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1991, Handbook of clinical neurology, ISBN 9780444812780, Volume rev. ser., 15 = v. 59., xiii, 529
Book
Neurology, ISSN 0028-3878, 03/2016, Volume 86, Issue 10, pp. 890 - 897
OBJECTIVE:To examine safety, tolerability, pharmacokinetics, and preliminary clinical efficacy of intrathecal nusinersen (previously ISIS-SMNRx), an antisense... 
PUNCTURE HEADACHE | ANTISENSE OLIGONUCLEOTIDE | FUNCTIONAL MOTOR SCALE | CLINICAL NEUROLOGY | Injections, Spinal | Muscular Atrophy, Spinal - diagnosis | Follow-Up Studies | Humans | Child, Preschool | Male | Dose-Response Relationship, Drug | Adolescent | Female | Muscular Atrophy, Spinal - drug therapy | Oligonucleotides - administration & dosage | Child | Cohort Studies | 324 | 117 | 227 | 252
Journal Article
Journal Article
11/2018, Advances in Experimental Medicine and Biology, ISBN 9789811314346, Volume 1088, 618
The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including... 
Molecular Medicine | Biomedicine | Human Physiology | Cell Biology
eBook
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 44, pp. 16260 - 16265
Maintaining muscle size and fiber composition requires contractile activity. Increased activity stimulates expression of the transcriptional coactivator PGC-1α... 
Fasting | Messenger RNA | Transgenic animals | Genes | Muscles | Muscle fibers | Diabetes | Muscular atrophy | Skeletal muscle | Denervation | SIGNALING PATHWAYS | denervation | muscle fiber | mitochondria | MULTIDISCIPLINARY SCIENCES | RATS | fasting | EXERCISE | FOOD-DEPRIVATION | COACTIVATOR PGC-1 | GROWTH | DEGRADATION | EXPRESSION | energy metabolism | DENERVATION ATROPHY | UBIQUITIN-PROTEASOME PATHWAY
Journal Article
The Journal of Physiology, ISSN 0022-3751, 10/2014, Volume 592, Issue 20, pp. 4575 - 4589
Key points Oxidative stress is widely considered a major cause of muscle loss not only in disuse but also in most chronic diseases, triggering carbonylation of... 
TIBIALIS ANTERIOR | SKELETAL-MUSCLE | GAMMA COACTIVATOR 1-ALPHA | OXIDATIVE STRESS | PHYSIOLOGY | MITOCHONDRIAL BIOGENESIS | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | UBIQUITIN LIGASES | PROTEIN-SYNTHESIS | NEUROSCIENCES | ANTIOXIDANT CAPACITY | Up-Regulation | Dynamins - metabolism | Superoxide Dismutase - genetics | Oxidative Stress | SKP Cullin F-Box Protein Ligases - genetics | Mitochondria, Muscle - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Autophagy | Tripartite Motif Proteins | Chromans - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | NF-E2-Related Factor 2 - genetics | Muscular Atrophy - prevention & control | Muscle Fibers, Skeletal - physiology | Superoxide Dismutase - metabolism | Beclin-1 | Muscular Atrophy - metabolism | Catalase - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Dynamins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Catalase - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Hindlimb Suspension - adverse effects | NF-E2-Related Factor 2 - metabolism | Mice | Mitochondria, Muscle - drug effects | Superoxide Dismutase-1 | Ubiquitin-Protein Ligases - genetics | Muscle
Journal Article
Neurologic Clinics, ISSN 0733-8619, 11/2015, Volume 33, Issue 4, pp. 831 - 846
Spinal muscular atrophy is an autosomal-recessive disorder characterized by degeneration of motor neurons in the spinal cord and caused by mutations in the... 
SMN2 | Motor neuron | Survival motor neuron gene | SMN1 | Spinal muscular atrophy | TERM VENTILATORY SUPPORT | MUSCLE ATROPHY | SURVIVAL-MOTOR-NEURON | NATURAL-HISTORY | RESPIRATORY MANAGEMENT | NEUROSCIENCES | CLINICAL NEUROLOGY | INTRONIC REPRESSOR | MOUSE MODEL | ANIMAL-MODEL | CONSENSUS STATEMENT | NONINVASIVE VENTILATION
Journal Article