Nature, ISSN 0028-0836, 05/2011, Volume 473, Issue 7347, pp. 326 - 335
Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle...
SMOOTH-MUSCLE | THERAPY | PLOIDY LEVEL | DNA-CONTENT | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | CARDIAC MYOCYTES | FUNCTIONAL CARDIOMYOCYTES | DIFFERENTIATION | FIBROBLASTS | TRANSPLANTATION | Heart Failure - surgery | Myocytes, Cardiac - cytology | Heart - growth & development | Heart - physiology | Humans | Heart Failure - genetics | Heart Failure - pathology | Regeneration - physiology | Regenerative Medicine - methods | Cellular Reprogramming | Stem Cell Transplantation | Heart Failure - therapy | Myocytes, Cardiac - pathology | Animals | Regeneration - genetics | Heart failure | Care and treatment | Usage | Tissue engineering | Heart cells | Physiological aspects | Research | Proteins | Medical research | Rodents | Stem cells
SMOOTH-MUSCLE | THERAPY | PLOIDY LEVEL | DNA-CONTENT | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | CARDIAC MYOCYTES | FUNCTIONAL CARDIOMYOCYTES | DIFFERENTIATION | FIBROBLASTS | TRANSPLANTATION | Heart Failure - surgery | Myocytes, Cardiac - cytology | Heart - growth & development | Heart - physiology | Humans | Heart Failure - genetics | Heart Failure - pathology | Regeneration - physiology | Regenerative Medicine - methods | Cellular Reprogramming | Stem Cell Transplantation | Heart Failure - therapy | Myocytes, Cardiac - pathology | Animals | Regeneration - genetics | Heart failure | Care and treatment | Usage | Tissue engineering | Heart cells | Physiological aspects | Research | Proteins | Medical research | Rodents | Stem cells
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2006, Volume 47, Issue 9, pp. 1769 - 1776
Cardiac Regeneration Piero Anversa, Annarosa Leri, Jan Kajstura Heart homeostasis is regulated by a stem cell compartment characterized by multipotent cardiac...
MYOCARDIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTE PROLIFERATION | MULTIPOTENT | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | HEART-FAILURE | MUSCLE | CARDIOMYOCYTES | DIFFERENTIATION | EXPRESSION | Regeneration | Animals | Bone Marrow Cells - cytology | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Heart - physiology | Humans | Bone Marrow Cells - physiology | Cell Transplantation | Cell Differentiation | Multipotent Stem Cells - physiology | Myocardium - cytology | Heart failure | Fluorescence | Stem cells | Heart | Transcription factors | Rodents | Muscular system | Deoxyribonucleic acid--DNA | Apoptosis
MYOCARDIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTE PROLIFERATION | MULTIPOTENT | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | HEART-FAILURE | MUSCLE | CARDIOMYOCYTES | DIFFERENTIATION | EXPRESSION | Regeneration | Animals | Bone Marrow Cells - cytology | Heart Diseases - therapy | Myocytes, Cardiac - physiology | Heart - physiology | Humans | Bone Marrow Cells - physiology | Cell Transplantation | Cell Differentiation | Multipotent Stem Cells - physiology | Myocardium - cytology | Heart failure | Fluorescence | Stem cells | Heart | Transcription factors | Rodents | Muscular system | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Transplantation, ISSN 0041-1337, 08/2010, Volume 90, Issue 4, pp. 364 - 372
Background. We hypothesized that autologous skeletal cell (SC) sheets regenerate the infract myocardium in porcine heart as a preclinical trial. Methods and...
