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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2010, Volume 30, Issue 6, pp. 1118 - 1126
OBJECTIVE—Regulation of vascular smooth muscle (VSM) proliferation and contractile differentiation is an important factor in vascular development and... 
Molecular biology | Contractile proteins | Vascular biology | Vascular muscle | molecular biology | ACTIVATION | PHENOTYPE | vascular biology | ACTIN DYNAMICS | PROLIFERATION | DICER | vascular muscle | MOUSE DEVELOPMENT | NEOINTIMAL LESION FORMATION | EMBRYONIC STEM-CELLS | SERUM RESPONSE FACTOR | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | contractile proteins | Endoribonucleases - genetics | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Transcriptional Activation | Actins - metabolism | Male | MicroRNAs - metabolism | Aorta - metabolism | Muscle, Smooth, Vascular - physiopathology | Muscle, Smooth, Vascular - embryology | Cell Differentiation - genetics | Vasodilation - genetics | Transfection | Gene Expression Regulation, Developmental | DEAD-box RNA Helicases - deficiency | Trans-Activators - genetics | Hemorrhage - embryology | Endoribonucleases - deficiency | Nuclear Proteins - genetics | Microfilament Proteins - genetics | Vasoconstriction - genetics | Liver Diseases - embryology | Hemorrhage - genetics | Liver Diseases - genetics | Umbilical Arteries - pathology | Muscle, Smooth, Vascular - ultrastructure | Cells, Cultured | Umbilical Arteries - embryology | Aorta - embryology | Genotype | Nuclear Proteins - metabolism | Hemorrhage - metabolism | Gestational Age | Mice, Knockout | Aorta - pathology | Muscle Proteins - genetics | DEAD-box RNA Helicases - genetics | Embryo Loss | Phenotype | Stress Fibers - metabolism | Animals | Ribonuclease III | Muscle Development - genetics | Trans-Activators - metabolism | Mice | Liver Diseases - metabolism | Integrases - genetics | Umbilical Arteries - metabolism | Index Medicus
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 11/2004, Volume 95, Issue 10, pp. 989 - 997
Stimulation of α1-adrenoceptors induces proliferation of vascular smooth muscle cells (SMCs) and contributes to arterial remodeling. Although activation of... 
Vascular smooth muscle cell proliferation | Signal transduction | α-adrenergic receptor | Reactive oxygen species | Metalloproteinase | ADVENTITIAL FIBROBLASTS | CARDIAC & CARDIOVASCULAR SYSTEMS | signal transduction | HB-EGF | metalloproteinase | PROTEIN-COUPLED RECEPTORS | ANGIOTENSIN-II | CELL REPLICATION | vascular smooth muscle cell proliferation | MATRIX METALLOPROTEINASES | IN-VITRO | SIGNALING PATHWAY | RAT CAROTID-ARTERY | reactive oxygen species | BALLOON INJURY | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | alpha-adrenergic receptor | Glycine - analogs & derivatives | MAP Kinase Signaling System - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Adrenergic alpha-1 Receptor Agonists | Receptor, Epidermal Growth Factor - drug effects | MAP Kinase Kinase 1 - physiology | Quinazolines | Phenylephrine - pharmacology | Thrombin - pharmacology | Protein Processing, Post-Translational - drug effects | Cell Division | Flavonoids - pharmacology | Phosphorylation - drug effects | Benzopyrans - pharmacology | Myocytes, Smooth Muscle - drug effects | Receptor, Epidermal Growth Factor - physiology | Hydroxamic Acids - pharmacology | Myocytes, Smooth Muscle - cytology | Aorta, Thoracic - pathology | Organ Culture Techniques | Receptors, Adrenergic, alpha-1 - physiology | Butadienes - pharmacology | Mitogen-Activated Protein Kinase 1 - physiology | Myocytes, Smooth Muscle - enzymology | Dipeptides - pharmacology | Rats | Aorta, Thoracic - injuries | Imidazoles - pharmacology | Tyrphostins - pharmacology | Muscle, Smooth, Vascular - cytology | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - physiology | Bacterial Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Glycine - pharmacology | Catheterization - adverse effects | Pyridines - pharmacology | Index Medicus
Journal Article
by Sun, Y and Gao, Y and Song, T and Yu, CW and Nie, ZL and Wang, XG
EXPERIMENTAL AND THERAPEUTIC MEDICINE, ISSN 1792-0981, 07/2019, Volume 18, Issue 1, pp. 77 - 84
As an atherosclerotic disease, the process of peripheral arterial disease (PAD) is complicated and includes the abnormal proliferation of vascular smooth... 
