Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (49342) 49342
Publication (5463) 5463
Book Review (638) 638
Book / eBook (395) 395
Book Chapter (211) 211
Newspaper Article (170) 170
Newsletter (74) 74
Conference Proceeding (47) 47
Dissertation (35) 35
Magazine Article (21) 21
Reference (12) 12
Trade Publication Article (5) 5
Web Resource (5) 5
Data Set (4) 4
Presentation (2) 2
Government Document (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (35150) 35150
male (23707) 23707
humans (15420) 15420
rats (14429) 14429
in vitro techniques (14131) 14131
index medicus (12736) 12736
female (12244) 12244
pharmacology & pharmacy (11640) 11640
muscle contraction - drug effects (10713) 10713
muscle, smooth, vascular - drug effects (7837) 7837
muscle relaxation - drug effects (7823) 7823
physiology (7401) 7401
dose-response relationship, drug (6620) 6620
muscle, smooth - drug effects (6447) 6447
smooth-muscle (6077) 6077
nitric oxide (5856) 5856
nitric-oxide (4776) 4776
guinea pigs (4364) 4364
endothelium (4359) 4359
rabbits (4276) 4276
rats, sprague-dawley (4239) 4239
rats, wistar (4224) 4224
vasodilation - drug effects (4224) 4224
relaxation (4099) 4099
smooth muscle (4057) 4057
acetylcholine - pharmacology (3964) 3964
mice (3931) 3931
adult (3925) 3925
calcium - metabolism (3885) 3885
vasodilator agents - pharmacology (3744) 3744
electric stimulation (3591) 3591
middle aged (3508) 3508
muscle, smooth, vascular - physiology (3484) 3484
biochemistry & molecular biology (3395) 3395
cardiac & cardiovascular systems (3395) 3395
endothelium, vascular - drug effects (3318) 3318
muscle, smooth - physiology (3267) 3267
cells (3104) 3104
endothelium, vascular - physiology (2981) 2981
enzyme inhibitors - pharmacology (2931) 2931
vascular smooth-muscle (2775) 2775
physiological aspects (2750) 2750
neurosciences (2738) 2738
nitric oxide - metabolism (2738) 2738
peripheral vascular disease (2717) 2717
norepinephrine - pharmacology (2711) 2711
cell biology (2671) 2671
hypertension (2611) 2611
acetylcholine (2585) 2585
nitric-oxide synthase (2580) 2580
time factors (2578) 2578
muscle contraction (2572) 2572
dogs (2560) 2560
vasoconstriction - drug effects (2553) 2553
smooth-muscle-cells (2506) 2506
muscle contraction - physiology (2503) 2503
calcium (2482) 2482
contraction (2407) 2407
cells, cultured (2381) 2381
rat (2371) 2371
research (2339) 2339
muscle, smooth, vascular - metabolism (2289) 2289
analysis (2236) 2236
aorta, thoracic - drug effects (2186) 2186
aged (2178) 2178
muscles (2175) 2175
blood pressure - drug effects (2152) 2152
rodents (2144) 2144
expression (2116) 2116
nitroprusside - pharmacology (2110) 2110
inhibition (2029) 2029
activation (2007) 2007
research article (1990) 1990
nitric oxide - physiology (1956) 1956
skeletal-muscle (1907) 1907
phosphorylation (1893) 1893
swine (1883) 1883
oxidative stress (1856) 1856
vasoconstrictor agents - pharmacology (1846) 1846
vasodilation (1804) 1804
muscle (1791) 1791
isoproterenol - pharmacology (1753) 1753
trachea - drug effects (1724) 1724
phenylephrine - pharmacology (1715) 1715
relaxing factor (1700) 1700
aorta (1694) 1694
article (1677) 1677
urology & nephrology (1669) 1669
vasodilation - physiology (1652) 1652
smooth-muscle cells (1644) 1644
respiratory system (1627) 1627
proteins (1626) 1626
disease models, animal (1624) 1624
receptors (1596) 1596
aorta - drug effects (1587) 1587
medicine, research & experimental (1571) 1571
endothelium, vascular - metabolism (1564) 1564
medicine (1561) 1561
muscle, smooth - metabolism (1559) 1559
heart (1555) 1555
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (315) 315
UTL at Downsview - May be requested (25) 25
Collection Dvlpm't (Acquisitions) - Closed Orders (13) 13
