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Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 614 - 625
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we... 
WILD-TYPE CONFORMATION | DNA-BINDING DOMAIN | RESCUE | ONCOLOGY | IRON CHELATORS | MUTATION | REDOX ACTIVITY | TUMOR-SUPPRESSOR | CANCER MUTANTS | RESTORATION | ANTITUMOR-ACTIVITY | CELL BIOLOGY | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Zinc - metabolism | Humans | Transcriptional Activation - drug effects | Structure-Activity Relationship | Mutation, Missense | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Cell Line | Cell Survival - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Chelating Agents - pharmacology | DNA - metabolism | Tumor Suppressor Protein p53 - drug effects | Gene Knock-In Techniques | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Alleles | Protein Conformation | Mice | Mice, Inbred BALB C | Tumor Suppressor Protein p53 - chemistry | Oxidative Stress - drug effects | Neoplasms - pathology | Care and treatment | Nuclear radiation | Oncology, Experimental | Research | Tumor proteins | Health aspects | Cancer | Antitumor agents | Lymphocytes B | Xenografts | Data processing | Drug development | Zinc | p53 protein | Apoptosis | Structure-function relationships | Tumors
Journal Article
Plant Biotechnology Journal, ISSN 1467-7644, 02/2019, Volume 17, Issue 2, pp. 319 - 321
A number of mutants with mutations affecting the DELLA domain that increase the abundance of DELLA by weakening the interaction with the GA‐GID1 complex are... 
CRISPR/cas9 | PROCERA | reduced GA sensitivity | dwarf | seed germination | mutagenesis | semidominant | gain‐of‐function mutant | gain-of-function mutant | MUTANT | GIBBERELLIN | RECEPTOR | PLANT SCIENCES | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRISPR | Seeds | Amino acids | Variance analysis | Suppressors | Mutants | Seedlings | Proteins | Leaves | Hydrogen bonds | Alleles | Pollen | Mutation | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus | Letter | cas9
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 03/2016, Volume 98, Issue 3, pp. 553 - 561
Journal Article
Circulation Research, ISSN 0009-7330, 06/2017, Volume 121, Issue 5, pp. 525 - 536
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1666, pp. 61 - 81
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7380, pp. 185 - 191
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2017, Volume 25, Issue 1, pp. 12 - 23
Journal Article