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Molecular cell, ISSN 1097-2765, 2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and nutrients (e.g., amino acids... 
CELLBIO | PROTEINS | SIGNALING | YEAST SACCHAROMYCES-CEREVISIAE | CELL-GROWTH CONTROL | SIGNALING PATHWAYS | FUNCTIONAL HOMOLOG | RAG GTPASES | VACUOLE FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMINO-ACID PERMEASE | COMPONENT | GTP-BINDING PROTEINS | GAP1 PERMEASE | CELL BIOLOGY | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine
Journal Article
Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
.... Mechanistically, we show that C2Oorf196 and FAM35A form a complex, 'Shieldin' (SHLD1/2), with FAM35A interacting with single-stranded DNA through its C-terminal oligonucleotide/oligosaccharide-binding fold region... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Polymerase | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2011, Volume 43, Issue 1, pp. 19 - 32
Journal Article
Cell metabolism, ISSN 1550-4131, 2013, Volume 18, Issue 5, pp. 726 - 739
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2012, Volume 45, Issue 3, pp. 344 - 356
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 355, Issue 6331, pp. 1306 - 1311
Journal Article
Molecular biology of the cell, ISSN 1939-4586, 2008, Volume 19, Issue 12, pp. 5360 - 5372
.... In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15, Vps30/Atg6, and Atg14... 
PRE-AUTOPHAGOSOMAL STRUCTURE | LATE ENDOSOMES | MOLECULAR MACHINERY | PROTEIN-KINASE | TRANS-GOLGI NETWORK | TUMOR-SUPPRESSOR | VPS34 PTDINS 3-KINASE | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | SELF-DIGESTION | CELL BIOLOGY | Autophagy-Related Proteins | Adaptor Proteins, Vesicular Transport - classification | Humans | Adaptor Proteins, Vesicular Transport - genetics | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Autophagy - physiology | Phosphatidylinositol 3-Kinases - metabolism | Phylogeny | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Phagosomes - ultrastructure | Cell Membrane - metabolism | Membrane Proteins - metabolism | Androstadienes - metabolism | Beclin-1 | rab GTP-Binding Proteins - metabolism | Amino Acid Sequence | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Phagosomes - metabolism | Apoptosis Regulatory Proteins - metabolism | Endocytosis - physiology | Phosphatidylinositol 3-Kinases - genetics | Multiprotein Complexes - chemistry | Sequence Alignment | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 547, Issue 7662, pp. 227 - 231
...). The dystrophingly-coprotein complex (DGC), a multicomponent transmembrane complex linking the actin cytoskeleton to extracellular matrix, is essential for cardiomyocyte homeostasis... 
PRESSURE-OVERLOAD | GENE | ADULT HEART REGENERATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MOUSE MODEL | MUSCLE | DUCHENNE MUSCULAR-DYSTROPHY | MICE | Protein-Serine-Threonine Kinases - deficiency | Phosphorylation | Cell Proliferation | Glycoproteins - metabolism | Dystroglycans - metabolism | Male | Phosphoproteins - metabolism | Heart Failure - prevention & control | Multiprotein Complexes - metabolism | Dystrophin - deficiency | Mice, Inbred mdx | Cardiomyopathies | Glycoproteins - deficiency | Multiprotein Complexes - deficiency | Dystrophin - metabolism | Protein-Serine-Threonine Kinases - metabolism | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Organ Size | Heart Failure - genetics | Pressure | Multiprotein Complexes - chemistry | Animals | Dystrophin - genetics | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Muscular Dystrophy, Duchenne - metabolism | Muscular Dystrophy, Duchenne - genetics | Adaptor Proteins, Signal Transducing - metabolism | Heart | Genes | Homeostasis | Genomes | Kinases | Muscular dystrophy | Cell growth | Actin | Duchenne's muscular dystrophy | Cell cycle | Extracellular matrix | Heart diseases | Dystrophin | Deoxyribonucleic acid--DNA | Heart failure | Dystroglycan | Cardiomyocytes | Glycoproteins | Studies | Yes-associated protein | Regeneration | Point mutation | Cytoskeleton | Mutation | Dystrophy
Journal Article