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Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2016, Volume 59, Issue 1, pp. 44 - 60
Undesirable side effects associated with orthosteric agonists/antagonists of cannabinoid 1 receptor (CB1R), a tractable target for treating several pathologies... 
ACTIVATION | CHEMISTRY, MEDICINAL | ENDOCANNABINOID SYSTEM | INVERSE AGONIST | INDOLE-2-CARBOXAMIDES | PROTEIN-COUPLED RECEPTORS | LIGAND | PHARMACOLOGICAL EVALUATION | MODULATION | MUSCARINIC ACETYLCHOLINE-RECEPTOR | CB2 SELECTIVE AGONISTS
Journal Article
Journal Article
NEUROSCIENCE, ISSN 0306-4522, 08/2019, Volume 414, pp. 60 - 76
Activation of the M-1 muscarinic acetylcholine receptor (M1R) may be an effective therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies,... 
DEMENTIA | xanomeline | ALZHEIMERS-DISEASE | MEMORY IMPAIRMENT | c-Fos | SCHIZOPHRENIA | NEUROSCIENCES | PREFRONTAL CORTEX | COGNITIVE DYSFUNCTION | M-1 muscarinic acetylcholine receptor | ENTORHINAL CORTEX | POTENT | TAK-071 | donepezil | BINDING | C-FOS EXPRESSION
Journal Article
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2010, Volume 83, Issue 2, pp. 307 - 317
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 11/2018, Volume 8
Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A(1) receptor (A(1)AR), structural binding... 
ACCELERATED MOLECULAR-DYNAMICS | FREE-ENERGY CALCULATION | ACTIVATION | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | A(2A) RECEPTOR | SIMULATIONS | ENHANCERS | ADENOSINE-A1-RECEPTOR BINDING | MODULATION | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 12/2016, Volume 90, Issue 6, pp. 703 - 714
The adenosine A(1) G protein-coupled receptor (A(1)AR) is an important therapeutic target implicated in a wide range of cardiovascular and neuronal disorders.... 
BIASED AGONISM | PROTEIN-COUPLED RECEPTOR | STRUCTURAL BASIS | BINDING-SITE | PHARMACOLOGY & PHARMACY | GENERAL FORCE-FIELD | A(2A) RECEPTOR | MOLECULAR-DYNAMICS SIMULATIONS | SITE-DIRECTED MUTAGENESIS | CYSTEINE RESIDUES | MUSCARINIC ACETYLCHOLINE-RECEPTORS
Journal Article
Neurogastroenterology & Motility, ISSN 1350-1925, 11/2019, Volume 31, Issue 11, pp. e13692 - n/a
Background Because M1 muscarinic receptors are expressed by enteric neurons, we investigated whether positive allosteric modulators of these receptors (M1PAMs)... 
constipation | defecation | muscarinic receptors | colokinetics | enteric nervous system | Physiological aspects | Constipation | Dogs | Animal models | Acetylcholine receptors (muscarinic) | Oral administration | Neuromodulation | Enteric nervous system | Allosteric properties | Rodents | Nerves | Aging | Agonists | Colon | Defecation
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 12/2016, Volume 90, Issue 6, pp. 715 - 725
Allosteric modulation of adenosine A1 receptors (A1ARs) offers a novel therapeutic approach for the treatment of numerous central and peripheral disorders;... 
MOLECULAR-DYNAMICS | ACTIVATION | BIASED AGONISM | DRUG DISCOVERY | 2-AMINO-3-BENZOYLTHIOPHENES | PROTEIN-COUPLED RECEPTORS | PHARMACOLOGY & PHARMACY | GENERAL FORCE-FIELD | A(2A) RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTORS | ADENOSINE-A1-RECEPTOR BINDING
Journal Article
by Li, Y and Yin, C and Liu, P and Li, DM and Lin, JP
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2017, Volume 7
The human P2Y(1) receptor (P2Y(1)R) is a purinergic G-protein-coupled receptor (GPCR) that functions as a receptor for adenosine 5'-diphosphate (ADP). An... 
ACCELERATED MOLECULAR-DYNAMICS | MUTAGENESIS | NUCLEOTIDE RECEPTORS | ANTAGONIST | RECOGNITION | PATHWAY | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | M2 MUSCARINIC RECEPTOR | SIMULATIONS | CONFORMATION
Journal Article