INSULIN | MEDICINE, RESEARCH & EXPERIMENTAL | human vascular smooth muscle cells | insulin-like growth factor 1 receptor | microRNA-15b | GENE-EXPRESSION | peripheral arterial disease
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2015, Volume 464, Issue 1, pp. 57 - 62
Mammalian target of rapamycin complex (mTORC) regulates various cellular processes including proliferation, growth, migration and differentiation. In this... 
mTOR | Phenotype | Rapamycin | VSMC | PDGF | FACTOR-BB | MECHANISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | BIOPHYSICS | PRAS40 | DISEASE | GENES | CELL-DIFFERENTIATION | INHIBITOR | MODULATION | RNA, Small Interfering - genetics | Muscle, Smooth, Vascular - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - antagonists & inhibitors | Aorta - metabolism | Phosphoproteins - metabolism | Platelet-Derived Growth Factor - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Myocytes, Smooth Muscle - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Muscle, Smooth, Vascular - drug effects | Rapamycin-Insensitive Companion of mTOR Protein | Angiotensin II - pharmacology | Aorta - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Rats | Phosphoproteins - genetics | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Sirolimus - pharmacology | Carrier Proteins - genetics | Cell Movement - drug effects | Platelet-Derived Growth Factor - metabolism | Animals | Carrier Proteins - metabolism | Cell Proliferation - drug effects | Aorta - cytology | Primary Cell Culture | RNA, Small Interfering - metabolism | Medical colleges | Smooth muscle | Genetic aspects | Platelet-derived growth factor | Gene expression | Angiotensin | Index Medicus | STIMULATION | CONVERSION | PHENOTYPE | SIGNALS | 60 APPLIED LIFE SCIENCES | ANGIOTENSIN | GROWTH FACTORS | INHIBITION | CONTRACTION | DOSES | MUSCLES | PLANT GROWTH
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1120 - 1132
RATIONALE:Neointimal hyperplasia characterized by abnormal accumulation of vascular smooth muscle cells (SMCs) is a hallmark of occlusive disorders such as... 
Smooth muscle cell | Cyclic nucleotide phosphodiesterases, type 1C | Neointima formation | neointima formation | CARDIAC & CARDIOVASCULAR SYSTEMS | smooth muscle cell | TYROSINE PHOSPHORYLATION | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | DEPENDENT PROTEIN-KINASE | cyclic nucleotide phosphodiesterases, type 1C | CORONARY-ARTERY | ELUTING STENTS | CORECEPTOR FUNCTION | MEDIATED ENDOCYTOSIS | MOUSE MODEL | BETA PDGFR-BETA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MACROPHAGE DIFFERENTIATION | Humans | Male | Lysosomes - physiology | Cyclic AMP - physiology | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | RNA Interference | Proteolysis | Cell Division | Neointima - enzymology | Models, Animal | Protein Stability | Myocytes, Smooth Muscle - cytology | Cyclic Nucleotide Phosphodiesterases, Type 1 - physiology | Carotid Artery Injuries - pathology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Enzyme Induction | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Rats | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Endocytosis - physiology | Mice, Knockout | Protein Interaction Mapping | Neointima - physiopathology | Cyclic Nucleotide Phosphodiesterases, Type 1 - deficiency | Animals | Carotid Artery Injuries - enzymology | Signal Transduction - physiology | Mice | Cell Movement | Index Medicus | smooth muscle cells | phosphodiesterase | cyclic nucleotide | and neointimal hyperplasia
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2011, Volume 339, Issue 2, pp. 394 - 402
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2014, Volume 115, Issue 10, pp. 1752 - 1761
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2010, Volume 285, Issue 41, pp. 31829 - 31839
Stretch of the vascular wall stimulates smooth muscle hypertrophy by activating the MAPK and Rho/Rho kinase (ROK) pathways. We investigated the role of calcium... 
CARDIOVASCULAR DEVELOPMENT | MYOCARDIN | OPERATED CA2+ ENTRY | ACTIVATION | ACTIN POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GENE-EXPRESSION | CELL-PROLIFERATION | PROTEINS | TRANSCRIPTION FACTOR | Phosphorylation - physiology | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Cell Membrane - genetics | Gene Knockdown Techniques | Lim Kinases - metabolism | RNA, Messenger - biosynthesis | Nuclear Proteins - biosynthesis | rho-Associated Kinases - metabolism | Trans-Activators - genetics | Female | Cell Membrane - metabolism | Trans-Activators - biosynthesis | Cofilin 2 - genetics | Nuclear Proteins - genetics | Cell Differentiation - physiology | Portal Vein - cytology | MEF2 Transcription Factors | Portal Vein - metabolism | Histone Deacetylases - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Myogenic Regulatory Factors - genetics | Proto-Oncogene Proteins c-jun - genetics | rho GTP-Binding Proteins - genetics | RNA, Messenger - genetics | Proto-Oncogene Proteins c-fos - metabolism | Gene Expression Regulation - physiology | Myogenic Regulatory Factors - metabolism | rho-Associated Kinases - genetics | Histone Deacetylases - metabolism | Muscle, Smooth, Vascular - cytology | Cofilin 2 - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Proto-Oncogene Proteins c-jun - metabolism | rho GTP-Binding Proteins - metabolism | Lim Kinases - genetics | Proto-Oncogene Proteins c-fos - genetics | Signal Transduction - physiology | Mice | Index Medicus | Gene Regulation | Transcription Coactivators | MEF2 | Protein Synthesis | Signal Transduction | Calcium Channels | Actin | Rho | Cytoskeleton | siRNA | Myocardin | Smooth Muscle | Basic Medicine | Physiology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Fysiologi
Journal Article
14.