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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 30, pp. 13384 - 13389
The DNA mismatchrepair protein PMS2was recentlyfound to encode a novel endonuclease activity. To determine the biological functions of this activity in... 
B lymphocytes | Spermatogenesis | DNA | Cell lines | Measels mumps rubella vaccine | Mice | Genetic mutation | DNA mismatch repair | Cell extracts | Tumors | Somatic hypermutation | Class switch recombination | B cell lymphoma | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | MLH1 | class switch recombination | somatic hypermutation | POLYMERASE-ETA | MUTATION | spermatogenesis | PMS2-DEFICIENT MICE | CLASS-SWITCH RECOMBINATION | MUTL-ALPHA | Genomic Instability | Endonucleases - genetics | Humans | DNA Repair Enzymes - genetics | Male | Endonucleases - metabolism | DNA Mismatch Repair - genetics | DNA-Binding Proteins - metabolism | Fertility - genetics | DNA Repair Enzymes - metabolism | Female | Mismatch Repair Endonuclease PMS2 | Fibroblasts - metabolism | Genetic Predisposition to Disease - genetics | Cells, Cultured | Adenosine Triphosphatases - metabolism | Lymphoma - genetics | Genotype | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Immunoglobulin G - genetics | Embryo, Mammalian - cytology | Adenosine Triphosphatases - genetics | Fibroblasts - cytology | Mutation | Immunoglobulin Class Switching - genetics | Prevention | Nucleases | Physiological aspects | Genetic aspects | Research | Genetic recombination | Proteins | Genomics | Rodents | Genetics | Gene expression | DNA repair | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 23, pp. 9403 - 9408
Journal Article
Human Genetics, ISSN 0340-6717, 2/2010, Volume 127, Issue 2, pp. 207 - 221
Toll-like, vitamin A and D receptors and other innate proteins participate in various immune functions. We determined whether innate gene-sequence variations... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | MEASLES-VACCINE | DENDRITIC CELLS | GENETICS & HEREDITY | RIG-I | CYTOKINE | ANTIBODY-RESPONSE | HIV-1 INFECTION | RNA VIRUSES | EXPRESSION | SINGLE-NUCLEOTIDE POLYMORPHISMS | TRIM5-ALPHA | Leukocytes, Mononuclear - metabolism | Humans | Immunity, Innate - genetics | Male | Receptors, Retinoic Acid - genetics | Young Adult | Poly-ADP-Ribose Binding Proteins | Granulocyte-Macrophage Colony-Stimulating Factor - secretion | Rubella Vaccine - immunology | Leukocytes, Mononuclear - immunology | Female | Interleukin-10 - secretion | Toll-Like Receptor 3 - genetics | Child | DEAD Box Protein 58 | Immunity, Cellular - genetics | Tumor Necrosis Factor-alpha - secretion | Cytokines - secretion | DNA-Binding Proteins - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Immunity, Cellular - immunology | Immunity, Innate - immunology | Adolescent | Retinoid X Receptor alpha - genetics | DNA Topoisomerases, Type II - genetics | Leukocytes, Mononuclear - cytology | Polymorphism, Single Nucleotide | Interleukin-2 - secretion | Retinoic Acid Receptor alpha | Rubella | Immune response | Measles-mumps-rubella vaccine | Genes | Calcifediol | Vaccines | Toy industry | Vitamin A | Vitamin D | Tumor necrosis factor | Genetic aspects | Interferon | Alfacalcidol | Health aspects | Enzyme-linked immunosorbent assay
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 30, Issue 37, pp. 5453 - 5458
Highlights ► We created live rubella vectors expressing HIV/SIV antigens in the non-structural gene region. ► Inserts up to 267 bp were stably expressed for at... 
