Sectional Studies | Follow-Up Studies | Multiple Sclerosis - blood | Multiple Sclerosis - cerebrospinal fluid | Humans | Middle Aged | Spinal Cord - diagnostic imaging | Male | Multiple Sclerosis - diagnostic imaging | Biomarkers - blood | Multiple Sclerosis - physiopathology | Neurofilament Proteins - blood | Pilot Projects | Adult | Biological Assay | Female | Aged | Neuroimaging | Brain | Multiple sclerosis | Low concentrations | Medical services | Gadolinium | Cerebrospinal fluid | Patients | Blood | Incidence | Confidence intervals | Light chains | Peripheral blood | Biomarkers | Measurement methods | Bioindicators | Lesions | Damage | Cross sections
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6. Full Text Immunomodulatory effects of Vitamin D in multiple sclerosis
by Correale, Jorge and Ysrraelit, María Célica and Gaitán, María Inés
Brain, ISSN 0006-8950, 5/2009, Volume 132, Issue 5, pp. 1146 - 1160
Although Vitamin D is best known as a modulator of calcium homeostasis, it also has immune modulating potential. A protective effect of Vitamin D on multiple... 
Multiple sclerosis | Cytokines | Vitamin D | Regulatory T cells | T cells | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | multiple sclerosis | vitamin D | INDOLEAMINE 2,3-DIOXYGENASE | NEUROSCIENCES | TRYPTOPHAN CATABOLISM | CLINICAL NEUROLOGY | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | regulatory T cells | NONOBESE DIABETIC MICE | REGULATORY T-CELLS | cytokines | ENVIRONMENTAL RISK-FACTORS | D-RECEPTOR LIGANDS | 1,25-DIHYDROXYVITAMIN D-3 | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Multiple Sclerosis - blood | Vitamin D Deficiency - complications | Humans | Middle Aged | Calcitriol - physiology | Male | Case-Control Studies | CD4-Positive T-Lymphocytes - immunology | Vitamin D Deficiency - blood | Forkhead Transcription Factors - metabolism | Adult | Female | Calcitriol - metabolism | Multiple Sclerosis, Chronic Progressive - complications | Vitamin D Deficiency - immunology | Cytokines - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Multiple Sclerosis, Relapsing-Remitting - complications | Cell Line | Multiple Sclerosis, Relapsing-Remitting - immunology | Multiple Sclerosis, Chronic Progressive - immunology | Multiple Sclerosis, Relapsing-Remitting - blood | Lymphocyte Activation | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Multiple Sclerosis, Chronic Progressive - blood | Receptors, Calcitriol - metabolism | Vitamin D - blood | Multiple Sclerosis - complications | Calcitriol - pharmacology | Multiple Sclerosis - immunology | Vitamin D - analogs & derivatives | Vitamin D - metabolism
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7. Full Text Relapsing-remitting multiple sclerosis: Blood-brain barrier permeability and intravascular leakage measurement by dynamic contrast-enhanced MRI and the extended Tofts linear model
by Puri, BK
NEUROLOGY INDIA, ISSN 0028-3886, 05/2018, Volume 66, Issue 3, pp. 667 - 668
NEUROSCIENCES | Multiple sclerosis | Medical examination | Magnetic resonance imaging | Blood-brain barrier | Development and progression | Diagnosis | Methods | Illnesses | Medical imaging | Nuclear magnetic resonance--NMR | Brain research | Biomarkers | Tomography | Permeability | Chronic fatigue syndrome | Blood
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8. Full Text Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study
by Nielsen, Nete Munk and Munger, Kassandra L and Koch-Henriksen, Nils and Hougaard, David M and Magyari, Melinda and Jørgensen, Kristian T and Lundqvist, Marika and Simonsen, Jacob and Jess, Tine and Cohen, Arieh and Stenager, Egon and Ascherio, Alberto
Neurology, ISSN 0028-3878, 11/2016, Volume 88, Issue 1, pp. 44 - 51
OBJECTIVE:As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we... 
