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Circulation Research, ISSN 0009-7330, 05/2012, Volume 110, Issue 11, pp. 1484 - 1497
RATIONALE:Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction caused, in part, by pulmonary artery... 
mitotic checkpoint | cyclin B1/cyclin-dependent kinase 1 | mitochondrial fission | hypoxia-inducible factor-1 | mitochondrial division inhibitor-1 | CARDIAC & CARDIOVASCULAR SYSTEMS | ENTRY | INDUCIBLE FACTOR 1-ALPHA | HYPOXIA | DRP1 | PATHWAY | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | GENE-EXPRESSION | GERMLINE MUTATIONS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | K+ CHANNELS | Antihypertensive Agents - pharmacology | Humans | Monocrotaline | Male | Cyclin B1 - metabolism | Cobalt | Hypertension, Pulmonary - therapy | CDC2 Protein Kinase - metabolism | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Myocytes, Smooth Muscle - drug effects | Hypertension, Pulmonary - enzymology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Myocytes, Smooth Muscle - enzymology | Dynamins - genetics | Rats | Familial Primary Pulmonary Hypertension | Hypoxia - complications | Rats, Sprague-Dawley | Pulmonary Artery - enzymology | Cell Cycle Checkpoints | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Mitochondria, Muscle - drug effects | Enzyme Activation | Hypertension, Pulmonary - etiology | Muscle, Smooth, Vascular - enzymology | Dynamins - metabolism | Phosphorylation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Serine | Myocytes, Smooth Muscle - pathology | Mitochondrial Proteins - genetics | Case-Control Studies | Transfection | Quinazolinones - pharmacology | Mitochondria, Muscle - enzymology | Mitochondria, Muscle - pathology | Cells, Cultured | Muscle, Smooth, Vascular - pathology | Animals | Mitosis - drug effects | Glycolysis | Cell Proliferation - drug effects | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Genetic Therapy - methods | Hypoxia-inducible factor 1 | CDK1-cyclin B1 | Mitochondrial division inhibitor-1 (Mdivi-1) | Mitochondrial fission | Mitotic check point
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2015, Volume 17, Issue 8, pp. 994 - 1003
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant... 
DIRECTED DIFFERENTIATION | IN-VIVO | MOUSE | DEFINITIVE ENDODERM | GROWTH-FACTOR | HUMAN BLASTOCYSTS | STROMAL CELLS | WNT | CULTURE | LINES | CELL BIOLOGY | Coculture Techniques | Humans | Endothelial Cells - transplantation | Glycogen Synthase Kinase 3 beta | Cell Lineage - drug effects | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Transfection | Time Factors | Gene Expression Regulation, Developmental | Transcription, Genetic | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - transplantation | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Cell Line | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Myocytes, Smooth Muscle - enzymology | Induced Pluripotent Stem Cells - transplantation | Myocytes, Smooth Muscle - physiology | Gene Expression Profiling - methods | Muscle, Smooth, Vascular - transplantation | Glycogen Synthase Kinase 3 - metabolism | Mice, SCID | Muscle, Smooth, Vascular - cytology | Metabolomics - methods | Bone Morphogenetic Protein 4 - pharmacology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Endothelial Cells - drug effects | Usage | Cell research | Growth | Stem cells | Muscle cells | Research | Cell differentiation | Endothelium
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 02/2016, Volume 5, Issue 2, p. n/a
Background The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary... 
atherosclerosis | cardiovascular disease | inflammation | endothelial cell | nuclear factor‐κB signaling | vascular smooth muscle cell | leukocyte adhesion | trimethylamine N‐oxide | Endothelial cell | Trimethylamine N-oxide | Nuclear factor-κB signaling | Atherosclerosis | Cardiovascular disease | Leukocyte adhesion | Vascular smooth muscle cell | Inflammation | MICROBIAL-METABOLISM | CARDIAC & CARDIOVASCULAR SYSTEMS | HYDROSTATIC-PRESSURE | HEART-FAILURE | ADHESION MOLECULES | trimethylamine N-oxide | HUMAN ENDOTHELIAL-CELLS | L-CARNITINE | LYSOPHOSPHATIDIC ACID | CARDIOVASCULAR-DISEASE | PHOSPHATIDYLCHOLINE | nuclear factor-kappa B signaling | Atherosclerosis - genetics | Coculture Techniques | Humans | Myocytes, Smooth Muscle - pathology | Aortitis - enzymology | NF-kappa B - metabolism | Aortitis - chemically induced | Leukocytes - enzymology | Atherosclerosis - enzymology | Receptors, LDL - deficiency | Female | Aortitis - pathology | Myocytes, Smooth Muscle - drug effects | Aorta - enzymology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | Aorta - drug effects | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Aortitis - genetics | Cell Adhesion - drug effects | Mice, Knockout | Aorta - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Choline | Leukocytes - drug effects | Enzyme Activation | Methylamines - toxicity | Endothelial Cells - pathology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 09/2007, Volume 34, Issue 9, pp. 906 - 911
SUMMARY • Arginase is the focal enzyme of the urea cycle hydrolysingl-arginine to urea andl-ornithine. Emerging studies have identified arginase in the... 