Allergy and Immunology | HIV MPER | Stable expression | Live viral vectors | Rubella vaccine strain RA27/3 | Vaccine antigen | SIV Gag | MEDICINE, RESEARCH & EXPERIMENTAL | EQUINE ENCEPHALITIS-VIRUS | NEUTRALIZING ANTIBODY | NEF GENE | HUMAN MONOCLONAL-ANTIBODY | IMMUNOLOGY | PROXIMAL EXTERNAL REGION | REPLICATION | IMMUNODEFICIENCY-VIRUS TYPE-1 | CLASS-I MOLECULE | NONSTRUCTURAL PROTEIN | RHESUS MACAQUES | Vero Cells - virology | AIDS Vaccines - immunology | Macaca mulatta - immunology | Cercopithecus aethiops | Antigens, Viral - genetics | Simian Immunodeficiency Virus - genetics | Rubella virus - genetics | Rubella virus - immunology | Simian Immunodeficiency Virus - immunology | Promoter Regions, Genetic | Gene Products, gag - genetics | Viral Nonstructural Proteins - genetics | Recombinant Proteins - genetics | Epitopes - genetics | Viral Load - genetics | Genetic Vectors - genetics | Antigens, Viral - immunology | SAIDS Vaccines - genetics | Vaccines, Attenuated - immunology | Animals | SAIDS Vaccines - immunology | HIV Antigens - genetics | HIV Antigens - immunology | Recombinant Proteins - immunology | AIDS Vaccines - genetics | Vaccines, Attenuated - genetics | Virus diseases | Rubella | Antigens | Measles-mumps-rubella vaccine | Genes | Vaccines | Simian immunodeficiency virus | HIV (Viruses) | Enzymes | Cytomegalovirus | Cloning | Viruses | Infections | Proteins | Acquired immune deficiency syndrome--AIDS | Plasmids | Human immunodeficiency virus--HIV | Adenoviruses | Licensed products | Deoxyribonucleic acid--DNA | vaccine antigen | rubella vaccine strain RA27 | stable expression | live viral vectors
Journal Article
Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 17, pp. 2119 - 2125
Highlights ► Live attenuated rubella vectors express vaccine inserts in the structural gene region. ► Inserts up to 402 bp were stably expressed as the vectors... 
Allergy and Immunology | HIV MPER | Stable expression | Live viral vectors | Antigen incorporation | Rubella vaccine strain RA27/3 | SIV Gag | MEDICINE, RESEARCH & EXPERIMENTAL | CAPSID PROTEIN | NEUTRALIZING ANTIBODY | HUMAN MONOCLONAL-ANTIBODY | ENVELOPE GLYCOPROTEIN | IMMUNOLOGY | PROXIMAL EXTERNAL REGION | EPITOPE | IMMUNODEFICIENCY-VIRUS TYPE-1 | NONSTRUCTURAL PROTEIN | CD4 BINDING | RHESUS MACAQUES | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | AIDS Vaccines - immunology | Macaca mulatta - immunology | Cercopithecus aethiops | Virion - genetics | Recombinant Proteins - biosynthesis | Promoter Regions, Genetic - genetics | HIV Infections - immunology | Macaca mulatta - virology | Viral Structural Proteins - genetics | env Gene Products, Human Immunodeficiency Virus - genetics | Rubella virus - genetics | Vero Cells | Recombinant Proteins - metabolism | Virion - immunology | Gene Products, gag - immunology | Gene Expression | Gene Products, gag - genetics | Recombinant Proteins - genetics | Genetic Vectors - genetics | Rubella virus - growth & development | SAIDS Vaccines - genetics | Animals | Genetic Engineering | SAIDS Vaccines - immunology | HIV Antigens - genetics | HIV Antigens - immunology | Virus Replication | AIDS Vaccines - genetics | HIV Antigens - biosynthesis | Serial Passage | Vaccines, Attenuated - genetics | Antigens | Rubella | Measles-mumps-rubella vaccine | Genes | Vaccines | Simian immunodeficiency virus | HIV (Viruses) | Proteins | Infections | Polyclonal antibodies | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173948
Introduction Accurate etiological diagnosis of meningitis is important, but difficult in resource-limited settings due to prior administration of antibiotics... 