Heart failure | Myocardial infarction | Tissue | Transplantation | Cells | SURVIVAL | SURGERY | CARDIOMYOPLASTY | CARDIOMYOCYTE SHEETS | DIASTOLIC FUNCTION | HEART-FAILURE | IMMUNOLOGY | BIOENGINEERED CARDIAC GRAFTS | MYOBLAST SHEETS | REPAIR | GROWTH | CORONARY-ARTERY-DISEASE | Heart - physiopathology | Myocardial Contraction | Myocardial Infarction - surgery | Anesthesia - methods | Tissue Engineering - methods | Diastole | Muscle, Skeletal - transplantation | Tissue Engineering - trends | Myocardial Infarction - diagnostic imaging | Muscle, Skeletal - physiology | Regeneration - physiology | Stroke Volume | Animals | Myoblasts, Skeletal - transplantation | Swine | Guided Tissue Regeneration - methods | Myocardial Infarction - pathology | Systole - physiology | Ultrasonography | Myocardial Infarction - physiopathology | Anesthesia - veterinary
Heart failure | Myocardial infarction | Tissue | Transplantation | Cells | SURVIVAL | SURGERY | CARDIOMYOPLASTY | CARDIOMYOCYTE SHEETS | DIASTOLIC FUNCTION | HEART-FAILURE | IMMUNOLOGY | BIOENGINEERED CARDIAC GRAFTS | MYOBLAST SHEETS | REPAIR | GROWTH | CORONARY-ARTERY-DISEASE | Heart - physiopathology | Myocardial Contraction | Myocardial Infarction - surgery | Anesthesia - methods | Tissue Engineering - methods | Diastole | Muscle, Skeletal - transplantation | Tissue Engineering - trends | Myocardial Infarction - diagnostic imaging | Muscle, Skeletal - physiology | Regeneration - physiology | Stroke Volume | Animals | Myoblasts, Skeletal - transplantation | Swine | Guided Tissue Regeneration - methods | Myocardial Infarction - pathology | Systole - physiology | Ultrasonography | Myocardial Infarction - physiopathology | Anesthesia - veterinary
Journal Article
Cell and Tissue Research, ISSN 0302-766X, 3/2012, Volume 347, Issue 3, pp. 759 - 774
Skeletal muscle has a robust capacity for regeneration following injury. However, few if any effective therapeutic options for volumetric muscle loss are...
Human Genetics | Biomedicine | Proteomics | Stem cells | Molecular Medicine | Inflammation | Microenvironment | Repair | Skeletal muscle | MULTIPOTENT PROGENITOR CELLS | EXTRACELLULAR-MATRIX SCAFFOLDS | STRESS URINARY-INCONTINENCE | HEPATOCYTE GROWTH-FACTOR | MACROPHAGE-SECRETED FACTORS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BIAXIAL MECHANICAL-BEHAVIOR | MARROW-DERIVED CELLS | MYOGENIC REGULATORY FACTORS | DECELLULARIZED PERICARDIAL BIOMATERIAL | Animals | Muscle, Skeletal - immunology | Humans | Biomechanical Phenomena - physiology | Muscle, Skeletal - innervation | Stem Cells - cytology | Muscle, Skeletal - physiology | Wound Healing | Regeneration - physiology | Neovascularization, Physiologic | Muscle, Skeletal - blood supply | Muscles | Health aspects | Genetic disorders | Skeletal system | Muscular system | Inflammatory diseases
Human Genetics | Biomedicine | Proteomics | Stem cells | Molecular Medicine | Inflammation | Microenvironment | Repair | Skeletal muscle | MULTIPOTENT PROGENITOR CELLS | EXTRACELLULAR-MATRIX SCAFFOLDS | STRESS URINARY-INCONTINENCE | HEPATOCYTE GROWTH-FACTOR | MACROPHAGE-SECRETED FACTORS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BIAXIAL MECHANICAL-BEHAVIOR | MARROW-DERIVED CELLS | MYOGENIC REGULATORY FACTORS | DECELLULARIZED PERICARDIAL BIOMATERIAL | Animals | Muscle, Skeletal - immunology | Humans | Biomechanical Phenomena - physiology | Muscle, Skeletal - innervation | Stem Cells - cytology | Muscle, Skeletal - physiology | Wound Healing | Regeneration - physiology | Neovascularization, Physiologic | Muscle, Skeletal - blood supply | Muscles | Health aspects | Genetic disorders | Skeletal system | Muscular system | Inflammatory diseases
Journal Article
Immunity, ISSN 1074-7613, 03/2016, Volume 44, Issue 3, pp. 450 - 462
Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue repair, regeneration, and fibrosis. After tissue injury, monocytes and...
