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Immunity, ISSN 1074-7613, 08/2012, Volume 37, Issue 2, pp. 223 - 234
Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous... 
IMMUNITY | MYCOBACTERIUM-TUBERCULOSIS INFECTION | MUTANT HUNTINGTIN | P62/SQSTM1 | ADAPTER | INNATE | KAPPA-B | IMMUNOLOGY | PROTEINS | HUNTINGTONS-DISEASE | CELL | Green Fluorescent Proteins | Phosphorylation | Mycobacterium bovis - immunology | Microtubule-Associated Proteins - genetics | Sequestosome-1 Protein | Humans | rab GTP-Binding Proteins - genetics | Serine - immunology | Autophagy - immunology | Phagosomes - immunology | Interleukin-1beta - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - immunology | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Phagosomes - drug effects | Heat-Shock Proteins - metabolism | Phagosomes - metabolism | Interleukin-1beta - immunology | Microtubule-Associated Proteins - antagonists & inhibitors | Serine - metabolism | Heat-Shock Proteins - immunology | Tuberculosis - immunology | Microscopy, Confocal | Autophagy-Related Protein 7 | Macrophages - metabolism | Animals | rab GTP-Binding Proteins - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Mice | RNA, Small Interfering | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Research | Universities and colleges | Macrophages | Oncology, Experimental | Cancer | Proteins | Antimicrobial agents | Microscopy | Kinases | Autophagy | Rodents | Index Medicus | Pathogens | BCG | Interleukin 1 | Phagosomes | Inflammation | Immunity | Organelles | Phagocytosis | membrane trafficking
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | Index Medicus | 309
Journal Article
Nature, ISSN 0028-0836, 10/2003, Volume 425, Issue 6961, pp. 973 - 977
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2012, Volume 8, Issue 11, pp. e1003016 - e1003016
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3981 - 3991
Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate complete regression of metastatic melanoma have been shown to recognize mutated... 
CD4+T CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | TCR | THERAPY | RECOGNITION | ANTI-CTLA-4 | MUTATIONAL LANDSCAPE | CD4(+) | ANTIGENS | BLOCKADE | Humans | Middle Aged | Neoplasm Proteins - immunology | Molecular Sequence Data | Male | Antigen-Antibody Reactions | Epitopes - immunology | Exome | Melanoma - genetics | Peptide Fragments - immunology | Adult | Female | Receptor, ErbB-2 - immunology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Transcription Factors - immunology | Amino Acid Sequence | Antigens, Neoplasm - genetics | DNA-Binding Proteins - immunology | HLA-A2 Antigen - immunology | Antigens, Neoplasm - immunology | Interferon-gamma Release Tests | Cells, Cultured | HLA-A1 Antigen - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Epitopes - genetics | Nuclear Proteins - immunology | Melanoma - secondary | HLA-A2 Antigen - chemistry | Algorithms | Genes, erbB-2 | Melanoma - immunology | Adolescent | RNA, Neoplasm - genetics | T-Cell Antigen Receptor Specificity | T-Lymphocytes - immunology | HLA-A1 Antigen - immunology | DNA, Neoplasm - genetics | Mutation | Antigens, Neoplasm - classification | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | T cells | Lymphocytes | Identification and classification | Health aspects | Tumors | Antigens | Peptides | Cloning | Melanoma | T cell receptors | Metastasis | Cancer therapies | Patients | Studies | Immunotherapy | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7385, pp. 400 - 404
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8744 - 8749
In animals and plants, pathogen recognition triggers the local activation of intracellular signaling that is prerequisite for mounting systemic defenses in the... 
Proteins | Oxidases | Pathogens | Enzymes | Phosphorylation | Reactive oxygen species | Calcium | Plant propagation | Protoplasts | Biochemistry | ANION CHANNEL | ABIOTIC STRESS | PATHOGEN | MULTIDISCIPLINARY SCIENCES | ROS signaling | RECEPTOR | IMMUNE | disease resistance | plant innate immunity | CA2 | ROS | RESISTANCE | ACCUMULATION | KINASES | Arabidopsis - enzymology | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Arabidopsis - immunology | NADPH Oxidases - immunology | Cell Communication - physiology | Enzyme Activation - immunology | Tobacco - immunology | Arabidopsis Proteins - metabolism | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Calcium-Calmodulin-Dependent Protein Kinases - immunology | Arabidopsis Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Plants, Genetically Modified - genetics | Plants, Genetically Modified - immunology | Plants, Genetically Modified - enzymology | Plant Immunity - physiology | Arabidopsis Proteins - immunology | Arabidopsis - genetics | Tobacco - genetics | Signal Transduction - physiology | Mutation | Plant Diseases | Enzyme Activation - genetics | Tobacco - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Arabidopsis thaliana | Physiological aspects | Research | Protein kinases | Plant immunology | Flowers & plants | Kinases | Gene expression | Cells | Index Medicus | Biological Sciences
Journal Article
PLoS Pathogens, ISSN 1553-7366, 02/2011, Volume 7, Issue 2, pp. e1001289 - e1001289
The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires' Disease. For virulence, L. pneumophila... 
CELLS | ACTIVATION | RECOGNITION | CYTOSOLIC DNA | MICROBIOLOGY | LEGIONNAIRES-DISEASE | IL-23 | VIROLOGY | I INTERFERONS | INFLAMMATION | GENE-EXPRESSION | INFECTION | PARASITOLOGY | Molecular Chaperones - metabolism | Virulence Factors - genetics | I-kappa B Proteins - immunology | NF-kappa B - immunology | Protein Biosynthesis - immunology | NF-kappa B - metabolism | Legionella pneumophila - genetics | Virulence Factors - immunology | Bacterial Proteins - secretion | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Legionnaires' Disease - immunology | Signal Transduction - immunology | Immunity, Innate - physiology | Bacterial Proteins - immunology | Legionnaires' Disease - microbiology | Membrane Proteins - metabolism | Toll-Like Receptors - metabolism | Legionella pneumophila - pathogenicity | Transcription Factors - immunology | Macrophages - immunology | Macrophages - microbiology | Legionella pneumophila - immunology | Legionnaires' Disease - genetics | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Bacterial Proteins - genetics | Cells, Cultured | Transcription Factors - genetics | Protein Transport | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | Bacterial Proteins - metabolism | Legionella pneumophila - physiology | Virulence Factors - metabolism | Mice | Mutation | Host-Pathogen Interactions - physiology | Immune response | Physiological aspects | Protein biosynthesis | Legionella pneumophila | Genetic aspects | Research | Genetic transcription | Health aspects | Proteins | Bacterial infections | Microbiology | Protein synthesis | Legionnaires disease | Bacteriology | Immune system | Index Medicus
Journal Article