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1. Full Text Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation
by Srihirun, Sirada and Sriwantana, Thanaporn and Unchern, Supeenun and Kittikool, Dusadee and Noulsri, Egarit and Pattanapanyasat, Kovit and Fucharoen, Suthat and Piknova, Barbora and Schechter, Alan N and Sibmooh, Nathawut
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30380
Background: Nitrite is a nitric oxide (NO) metabolite in tissues and blood, which can be converted to NO under hypoxia to facilitate tissue perfusion. Although... 
CYTOPLASMIC DOMAIN | HEMOGLOBIN | OXIDE SYNTHASE | SMOOTH-MUSCLE | REDUCTION | DEOXYHEMOGLOBIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RED-BLOOD-CELLS | AGGREGATION | Humans | Cells, Cultured | Male | Nitrites - pharmacology | Oxygen - blood | Erythrocytes - drug effects | Young Adult | Flow Cytometry | Blood Platelets - metabolism | Erythrocytes - metabolism | Adult | Female | Platelet Activation - drug effects | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Metabolites | Physiological aspects | Nitric oxide | Physiological effects | Nitrites | Erythrocytes | Science | Agglomeration | Tissues | ADP | Blood | Vasodilation | Proteins | Reduction | Red blood cells | Blood platelets | Cyclic GMP | Deoxygenation | Physiology | Inhibition | Research & development--R&D | Anemia | Pharmacology | Platelet aggregation | Medicine | Perfusion | Collagen | Hypoxia | Diabetes | Kidney diseases | Platelets | P-selectin | Research & development | R&D
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2. Full Text Impaired Skeletal Muscle Blood Flow Control With Advancing Age in Humans: Attenuated ATP Release and Local Vasodilation During Erythrocyte Deoxygenation
by Kirby, Brett S and Crecelius, Anne R and Voyles, Wyatt F and Dinenno, Frank A
Circulation Research, ISSN 0009-7330, 07/2012, Volume 111, Issue 2, pp. 220 - 230
RATIONALE:Skeletal muscle blood flow is coupled with the oxygenation state of hemoglobin in young adults, whereby the erythrocyte functions as an oxygen sensor... 
hypoxia | erythrocytes | aging | ATP | blood flow | HYPOXIC VASODILATION | COMBINED INHIBITION | CARDIAC & CARDIOVASCULAR SYSTEMS | VASCULAR CONTROL | ADENINE-NUCLEOTIDES | AGING HUMANS | NITRIC-OXIDE | SYSTEMIC HYPOXIA | HEALTHY OLDER-ADULTS | PERIPHERAL VASCULAR DISEASE | EXERCISE HYPEREMIA | HEMATOLOGY | ALPHA-ADRENERGIC VASOCONSTRICTION | Erythrocytes - secretion | Humans | Middle Aged | Adenosine Triphosphate - secretion | Male | Oximetry - methods | Adenosine Triphosphate - blood | Oxygen Consumption - physiology | Aging - pathology | Young Adult | Aging - physiology | Muscle, Skeletal - physiopathology | Erythrocytes - metabolism | Forearm - blood supply | Erythrocytes - pathology | Female | Aged | Muscle, Skeletal - pathology | Vasodilation - physiology | Blood Flow Velocity - physiology | Muscle, Skeletal - blood supply | Erythrocyte | Aging | Blood Flow | Hypoxia
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3. Full Text Reduced deformability contributes to impaired deoxygenation‐induced ATP release from red blood cells of older adult humans
by Racine, Matthew L and Dinenno, Frank A
The Journal of Physiology, ISSN 0022-3751, 09/2019, Volume 597, Issue 17, pp. 4503 - 4519
Key points Red blood cells (RBCs) release ATP in response to deoxygenation, which can increase blood flow to help match oxygen supply with tissue metabolic... 
red blood cells | deoxygenation | hypoxia | ATP release | OXIDATIVE STRESS | PHYSIOLOGY | ERYTHROCYTE DEFORMABILITY | OXYGEN DELIVERY | RABBIT ERYTHROCYTES | NEUROSCIENCES | SKELETAL-MUSCLE | HEART-DISEASE | NITRIC-OXIDE | C-PEPTIDE | INTRAVASCULAR ATP | SIGNAL-TRANSDUCTION PATHWAY | Physiological aspects | Muscles | Cyclic adenylic acid | Aged | Young adults | Deformability | Purine receptors | Blood cells | Erythrocytes | Hemoglobin | Cyclic AMP | Hypoxia | Age | Vasodilation | Phosphodiesterase
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4. Full Text Coupling of local muscle deoxygenation and autonomic control depends on exercise intensity - Insights from transfer entropy analysis
by Petelczyc, M and Bruhn, S and Weippert, M
Physiological Measurement, ISSN 0967-3334, 12/2018, Volume 39, Issue 12, p. 125005
Objective: We analyzed the driving component between the periods of adjacent heartbeats (R-R intervals) and vastus lateralis-deoxygenation (% HHb) during... 
