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PLoS Biology, ISSN 1544-9173, 02/2017, Volume 15, Issue 2, p. e1002597
.... Further investigation suggested that ncls achieves these beneficial effects by promoting a shift from glycolytic to oxidative muscle fibers in the DIO mice thereby enhancing mitochondrial respiration... 
ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | MITOCHONDRIAL BIOGENESIS | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | COACTIVATOR PGC-1 | BIOLOGY | FIBER-TYPE | AMPK | ENERGY-METABOLISM | INSULIN SENSITIVITY | AMARYLLIDACEAE ISOCARBOSTYRILS | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Obesity - drug therapy | Diet - adverse effects | Humans | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - drug effects | Protective Agents - therapeutic use | Membrane Potential, Mitochondrial - drug effects | Phenanthridines - pharmacology | Protective Agents - pharmacology | Adenosine Triphosphate - metabolism | Diet, High-Fat | Muscle, Skeletal - drug effects | Cell Respiration - drug effects | Oxidation-Reduction - drug effects | Cyclic AMP - metabolism | Fatty Acids - metabolism | Physical Conditioning, Animal | Biomarkers - metabolism | Phenanthridines - therapeutic use | Mice, Inbred C57BL | Cells, Cultured | Amaryllidaceae Alkaloids - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Obesity - metabolism | Animals | Signal Transduction - drug effects | Amaryllidaceae Alkaloids - therapeutic use | Mice | Adenosine Diphosphate - metabolism | Energy Metabolism - drug effects | Prevention | Muscles | Obesity | Alkaloids | Health aspects | Statistical analysis | Laboratories | Colleges & universities | Biology | Kinases | Metabolism | Fatty acids | Proteins | Medicine | Consortia | Musculoskeletal system | Weight control | Rodents | Spectrum analysis | Stem cells | Expenditures | Life sciences | Respiration | Bioinformatics
Journal Article
Cell stem cell, ISSN 1934-5909, 2017, Volume 20, Issue 1, pp. 56 - 69
Satellite cells, the predominant stem cell population in adult skeletal muscle, are activated in response to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs... 
hypertrophy | Pax7 | exosomes | muscle | collagen | microRNA | fibrosis | muscle progenitor cells | extracellular matrix | satellite cells | FIBROSIS | REGENERATION | GENE-EXPRESSION | EXOSOMES | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | MIRNAS | SATELLITE CELL | DIFFERENTIATION | CONNECTIVE-TISSUE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Exosomes - drug effects | Exosomes - metabolism | NIH 3T3 Cells | Cell Survival - genetics | Extracellular Matrix - metabolism | MicroRNAs - metabolism | PAX7 Transcription Factor - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Stem Cells - metabolism | Gene Knockdown Techniques | Cell Differentiation - genetics | Extracellular Matrix - genetics | Cell Nucleus - metabolism | Gene Deletion | Collagen - genetics | Fibroblasts - metabolism | Cell Survival - drug effects | Ribonuclease III - metabolism | Extracellular Matrix - drug effects | Satellite Cells, Skeletal Muscle - metabolism | Down-Regulation - drug effects | Fibroblasts - pathology | Down-Regulation - genetics | Collagen - metabolism | Satellite Cells, Skeletal Muscle - drug effects | Animals | Carrier Proteins - metabolism | Muscle Development - drug effects | Cell Differentiation - drug effects | Models, Biological | Fibroblasts - drug effects | Muscle Fibers, Skeletal - pathology | Tamoxifen - pharmacology | Muscle Development - genetics | Stem Cells - drug effects | Mice | MicroRNAs - genetics | Muscle, Skeletal - pathology | Cell Nucleus - drug effects | Hypertrophy | miRNA | Dicer | Muscle extracellular matrix
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e30063
.... Given that it has been shown that slow fibers produce and maintain more utrophin than fast skeletal muscle fibers, we hypothesized that over-expression of PGC-1 alpha in post-natal mdx mice would... 
RESVERATROL | MITOCHONDRIAL BIOGENESIS | CALCIUM | BIOLOGY | GENE-EXPRESSION | DUCHENNE MUSCULAR-DYSTROPHY | MICE | NEUROMUSCULAR-JUNCTION | SIRT1 | UTROPHIN GENE | CELL-DEATH | Stilbenes - administration & dosage | Muscle Fibers, Fast-Twitch - drug effects | Recovery of Function - drug effects | Muscular Dystrophy, Animal - physiopathology | Body Weight - drug effects | Muscular Dystrophy, Animal - complications | Muscle Fibers, Slow-Twitch - drug effects | Stilbenes - pharmacology | Dependovirus - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Mice, Inbred mdx | Recovery of Function - physiology | Myosins - metabolism | Muscle Fatigue | Gene Transfer Techniques | Dependovirus - metabolism | Organ Size | Biomechanical Phenomena | Animals | Muscle Contraction | Muscle Fibers, Slow-Twitch - pathology | Muscle Fibers, Fast-Twitch - pathology | Trans-Activators - metabolism | Mice | Transcription Factors | Dietary Supplements | Neonates | Oxidative stress | Phosphorylation | Transgenic | Viruses | mRNA | Insulin-like growth factors | Contraction | Muscular dystrophy | Crack propagation | Fibers | Proteins | Signal transduction | Mitochondria | Oxidation resistance | Fatigue strength | Rodents | Myosin | Resveratrol | Physiology | Localization | Dystrophin | Muscles | Fatigue | Glycoproteins | Histology | Pharmacology | Fatigue failure | Gene expression | Muscle contraction | Skeletal muscle | Medicine | Musculoskeletal system | Signaling | Overexpression | Utrophin | Muscle function | Gene therapy
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 21, pp. 14913 - 14924
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy... 