smooth muscle cell proliferation | arginine | nitric oxide synthase | diabetes | endothelial dysfunction | hypertension | arginase | Hypertension | Arginine | Endothelial dysfunction | Smooth muscle cell proliferation | Arginase | Nitric oxide synthase | Diabetes | PHYSIOLOGY | LIVER ARGINASE | TRANSLATIONAL CONTROL | AMINO-ACID TRANSPORTER | INTIMAL HYPERPLASIA | ENDOTHELIAL-CELLS | SYNTHASE ACTIVITY | ARTERIAL-HYPERTENSION | L-ARGININE TRANSPORT | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | ISCHEMIA-REPERFUSION | Cardiovascular Diseases - physiopathology | Cell Proliferation | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Arginase - metabolism | Endothelium, Vascular - physiopathology | Homeostasis | Cardiovascular Diseases - enzymology | Endothelium, Vascular - enzymology | Muscle, Smooth, Vascular - physiopathology | Arginine - analogs & derivatives | Collagen - metabolism | Animals | Endothelium, Vascular - metabolism | Urea - metabolism | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Muscle, Smooth, Vascular - enzymology | Arginine - metabolism | Muscle, Smooth, Vascular, metabolism | Collagen, metabolism | Endothelium, Vascular, physiopathology | Arginine, analogs and derivatives | Nitric Oxide, metabolism | Endothelium, Vascular, metabolism | Urea, metabolism | Nitric Oxide Synthase Type III, metabolism | Arginine, metabolism | Cardiovascular Diseases, enzymology | Endothelium, Vascular, enzymology | Muscle, Smooth, Vascular, physiopathology | Cardiovascular Diseases, physiopathology | Cardiovascular Diseases, metabolism | Arginase, metabolism | Muscle, Smooth, Vascular, enzymology | Reactive Oxygen Species, metabolism | Deicing chemicals | Physiological aspects | Endothelium-derived relaxing factors | Nitric oxide
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 05/2015, Volume 30, Issue 5, pp. 824 - 836
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2009, Volume 29, Issue 4, pp. 480 - 487
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2016, Volume 31, Issue 10, pp. 1865 - 1876
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2012, Volume 32, Issue 11, pp. 2580 - 2588
OBJECTIVE—Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the deficiency of cartilage... 
Smooth muscle cell | Calcification | Animal model of human disease remodeling | MicroRNA | Protease | animal model of human disease remodeling | CELLS | smooth muscle cell | PATHOBIOLOGY | MECHANISMS | OLIGOMERIC MATRIX PROTEIN | protease | PHOSPHATE | IN-VITRO | ROLES | ARTERIAL CALCIFICATION | ANEURYSM DEVELOPMENT | microRNA | PERIPHERAL VASCULAR DISEASE | calcification | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | Up-Regulation | Carotid Artery Diseases - chemically induced | Humans | MicroRNAs - metabolism | Matrilin Proteins | Nephrectomy | RNA Interference | Time Factors | Carotid Artery Diseases - pathology | Transcription, Genetic | 3' Untranslated Regions | Real-Time Polymerase Chain Reaction | Organ Culture Techniques | Disease Models, Animal | Uremia - enzymology | Myocytes, Smooth Muscle - enzymology | Down-Regulation | Computational Biology | Rats | Vascular Calcification - pathology | Rats, Sprague-Dawley | Kidney Failure, Chronic - genetics | ADAM Proteins - metabolism | Aortic Diseases - genetics | Carotid Artery Diseases - enzymology | Carotid Artery, Common - enzymology | Carotid Artery Diseases - genetics | Kidney Failure, Chronic - complications | ADAMTS7 Protein | Carotid Artery, Common - pathology | ADAM Proteins - genetics | Muscle, Smooth, Vascular - enzymology | Vascular Calcification - genetics | Glycoproteins - metabolism | Myocytes, Smooth Muscle - pathology | Aortic Diseases - chemically induced | Transfection | Uremia - pathology | Female | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Aorta, Abdominal - pathology | Kidney Failure, Chronic - enzymology | Extracellular Matrix Proteins - metabolism | Aortic Diseases - pathology | Promoter Regions, Genetic | Calcium Chloride | Cartilage Oligomeric Matrix Protein | Cells, Cultured | Aorta, Abdominal - enzymology | Gene Expression Regulation, Enzymologic | Muscle, Smooth, Vascular - pathology | Animals | Vascular Calcification - chemically induced
Journal Article