ramp incremental test | R-R intervals | deoxygenated hemoglobin | transfer entropy | NEURAL-CONTROL | PHYSIOLOGY | O-2 EXTRACTION | ENGINEERING, BIOMEDICAL | VASOCONSTRICTOR RESPONSIVENESS | BLOOD-FLOW | CARDIOVASCULAR CONTROL | HETEROGENEITY | BIOPHYSICS | CONTRACTION | SYMPATHETIC-NERVE ACTIVITY | CENTRAL COMMAND | FUNCTIONAL SYMPATHOLYSIS | Exercise | Humans | Muscles - physiology | Autonomic Nervous System - physiology | Adult | Female | Male | Entropy | Muscles - metabolism | Oxygen - metabolism
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5. Full Text Masseter Deoxygenation in Adults at Risk for Temporomandibular Disorders
by Shah, N and Melo, L and Reid, W.D and Cioffi, I
Journal of Dental Research, ISSN 0022-0345, 6/2019, Volume 98, Issue 6, pp. 666 - 672
Patients with muscular temporomandibular disorder (TMD) present with abnormal oxygenation of the jaw muscles. Nonetheless, the deoxygenation pattern of jaw... 
musculoskeletal pain | near-infrared spectroscopy | mastication | bruxism | masseter muscle | facial pain | HABIT REVERSAL TREATMENT | RELIABILITY | SORENESS | TMD | LEVEL | MUSCLE PAIN | FORCE | CONTRACTION | DENTISTRY, ORAL SURGERY & MEDICINE | EMG ACTIVITY
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6. Full Text Influence of averaging method on muscle deoxygenation interpretation during repeated‐sprint exercise
by Rodriguez, R. F and Townsend, N. E and Aughey, R. J and Billaut, F
Scandinavian Journal of Medicine & Science in Sports, ISSN 0905-7188, 11/2018, Volume 28, Issue 11, pp. 2263 - 2271
Near‐infrared spectroscopy (NIRS) is a common tool used to study oxygen availability and utilization during repeated‐sprint exercise. However, there are... 
Butterworth filter | near‐infrared spectroscopy | tissue oxygenation | deoxyhaemoglobin | near-infrared spectroscopy | SPORT SCIENCES | PASSIVE RECOVERY | OXYGENATION | PERFORMANCE | HYPOXIA | BLOOD-VOLUME | RESPONSES | BUTTERWORTH | CYCLING EXERCISE | KINETICS | Young Adult | Data Interpretation, Statistical | Spectroscopy, Near-Infrared | Humans | Oxygen Consumption | Adult | Male | Exercise - physiology | Muscle, Skeletal - physiology | Hemoglobins - analysis | Data smoothing | Trends
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7. Full Text Spatial heterogeneity of quadriceps muscle deoxygenation kinetics during cycle exercise
by Shunsaku Koga and David C. Poole and Leonard F. Ferreira and Brian J. Whipp and Narihiko Kondo and Tadashi Saitoh and Etsuko Ohmae and Thomas J. Barstow
Journal of Applied Physiology, ISSN 8750-7587, 12/2007, Volume 103, Issue 6, pp. 2049 - 2056
To test the hypothesis that, during exercise, substantial heterogeneity of muscle hemoglobin and myoglobin deoxygenation [deoxy(Hb + Mb)] dynamics exists and... 
Muscle oxygen delivery | Oxygen uptake kinetics | Muscle oxygen utilization | Near-infrared spectroscopy | SPORT SCIENCES | near-infrared spectroscopy | PHYSIOLOGY | ARTERY BLOOD-FLOW | muscle oxygen utilization | TIME-RESOLVED SPECTROSCOPY | muscle oxygen delivery | KNEE EXTENSION | SKELETAL-MUSCLE | PULMONARY O-2 UPTAKE | OXYGEN-UPTAKE KINETICS | PRIOR HEAVY EXERCISE | MODERATE-INTENSITY EXERCISE | oxygen uptake kinetics | FEMORAL-ARTERY | Microcirculation - metabolism | Myoglobin - metabolism | Humans | Oxygen Consumption | Hemoglobins - metabolism | Male | Oxygen - blood | Quadriceps Muscle - blood supply | Muscle Contraction | Spectroscopy, Near-Infrared | Bicycling | Adult | Female | Pulmonary Gas Exchange | Exercise - physiology | Kinetics | Quadriceps Muscle - metabolism | Research Design
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8. Full Text Methodological validation of the dynamic heterogeneity of muscle deoxygenation within the quadriceps during cycle exercise
by Koga, Shunsaku and Poole, David C and Fukuoka, Yoshiyuki and Ferreira, Leonardo F and Kondo, Narihiko and Ohmae, Etsuko and Barstow, Thomas J
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 08/2011, Volume 301, Issue 2, pp. R534 - R541
Koga S, Poole DC, Fukuoka Y, Ferreira LF, Kondo N, Ohmae E, Barstow TJ. Methodological validation of the dynamic heterogeneity of muscle deoxygenation within... 
