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Cancer Cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 516 - 532
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 17 - 26
Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency.... 
adoptive T cell therapy | 4-1BB | chimeric antigen receptor | costimulation | T cells | adoptive T cell therapy | ACTIVATION | LIGAND EXPRESSION | CAR | EFFECTOR FUNCTION | GENE-EXPRESSION | FAS | DEATH | ANTITUMOR-ACTIVITY | NF-KAPPA-B | SIGNALING COMPLEX | CELL BIOLOGY | Neoplasm Transplantation | Humans | Mutant Chimeric Proteins - genetics | NF-kappa B - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Leukemia-Lymphoma, Adult T-Cell - immunology | Lentivirus - metabolism | fas Receptor - immunology | Cell Death | fas Receptor - genetics | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | 4-1BB Ligand - immunology | T-Lymphocytes - pathology | 4-1BB Ligand - genetics | Antigens, Neoplasm - genetics | Genetic Vectors - chemistry | Signal Transduction | Antigens, Neoplasm - immunology | Cell Survival | Leukemia-Lymphoma, Adult T-Cell - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Gammaretrovirus - metabolism | Animals | Gammaretrovirus - genetics | NF-kappa B - genetics | Mice, Inbred NOD | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Index Medicus | Chimeric antigen receptor
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e64138 - e64138
Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to... 
THERAPY | SPECIFICITY | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | MALIGNANCIES | ADOPTIVE IMMUNOTHERAPY | TRANSPOSITION | Cell Proliferation | Antigen-Presenting Cells - cytology | Coculture Techniques | Humans | Mutant Chimeric Proteins - genetics | DNA Transposable Elements - immunology | Antigens, CD19 - genetics | Leukemia, B-Cell - therapy | T-Lymphocytes - transplantation | CD3 Complex - genetics | Interleukin-2 - immunology | CD28 Antigens - genetics | T-Lymphocytes - metabolism | Transposases - genetics | DNA Transposable Elements - genetics | Antigens, CD19 - immunology | Gene Transfer Techniques | Antigen-Presenting Cells - metabolism | Gene Expression | Immunotherapy, Adoptive - methods | Lymphocyte Activation | Hematopoietic Stem Cell Transplantation | Leukemia, B-Cell - pathology | Electroporation | Transposases - immunology | CD28 Antigens - immunology | Clinical Trials as Topic | Antigen-Presenting Cells - immunology | Interleukin-2 - genetics | T-Lymphocytes - cytology | CD3 Complex - immunology | K562 Cells | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Leukemia, B-Cell - immunology | Genetic Therapy - methods | Antigens | Immunotherapy | Genetically modified organisms | Transplantation | T cells | Gene therapy | Hematopoietic stem cells | Cell culture | Pediatrics | Propagation | Interleukin | Adoptive immunotherapy | Clinical trials | Stem cell transplantation | Lymphocytes T | CD28 antigen | Adoptive transfer | Infusion | Transposition | Lymphocytes | Manufacturing | Genetic modification | Deoxyribonucleic acid--DNA | Autografts | Medical research | Cytomegalovirus | CD19 antigen | Risk groups | Cloning | Zebrafish | CD3 antigen | T cell receptors | Gene expression | Transposase | Hemopoiesis | Children & youth | Plasmids | Biopsy | Antigen-presenting cells | Quality control | Stem cells | Umbilical cord | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Genome Research, ISSN 1088-9051, 07/2012, Volume 22, Issue 7, pp. 1231 - 1242
Journal Article
The Plant Cell, ISSN 1040-4651, 8/2006, Volume 18, Issue 8, pp. 1791 - 1802
Journal Article
Journal Article
Haematologica, ISSN 0390-6078, 2015, Volume 100, Issue 3, pp. 336 - 344
Journal Article