Collection Dvlpm't (Acquisitions) - Vendor file (13) 13
UofT at Mississauga - Stacks (12) 12
UofT at Scarborough - Stacks (11) 11
Holland Bloorview Kids Rehabilitation - Stacks (10) 10
Online Resources - Online (9) 9
Robarts - Stacks (5) 5
Dentistry (Harry R Abbott) - Stacks (4) 4
Dentistry (Harry R Abbott) - Withdrawn (4) 4
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (4) 4
Providence Healthcare - Stacks (3) 3
St. Michael's Hospital - Stacks (3) 3
Gerstein Science - Missing (2) 2
Humber River Regional Hospital - Church Stacks (2) 2
Physics - Stacks (2) 2
Providence Healthcare - Reference (2) 2
Royal Ontario Museum - Stacks (2) 2
Scarborough Hospital - Birchmount (2) 2
Sunnybrook Health Sciences Centre - Holland Stacks (2) 2
Credit Valley Hospital - Stacks (1) 1
Earth Sciences (Noranda) - Missing (1) 1
Engineering & Comp. Sci. - Stacks (1) 1
Gerstein Science - Circulation Desk (1) 1
Gerstein Science - Not Returned (1) 1
Gerstein Science - Searching (1) 1
Lakeridge Health Sciences - Oshawa (1) 1
Markham Stouffville Hospital - Stacks (1) 1
Mt Sinai Hospital - Pathology (1) 1
OISE - Curriculum Resources (1) 1
Scarborough Hospital - General (1) 1
Thomas Fisher Rare Book - Rare Book (1) 1
Toronto East General Hospital - Stacks (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
West Park Healthcare Centre - Hospital Department (1) 1
West Park Healthcare Centre - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (49338) 49338
Japanese (192) 192
Russian (181) 181
German (152) 152
French (89) 89
Chinese (86) 86
Spanish (45) 45
Italian (34) 34
Ukrainian (29) 29
Portuguese (10) 10
Polish (8) 8
Romanian (8) 8
Czech (5) 5
Korean (5) 5
Danish (4) 4
Turkish (4) 4
Arabic (3) 3
Bulgarian (3) 3
Dutch (3) 3
Hungarian (3) 3
Lithuanian (3) 3
Slovak (3) 3
Croatian (2) 2
Latin (2) 2
Swedish (2) 2
Norwegian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Augmentation pressure is influenced by ventricular contractility/relaxation dynamics novel mechanism of reduction of pulse pressure by nitrates
by Fok, Henry and Guilcher, Antoine and Li, Ye and Brett, Sally and Shah, Ajay and Clapp, Brian and Chowienczyk, Phil
Hypertension, ISSN 0194-911X, 2014, Volume 63, Issue 5, pp. 1050 - 1055
Augmentation pressure (AP), the increment in aortic pressure above its first systolic shoulder, is thought to be determined mainly by pressure wave reflection... 
Pulse wave analysis | VELOCITY | STIFFNESS | WAVE REFLECTION | PERIPHERAL ARTERIES | pulse wave analysis | CARDIAC MYOCYTES | NITROGLYCERIN | NITRIC-OXIDE | HUMANS | PERIPHERAL VASCULAR DISEASE | GLYCERYL TRINITRATE | BLOOD-PRESSURE | Ventricular Function - physiology | Pulse Wave Analysis | Humans | Middle Aged | Myocardial Contraction - physiology | Myocardial Contraction - drug effects | Nitrates - pharmacology | Male | Hemodynamics - physiology | Nitroglycerin - pharmacology | Dose-Response Relationship, Drug | Cardiac Catheterization | Regional Blood Flow - drug effects | Muscle Relaxation - physiology | Arterial Pressure - drug effects | Adult | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Ventricular Function - drug effects | Stroke Volume - physiology | Stroke Volume - drug effects | Arterial Pressure - physiology | Aged | Hemodynamics - drug effects | Muscle Relaxation - drug effects | Regional Blood Flow - physiology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
by Deshpande, Deepak A and Wang, Wayne C. H and McIlmoyle, Elizabeth L and Robinett, Kathryn S and Schillinger, Rachel M and An, Steven S and Sham, James S. K and Liggett, Stephen B
Nature Medicine, ISSN 1078-8956, 11/2010, Volume 16, Issue 11, pp. 1299 - 1304