Muscle oxygen delivery | Oxygen uptake kinetics | Muscle oxygen utilization | Near-infrared spectroscopy | near-infrared spectroscopy | PHYSIOLOGY | muscle oxygen utilization | TIME-RESOLVED SPECTROSCOPY | muscle oxygen delivery | SKELETAL-MUSCLE | HEAVY | PULMONARY O-2 UPTAKE | OXYGEN-UPTAKE KINETICS | MUSCULAR-ACTIVITY | BLOOD-FLOW KINETICS | GAS-EXCHANGE | PERFUSION | oxygen uptake kinetics | Reproducibility of Results | Humans | Hemoglobins - metabolism | Myoglobin - physiology | Muscle, Skeletal - physiology | Spectroscopy, Near-Infrared - methods | Oxygen - metabolism | Young Adult | Time Factors | Bicycling | Muscle Contraction - physiology | Adult | Exercise - physiology | Adipose Tissue - anatomy & histology | Near infrared spectroscopy | Oxygen | Cycling | Extremities, Lower | Muscles | Physiological aspects | Health aspects | Methods | Leg
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9. Full Text Aerobic training enhances muscle deoxygenation in early post-myocardial infarction
by Takagi, Shun and Murase, Norio and Kime, Ryotaro and Niwayama, Masatsugu and Osada, Takuya and Katsumura, Toshihito
European Journal of Applied Physiology, ISSN 1439-6319, 4/2016, Volume 116, Issue 4, pp. 673 - 685
Exercise-induced skeletal muscle deoxygenation is startling by its absence in early post-myocardial infarction (MI) patients. Exercise training early post-MI... 
Ischemic heart disease | Microcirculation | Biomedicine | Human Physiology | Occupational Medicine/Industrial Medicine | Sports Medicine | Oxygen transport | Cycling training | Near-infrared spectroscopy | CHRONIC HEART-FAILURE | SPORT SCIENCES | PHYSIOLOGY | ANAEROBIC THRESHOLD | HIGH-INTENSITY | HETEROGENEITY | SKELETAL-MUSCLE | RAMP EXERCISE | ACUTE MYOCARDIAL-INFARCTION | GAS-EXCHANGE | LEG MUSCLES | LEFT-VENTRICULAR FUNCTION | Exercise | Humans | Middle Aged | Oxygen Consumption | Adult | Female | Male | Myocardial Infarction - physiopathology | Aged | Muscle, Skeletal - physiology | Myocardial Infarction - rehabilitation | Exercise Therapy | Original
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10. Full Text Muscle deoxygenation in the quadriceps during ramp incremental cycling: Deep vs. superficial heterogeneity
by Okushima, Dai and Poole, David C and Rossiter, X. Harry B and Barstow, Thomas J and Kondo, Narihiko and Ohmae, Etsuko and Koga, Shunsaku
Journal of Applied Physiology, ISSN 8750-7587, 12/2015, Volume 119, Issue 11, pp. 1313 - 1319
Muscle deoxygenation (i.e., deoxy[Hb + Mb]) during exercise assesses the matching of oxygen delivery ((Q) over dot(O2)) to oxygen utilization ((V) over... 
Deep and superficial muscle | Oxygen uptake | Oxygen delivery | Time-resolved near-infrared spectroscopy | PERFUSION HETEROGENEITY | SPORT SCIENCES | PHYSIOLOGY | MAXIMAL EXERCISE | oxygen uptake | CENTRAL MOTOR DRIVE | BLOOD-FLOW | deep and superficial muscle | OXYGEN EXTRACTION | UPTAKE KINETICS | SKELETAL-MUSCLE | PULMONARY O-2 UPTAKE | time-resolved near-infrared spectroscopy | NEAR-INFRARED SPECTROSCOPY | oxygen delivery | DIFFERENT FIBER TYPES | Leg - physiology | Myoglobin - metabolism | Humans | Hemoglobins - metabolism | Male | Muscle, Skeletal - metabolism | Lung - diagnostic imaging | Muscle Fibers, Slow-Twitch - metabolism | Oxygen Consumption - physiology | Young Adult | Bicycling - physiology | Spectroscopy, Near-Infrared | Muscle, Skeletal - diagnostic imaging | Ultrasonography | Exercise - physiology | Lung - metabolism
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11. Full Text Accelerated point of muscle deoxygenation during the 20‐m shuttle run test
by Kume, Daisuke and Iguchi, Akira and Endoh, Hiroshi
Clinical Physiology and Functional Imaging, ISSN 1475-0961, 05/2018, Volume 38, Issue 3, pp. 390 - 395
Summary This study examined whether the point of accelerated deoxygenation of active muscle occurs during the 20‐m shuttle run test (20mSRT) and, if so,... 
