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Molecular Therapy, ISSN 1525-0016, 05/2017, Volume 25, Issue 5, pp. 1117 - 1124
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T lymphocytes to target chosen antigens. The targeting of CD19, a cell surface... 
genome editing | vectors | T cells | CAR | genetic engineering | immunotherapy | MEDICINE, RESEARCH & EXPERIMENTAL | ADENOSINE-DEAMINASE | REVERSE-TRANSCRIPTASE | ZINC-FINGER NUCLEASES | B-CELL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | IMMUNODEFICIENCY-VIRUS TYPE-1 | HUMAN T-LYMPHOCYTES | PERIPHERAL-BLOOD LYMPHOCYTES | RETROVIRAL VECTOR | ADOPTIVE IMMUNOTHERAPY | HEMATOPOIETIC STEM | Cell- and Tissue-Based Therapy - methods | Immunotherapy - methods | Leukemia - pathology | Lentivirus - immunology | Protein Engineering - methods | Humans | Mutant Chimeric Proteins - genetics | Antigens, CD19 - genetics | T-Lymphocytes - classification | Cell Engineering - methods | Lymphoma - therapy | Retroviridae - genetics | Lentivirus - genetics | Lymphoma - pathology | Receptors, Antigen, T-Cell - immunology | Leukemia - genetics | Antigens, CD19 - immunology | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - immunology | Lymphoma - immunology | Leukemia - therapy | Lymphoma - genetics | Retroviridae - immunology | T-Lymphocytes - cytology | Leukemia - immunology | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | CRISPR | Antigens | CD19 antigen | Leukemia | T cell receptors | Lymphocytes T | Genomes | Biology | Vectors (Biology) | Cell surface | Lymphocytes | Immunotherapy | Cell cycle | Physiology | Lymphomas | Genetic engineering | Manufacturing | Gene therapy | Tumors | Cancer | Review
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64138
Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to... 
THERAPY | SPECIFICITY | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | MALIGNANCIES | ADOPTIVE IMMUNOTHERAPY | TRANSPOSITION | Cell Proliferation | Antigen-Presenting Cells - cytology | Coculture Techniques | Humans | Mutant Chimeric Proteins - genetics | DNA Transposable Elements - immunology | Antigens, CD19 - genetics | Leukemia, B-Cell - therapy | T-Lymphocytes - transplantation | CD3 Complex - genetics | Interleukin-2 - immunology | CD28 Antigens - genetics | T-Lymphocytes - metabolism | Transposases - genetics | DNA Transposable Elements - genetics | Antigens, CD19 - immunology | Gene Transfer Techniques | Antigen-Presenting Cells - metabolism | Gene Expression | Immunotherapy, Adoptive - methods | Lymphocyte Activation | Hematopoietic Stem Cell Transplantation | Leukemia, B-Cell - pathology | Electroporation | Transposases - immunology | CD28 Antigens - immunology | Clinical Trials as Topic | Antigen-Presenting Cells - immunology | Interleukin-2 - genetics | T-Lymphocytes - cytology | CD3 Complex - immunology | K562 Cells | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Leukemia, B-Cell - immunology | Genetic Therapy - methods | Antigens | Immunotherapy | Genetically modified organisms | Transplantation | T cells | Gene therapy | Hematopoietic stem cells | Cell culture | Pediatrics | Propagation | Interleukin | Adoptive immunotherapy | Clinical trials | Stem cell transplantation | Lymphocytes T | CD28 antigen | Adoptive transfer | Infusion | Transposition | Lymphocytes | Manufacturing | Genetic modification | Deoxyribonucleic acid--DNA | Autografts | Medical research | Cytomegalovirus | CD19 antigen | Risk groups | Cloning | Zebrafish | CD3 antigen | T cell receptors | Gene expression | Transposase | Hemopoiesis | Children & youth | Plasmids | Biopsy | Antigen-presenting cells | Quality control | Stem cells | Umbilical cord | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 17 - 26
Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency.... 