Bitter taste receptors (TAS2Rs) on the tongue probably evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CONTRACTILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELAXATION | CELL BIOLOGY | HETEROGENEITY | LACTONES | ASTHMA | CHANNELS | MAMMALIAN TASTE | EXPRESSION | SPARKS | Asthma - metabolism | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Bronchi - physiopathology | Myocytes, Smooth Muscle - pathology | RNA, Messenger - metabolism | Airway Obstruction - metabolism | Bronchi - drug effects | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Muscle Relaxation - physiology | Bronchoconstriction - drug effects | Bronchi - metabolism | Bronchi - pathology | Myocytes, Smooth Muscle - metabolism | Membrane Potentials - drug effects | Bronchoconstriction - physiology | Asthma - physiopathology | Cell Separation | RNA, Messenger - genetics | Airway Obstruction - physiopathology | Muscle, Smooth - metabolism | Membrane Potentials - physiology | Taste - physiology | Gene Expression Regulation - drug effects | Animals | Taste - drug effects | Asthma - complications | Calcium Signaling - drug effects | Airway Obstruction - pathology | Muscle, Smooth - physiopathology | Mice | Receptors, G-Protein-Coupled - genetics | Muscle Relaxation - drug effects | Muscle, Smooth - pathology | Saccharin - pharmacology | Taste buds | Care and treatment | Usage | Animal models in research | Physiological aspects | Smooth muscle | Genetic aspects | Airway obstruction (Medicine) | Research | Risk factors | Signal transduction | Taste | Calcium | Cellular biology | Respiratory diseases
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Determinants of left ventricular early-diastolic lengthening velocity independent contributions from left ventricular relaxation, restoring forces, and lengthening load
by Opdahl, Anders and Remme, Espen W and Helle-Valle, Thomas and Lyseggen, Erik and Vartdal, Trond and Pettersen, Eirik and Edvardsen, Thor and Smiseth, Otto A
Circulation, ISSN 0009-7322, 05/2009, Volume 119, Issue 19, pp. 2578 - 2586
Background-Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This... 
Heart failure | Mechanics | Echocardiography | Hemodynamics | Diastole | heart failure | FILLING PRESSURES | CONSCIOUS DOG | CARDIAC & CARDIOVASCULAR SYSTEMS | PRELOAD | echocardiography | HEART-FAILURE | mechanics | TIME | SYSTOLIC FUNCTION | TISSUE DOPPLER | hemodynamics | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | diastole | HEMODYNAMIC DETERMINANTS | Manometry | Ventricular Function, Left - drug effects | Myocardial Contraction - drug effects | Ventricular Dysfunction, Left - etiology | Male | Echocardiography, Doppler, Pulsed | Heart Ventricles - diagnostic imaging | Coronary Occlusion - complications | Dobutamine - pharmacology | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Mitral Valve - physiology | Animals | Mitral Valve - diagnostic imaging | Dogs | Electrocardiography | Female | Ventricular Function, Left - physiology | Diastole - drug effects | Muscle Relaxation - drug effects | Coronary Occlusion - physiopathology | Heart Ventricles - drug effects | Physiological aspects | Usage | Diastole (Cardiac cycle) | Doppler echocardiography | Research | Heart ventricle, Left
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Angiotensin II Type 2 Receptor– and Acetylcholine-Mediated Relaxation: Essential Contribution of Female Sex Hormones and Chromosomes
by Pessôa, Bruno Sevá and Slump, Denise E and Ibrahimi, Khatera and Grefhorst, Aldo and van Veghel, Richard and Garrelds, Ingrid M and Roks, Anton J.M and Kushner, Steven A and Danser, A.H Jan and van Esch, Joep H.M
Hypertension, ISSN 0194-911X, 08/2015, Volume 66, Issue 2, pp. 396 - 402
Angiotensin-induced vasodilation, involving type 2 receptor (AT2R)–induced generation of nitric oxide (NO; by endothelial NO synthase) and endothelium-derived... 