lactate threshold | running | muscle oxygenation | change of direction | near‐infrared spectroscopy | near-infrared spectroscopy | PHYSIOLOGY | AEROBIC FITNESS | INCREMENTAL EXERCISE | RELIABILITY | OXYHEMOGLOBIN DISSOCIATION | OXYGEN-UPTAKE | SKELETAL-MUSCLE | RESPONSES | THRESHOLD | SOCCER PLAYERS | Muscles | Infrared spectroscopy | Portable equipment | Oxygenation | Health risk assessment | Deoxygenation
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12. Full Text Effect of heavy-intensity ‘priming' exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity step-transitions initiated from an elevated work rate
by Nederveen, Joshua P and Keir, Daniel A and Love, Lorenzo K and Rossiter, Harry B and Kowalchuk, John M
Respiratory Physiology & Neurobiology, ISSN 1569-9048, 2016, Volume 235, pp. 62 - 70
Highlights • Priming exercise speeds O2 uptake kinetics in those whose kinetics are slow. • Slower muscle deoxygenation kinetics accompany this faster rate of... 
Medical Education | Pulmonary/Respiratory | O2 uptake kinetics | Priming exercise | Muscle oxygenation | Near-infrared spectroscopy | uptake kinetics | O | YOUNG-ADULTS | OXIDATIVE-PHOSPHORYLATION | BASE-LINE | PHYSIOLOGY | O-2 uptake kinetics | BLOOD-FLOW | PULMONARY O-2 UPTAKE | PYRUVATE-DEHYDROGENASE ACTIVITY | RESPIRATORY SYSTEM | GAS-EXCHANGE KINETICS | DOTO KINETICS | METABOLIC-RATE | DIFFERENT FIBER TYPES | Exercise Test | Spectroscopy, Near-Infrared | Humans | Adult | Male | Muscle, Skeletal - metabolism | Exercise - physiology | Kinetics | Oxygen Consumption - physiology | Oxygen - metabolism
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13. Full Text Skeletal Muscle Deoxygenation Abnormalities in Early Post-Myocardial Infarction
by Takagi, Shun and Murase, Norio and Kime, Ryotaro and Niwayama, Masatsugu and Osada, Takuya and Katsumura, Toshihito
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 11/2014, Volume 46, Issue 11, pp. 2062 - 2069
PURPOSEReduced peak aerobic capacity in chronic heart failure can be partly explained by impaired peripheral factors. However, skeletal muscle deoxygenation... 
Near infrared spectroscopy | Microcirculation | Oxygen transport | Heart disease | Cycling exercise | CHRONIC HEART-FAILURE | SPORT SCIENCES | MYOCARDIAL-INFARCTION | METABOLIC ABNORMALITIES | MICROCIRCULATION | ANAEROBIC THRESHOLD | OXIDATIVE-METABOLISM | NEAR INFRARED SPECTROSCOPY | OXYGEN TRANSPORT | VENOUS OXYGEN-SATURATION | CYCLING EXERCISE | NEAR-INFRARED SPECTROSCOPY | SUPINE BICYCLE EXERCISE | HEART DISEASE | GAS-EXCHANGE | PERIPHERAL ARTERIAL-DISEASE | Heart Rate | Humans | Middle Aged | Oxygen Consumption | Hemoglobins - metabolism | Male | Muscle, Skeletal - metabolism | Myocardial Infarction - metabolism | Exercise Test | Time Factors | Female | Aged | Respiration | Myoglobin - blood | Physiological aspects | Cardiac patients | Exercise
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14. Full Text Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans
by Stephen J. Bailey and Daryl P. Wilkerson and Fred J. DiMenna and Andrew M. Jones
Journal of Applied Physiology, ISSN 8750-7587, 06/2009, Volume 106, Issue 6, pp. 1875 - 1887
We hypothesized that a short-term training program involving repeated all-out sprint training (RST) would be more effective than work-matched, low-intensity... 
Oxygen uptake kinetics | Exercise performance | Near-infrared spectroscopy | Humans | Adaptation, Physiological - physiology | Hemoglobins - metabolism | Male | Muscle, Skeletal - metabolism | Oxygen Consumption - physiology | Oxygen - metabolism | Young Adult | Exercise Test | Bicycling - physiology | Spectroscopy, Near-Infrared | Female | Exercise - physiology | Lung - metabolism | Hemoglobins - analysis
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