M2 MACROPHAGES | MURINE LIVER FIBROSIS | INJURED SPINAL-CORD | REGULATORY T-CELLS | GROWTH-FACTOR | IMMUNOLOGY | SKELETAL-MUSCLE REGENERATION | RENAL INJURY | MESENCHYMAL STEM-CELLS | RESIDENT MACROPHAGES | INNATE IMMUNITY | Macrophages - physiology | Regeneration | Phenotype | Animals | Macrophages - pathology | Humans | Fibrosis | Cell Communication | Cell Differentiation | Wound Healing | Macrophage Activation | Macrophages | Hair | Studies | Genotype & phenotype | Wound healing | Tissue engineering | Stem cells | Neutrophils | Fibroblasts | Growth factors | Apoptosis | Recruitment
M2 MACROPHAGES | MURINE LIVER FIBROSIS | INJURED SPINAL-CORD | REGULATORY T-CELLS | GROWTH-FACTOR | IMMUNOLOGY | SKELETAL-MUSCLE REGENERATION | RENAL INJURY | MESENCHYMAL STEM-CELLS | RESIDENT MACROPHAGES | INNATE IMMUNITY | Macrophages - physiology | Regeneration | Phenotype | Animals | Macrophages - pathology | Humans | Fibrosis | Cell Communication | Cell Differentiation | Wound Healing | Macrophage Activation | Macrophages | Hair | Studies | Genotype & phenotype | Wound healing | Tissue engineering | Stem cells | Neutrophils | Fibroblasts | Growth factors | Apoptosis | Recruitment
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 2011, Volume 105, Issue S 06, pp. S13 - S33
Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding...
acquired diseases with platelet involvement | wound healing | immunity | Platelets | inflammation | angiogenesis | Thrombosis and Haemostasis Supplement | Angiogenesis | Inflammation | Wound healing | Immunity | Acquired diseases with platelet involvement | SOLUBLE CD40 LIGAND | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | AMYLOID PRECURSOR PROTEIN | VON-WILLEBRAND-FACTOR | MATRIX METALLOPROTEINASES | NEUTROPHIL EXTRACELLULAR TRAPS | GLYCOPROTEIN IB-ALPHA | TOLL-LIKE RECEPTORS | P-SELECTIN | MUSCLE-CELL MIGRATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Blood Platelets - pathology | Alzheimer Disease - physiopathology | Atherosclerosis - pathology | Atherosclerosis - immunology | Blood Platelets - immunology | Atherosclerosis - physiopathology | Humans | Platelet Activation - physiology | Alzheimer Disease - pathology | Regeneration | Animals | Blood Platelets - metabolism | Neoplasms - immunology | Inflammation Mediators - metabolism | Neoplasms - physiopathology | Alzheimer Disease - immunology | Neoplasms - pathology
acquired diseases with platelet involvement | wound healing | immunity | Platelets | inflammation | angiogenesis | Thrombosis and Haemostasis Supplement | Angiogenesis | Inflammation | Wound healing | Immunity | Acquired diseases with platelet involvement | SOLUBLE CD40 LIGAND | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | AMYLOID PRECURSOR PROTEIN | VON-WILLEBRAND-FACTOR | MATRIX METALLOPROTEINASES | NEUTROPHIL EXTRACELLULAR TRAPS | GLYCOPROTEIN IB-ALPHA | TOLL-LIKE RECEPTORS | P-SELECTIN | MUSCLE-CELL MIGRATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Blood Platelets - pathology | Alzheimer Disease - physiopathology | Atherosclerosis - pathology | Atherosclerosis - immunology | Blood Platelets - immunology | Atherosclerosis - physiopathology | Humans | Platelet Activation - physiology | Alzheimer Disease - pathology | Regeneration | Animals | Blood Platelets - metabolism | Neoplasms - immunology | Inflammation Mediators - metabolism | Neoplasms - physiopathology | Alzheimer Disease - immunology | Neoplasms - pathology
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 07/2016, Volume 1863, Issue 7, pp. 1749 - 1759
Regenerating an injured heart holds great promise for millions of patients suffering from heart diseases. Since the human heart has very limited regenerative...
Cardiac reprogramming | Cardiomyocyte proliferation | Transplantation | Human PSC-based cellular therapies | Tissue engineering | Cardiac regeneration | ENGINEERED CARDIAC TISSUE | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | HIPPO PATHWAY | MUSCLE | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | DIFFERENTIATED CARDIOMYOCYTES | IN-VITRO | GENE-THERAPY | Heart | Embryonic stem cells | Cardiac patients | Index Medicus
Cardiac reprogramming | Cardiomyocyte proliferation | Transplantation | Human PSC-based cellular therapies | Tissue engineering | Cardiac regeneration | ENGINEERED CARDIAC TISSUE | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | HIPPO PATHWAY | MUSCLE | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | DIFFERENTIATED CARDIOMYOCYTES | IN-VITRO | GENE-THERAPY | Heart | Embryonic stem cells | Cardiac patients | Index Medicus
Journal Article