Angiotensinogen | Angiotensins | Receptor, angiotensin, type 2 | Acetylcholine | Genes, sry | SYSTEM | AT RECEPTOR | RENIN | genes | receptor, angiotensin, type 2 | SPONTANEOUSLY HYPERTENSIVE-RATS | RENAL-FUNCTION | angiotensinogen | BRADYKININ-INDUCED RELAXATION | HUMAN CORONARY MICROARTERIES | THERAPEUTIC TARGET | S-NITROSOTHIOLS | PERIPHERAL VASCULAR DISEASE | VASODILATION | acetylcholine | sry | angiotensins | Iliac Artery - drug effects | Receptor, Angiotensin, Type 2 - physiology | Male | Muscle Relaxation - physiology | Female | Models, Animal | Vasodilation - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Estrogens - physiology | Angiotensin II - pharmacology | X Chromosome - physiology | Acetylcholine - pharmacology | Mice, Inbred C57BL | Genotype | Iliac Artery - physiology | Phenotype | Animals | Sex Factors | Genes, sry - genetics | Mice | Muscle Relaxation - drug effects | Vasodilation - drug effects | Acetylcholine - physiology | Nitric Oxide - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Involvement of Potassium Channels and Calcium-Independent Mechanisms in Hydrogen Sulfide-Induced Relaxation of Rat Mesenteric Small Arteries
by Hedegaard, Elise R and Hedegaard, Elise R and Gouliaev, Anja and Gouliaev, Anja and Winther, Anna K and Winther, Anna K and Arcanjo, Daniel D. R and Arcanjo, Daniel D.R and Aalling, Mathilde and Aalling, Mathilde and Renaltan, Nirthika S and Renaltan, Nirthika S and Wood, Mark E and Wood, Mark E and Whiteman, Matthew and Whiteman, Matthew and Skovgaard, Nini and Skovgaard, Nini and Simonsen, Ulf and Simonsen, Ulf
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 01/2016, Volume 356, Issue 1, pp. 53 - 63
Endogenous hydrogen sulfide (H2S) is involved in the regulation of vascular tone. We hypothesized that the lowering of calcium and opening of potassium (K)... 
SMOOTH-MUSCLE | IN-VITRO | ACTIVATION | VASORELAXATION | TONE | K-ATP CHANNELS | SENSITIVITY | PHARMACOLOGY & PHARMACY | VASODILATATION | SENSORY NERVES | HYPERTENSION | Hydrogen Sulfide - metabolism | Hydrogen Sulfide - pharmacology | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Calcium - metabolism | Rats | Mesenteric Arteries - drug effects | Myosin Light Chains - drug effects | Mesenteric Arteries - metabolism | Potassium Channels - drug effects | Electron Transport Complex I - drug effects | KCNQ Potassium Channels - drug effects | Myosin-Light-Chain Phosphatase - antagonists & inhibitors | Animals | Electron Transport Complex III - antagonists & inhibitors | Myosin Light Chains - metabolism | Protein Kinase Inhibitors - pharmacology | Muscle Relaxation - drug effects | Vasodilation - drug effects | In Vitro Techniques | Potassium Channel Blockers - pharmacology | Muscle, Smooth, Vascular - drug effects
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Pleiotropic effects of bitter taste receptors on [Ca 2+ ] i mobilization, hyperpolarization, and relaxation of human airway smooth muscle cells
by Camoretti-Mercado, Blanca and Pauer, Susan H and Yong, Hwan Mee and Smith, Dan'elle C and Deshpande, Deepak A and An, Steven S and Liggett, Stephen B
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0131582
Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local... 
Histamine - pharmacology | Receptors, G-Protein-Coupled - metabolism | Endothelin-1 - metabolism | Humans | Cells, Cultured | Genetic Pleiotropy | Receptors, G-Protein-Coupled - agonists | Lung - cytology | Chloroquine - pharmacology | Receptors, Histamine - metabolism | Aristolochic Acids - pharmacology | Calcium Signaling - drug effects | Muscle Relaxation - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Action Potentials - drug effects | Health sciences | Endothelin | G protein-coupled receptors | Genomics | Chloroquine | Bronchi | Smooth muscle | Aristolochic acid | Kinases | Contraction | Proteins | Taste receptors | Respiratory tract | Heterogeneity | Receptors | Precision medicine | Bradykinin | Respiratory tract diseases | Stiffness | Ferromagnetism | Inhibition | Public health | Phenotypes | Calcium mobilization | Calcium (intracellular) | Twisting | Environmental health | Bitter taste | Muscles | Bronchus | Endothelin 1 | Stiffening | Muscle contraction | Asthma | Cytometry | Histamine | Air flow | Acids | Correlation analysis | Angiotensin | Taste | Acetylcholine | Beads | Hyperpolarization | Calcium ions
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text beta-Alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity
by Hannah, R and Stannard, RL and Minshull, C and Artioli, GG and Harris, RC and Sale, C
JOURNAL OF APPLIED PHYSIOLOGY, ISSN 8750-7587, 03/2015, Volume 118, Issue 5, pp. 604 - 612
beta-Alanine (BA) supplementation improves human exercise performance. One possible explanation for this is an enhancement of muscle contractile properties,... 
