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JAMA : the journal of the American Medical Association, ISSN 0098-7484, 06/2011, Volume 305, Issue 22, pp. 2304 - 2310
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | MutL Protein Homolog 1 | Age Factors | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Incidence | Ovarian Neoplasms - genetics | Young Adult | Endometrial Neoplasms - genetics | Aged, 80 and over | Germ-Line Mutation | Adult | Female | Nuclear Proteins - genetics | Colorectal Neoplasms - epidemiology | France - epidemiology | Genetic Predisposition to Disease | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Genotype | MutS Homolog 2 Protein - genetics | Endometrial Neoplasms - epidemiology | DNA-Binding Proteins - genetics | Ovarian Neoplasms - epidemiology | Adaptor Proteins, Signal Transducing - genetics | Aged | Bacteria | Mutation | Womens health | Risk factors | Colorectal cancer | Ovarian cancer
Journal Article
Journal of clinical oncology, ISSN 0732-183X, 04/2017, Volume 35, Issue 10, pp. 1086 - 1095
Life Sciences & Biomedicine | Oncology | Science & Technology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Colorectal Neoplasms - chemistry | DNA-Binding Proteins - analysis | Male | Tumor Suppressor Protein p53 - genetics | Young Adult | Checkpoint Kinase 2 - genetics | DNA Mutational Analysis | Tumor Suppressor Proteins - genetics | Epithelial Cell Adhesion Molecule - genetics | Aged, 80 and over | Genes, BRCA2 | Germ-Line Mutation | Adult | Female | Genes, BRCA1 | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Adenomatous Polyposis Coli Protein - genetics | Genetic Predisposition to Disease | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Mismatch Repair Endonuclease PMS2 - analysis | DNA Glycosylases - genetics | Penetrance | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | Genes, p16 | MutL Protein Homolog 1 - analysis | MutL Protein Homolog 1 - genetics | Aged | MutS Homolog 2 Protein - analysis | Mismatch Repair Endonuclease PMS2 - genetics | Epithelial Cell Adhesion Molecule - analysis | Index Medicus | Genetic epidemiology | Epidemiology | Hereditary Cancers & Genetic Predisposition | ORIGINAL REPORTS
Journal Article
Molecular cell, ISSN 1097-2765, 09/2015, Volume 59, Issue 5, pp. 831 - 839
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Adaptor Proteins, Signal Transducing - chemistry | Chromatin - metabolism | MutL Protein Homolog 1 | Microsatellite Instability | Humans | Minichromosome Maintenance Proteins - metabolism | DNA Mismatch Repair - genetics | MutS Homolog 2 Protein - metabolism | DNA-Binding Proteins - metabolism | DNA Mismatch Repair - physiology | Base Sequence | Minichromosome Maintenance Proteins - genetics | MutS Homolog 3 Protein | Minichromosome Maintenance Proteins - deficiency | Nuclear Proteins - genetics | DNA Helicases - genetics | DNA Helicases - chemistry | Nuclear Proteins - metabolism | MutS Homolog 2 Protein - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | Gene Knockout Techniques | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | MutS Homolog 2 Protein - chemistry | DNA - genetics | DNA Helicases - metabolism | Adaptor Proteins, Signal Transducing - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Chromatin - genetics | Proteins | Excavating machinery | DNA replication | Escherichia coli | Genomics | DNA | Index Medicus | Life Sciences | Genetics
Journal Article
JAMA oncology, ISSN 2374-2437, 09/2017, Volume 3, Issue 9, pp. 1190 - 1196
Life Sciences & Biomedicine | Oncology | Science & Technology | Genetic Testing | Humans | Middle Aged | DNA Repair Enzymes - genetics | Case-Control Studies | Cyclin-Dependent Kinase Inhibitor p16 | Ovarian Neoplasms - genetics | Checkpoint Kinase 2 - genetics | MRE11 Homologue Protein | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Germ-Line Mutation | Adult | Female | RNA Helicases - genetics | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Risk Factors | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | Fanconi Anemia Complementation Group Proteins | Phenotype | Breast Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p18 - genetics | MutL Protein Homolog 1 - genetics | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Mismatch Repair Endonuclease PMS2 - genetics | Neurofibromin 1 - genetics