SOUTH-AFRICA | ANTIBIOTIC PRETREATMENT | INFLUENZAE TYPE-B | BACTERIAL-MENINGITIS | STREPTOCOCCUS-PNEUMONIAE | GRAM STAIN | MULTIDISCIPLINARY SCIENCES | NEISSERIA-MENINGITIDIS | HAEMOPHILUS-INFLUENZAE | CEREBROSPINAL-FLUID | PCR ASSAY | Meningitis, Bacterial - cerebrospinal fluid | Viruses - genetics | Humans | Child, Preschool | Male | Meningitis, Viral - cerebrospinal fluid | Meningitis, Viral - epidemiology | Enterovirus - genetics | Streptococcus pneumoniae - isolation & purification | Sensitivity and Specificity | Streptococcus pneumoniae - genetics | Female | Neisseria meningitidis - genetics | Nucleic Acids - genetics | Child | Viruses - isolation & purification | Meningitis, Bacterial - microbiology | Multiplex Polymerase Chain Reaction - methods | DNA, Bacterial - isolation & purification | Meningitis, Bacterial - diagnosis | Meningitis, Viral - diagnosis | Meningitis, Viral - virology | Mumps virus - isolation & purification | Simplexvirus - genetics | Haemophilus influenzae - genetics | Enterovirus - isolation & purification | Bacteria - genetics | Neisseria meningitidis - isolation & purification | Haemophilus influenzae - isolation & purification | Bacteria - isolation & purification | DNA, Bacterial - genetics | Mumps virus - genetics | Meningitis, Bacterial - epidemiology | Simplexvirus - isolation & purification | Nucleic Acids - isolation & purification | South Africa | Polymerase chain reaction | Viral meningitis | Usage | Care and treatment | Analysis | Children | Diagnosis | Research | Health aspects | Multiplexing | Brain | Cell culture | Pediatrics | Aseptic meningitis | Diagnostic tests | Gram stain | Cerebrospinal fluid | Assaying | Microorganisms | Winter | Primers | Surgery | Mumps | Fusion protein | Archives | Probes | Deoxyribonucleic acid--DNA | Pathogens | Nucleic acids | Deer | Drainage area | Amplification | Laboratory tests | Pathology | Dilution | Hospitals | Infectious diseases | Inhibitors | Surveillance | Genotyping | Herpes viruses | Adults | Pneumonia | Transparency | Microbiology | Laboratories | Medical services | Developing countries | Viruses | Infections | Public sector | Streptococcus infections | Accuracy | Bacteria | Meningitis | Stains | Clinical microbiology | Encephalitis | Statistical analysis | DNA probes | Hypersensitivity | Ribonucleic acid--RNA | Contamination | Standards | Virology | Drainage | Sensitivity | Algorithms | Antibiotics | Microscopy | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, p. e11806
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2014, Volume 46, Issue 12, pp. 1274 - 1282
Journal Article
Immunogenetics, ISSN 0093-7711, 10/2015, Volume 67, Issue 10, pp. 547 - 561
The observed heterogeneity in rubella-specific immune response phenotypes post-MMR vaccination is thought to be explained, in part, by inter-individual genetic... 
Human Genetics | Gene Function | Rubella | Cytokines | Measles-mumps-rubella vaccine | Rubella vaccine | Neutralizing antibodies | Antibodies | Single nucleotide polymorphisms (SNPs) | Rubella virus | Cell Biology | Allergology | Biomedicine | Immunology | Neutralizing | Genetic association studies | Single nucleotide polymorphism | Genetic association | TRANSCRIPTION FACTORS | CELLULAR-IMMUNITY | GAMMA-INTERFERON | VACCINE | MEASLES | RECEPTOR | IMMUNOLOGY | VITAMIN-A | TOLL-LIKE | GENES | GENETICS & HEREDITY | NF-KAPPA-B | Cell Adhesion Molecules - genetics | Minor Histocompatibility Antigens | Humans | Male | Cell Adhesion Molecules - immunology | Nectins | Adaptive Immunity - genetics | Interleukin-10 Receptor beta Subunit - immunology | Tripartite Motif Proteins | Young Adult | Antibodies, Neutralizing - immunology | Female | Rubella virus - immunology | Interleukin-10 Receptor beta Subunit - genetics | Adaptive Immunity - immunology | Child | Polymorphism, Single Nucleotide - immunology | Rubella - immunology | Genetic Predisposition to Disease - genetics | Gene Frequency | Interferon-gamma - secretion | Repressor Proteins - genetics | Toll-Like Receptor 4 - genetics | Genotype | Toll-Like Receptor 4 - immunology | Measles-Mumps-Rubella Vaccine - administration & dosage | Interleukin-6 - secretion | Rubella - genetics | Measles-Mumps-Rubella Vaccine - immunology | Rubella - virology | Interferon-gamma - immunology | Repressor Proteins - immunology | Adolescent | Interleukin-6 - immunology | Antibodies, Viral - immunology | Haplotypes - immunology | AIDS vaccines | Immune response | Analysis | Vaccination | Measles | Single nucleotide polymorphisms | Chromosomes | Personal video recorders | Genetic Association Studies | genetic association | neutralizing antibodies | Single Nucleotide | single nucleotide polymorphisms (SNPs) | Measles-Mumps-Rubella Vaccine | cytokines | Polymorphism
Journal Article