electrical stimulation | force-frequency relationship | SPORT SCIENCES | PHYSIOLOGY | CARNOSINE CONCENTRATIONS | EXERCISE PERFORMANCE | RELIABILITY | muscle contractile properties | CONTRACTIONS | FIBERS | beta-alanine | POTENTIATION | CALCIUM-RELEASE | QUADRICEPS | FREQUENCY-RELATIONSHIP | ELECTROMECHANICAL DELAY | Calcium - metabolism | Isometric Contraction - drug effects | Humans | Male | Muscle, Skeletal - metabolism | Rest - physiology | Muscle Relaxation - physiology | Muscle Fatigue - drug effects | Muscle, Skeletal - drug effects | Adult | Muscle Fatigue - physiology | Electric Stimulation - methods | Isometric Contraction - physiology | Knee Joint - metabolism | Double-Blind Method | Knee - physiology | Knee Joint - drug effects | beta-Alanine - administration & dosage | Muscle, Skeletal - physiology | Knee Joint - physiology | Muscle Contraction - drug effects | Muscle Contraction - physiology | Exercise - physiology | Muscle Relaxation - drug effects | Electromyography - methods | Dietary Supplements | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPRα (PAQR7)
by Pang, Yefei and Thomas, Peter
Molecular and Cellular Endocrinology, ISSN 0303-7207, 10/2018, Volume 474, pp. 20 - 34
Progesterone effects on vascular smooth muscle cell (VSMC) relaxation and the mechanism were investigated in cultured human umbilical vein VSMCs. Membrane... 
mPRα | Smooth muscle relaxation | Progesterone | Membrane progesterone receptor alpha | Vascular smooth muscle cells | RAT AORTA | SEX-HORMONES | NITRIC-OXIDE SYNTHASE | mPR alpha | CARDIOVASCULAR-SYSTEM | RECEPTOR | G-PROTEIN | LIGHT-CHAIN PHOSPHORYLATION | BLOOD-PRESSURE | CELL BIOLOGY | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | MYOSIN PHOSPHATASE | Progestins - metabolism | Humans | Umbilical Cord - cytology | Myocytes, Smooth Muscle - physiology | Umbilical Arteries - physiology | Phosphatidylinositol 3-Kinases - metabolism | Receptors, Progesterone - metabolism | Tritium - metabolism | Signal Transduction - drug effects | Cell Membrane - metabolism | Myosin Light Chains - metabolism | Muscle Relaxation - drug effects | Phosphorylation - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Progesterone - pharmacology | Cell Membrane - drug effects | Second Messenger Systems | GTP-Binding Proteins - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea
by Ville Pulkkinen and Martijn L. Manson and Jesper Säfholm and Mikael Adner and Sven-Erik Dahlén
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2012, Volume 303, Issue 11, pp. 956 - 966
Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause bronchodilation. The aim of this study was to extend the information... 