Journal Article
Clinical cancer research, ISSN 1078-0432, 06/2017, Volume 23, Issue 11, pp. e32 - e37
Life Sciences & Biomedicine | Oncology | Science & Technology | Microsatellite Instability | Neoplastic Syndromes, Hereditary - pathology | Colorectal Neoplasms - genetics | Humans | Brain Neoplasms - pathology | Germ-Line Mutation - genetics | MutL Protein Homolog 1 - deficiency | Colorectal Neoplasms - diagnosis | DNA-Binding Proteins - deficiency | Neoplastic Syndromes, Hereditary - epidemiology | MutS Homolog 2 Protein - deficiency | Neoplastic Syndromes, Hereditary - genetics | Child | Mismatch Repair Endonuclease PMS2 - deficiency | Colorectal Neoplasms - epidemiology | Early Detection of Cancer | Brain Neoplasms - diagnosis | Brain Neoplasms - genetics | Neoplastic Syndromes, Hereditary - diagnosis | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | MutL Protein Homolog 1 - genetics | Colorectal Neoplasms - pathology | Mismatch Repair Endonuclease PMS2 - genetics | Brain Neoplasms - epidemiology | Yeast | MLH1 protein | Therapeutic applications | Genes | Organs | MSH2 protein | Disorders | Health risks | MSH6 protein | Exonuclease | Surveillance | Proofreading | Mismatch repair | Replication | Diagnostic systems | Mutation | Children | Genetic recombination | Repair | DNA-directed DNA polymerase | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
Human mutation, ISSN 1059-7794, 06/2011, Volume 32, Issue 6, pp. 661 - 668
SIFT | MSH2 | Xvar | multiple sequence alignment | BRCA1 | MLH1 | Align‐GVGD | TP53 | PolyPhen‐2 | Multiple sequence alignment | Align-GVGD | PolyPhen-2 | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | MutL Protein Homolog 1 | Humans | Computational Biology | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | MutS Homolog 2 Protein - genetics | MutS Homolog 2 Protein - metabolism | Mutation, Missense - genetics | Tumor Suppressor Protein p53 - genetics | BRCA1 Protein - genetics | Sequence Alignment - methods | Sequence Analysis, Protein | Algorithms | BRCA1 Protein - metabolism | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | Nuclear Proteins - genetics | Genes, Tumor Suppressor | Missense mutation | BRCA1 protein | MLH1 protein | Nucleotide sequence | MSH2 protein | Evolution | Protein structure | p53 protein | Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2014, Volume 147, Issue 6, pp. 1308 - 1316.e1
Gastroenterology and Hepatology | dMMR | Genomic Instability | MSI | Colon Cancer | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | MutL Protein Homolog 1 | Cell Adhesion Molecules - genetics | Colonic Neoplasms - genetics | Microsatellite Instability | DNA Polymerase III - genetics | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | DNA Mismatch Repair - genetics | Epithelial Cell Adhesion Molecule | Poly-ADP-Ribose Binding Proteins | Endometrial Neoplasms - genetics | Aged, 80 and over | Germ-Line Mutation | Adult | Female | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - genetics | DNA Polymerase II - genetics | Antigens, Neoplasm - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Adenosine Triphosphatases - genetics | Aged | Proteins | Endometrial cancer | Gene mutations | Medical genetics | Genetic research | Genetic aspects | Diagnosis | Cancer | Index Medicus | Abridged Index Medicus | genomic instability | colon cancer
Journal Article
Biomedical Journal, ISSN 2319-4170, 02/2017, Volume 40, Issue 1, pp. 39 - 48
Colon cancer | MSH2 | MLH1 | Mismatch repair | CEA | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Prognosis | Humans | Middle Aged | Colonic Neoplasms - diagnosis | Male | Nuclear Proteins - metabolism | Survival Rate | MutS Homolog 2 Protein - genetics | DNA Repair - genetics | MutS Homolog 2 Protein - metabolism | Mutation - genetics | Neoplasm Staging - methods | Neoplasm Metastasis - genetics | Adenocarcinoma - diagnosis | MutL Protein Homolog 1 - genetics | Adult | Female | Adenocarcinoma - genetics | Aged | MutL Protein Homolog 1 - metabolism | Nuclear Proteins - genetics | Disease | p53 Protein | Colorectal cancer | Homology | Metastasis | Multivariate analysis | Lymph nodes | Metastases | Proteins | Genotype & phenotype | Carcinoembryonic antigen | Epidermal growth factor | Colon | Growth factors | Lymphatic system | MLH1 protein | MSH2 protein | Histology | Patients | Survival | Chemotherapy | Medical prognosis | Surgeons | Biomarkers | Mutation | Cancer | Tumors | Index Medicus | Original