SYSTEM | D DEFICIENCY ALTERS | ADULT-RAT | BIRTH | EXPRESSION | DRIED BLOOD SPOTS | BRAIN | CLINICAL NEUROLOGY | REGISTRY | Infant, Newborn - blood | Multivariate Analysis | Multiple Sclerosis - blood | Humans | Community Health Planning | Parents | Male | Multiple Sclerosis - epidemiology | Case-Control Studies | Vitamin D - blood | Vitamin D Deficiency - epidemiology | Denmark - epidemiology | Adult | Female | Vitamin D - analogs & derivatives | Odds Ratio | 132 | 307
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9. Full Text Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression
by Ascherio, Alberto and Munger, Kassandra L and White, Rick and Köchert, Karl and Simon, Kelly Claire and Polman, Chris H and Freedman, Mark S and Hartung, Hans-Peter and Miller, David H and Montalbán, Xavier and Edan, Gilles and Barkhof, Frederik and Pleimes, Dirk and Radü, Ernst-Wilhelm and Sandbrink, Rupert and Kappos, Ludwig and Pohl, Christoph
JAMA Neurology, ISSN 2168-6149, 03/2014, Volume 71, Issue 3, pp. 306 - 314
IMPORTANCE It remains unclear whether vitamin D insufficiency, which is common in individuals with multiple sclerosis (MS), has an adverse effect on MS... 
GENETIC-DETERMINANTS | RELAPSE RISK | 25-HYDROXYVITAMIN D | DOUBLE-BLIND | INTERFERON BETA-1B | CLINICALLY ISOLATED SYNDROMES | PLACEBO-CONTROLLED TRIAL | DIAGNOSTIC-CRITERIA | AUTOIMMUNE ENCEPHALOMYELITIS | CLINICAL NEUROLOGY | GENOME-WIDE ASSOCIATION | Predictive Value of Tests | Recurrence | Demyelinating Diseases - blood | Follow-Up Studies | Multiple Sclerosis - blood | Humans | Risk Factors | Male | Biomarkers - blood | Disease Progression | Randomized Controlled Trials as Topic | Vitamin D - blood | Magnetic Resonance Imaging | Time Factors | Multiple Sclerosis - pathology | Adult | Female | Vitamin D - analogs & derivatives | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Multiple Sclerosis - drug therapy | Index Medicus | Abridged Index Medicus | Life Sciences | Neurons and Cognition
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10. Full Text Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis
by Munger, Kassandra L and Levin, Lynn I and Hollis, Bruce W and Howard, Noel S and Ascherio, Alberto
JAMA, ISSN 0098-7484, 12/2006, Volume 296, Issue 23, pp. 2832 - 2838
CONTEXT Epidemiological and experimental evidence suggests that high levels of vitamin D, a potent immunomodulator, may decrease the risk of multiple... 
VITAMIN-D SUPPLEMENTATION | MEDICINE, GENERAL & INTERNAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SUNLIGHT | DISEASE | SUSCEPTIBILITY | D DEFICIENCY | PREVENTION | PREVALENCE | HEALTH | EXPOSURE | Prospective Studies | Multiple Sclerosis - blood | Humans | Middle Aged | European Continental Ancestry Group - statistics & numerical data | Male | Risk | Multiple Sclerosis - epidemiology | Case-Control Studies | Vitamin D - blood | African Continental Ancestry Group - statistics & numerical data | Adolescent | Adult | Female | Vitamin D - analogs & derivatives | Multiple sclerosis | Vitamin D | Calcifediol | Research | Alfacalcidol | Health aspects | Risk factors | Blood tests | Clinical trials | Military personnel | Epidemiology | Data bases
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11. Full Text High‐throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV‐reactive CD8+ T cells
by Lossius, Andreas and Johansen, Jorunn N and Vartdal, Frode and Robins, Harlan and Jūratė Šaltytė, Benth and Holmøy, Trygve and Olweus, Johanna
European Journal of Immunology, ISSN 0014-2980, 11/2014, Volume 44, Issue 11, pp. 3439 - 3452
Epstein‐Barr virus (EBV) has long been suggested as a pathogen in multiple sclerosis (MS). Here, we used high‐throughput sequencing to determine the diversity,... 
TCR | Cerebrospinal fluid | High‐throughput sequencing | Epstein‐Barr virus | Epstein-Barr virus | High-throughput sequencing | IMMUNE-RESPONSE | SPECIFICITY | IMMUNOLOGY | CEREBROSPINAL-FLUID | CLONAL EXPANSIONS | FREQUENCY | INFECTION | EXPRESSION | EPSTEIN-BARR-VIRUS | BRAIN | LYMPHOCYTES | Infectious Mononucleosis - immunology | Multiple Sclerosis - blood | Receptors, Antigen, T-Cell, alpha-beta - blood | Humans | Middle Aged | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | CD4-Positive T-Lymphocytes - immunology | Young Adult | Base Sequence | B-Lymphocytes - virology | Adult | Female | Multiple Sclerosis - cerebrospinal fluid | HLA-DRB1 Chains - immunology | Multiple Sclerosis - virology | HLA-B Antigens - immunology | Herpesvirus 4, Human - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | Sequence Analysis, DNA | HLA-A Antigens - immunology | B-Lymphocytes - immunology | Infectious Mononucleosis - virology | CD8-Positive T-Lymphocytes - virology | Multiple Sclerosis - immunology | High-Throughput Nucleotide Sequencing | CD8-Positive T-Lymphocytes - immunology | Antiviral agents | Multiple sclerosis | Histocompatibility antigens | Analysis | HLA histocompatibility antigens | B cells | T cells
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12. Full Text Primary infection with the Epstein‐Barr virus and risk of multiple sclerosis
by Levin, Lynn I and Munger, Kassandra L and O'Reilly, Eilis J and Falk, Kerstin I and Ascherio, Alberto
Annals of Neurology, ISSN 0364-5134, 06/2010, Volume 67, Issue 6, pp. 824 - 830
To determine whether multiple sclerosis (MS) risk increases following primary infection with the Epstein‐Barr virus (EBV), we conducted a nested case‐control... 
FOLLOW-UP | MONONUCLEOSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | Military Personnel | Multiple Sclerosis - blood | Humans | Multiple Sclerosis - virology | Risk Factors | Viral Proteins - immunology | Viral Proteins - blood | Male | Antibodies, Viral - blood | Case-Control Studies | Young Adult | Antigens, Viral - immunology | Adolescent | Adult | Epstein-Barr Virus Infections - complications | Female | Epstein-Barr Virus Infections - blood | Multiple Sclerosis - etiology
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13. Full Text Body fluid biomarkers in multiple sclerosis
by Comabella, Manuel, Dr and Montalban, Xavier, Prof
Lancet Neurology, The, ISSN 1474-4422, 2014, Volume 13, Issue 1, pp. 113 - 126
Summary Biomarkers can be thought of as multifaceted indicators of healthy status or of pathological disorders. The study of multiple sclerosis can benefit... 
Neurology | MYELIN BASIC-PROTEIN | CLINICALLY ISOLATED SYNDROME | TUMOR-NECROSIS-FACTOR | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | FREE LIGHT-CHAINS | ANTI-NATALIZUMAB ANTIBODIES | INTERFERON-BETA THERAPY | NITRIC-OXIDE METABOLITES | EPSTEIN-BARR-VIRUS | CLINICAL NEUROLOGY | GENOME-WIDE ASSOCIATION | Multiple Sclerosis - diagnosis | Animals | Multiple Sclerosis - blood | Body Fluids - metabolism | Multiple Sclerosis - cerebrospinal fluid | Humans | Biomarkers - blood | Biomarkers - cerebrospinal fluid | Biological markers | Multiple sclerosis
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