Bronchodilation | Prostaglandins | Airway smooth muscle | Asthma | ACTIVATION | PHYSIOLOGY | POTASSIUM CHANNELS | INDUCED BRONCHODILATION | airway smooth muscle | asthma | ANTAGONISM | RESPONSES | BK CHANNELS | TONE | RESPIRATORY SYSTEM | OBSTRUCTION | prostaglandins | bronchodilation | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Respiratory Mucosa - drug effects | Receptors, G-Protein-Coupled - metabolism | Albuterol - pharmacology | Male | Trachea - drug effects | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Trachea - metabolism | Receptors, G-Protein-Coupled - agonists | Chloroquine - pharmacology | Muscle, Smooth - drug effects | Large-Conductance Calcium-Activated Potassium Channels - physiology | Charybdotoxin - pharmacology | Trachea - physiology | Indoles - pharmacology | Muscle, Smooth - physiology | Cholinergic Agonists - pharmacology | Gene Expression | Guinea Pigs | Bronchodilator Agents - pharmacology | Indomethacin - pharmacology | Peptides - pharmacology | Carbachol - pharmacology | Animals | Muscle Contraction - drug effects | Receptors, G-Protein-Coupled - genetics | Muscle Relaxation - drug effects | In Vitro Techniques | Quaternary Ammonium Compounds - pharmacology | Physiological aspects | Taste | Genetic aspects | Research | Drug therapy | Trachea | Bronchodilator agents
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text TAS2R activation promotes airway smooth muscle relaxation despite beta(2)-adrenergic receptor tachyphylaxis
by An, SS and Wang, WCH and Koziol-White, CJ and Ahn, K and Lee, DY and Kurten, RC and Panettieri, RA and Liggett, SB
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, ISSN 1040-0605, 08/2012, Volume 303, Issue 4, pp. L304 - L311
An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA Jr, Liggett SB. TAS2R activation promotes airway smooth muscle relaxation despite... 
BITTER TASTE RECEPTORS | MILD ASTHMA | PHYSIOLOGY | PROTEIN | BETA-ADRENERGIC-RECEPTORS | PHOSPHORYLATION | DIFFERENT MECHANISMS | DESENSITIZATION | PHOSPHOLIPASE-C | airway smooth muscle | beta-adrenergic receptor desensitization | asthma | SALMETEROL | chloroquine | RESPIRATORY SYSTEM | bitter taste receptor | AGONIST | Receptors, G-Protein-Coupled - metabolism | Albuterol - pharmacology | Humans | Adrenergic beta-Agonists - pharmacology | Respiratory Physiological Phenomena - drug effects | Receptors, G-Protein-Coupled - agonists | Receptors, Adrenergic, beta-2 - metabolism | Tachyphylaxis - physiology | Chloroquine - pharmacology | Muscle, Smooth - drug effects | Animals | Muscle Relaxation - physiology | Respiratory System - metabolism | Isoproterenol - pharmacology | Methacholine Chloride - pharmacology | Respiratory System - drug effects | Muscle, Smooth - physiology | Mice | Muscle Relaxation - drug effects | In Vitro Techniques
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Hydrogen Sulfide as a Mediator of Human Corpus Cavernosum Smooth-Muscle Relaxation
by Roberta D'Emmanuele di Villa Bianca and Raffaella Sorrentino and Pasquale Maffia and Vincenzo Mirone and Ciro Imbimbo and Ferdinando Fusco and Raffaele De Palma and Louis J. Ignarro and Giuseppe Cirino
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2009, Volume 106, Issue 11, pp. 4513 - 4518
Hydrogen sulfide (H₂S) is synthesized by 2 enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). L-Cysteine (L-Cys) acts as a natural... 
Sulfides | Messenger RNA | Hydrogen | Penile erection | Rats | Oxides | Blood pressure | Dosage | Body tissues | Endothelium | H2s penile erection | L-cysteine | Cystathionine β-synthase (CBS) | Cystathionine γ-lyase (CSE) | cystathionine beta-synthase (CBS) | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | H2S | CYSTATHIONINE GAMMA-LYASE | IN-VITRO | INHIBITION | ERECTILE FUNCTION | CYCLIC-GMP | cystathionine gamma-lyase (CSE) | CARDIOVASCULAR-DISEASE | MICE | DYSFUNCTION | BETA-SYNTHASE | penile erection | Dose-Response Relationship, Drug | Hydrogen Sulfide - pharmacology | Penis - physiology | Animals | Penile Erection - drug effects | Humans | Male | Muscle, Smooth - physiology | Cysteine - metabolism | Muscle Relaxation - drug effects | Cysteine - physiology | Hydrogen sulfide | Physiological aspects | Muscle relaxation | Research | Biological Sciences | cystathionine β-synthase (CBS) | cystathionine γ-lyase (CSE)
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle
by Manson, Martijn L and Säfholm, Jesper and Al-Ameri, Mamdoh and Bergman, Per and Orre, Ann-Charlotte and Swärd, Karl and James, Anna and Dahlén, Sven-Erik and Adner, Mikael and Cellular Biomechanics and Klinisk och experimentell allergiforskning and Lund University and Clinical and Experimental Allergy Research and Lunds universitet and Cellulär biomekanik
European Journal of Pharmacology, ISSN 0014-2999, 10/2014, Volume 740, Issue Jul 15, pp. 302 - 311
Taste-sensing type 2 receptors (TAS2Rs) have been implicated in extraoral functions. Airway smooth muscle expresses TAS2Rs and is strongly relaxed by TAS2R... 