HYPERTROPHY | ALPHA-TOMATINE | ACTIVATION | MANAGEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOMATOES | SARCOPENIA | DEFICIENT MICE | EXPRESSION SIGNATURES | FAT MASS | PROTECTS | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondria, Muscle - metabolism | Drug Discovery - methods | Immunoblotting | Male | Multiprotein Complexes - genetics | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Tomatine - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Myoblasts, Skeletal - cytology | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Muscular Atrophy - prevention & control | Mitochondria, Muscle - genetics | Myoblasts, Skeletal - metabolism | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Cells, Cultured | Muscular Atrophy - genetics | Tomatine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Cell Line, Tumor | HL-60 Cells | Muscle Fibers, Skeletal - cytology | Mice | Mitochondria, Muscle - drug effects | Muscle, Skeletal - pathology | Myoblasts, Skeletal - drug effects | Skeletal Muscle | Skeletal Muscle Metabolism | Muscle Atrophy | Tomatidine | Metabolism | Systems Biology | mTOR complex (mTORC)
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2010, Volume 285, Issue 29, pp. 22619 - 22629
Journal Article
Journal Article
The FASEB journal, ISSN 1530-6860, 2014, Volume 28, Issue 4, pp. 1654 - 1665
Journal Article
American journal of physiology. Regulatory, integrative and comparative physiology, ISSN 1522-1490, 2014, Volume 306, Issue 7, pp. R470 - R482
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2010, Volume 285, Issue 1, pp. 705 - 712
...) with transgenic overexpression of the human SOD1 G93A mutant. The G93A skeletal muscle fibers display localized loss of mitochondrial inner membrane potential in fiber segments near the neuromuscular junction... 
WILD-TYPE | FIBERS | PRIMARY TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN MUSCLE | MOUSE MOTOR TERMINALS | MUTANT SOD1 | UP-REGULATION | MDX MICE | CA2+ SPARKS | DEGENERATION | Calcium - metabolism | Neuromuscular Junction - drug effects | Neuromuscular Junction - metabolism | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Membrane Potential, Mitochondrial - drug effects | Mitochondria - ultrastructure | Muscle Fibers, Skeletal - ultrastructure | Muscle, Skeletal - drug effects | Stress, Physiological - drug effects | Neuromuscular Junction - pathology | Disease Models, Animal | Intracellular Space - drug effects | Muscle, Skeletal - ultrastructure | Mitochondria - drug effects | Mitochondria - pathology | Neuromuscular Junction - ultrastructure | Amyotrophic Lateral Sclerosis - pathology | Animals | Calcium Signaling - drug effects | Models, Biological | Intracellular Space - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Muscle Fibers, Skeletal - pathology | Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology | Mice | Muscle, Skeletal - pathology | Ruthenium Compounds - pharmacology | Mechanisms of Signal Transduction | Amyotrophic Lateral Sclerosis | Skeletal Muscle | Calcium | Imaging | Neuromuscular Junction | Intracellular Ca2+ Release | Mitochondrial Ca2+ Uptake | Superoxide Dismutase
Journal Article
Aging Cell, ISSN 1474-9718, 06/2016, Volume 15, Issue 3, pp. 488 - 498
...‐recognized decrease in muscle mass; however, starting at middle‐age, the normalized force (force/muscle cross‐sectional area) in the knee extensors and single muscle fibers declines in a curvilinear manner... 
calcium channel | calpain | troponin T | aging | skeletal muscle | excitation–contraction coupling | Aging | Calpain | Excitation-contraction coupling | Calcium channel | Skeletal muscle | Troponin T | CHARGE MOVEMENT | NUCLEAR | TRANSCRIPTION | STRENGTH | BODY-COMPOSITION | WEAKNESS | TROPOMYOSIN | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | INTRACELLULAR CA2 | FIBERS | MASS | excitation-contraction coupling | Muscles | Calcium channels | Genetic transcription | Sensors | Analysis | Original
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 10, pp. 6968 - 6979
...)-induced skeletal muscle mitochondrial biogenesis. Using muscle-specific SirT1-deficient (KO... 
SKELETAL-MUSCLE | GLUCOSE-HOMEOSTASIS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | NAD(+) SALVAGE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | METABOLIC ADAPTATION | CALORIC RESTRICTION | CHRONIC CONTRACTILE ACTIVITY | AUTOREGULATORY LOOP | ENERGY-METABOLISM | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Mitochondria, Muscle - metabolism | Immunoblotting | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Stilbenes - pharmacology | Sirtuin 1 - genetics | Cell Nucleus - metabolism | Muscle, Skeletal - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Muscle Fibers, Skeletal - physiology | Cell Line | Vasodilator Agents - pharmacology | Mice, Transgenic | Muscle, Skeletal - physiology | Physical Conditioning, Animal - physiology | Mice, Knockout | Animals | Muscle Contraction - drug effects | Active Transport, Cell Nucleus - drug effects | Trans-Activators - metabolism | Mice | Mitochondria, Muscle - drug effects | Transcription Factors | Cell Nucleus - drug effects | Microscopy, Fluorescence | Exercise | Reactive Oxygen Species (ROS) | Skeletal Muscle | Cytochrome c Oxidase Activity | Nampt | Resveratrol | Sirt1 | PGC-1α | Metabolism | Mitochondrial Biogenesis | Mitochondrial Respiration
Journal Article