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Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 8, pp. 994 - 1003
.... Here, we report the rapid and efficient differentiation of human pluripotent stem cells into vascular endothelial and smooth muscle cells... 
DIRECTED DIFFERENTIATION | IN-VIVO | MOUSE | DEFINITIVE ENDODERM | GROWTH-FACTOR | HUMAN BLASTOCYSTS | STROMAL CELLS | WNT | CULTURE | LINES | CELL BIOLOGY | Coculture Techniques | Humans | Endothelial Cells - transplantation | Glycogen Synthase Kinase 3 beta | Cell Lineage - drug effects | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Transfection | Time Factors | Gene Expression Regulation, Developmental | Transcription, Genetic | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - transplantation | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Cell Line | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Myocytes, Smooth Muscle - enzymology | Induced Pluripotent Stem Cells - transplantation | Myocytes, Smooth Muscle - physiology | Gene Expression Profiling - methods | Muscle, Smooth, Vascular - transplantation | Glycogen Synthase Kinase 3 - metabolism | Mice, SCID | Muscle, Smooth, Vascular - cytology | Metabolomics - methods | Bone Morphogenetic Protein 4 - pharmacology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Endothelial Cells - drug effects | Usage | Cell research | Growth | Stem cells | Muscle cells | Research | Cell differentiation | Endothelium
Journal Article
Journal Article
Circulation research, ISSN 1524-4571, 2012, Volume 110, Issue 11, pp. 1484 - 1497
RATIONALE:Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction caused, in part, by pulmonary artery smooth muscle cell (PASMC) hyperproliferation... 
mitotic checkpoint | cyclin B1/cyclin-dependent kinase 1 | mitochondrial fission | hypoxia-inducible factor-1 | mitochondrial division inhibitor-1 | CARDIAC & CARDIOVASCULAR SYSTEMS | ENTRY | INDUCIBLE FACTOR 1-ALPHA | HYPOXIA | DRP1 | PATHWAY | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | GENE-EXPRESSION | GERMLINE MUTATIONS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | K+ CHANNELS | Antihypertensive Agents - pharmacology | Humans | Monocrotaline | Male | Cyclin B1 - metabolism | Cobalt | Hypertension, Pulmonary - therapy | CDC2 Protein Kinase - metabolism | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Myocytes, Smooth Muscle - drug effects | Hypertension, Pulmonary - enzymology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Myocytes, Smooth Muscle - enzymology | Dynamins - genetics | Rats | Familial Primary Pulmonary Hypertension | Hypoxia - complications | Rats, Sprague-Dawley | Pulmonary Artery - enzymology | Cell Cycle Checkpoints | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Mitochondria, Muscle - drug effects | Enzyme Activation | Hypertension, Pulmonary - etiology | Muscle, Smooth, Vascular - enzymology | Dynamins - metabolism | Phosphorylation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Serine | Myocytes, Smooth Muscle - pathology | Mitochondrial Proteins - genetics | Case-Control Studies | Transfection | Quinazolinones - pharmacology | Mitochondria, Muscle - enzymology | Mitochondria, Muscle - pathology | Cells, Cultured | Muscle, Smooth, Vascular - pathology | Animals | Mitosis - drug effects | Glycolysis | Cell Proliferation - drug effects | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Genetic Therapy - methods | Hypoxia-inducible factor 1 | CDK1-cyclin B1 | Mitochondrial division inhibitor-1 (Mdivi-1) | Mitochondrial fission | Mitotic check point
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2014, Volume 171, Issue 3, pp. 595 - 617
...) with a range of paracrine effects modulating vascular smooth muscle cell contraction, proliferation and migration... 
AMP‐activated protein kinase | atherosclerosis | adiponectin | perivascular fat | vascular reactivity | metformin | adipocytes | diabetes | leptin | hypertension | AMP-activated protein kinase | STIMULATES GLUCOSE-UTILIZATION | NITRIC-OXIDE SYNTHASE | ENDOTHELIUM-DEPENDENT RELAXATION | ENDOPLASMIC-RETICULUM STRESS | BROWN ADIPOSE-TISSUE | LOWERS BLOOD-PRESSURE | TUMOR-NECROSIS-FACTOR | AORTIC SMOOTH-MUSCLE | PHARMACOLOGY & PHARMACY | INDUCED CARDIAC-HYPERTROPHY | NF-KAPPA-B | Enzyme Activators - pharmacology | AMP-Activated Protein Kinases - metabolism | Vascular Diseases - pathology | Adipose Tissue, White - immunology | Muscle, Smooth, Vascular - metabolism | Enzyme Activators - therapeutic use | Humans | Adipose Tissue, White - metabolism | Muscle, Smooth, Vascular - immunology | Endothelium, Vascular - drug effects | Male | Autocrine Communication - drug effects | Adiposity | Female | Vascular Diseases - drug therapy | Adipose Tissue, Brown - immunology | Endothelium, Vascular - immunology | Muscle, Smooth, Vascular - drug effects | Adipose Tissue, White - pathology | Vascular Diseases - immunology | Enzyme Activation - drug effects | Adipose Tissue, Brown - pathology | Cardiovascular Agents - pharmacology | Cardiovascular Agents - therapeutic use | Muscle, Smooth, Vascular - pathology | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Models, Biological | Paracrine Communication - drug effects | Endothelium, Vascular - pathology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Vascular Diseases - metabolism | Adipose Tissue, White - drug effects | Blood circulation disorders | Protein kinases | Leptin | Atherosclerosis | Kinases | Metabolic disorders | Muscular system | Reactive oxygen species | Adipose tissue | Paracrine signalling | Smooth muscle | Adipocytes | Contraction | Protein turnover | Vascular diseases | Diabetes mellitus (non-insulin dependent) | Obesity | AMP | Cytokines | Therapeutic applications | Blood vessels | Vascular system | Muscle contraction | Protein kinase | Arteriosclerosis | Stromal cells | Metformin | Cardiovascular diseases | Thiazolidinediones | Cell migration | Review
Journal Article
Journal Article