Human pulmonary artery | TP receptor | Vascular smooth muscle | Taste physiology | Taste-sensing type 2 receptors (TAS2Rs) | Airway smooth muscle | TAENIA-COLI | ACTIVATION | RAT | AORTA | SENSITIVITY | CALCIUM-ANTAGONISTS | CONTRACTION | PHARMACOLOGY & PHARMACY | CHANNELS | CAVEOLAE | GUINEA-PIG TRACHEA | Colon - physiology | Humans | Middle Aged | Colon - drug effects | Male | Trachea - drug effects | Receptors, G-Protein-Coupled - agonists | Chloroquine - pharmacology | Noscapine - pharmacology | Aorta, Thoracic - physiology | Quinine - pharmacology | Trachea - physiology | Female | Aorta, Thoracic - drug effects | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Receptors, G-Protein-Coupled - physiology | Dextromethorphan - pharmacology | Guinea Pigs | Pulmonary Artery - drug effects | Mice, Knockout | Pulmonary Artery - physiology | Animals | Aged | Mice | Taste | Muscle Relaxation - drug effects | In Vitro Techniques | Saccharin - pharmacology | Quaternary Ammonium Compounds - pharmacology | Animal experimentation | Smooth muscle | RNA | Basic Medicine | Farmakologi och toxikologi | Medical and Health Sciences | Pharmacology and Toxicology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Coupling of airway smooth muscle bitter taste receptors to intracellular signaling and relaxation is via Gαi1,2,3
by Kim, Donghwa and Woo, Jung A and Geffken, Ezekiel and An, Steven S and Liggett, Stephen B
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 06/2017, Volume 56, Issue 6, pp. 762 - 771
Bitter taste receptors (TAS2Rs) are expressed on human airway smooth muscle (HASM) and evoke marked relaxation. Agonist interaction with TAS2Rs activates... 
Bitter taste receptors | Chronic obstructive pulmonary disease | G proteins | Airway smooth muscle | Asthma | Amino Acid Sequence | Intracellular Space - drug effects | Receptors, G-Protein-Coupled - metabolism | Humans | Mice, Transgenic | Muscle, Smooth - metabolism | GTP-Binding Protein alpha Subunits, Gi-Go - chemistry | Protein Subunits - metabolism | Gene Knockdown Techniques | Peptides - pharmacology | Animals | Signal Transduction - drug effects | Intracellular Space - metabolism | HEK293 Cells | Lung - metabolism | Muscle Relaxation - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Pertussis Toxin - toxicity | RNA, Small Interfering - metabolism | Index Medicus | bitter taste receptors | airway smooth muscle | asthma | Original Research | chronic obstructive pulmonary disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Tunable stress relaxation behavior of an alginate-polyacrylamide hydrogel: Comparison with muscle tissue
by Fitzgerald, Martha M and Bootsma, Katherine and Berberich, Jason A and Sparks, Jessica L
Biomacromolecules, ISSN 1525-7797, 05/2015, Volume 16, Issue 5, pp. 1497 - 1505
Factors controlling the time-dependent mechanical properties of interpenetrating network (IPN) hydrogel Materials, ate net well understood. In this study,... 
CELLS | POLYMER SCIENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PROLIFERATION | COMPRESSION | RELEASE | MECHANICAL-PROPERTIES | NETWORK HYDROGELS | SKELETAL-MUSCLE | BIOLOGY | ACRYLAMIDE | STRAIN | Alginates - pharmacology | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Elastic Modulus - drug effects | Acrylic Resins - pharmacology | Biocompatible Materials - pharmacology | Hexuronic Acids - chemistry | Acrylic Resins - chemistry | Glucuronic Acid - pharmacology | Animals | Swine | Alginates - chemistry | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology | Stress, Physiological - drug effects | Muscle Relaxation - drug effects | Glucuronic Acid - chemistry | Hexuronic Acids - pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights