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Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 749 - 757
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 8, pp. 838 - 849
Interferon-gamma (IFN-gamma) primes macrophages for enhanced microbial killing and inflammatory activation by Toll-like receptors (TLRs), but little is known... 
BACTERIAL PATHOGENS | DENDRITIC CELLS | PATHWAY | IMMUNE-RESPONSES | KINASE | IMMUNOLOGY | POLARIZATION | EXPRESSION | TRYPTOPHAN CATABOLISM | MTOR | I INTERFERON | Toll-Like Receptor 2 - genetics | TOR Serine-Threonine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | Protein Biosynthesis - immunology | Eukaryotic Initiation Factor-4E - metabolism | Multiprotein Complexes - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Base Sequence | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Macrophage Activation - immunology | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - metabolism | Signal Transduction - drug effects | Toll-Like Receptor 2 - immunology | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Multiprotein Complexes - immunology | RNA, Messenger - immunology | Transcription Factor HES-1 | Macrophage Activation - genetics | Intracellular Signaling Peptides and Proteins - immunology | Homeodomain Proteins - immunology | Mechanistic Target of Rapamycin Complex 1 | Signal Transduction - immunology | Eukaryotic Initiation Factor-4E - immunology | Protein Biosynthesis - genetics | Eukaryotic Initiation Factor-4E - genetics | Macrophages - immunology | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Homeodomain Proteins - genetics | TOR Serine-Threonine Kinases - immunology | Interferon-gamma - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 385 - 393
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1... 
PHAGOSOMAL ESCAPE | ACTIVATION | CASPASE-1 | ASC PYROPTOSOME | IMMUNOLOGY | NF-KAPPA-B | PATHOGEN RECOGNITION | NALP3 INFLAMMASOME | CYTOPLASMIC DNA | CELL-DEATH | PYRIN | L-Lactate Dehydrogenase - metabolism | Tularemia - metabolism | Humans | Protein Multimerization | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Caspase 1 - immunology | Interleukin-1beta - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Multiprotein Complexes - metabolism | L-Lactate Dehydrogenase - immunology | Tularemia - immunology | Calcium Signaling - immunology | Interleukin-1beta - biosynthesis | Nuclear Proteins - genetics | Macrophages - immunology | DNA-Binding Proteins | Interferon Regulatory Factor-3 - immunology | Francisella tularensis - immunology | Macrophages - pathology | Cells, Cultured | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | Macrophages - metabolism | Animals | L-Lactate Dehydrogenase - genetics | Caspase 1 - genetics | Interferon Regulatory Factor-3 - metabolism | Francisella tularensis - pathogenicity | Mice | Multiprotein Complexes - immunology | Interleukins | Bacterial proteins | Tularemia | Physiological aspects | Causes of | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 7, pp. 1333 - 1347
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1266 - 1276
Highly pathogenic avian influenza viruses pose a continuing global threat. Current vaccines will not protect against newly evolved pandemic viruses. The... 
CELLS | H5N1 | TRANSMISSION | ACTIVATION | PEPTIDE ARRAYS | MEMORY | CONSEQUENCES | IMMUNOLOGY | AID | NEUTRALIZATION | CYTOTOXICITY | Orthomyxoviridae Infections - prevention & control | TOR Serine-Threonine Kinases - metabolism | Influenza A Virus, H5N1 Subtype - physiology | Immunoglobulin Class Switching - immunology | Immunoglobulin M - immunology | Orthomyxoviridae - classification | Host-Pathogen Interactions - immunology | Mechanistic Target of Rapamycin Complex 1 | Orthomyxoviridae - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Flow Cytometry | T-Lymphocytes - metabolism | Female | Immunoglobulin Class Switching - drug effects | Adaptive Immunity - immunology | Immunosuppressive Agents - pharmacology | B-Lymphocytes - metabolism | Cell Line | Antibody Formation - immunology | Mice, Inbred C57BL | Influenza A Virus, H3N2 Subtype - immunology | Sirolimus - pharmacology | Mice, Knockout | TOR Serine-Threonine Kinases - immunology | Animals | B-Lymphocytes - immunology | Influenza A Virus, H5N1 Subtype - immunology | Survival Analysis | Antibodies, Viral - immunology | T-Lymphocytes - immunology | Influenza A Virus, H3N2 Subtype - physiology | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae - physiology | Orthomyxoviridae Infections - immunology | Multiprotein Complexes - immunology | Influenza viruses | Prevention | Immune response | Protein kinases | Health aspects | Testing | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2009, Volume 206, Issue 1, pp. 79 - 87
Influenza virus infection is recognized by the innate immune system through Toll like receptor (TLR) 7 and retinoic acid inducible gene I. These two... 
MEDICINE, RESEARCH & EXPERIMENTAL | STRANDED-RNA | DYING CELLS | HUMAN MACROPHAGES | INTERLEUKIN-1-BETA | INFECTION | IMMUNOLOGY | A-VIRUS | CASPASE-1 ACTIVATION | CRYOPYRIN/NALP3 | T-CELLS | NALP3 INFLAMMASOME | CD8-Positive T-Lymphocytes - cytology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Immunity, Innate - genetics | Cell Movement - genetics | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Lung - virology | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Lung - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Macrophages, Alveolar - immunology | Macrophages, Alveolar - virology | Antibody Formation - immunology | Immunity, Cellular - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Mice, Knockout | Carrier Proteins - genetics | Immunity, Cellular - immunology | Immunity, Innate - immunology | Immunoglobulin Isotypes - blood | Animals | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Survival Analysis | Nasal Lavage Fluid - immunology | Immunoglobulin Isotypes - immunology | Mice | Macrophages, Alveolar - metabolism | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Calcium-Binding Proteins - genetics | Multiprotein Complexes - immunology | Index Medicus | Brief Definitive Reports
Journal Article
Immunity, ISSN 1074-7613, 09/2016, Volume 45, Issue 3, pp. 540 - 554
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2013, Volume 110, Issue 51, pp. E4997 - E5005
Human cytomegalovirus (HCMV) can cause serious morbidity/ mortality in transplant patients, and congenital HCMV infection can lead to birth defects. Developing... 
Antiviral antibody | Monoclonal antibody | NATURAL INFECTION | VIRUS-INFECTION | LINKED-IMMUNOSORBENT-ASSAY | MULTIDISCIPLINARY SCIENCES | PRIMARY INFECTION | SMOOTH-MUSCLE | ORGAN TRANSPLANT RECIPIENTS | CMV-HYPERIMMUNE GLOBULIN | antiviral antibody | EPITHELIAL-CELLS | ENDOTHELIAL-CELLS | monoclonal antibody | ANTIBODY-RESPONSE | Complementarity Determining Regions - genetics | Humans | Multiprotein Complexes - genetics | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - genetics | Immunoglobulin Light Chains - genetics | Antibodies, Neutralizing - immunology | Cytomegalovirus Infections - prevention & control | Female | Membrane Glycoproteins - immunology | Immunoglobulin Heavy Chains - immunology | Antibodies, Monoclonal - immunology | Cytomegalovirus Vaccines - genetics | Immunoglobulin Light Chains - immunology | Cytomegalovirus - genetics | Rabbits | Viral Envelope Proteins - genetics | Antibodies, Neutralizing - genetics | Membrane Glycoproteins - genetics | Antibodies, Monoclonal - genetics | Cytomegalovirus - immunology | Animals | Complementarity Determining Regions - immunology | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Cytomegalovirus Vaccines - immunology | Antibodies, Viral - genetics | Immunoglobulin Heavy Chains - genetics | Multiprotein Complexes - immunology | Antigens | Immunology | Monoclonal antibodies | Viruses | Glycoproteins | Vaccines | Gene expression | Index Medicus | Biological Sciences | PNAS Plus
Journal Article