adoptive T cell therapy | 4-1BB | chimeric antigen receptor | costimulation | T cells | adoptive T cell therapy | ACTIVATION | LIGAND EXPRESSION | CAR | EFFECTOR FUNCTION | GENE-EXPRESSION | FAS | DEATH | ANTITUMOR-ACTIVITY | NF-KAPPA-B | SIGNALING COMPLEX | CELL BIOLOGY | Neoplasm Transplantation | Humans | Mutant Chimeric Proteins - genetics | NF-kappa B - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Leukemia-Lymphoma, Adult T-Cell - immunology | Lentivirus - metabolism | fas Receptor - immunology | Cell Death | fas Receptor - genetics | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | 4-1BB Ligand - immunology | T-Lymphocytes - pathology | 4-1BB Ligand - genetics | Antigens, Neoplasm - genetics | Genetic Vectors - chemistry | Signal Transduction | Antigens, Neoplasm - immunology | Cell Survival | Leukemia-Lymphoma, Adult T-Cell - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Gammaretrovirus - metabolism | Animals | Gammaretrovirus - genetics | NF-kappa B - genetics | Mice, Inbred NOD | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Chimeric antigen receptor
Journal Article
Haematologica, ISSN 0390-6078, 2015, Volume 100, Issue 3, pp. 336 - 344
Journal Article
Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 701 - 707
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2017, Volume 25, Issue 5, pp. 1234 - 1247
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2013, Volume 190, Issue 5, pp. 2455 - 2463
Tumor angiogenesis plays an important role in the development of solid tumors, and targeting the tumor vasculature has emerged as a strategy to prevent growth... 
INHIBITION | NK CELLS | ANGIOGENESIS | MICROENVIRONMENT | ENDOTHELIAL-CELLS | GROWTH | CXC CHEMOKINES | IMMUNOLOGY | GENETIC-MODIFICATION | ADOPTIVE IMMUNOTHERAPY | INFILTRATION | Pore Forming Cytotoxic Proteins - genetics | Humans | Mutant Chimeric Proteins - genetics | Neovascularization, Pathologic | NK Cell Lectin-Like Receptor Subfamily K - immunology | Molecular Targeted Therapy | T-Lymphocytes - transplantation | CD3 Complex - genetics | Melanoma, Experimental - immunology | Injections, Intralesional | Biological Assay | Skin Neoplasms - blood supply | Nucleocytoplasmic Transport Proteins - immunology | Melanoma, Experimental - blood supply | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Nuclear Matrix-Associated Proteins - immunology | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Retroviridae | Mice, Transgenic | NK Cell Lectin-Like Receptor Subfamily K - genetics | Nucleocytoplasmic Transport Proteins - genetics | Animals | Melanoma, Experimental - genetics | Nuclear Matrix-Associated Proteins - genetics | T-Lymphocytes - cytology | Pore Forming Cytotoxic Proteins - immunology | Interferon-gamma - immunology | Skin Neoplasms - genetics | CD3 Complex - immunology | Cell Line, Tumor | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Primary Cell Culture | Genetic Vectors
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57838
Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses. Most infuse T cells genetically modified to express a... 
SPECIFICITY | PERSISTENCE | CD19 | EXPRESS | MULTIDISCIPLINARY SCIENCES | SINGLE-CHAIN FV | LYMPHOMA | B-LINEAGE LEUKEMIA | ADOPTIVE IMMUNOTHERAPY | CLONES | Antibody Specificity | Antibodies, Monoclonal - biosynthesis | Humans | Lymphoma, B-Cell - therapy | Mutant Chimeric Proteins - genetics | Antigens, CD19 - genetics | Adoptive Transfer | T-Lymphocytes - transplantation | Single-Chain Antibodies - genetics | Receptors, Antigen, T-Cell - analysis | Lymphoma, B-Cell - immunology | Receptors, Antigen, T-Cell - immunology | Antibodies, Monoclonal - immunology | Antigens, CD19 - immunology | Clinical Trials as Topic | Mutant Chimeric Proteins - analysis | Antibodies, Monoclonal - genetics | Animals | T-Lymphocytes - cytology | Single-Chain Antibodies - biosynthesis | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Receptors, Antigen, T-Cell - genetics | Single-Chain Antibodies - immunology | Care and treatment | Monoclonal antibodies | Physiological aspects | Development and progression | Genetic aspects | Research | T cells | Tumors | Pediatrics | Leukemia | Clinical trials | Leukocytes (mononuclear) | Lymphocytes T | Adoptive transfer | Lymphocytes | Immunotherapy | Peripheral blood mononuclear cells | Genetic modification | Deoxyribonucleic acid--DNA | Medical research | Antigens | Immunization | Immunoglobulins | CD19 antigen | Cloning | T cell receptors | Fv | Microscopy | Lymphocytes B | Plasmids | Antigen (tumor-associated) | Lysis | Gene therapy | Prostate | Cancer | Deoxyribonucleic acid | DNA
Journal Article