Journal Article
Gynecologic oncology, ISSN 0090-8258, 2013, Volume 130, Issue 1, pp. 121 - 126
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Immunohistochemistry | Genetic counseling | Microsatellite instability | Genetic testing | Endometrial cancer | Lynch syndrome | Oncology | Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | MutL Protein Homolog 1 | MutS Homolog 2 Protein - biosynthesis | Early Detection of Cancer - methods | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | DNA Repair Enzymes - genetics | Genetic Counseling | DNA-Binding Proteins - deficiency | Endometrial Neoplasms - genetics | Nuclear Proteins - biosynthesis | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Adenosine Triphosphatases - biosynthesis | MutS Homolog 2 Protein - deficiency | Nuclear Proteins - deficiency | Female | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - genetics | DNA Repair Enzymes - deficiency | Microsatellite Repeats | Adenosine Triphosphatases - deficiency | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | MutS Homolog 2 Protein - genetics | Academic Medical Centers | DNA-Binding Proteins - genetics | Endometrial Neoplasms - diagnosis | Adaptor Proteins, Signal Transducing - deficiency | DNA Repair Enzymes - biosynthesis | Adaptor Proteins, Signal Transducing - genetics | Endometrial Neoplasms - pathology | Adaptor Proteins, Signal Transducing - biosynthesis | Adenosine Triphosphatases - genetics | DNA-Binding Proteins - biosynthesis | Diagnosis | Medical centers | Cancer | Index Medicus
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 3/1994, Volume 263, Issue 5153, pp. 1625 - 1629
Polymerase chain reaction | Complementary DNA | Genes | Genomics | Cell lines | Reports | Codons | Hereditary nonpolyposis colorectal neoplasms | Genetic mutation | Chromosomes | DNA mismatch repair | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | MutL Protein Homolog 1 | Sequence Deletion | Frameshift Mutation | Humans | MutL Proteins | Open Reading Frames | Bacterial Proteins - chemistry | Molecular Sequence Data | Male | Chromosomes, Human, Pair 3 | Codon | Base Sequence | Polymerase Chain Reaction | Female | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Carrier Proteins | DNA-Binding Proteins | Amino Acid Sequence | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Bacterial Proteins - genetics | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Chromosome Mapping | Genetic Markers | MutS Homolog 2 Protein | Nuclear Proteins | Adaptor Proteins, Signal Transducing | Escherichia coli Proteins | Adenosine Triphosphatases | DNA Repair | Mutation | Genetic aspects | Genetic disorders | Research | Colorectal cancer | Medical genetics | Cancer | Medical research | Genetics | Colon cancer | Index Medicus
Journal Article
Molecular cancer research, ISSN 1541-7786, 12/2010, Volume 8, Issue 12, pp. 1633 - 1642
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | MutS Homolog 2 Protein - antagonists & inhibitors | Up-Regulation | MutS Homolog 2 Protein - biosynthesis | Epithelial Cells - metabolism | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - administration & dosage | MutS Homolog 2 Protein - metabolism | Breast Neoplasms - metabolism | Genes, p53 | Transfection | DNA Mismatch Repair | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Promoter Regions, Genetic | MicroRNAs - administration & dosage | Down-Regulation | Epithelial Cells - pathology | Smad Proteins - genetics | MutS Homolog 2 Protein - genetics | Breast Neoplasms - drug therapy | Transforming Growth Factor beta - pharmacology | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | MicroRNAs - genetics | DNA Damage | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Cell Line, Transformed | Index Medicus | TGF-β | breast cancer | chemoresistance | MSH2 | DNA mismatch repair
Journal Article