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Journal Article
Cell stem cell, ISSN 1934-5909, 2017, Volume 20, Issue 1, pp. 56 - 69
Satellite cells, the predominant stem cell population in adult skeletal muscle, are activated in response to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs... 
hypertrophy | Pax7 | exosomes | muscle | collagen | microRNA | fibrosis | muscle progenitor cells | extracellular matrix | satellite cells | FIBROSIS | REGENERATION | GENE-EXPRESSION | EXOSOMES | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | MIRNAS | SATELLITE CELL | DIFFERENTIATION | CONNECTIVE-TISSUE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Exosomes - drug effects | Exosomes - metabolism | NIH 3T3 Cells | Cell Survival - genetics | Extracellular Matrix - metabolism | MicroRNAs - metabolism | PAX7 Transcription Factor - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Stem Cells - metabolism | Gene Knockdown Techniques | Cell Differentiation - genetics | Extracellular Matrix - genetics | Cell Nucleus - metabolism | Gene Deletion | Collagen - genetics | Fibroblasts - metabolism | Cell Survival - drug effects | Ribonuclease III - metabolism | Extracellular Matrix - drug effects | Satellite Cells, Skeletal Muscle - metabolism | Down-Regulation - drug effects | Fibroblasts - pathology | Down-Regulation - genetics | Collagen - metabolism | Satellite Cells, Skeletal Muscle - drug effects | Animals | Carrier Proteins - metabolism | Muscle Development - drug effects | Cell Differentiation - drug effects | Models, Biological | Fibroblasts - drug effects | Muscle Fibers, Skeletal - pathology | Tamoxifen - pharmacology | Muscle Development - genetics | Stem Cells - drug effects | Mice | MicroRNAs - genetics | Muscle, Skeletal - pathology | Cell Nucleus - drug effects | Hypertrophy | miRNA | Dicer | Muscle extracellular matrix
Journal Article
The EMBO Journal, ISSN 1460-2075, 2006, Volume 25, Issue 24, pp. 5826 - 5839
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 21, pp. 14913 - 14924
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy... 
HYPERTROPHY | ALPHA-TOMATINE | ACTIVATION | MANAGEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOMATOES | SARCOPENIA | DEFICIENT MICE | EXPRESSION SIGNATURES | FAT MASS | PROTECTS | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondria, Muscle - metabolism | Drug Discovery - methods | Immunoblotting | Male | Multiprotein Complexes - genetics | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Tomatine - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Myoblasts, Skeletal - cytology | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Muscular Atrophy - prevention & control | Mitochondria, Muscle - genetics | Myoblasts, Skeletal - metabolism | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Cells, Cultured | Muscular Atrophy - genetics | Tomatine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Cell Line, Tumor | HL-60 Cells | Muscle Fibers, Skeletal - cytology | Mice | Mitochondria, Muscle - drug effects | Muscle, Skeletal - pathology | Myoblasts, Skeletal - drug effects | Skeletal Muscle | Skeletal Muscle Metabolism | Muscle Atrophy | Tomatidine | Metabolism | Systems Biology | mTOR complex (mTORC)
Journal Article
Journal Article
PLoS biology, ISSN 1544-9173, 02/2017, Volume 15, Issue 2, p. e1002597
.... Further investigation suggested that ncls achieves these beneficial effects by promoting a shift from glycolytic to oxidative muscle fibers in the DIO mice thereby enhancing mitochondrial respiration... 
ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | MITOCHONDRIAL BIOGENESIS | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | COACTIVATOR PGC-1 | BIOLOGY | FIBER-TYPE | AMPK | ENERGY-METABOLISM | INSULIN SENSITIVITY | AMARYLLIDACEAE ISOCARBOSTYRILS | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Obesity - drug therapy | Diet - adverse effects | Humans | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - drug effects | Protective Agents - therapeutic use | Membrane Potential, Mitochondrial - drug effects | Phenanthridines - pharmacology | Protective Agents - pharmacology | Adenosine Triphosphate - metabolism | Diet, High-Fat | Muscle, Skeletal - drug effects | Cell Respiration - drug effects | Oxidation-Reduction - drug effects | Cyclic AMP - metabolism | Fatty Acids - metabolism | Physical Conditioning, Animal | Biomarkers - metabolism | Phenanthridines - therapeutic use | Mice, Inbred C57BL | Cells, Cultured | Amaryllidaceae Alkaloids - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Obesity - metabolism | Animals | Signal Transduction - drug effects | Amaryllidaceae Alkaloids - therapeutic use | Mice | Adenosine Diphosphate - metabolism | Energy Metabolism - drug effects | Prevention | Muscles | Obesity | Alkaloids | Health aspects | Statistical analysis | Laboratories | Colleges & universities | Biology | Kinases | Metabolism | Fatty acids | Proteins | Medicine | Consortia | Musculoskeletal system | Weight control | Rodents | Spectrum analysis | Stem cells | Expenditures | Life sciences | Respiration | Bioinformatics
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2009, Volume 54, Issue 10, pp. 919 - 927
Journal Article
BMC medicine, ISSN 1741-7015, 03/2012, Volume 10, Issue 1, pp. 24 - 24
Background: Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1... 
Muscle | NMJ | Survival motor neuron protein | Fasudil | Spinal muscular atrophy | PROTEIN | fasudil | RHO-KINASE INHIBITOR | LIM-KINASE | SMN EXPRESSION | SINGLE NUCLEOTIDE | DEGENERATION | MEDICINE, GENERAL & INTERNAL | GENE | muscle | survival motor neuron protein | spinal muscular atrophy | ACTIN CYTOSKELETON | DIFFERENTIATION | NEUROMUSCULAR-JUNCTION | Anterior Horn Cells - drug effects | Spinal Cord - drug effects | Longevity - drug effects | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Muscle Fibers, Skeletal - drug effects | Survival of Motor Neuron 2 Protein - metabolism | Motor Neurons - pathology | Dose-Response Relationship, Drug | Motor Endplate - drug effects | Spinal Cord - pathology | Motor Endplate - pathology | Muscle, Skeletal - drug effects | Weight Gain - drug effects | Survival of Motor Neuron 2 Protein - deficiency | Muscular Atrophy, Spinal - physiopathology | Motor Neurons - drug effects | Disease Models, Animal | Muscle, Skeletal - growth & development | Mice, Inbred C57BL | Anterior Horn Cells - pathology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - administration & dosage | Muscular Atrophy, Spinal - pathology | Gait - drug effects | Phenotype | Animals | Muscle Development - drug effects | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Muscle, Skeletal - physiopathology | Muscle Fibers, Skeletal - pathology | Survival Analysis | Muscular Atrophy, Spinal - drug therapy | Mice | Spinal Cord - physiopathology | Muscle, Skeletal - pathology | Myogenin - metabolism | Motor Endplate - physiopathology | Prevention | Complications and side effects | Prognosis | Vasodilators | Patient outcomes | Dosage and administration | Infants | Research | Drug therapy | Atrophy, Muscular | Risk factors | Medical research | Musculoskeletal system | Pathogenesis | Laboratories | Colleges & universities | Mutation | Muscular system | FDA approval | Kinases | Drug dosages
Journal Article
British journal of pharmacology, ISSN 0007-1188, 2015, Volume 172, Issue 11, pp. 2782 - 2798
Journal Article
Journal Article